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Drosophila melanogaster detonator (dtn), transcript variant B,


LOCUS       NM_132072               9144 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_132072
VERSION     NM_132072.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 9144)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9144)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9144)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 9144)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 9144)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 9144)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 9144)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 9144)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 9144)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 9144)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 9144)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 9144)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 9144)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 9144)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 9144)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 9144)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 9144)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 9144)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 9144)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 9144)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 9144)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 9144)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 9144)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132072.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9144
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..9144
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="detonator"
                     /map="5E1-5E1"
                     /db_xref="FLYBASE:FBgn0262730"
                     /db_xref="GeneID:31555"
     CDS             235..4197
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="CG14446 gene product from transcript CG14446-RB;
                     CG14446-PB; dtn-PB; mRNA-like ncRNA in embryogenesis 2"
                     /codon_start=1
                     /product="detonator, isoform B"
                     /protein_id="NP_572300.2"
                     /db_xref="FLYBASE:FBpp0297993"
                     /db_xref="GeneID:31555"
                     /db_xref="FLYBASE:FBgn0262730"
                     /translation="MMRYCLIIALQLSLAYSVEVHFEAPDSGFFLKHARQPPVTPEIA
                     NVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQTVPARYIVPD
                     TMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRVLFHAGADPGGHLQ
                     RQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPP
                     KVPQRYAQVSYSVFEPPLRNPEQCEPKVQIQPLTTFAQVPLLAARTPYRMLRADDAVT
                     FLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILGATASTDQWSVSVE
                     KENPKHTTARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEVAEDTNDIVDGGKIVWS
                     VTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGR
                     QVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASV
                     IVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRRRKKRS
