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Drosophila melanogaster biotinidase (Btnd), mRNA.


LOCUS       NM_132070               1907 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_132070
VERSION     NM_132070.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1907)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1907)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1907)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1907)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1907)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1907)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1907)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1907)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1907)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1907)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1907)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1907)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1907)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1907)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1907)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1907)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_132070.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1907
                     /gene="Btnd"
                     /locus_tag="Dmel_CG3599"
                     /gene_synonym="Btd; BTD; CG3599; CT12113; Dmel\CG3599"
                     /note="Biotinidase"
                     /map="5E1-5E1"
                     /db_xref="FLYBASE:FBgn0029848"
                     /db_xref="GeneID:31552"
     CDS             34..1695
                     /gene="Btnd"
                     /locus_tag="Dmel_CG3599"
                     /gene_synonym="Btd; BTD; CG3599; CT12113; Dmel\CG3599"
                     /EC_number="3.5.1.-"
                     /EC_number="3.5.1.12"
                     /note="CG3599 gene product from transcript CG3599-RA;
                     CG3599-PA; Btnd-PA"
                     /codon_start=1
                     /product="biotinidase"
                     /protein_id="NP_572298.1"
                     /db_xref="FLYBASE:FBpp0070843"
                     /db_xref="GeneID:31552"
                     /db_xref="FLYBASE:FBgn0029848"
                     /translation="MKSIQLSFLLLSVLFSSSHQLSKPEDPTYTAAVVEHSQPVGDSP
                     RARTTSASESFQKIIREVGDVDIIVFPEHILNSQATATFVPHESQNITPCYQTDYELF
                     LIELSCSARANHLYVVINVVEKELCAHGAGSDTYNPCPSSGVRYFNTNVVFDRRGRIV
                     SRYRKTHLWRHEYVSTSVLRSPDISIFRTDFGVTFGHFICFDMLFYDPAMKLVKEHKI
                     TDIVYPTYWFSELPFLGAVQLQEGWAFGNDVNVLAADASNPDGRTSGSGIYAGRGGRL
                     VAEIFEQPTTKLLIAEVPKREHGQLAPTFTPIFEPQRKTQRLTGLATYRDNNVDIFES
                     ELLDDDFLSFERQLCHGSFCCTFSIERKVTSAAENELPSSGAKSYRYRIGVYWGNETT
                     VIGVDRTEQATCALFACTDVRLASCGYIYPENEEVINTHHFTKLSISGNFPAAPRGRR
                     LIMPSSLNALFLPVSVSDYEWIESPEAANNLDKTILVDLKLAKAQNDLLTFAIWANYY
                     TDIPSTHNLDHMQPNGTQSNPSTSASSTVSAFWILCVLNCFISVL"
     misc_feature    118..957
                     /gene="Btnd"
                     /locus_tag="Dmel_CG3599"
                     /gene_synonym="Btd; BTD; CG3599; CT12113; Dmel\CG3599"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(247..249,526..528,538..540,547..549,631..636,
                     640..645,709..711)
                     /gene="Btnd"
                     /locus_tag="Dmel_CG3599"
                     /gene_synonym="Btd; BTD; CG3599; CT12113; Dmel\CG3599"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(247..249,526..528,631..633)
                     /gene="Btnd"
                     /locus_tag="Dmel_CG3599"
                     