                     YVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSGRTSYFISRRTGLRV
                     TDLVQPLLRVADPKIASLKGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNL
                     SKLIVRVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPL
                     RDIAVEDYFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRR
                     GTLSSSKQNKSNAAPLASALASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDL
                     ADIIVGIPLRDSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLL
                     TAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTN
                     AHDWVWLGRSTIDRQSIVAETNTHLNPRDSRMRITSNPIVNYDNGRRVSSFDQQPKLQ
                     THIVPASNLNKQHADHYLANERKDNALDYKPPVPPHRNVGARACLPVQPVLGTGSVKD
                     AAPNKRHSQLYRREHLQNSDSNANSQQSTPQPNQQLPTERPHPLAQAHPHPHPHQHQR
                     SHSHSHNFSQEPLIKAAHNKIKQQQQQQQQQQHEELHNAEKLVEYTNPHQKNAFQFDS
                     LTPKRVTKAAASSPATPSTSAVQGKAKENHSMASSTGDAANSNGTDEIIRLPASAVSQ
                     EPTTKSSRVKRATVVGNPMFSATVDESVAPGERLGLDDLDMDYEQIMHYFDNLKESNA
                     "
     misc_feature    286..744
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, N-term; Region: TMEM132D_N; pfam15705"
                     /db_xref="CDD:464813"
     misc_feature    1552..2622
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Transmembrane protein family 132; Region: TMEM132;
                     pfam16070"
                     /db_xref="CDD:465003"
     misc_feature    2875..3180
                     /gene="dtn"
                     /locus_tag="Dmel_CG14446"
                     /gene_synonym="CG14446; CG14446 CES; Dmel\CG14446;
                     lincRNA.S8753; MRE2"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, C-term; Region: TMEM132D_C; pfam15706"
                     /db_xref="CDD:464814"
ORIGIN      
        1 ataaaggatg tgctgcggat tgctgagcga gaaaaaagga cgaaaagtgc tagccagcgc
       61 gaattaacgg ttgacttttg gcacgattaa cggaataacg gtcaaataag ccacacaagc
      121 gagagaacag tgaaaataac gaaagtgcgg gcacagttaa ttagcaaatt aacgagtggg
      181 tgggcacagg atttcaggat ttcgatatat tttggattcc tgcacacgaa caagatgatg
      241 agatactgcc tcataattgc tttgcagctg tcgttggcat actccgtgga ggtgcacttc
      301 gaggcgccgg acagcggctt ctttctgaag cacgcccgcc aaccacctgt gacgccggag
      361 atcgccaatg tgcagacatc ctcggcggtg ccgccgttac ggcaacgatc ctcctatgat
      421 tccgtgttat ctctggacag attcactgtg gtcgagacca cgcagccggt gtccatacgc
      481 gccagctatg gaccgttttc cacgaaacaa acggtgccag cccgctacat tgtgccggac
      541 acaatggaca gccagtcggg cgattatatg aacaatgcca ctctactgga gctccagcag
      601 ccaaatatgc acctggacat atccgcccat ttggttcgct ccagtgtatc gcaggatgct
      661 cccgtgcttc gggtactatt ccacgccgga gccgatccgg gtggtcattt gcagcgccag
      721 aaggtctgtg tactcctgca cgtggcgatg ggttcggagc agccgctcaa aggacgctgc
      781 atgccggagg gcgaggacgg tgtctgcgta gccgaagtgg tcgtgcccct gggctggtgg
      841 ccccagctgc cggcgcccac acaagatggc agtggtcagg cgccacccaa agtaccgcag
      901 cggtatgccc aggtctcgta cagtgtcttt gaaccgcctt tgcgtaatcc cgagcaatgc
      961 gagccgaagg tgcagatcca accgttgacc acattcgccc aggtgccttt gttggccgcc
     1021 aggactccct atcgtatgtt gcgcgccgat gatgccgtca cctttctcct gccacaacat
     1081 ccgctgtatc cactctcccg tctacatgtg cccgtctttt tacatcaata tcccgatcag
     1141 cgggtggccg ccttcactgt gagagctcgt gttaaggcgg gcttaaagat tctgggcgcc
     1201 accgcctcca cagaccaatg gagcgtttct gtagagaagg aaaatcccaa acacactacc
     1261 gctcgcgtta ctgctttccg caaagaggcc gaatccagtc tggaaagtgg tggcaaccta
     1321 accagcgagg tgtttgaagt attctcatgg ctgctcgagg tggccgagga caccaatgat
     1381 attgtggacg gtggcaagat tgtgtggtcc gtgacgcatg tctatgacac gccaaaggac
     1441 aaggattccg gggaactggt tatacccgat gacaacaaga agcgactaat tgccaagctg
     1501 gagatcaaca aggatgacat tcaggcggtg ctaccgatgg ccaaaatctg ggaggtgatg
     1561 aacacggcgg tgctaacggg cagacaggtg gcccaggcga tgaaggtgtt catcgtttcg
     1621 caggcaggca aggtggccga tgtgacgcta cagagctcct gtcacgccga agatgaaagt
     1681 gtaatcaagg tctcctcctc ctgcagctct gtttatgtgg atggctccga gcagcgcggc
     1741 tcatccaatg cctcggtcat tgtcaagtat ggcacctatg tgggcgtggc caagttcatc
     1801 gtttggatgc ccgagtttcc gctggaagtt tacatatccg atttccgtct ctcccaaatc
     1861 aaaggatgga aagtaaccga tgacaatcac tatctacaca acaagcagtc tcgtcgaaga
     1921 aagaagagat cctacgtttg gggtcagcat ggaacgaact actataacaa tctgggagcg
     1981 gacaagacga tttgtcgcgc tcgctaccag caaagtcccg tggaggtgta tgccaagttc
     2041 ctggccgtgg accagaactc tggacgcacc agctacttta tctcacggcg tacaggctta
     2101 agagtgacgg atctggtgca accgctgctc cgtgtggccg atcccaagat cgcatctctg
     2161 aagggtcgaa ttctgcaggg caagtccatg ggacgcaccg atgtccaggt cctgtcaccc
     2221 ataacgggtc gagtaattgg caccaaggaa atccgtgtgg gcagcgacaa ggtgaacctt
     2281 tccaagctca tcgtgcgcgt tatttcgggt ctgcagctta ccatcagtcc ggacaacacg
     2341 attgagaacg gctacctggc ggagacttct gtcacacaca agctaactgc tcagtaccag
     2401 gagggattgc ttgacatcga tctggagttt accgatggct ccaaaactcc tttgcgagat
     2461 attgccgtgg aggactactt cctgctggtg gagagtttgg ataccgaggt ggtggcattt
     2521 gctcccatgc tggcttccca tcatccacgt gtcatagccg tcggcgaggg caatggtaac
     2581 ctgctgcgcg tgacccttct attatccgag gaatgccgtc agcgacgtgg cacgttgagc
     2641 agctccaaac agaacaaatc gaatgcagca ccattggcca gtgcattggc atctattgaa
     2701 gtggatttca acaatgtgga tatcgtgagc aagcaggagg ctatccaaaa tgatggcact
     2761 gtgggcaggg agagaaagaa ctataggcaa acaggagatc tggccgatat tatagtgggc
     2821 atccccttga gggactccag ccagctgtac gagcctactg ttcaggcgcg tcagcatcgg
     2881 ggcagcattc aggcggttca taagggtcat catggcaagg gactagctgg cacaggcacc
     2941 atgaccacca tggaactggg catgtacgtt ctgctcacgg cgttctgctt cgcaattatt
     3001 gtgtttgtga tctcttgcgt tgtgtatgcc tccaaatttc ggccagcaat gattgaatct
     3061 ggcttggatc ctctgtcggc gggcaagagc aatggttctg gtggatcggg tggcttccgg
     3121 gatgtgcgcc tgaaggagtc gacaacgaat gcacacgatt gggtctggct gggacgctcc
     3181 accatcgacc gccagtccat tgtggccgag accaacacgc atctgaatcc gagagattcc
     3241 cgcatgcgca tcactagcaa tccgattgtc aactacgaca atggacgccg tgttagctcc
     3301 tttgaccaac agcccaagct gcagacacat atcgtgccgg cctccaatct aaacaagcag
     3361 cacgccgacc actatttggc caacgagcgc aaggataatg ccctggacta caagccacca
     3421 gtgccgccgc acaggaatgt gggcgctcga gcctgcctgc cggtacagcc tgtgctcggt
     3481 actggatctg taaaggatgc ggcacccaac aagcgacaca gtcagctgta cagacgtgag
     3541 catttgcaga acagcgatag caatgccaat agccaacagt cgacaccgca gccgaatcag
     3601 caattgccaa cagaacgccc acatccactg gcccaagccc atccacatcc tcatccacat
     3661 cagcatcagc gcagccatag ccatagccac aacttcagtc aggagccact cattaaggcg
     3721 gcgcacaaca aaatcaagca gcagcaacaa caacaacagc agcagcaaca cgaggagctg
     3781 cacaacgccg agaagctggt ggagtacacg aatccgcacc agaagaacgc gttccagttc
     3841 gattcgctga caccaaagag agttaccaaa gcagccgcgt cctcgccggc aacgccgtcc
     3901 acatcagcag tccagggcaa agctaaagaa aaccatagca tggccagcag cactggggat
     3961 gcggccaact caaatggaac ggacgagatt ataaggctgc cagccagcgc cgtcagccag
     4021 gagcccacca cgaaatcgtc gcgtgttaag cgcgccaccg tggtgggcaa tccgatgttc
     4081 tcggccaccg tcgatgagtc tgtcgccccc ggagagcgtc ttggcctgga cgatctcgac
     4141 atggattacg agcagatcat gcactacttt gacaacctaa aggagtcaaa tgcctgagta
     4201 caggagatca ttgctaaaat tcgcgagata ttgtcgacgt tccatcaccg atatcaaacg
     4261 gttgccacgc ccctgacctc gcccactcga cagcagatgc agctgctcga cgaactggtc
     4321 gccggcgtgg caacggccac agccatcacc gcagccaagc caacaccatt ggtcctggat
     4381 ggtggagagg gagacgagtc ggctgatgca ttcgatgcct acgatggagc gttggacatc
     4441 gagagcaggc agttctagac gtcatcctgg cacacatcta aacgcaattc tagcaataac
     4501 ccccccactc agtactctaa aagcaaacct taaggccgtt ccatcaactc cgaaaagaat
     4561 ccatgctgtg gtcgagcaag gcagcccgga aacggacttg gtcagccgag cataggggca
     4621 aggcaaaagg agataagtcg atggataaac atatttattg ctaggctaag ttcatattta
     4681 aagcatacac ctataggcat atgtaaacgt ggagatataa tccaagtgta tctcgaggag
     4741 cgcgtgcctg acacaatcgg aatcgacggg caagcatata tagtatacaa ctatctatat
     4801 ctctgtaact gtaactgtat ctgtatctgt atcagtatct gcataagtac tatggtgtag
     4861 ttaaggatca gccatctaaa gcatagctta atccagacat ttttttccat tctcttcgct
     4921 tcacacacac gcatccttag ataatgtcgc atgtcccatc tgtctggttc gattcaactt
     4981 ttctatatat atatttatat atattcagac gatctctgcc cgatcttgca tatcctatat
     5041 cttactctct gttgtgtctg tgcgagtgtg agtgtgagtg cattttgcgt gcgtgtgtgt
     5101 gtgtgcgtgc gccagagaaa gtgagataga gagagagaga gagcgagcga gagcgaaagt
     5161 gagggagaca gcgacagaga gaagttaaga gaaagaggag agtttccaaa atgtgccggg
     5221 caccgctccc aaaagtcgct agaacttaaa aactgaataa tatacatgct atacacacgt
     5281 atatataaat atatatatat atatatttat gattatatag cgcgcgctaa aatttaaagc
     5341 aaatcaaagg ataatccaaa atgctacatt gtgtaaaatg gaaacttgaa cagaaatcgt
     5401 cgctttataa gttggcaatc gaagcccaat acctaatacc aatcataaat cgagaaacct
     5461 agaaagaaac acacaacaac acacaccaca cagatcacaa atcacagatc acaaataata
     5521 tatagacgct tatgagcttt atttgatcga ttgcattgaa aaggaagcag ctaaaagcag
     5581 aacagaaccc caaaaaccga atcacaaaga agtagcgggg aaatgtgtaa ccaaatatta
     5641 tatgatatta ccgagcgatc caagctttat ataacaaatt taccatattt atagcatacg
     5701 tgcatattta ttaccattat tattattacg attattatta ttatcttgtc ttacgattat
     5761 cattatcatt actgtattta ttaccaacga gaaaaggaac aagtgcaaaa ttacttcaaa
     5821 ctcaagtcga gaagctttga atagcgaaat tagccacgaa tcgaggacac acctgtaaca
     5881 cgcaaggata aatcaaatgc cacgtccttt cccccaactt acgcctctct atatacagat
     5941 atatatatat atatatatat atatttgatt atatattcat ttacttgtgt gtcacaatag
     6001 cgcggaagga gattctacgt taatttttga aattgtaatt gcatctgttc gttttcctta
     6061 taaaagttgt aagaatttat catagcaccc gaaagctact tcattccatt agcaaatcat
     6121 atatgtagcc actaaatgcg tttttgtctt ctttcgtttc tgtgtaagtc tgtttaattt
     6181 cgttcgtaag atcctgtagc tatgcataag tgtctcatcc gattagttta tattttagag
     6241 gccatctaag tattatgttc gtttctctca ttgtttcata atcatatgtt gtaaattgtt
     6301 ccgtccaaaa aaaaaaaaaa aaaaatatga aatgagaaac aaaaaaacaa aacaaaagct
     6361 gaatgaaacg ataaacaaaa gcaaacgaaa ctaagcaaat gcaaatgcaa atgccgaagc
     6421 aaaagcaaag caaacaattg taaaacgaaa ttaagcaatc tatatctcat tttttgtaag
     6481 gctccaaacg aggcccacaa tgaagcgcac gaatgcattg tttgtaaact aaatttgtag
     6541 tccttgtcag acgctcggac atctagtgca ctgtatactg tacataacgt gttgaaagtg
     6601 cagtgcgttt cgcggccata aggcagacga cgggctggga aataagatga agagtctttg
     6661 aattaactga aatagatctc gacttggtct tatagcacgc aaacgcactg taccgtatta
     6721 ttatacttag tcctgagttg ctccctatcg atctaaggac tgcaaagaca cacgcctaca
     6781 tcaaggacac atcactggac acatcctgtt gatttcgacc tgtaatatca ttagcatata
     6841 gtactagatg caattgcctg ttgtccctga catatccccg atcctagtcc gcacaagcca
     6901 atcgaaacat acaccaacac accacacaca ctctcagtcg agctgcactg ccattggtga
     6961 aagtgaaaat gagatttagg cctattgaag cttccagcat ttaccagtgc cataacttta
     7021 taactttata taactttacc cgcacgccca gcccagccca gtatgccgat caatccgatc
     7081 gattgatctc ggctagcatc gagcttagca ctagctttct tccgagcttg cttgttggac
     7141 agacagtgag aacgaacgaa gagacatcag cctccatcca ttaaagaact tagtcttagc
     7201 cgatctggag tccaaaattt cattggaaat tccgccatgc ggatcggaac cacctagtga
     7261 aaattgtaat ggcgtgaggc gattgatgac tattagcatt tttaatctag acaaatgctt
     7321 ggcttcaatt cgcggatcgg cttaatcctt cttgtacttg tatgtatgtg tttaacgatt
     7381 ccaatgcaaa gacttttata tatctttttt ttttaaacta aatatatata tatacatata
     7441 tacgtataca cccatatatt agattgtaca ttattgttta gcatgtttcg actgcaattt
     7501 aagccgaatt ttagatcttc tctagtcagt tcaaagcgtt ttttgttcgt tttgtcacgc
     7561 ccatcataca cacacacgca tacacaccaa cacaaacaca ctcatagttt tatatagtca
     7621 aggcaagctt ttaacgcccc ctgccacgcc ccctgccacg cccccgcccc taaacctaag
     7681 ctgtatgtac ttgtatgtaa tatcgaaaca cacaaaagca acaaaaaaaa tcacaaaaga
     7741 acatgaaaag aatgcacttc aaatatgaaa acaattcaaa atgaaactct tgattttttt
     7801 ttcgaaccca ttgaaacttg gaaattcatc gatttatata gttaataata ctacctatat
     7861 cgtgctaaac aaaaaaggcg ccggctaagt gtaatgcaaa ctaaaaacat aaaaagcaaa
     7921 acatatgcat atgaaatata atcgaaaaat tatacaaatg ctaagaaaaa ggagaatcac
     7981 aaaagttgtt tatgctgctt tttgcaaaaa aaaaaataat tgaaaatgaa aatgaaaacc
     8041 ggaaaattag gctatactta aatatacata caaattaaat acgtatatgt ttaaattgaa
     8101 tataaatgag tgtgtacgct tggcacaaaa agtaaaccaa aaccataaac aatccaaaaa
     8161 gagaaaaaaa aaaacgaaac aaaaaaaaag caagaaaaat aactaattac gctaaggagc
     8221 agaagaatcg gagtaattcg gaaaactact atacgaatct aatgttttgc catgtaagtt
     8281 ctatgaatgt cccacctgcc tgatgtcccc gcttcaagaa aatgcctaga tgcaatccac
     8341 acctcccccc cccccccaag ctacccgctg atttgcaccg cccctcccaa ctacccaaca
     8401 cctcgccaag gtcgttgggg aatttttgtg cgatgtagtg tacttctatg tccatcgatc
     8461 cgccgcataa ttgttaacat ttgtatcggt tattaacgta gttgttgtgt atgtatgtat
     8521 gtaagtatgt aaatgtgtgc ttacccccaa tgccagcgcc cacgccccgc ccccgctccc
     8581 cttcgccaac cctgagaaaa taacgattac gattaacggt aaagatagcg atactcaatt
     8641 cttgttgtta ttggcagcgc atgtcttttt aagagctagt gatatatgat ttatcctcga
     8701 ttcttctccc aaaaatcaga cgttttttag caagcaaaac cacacacaca cacacacacc
     8761 atatacacac ccaaacacac acacactagg acacaagaga gtgatctcca cgaaatgctt
     8821 atattactat atagtatata cacacccata tataaacagc gtataaagat tataaaagta
     8881 tatatatata tataaatcat accaattgta taacaccact ttcgagcagt gaaattccaa
     8941 aaccctatca tcatatagaa gacgatcaaa tccaaatgag acgtacactt ttgcttgctc
     9001 ctcagttcca tcaatcagtt caatgccgat ccttccgatc gttgagtcct tgtttatcat
     9061 ccaacaccga aaaccaaatc gaatccatca taacgaggcg aaacgaaccg aatcgaatcg
     9121 aaacgaaatg aaattaaatg ttgc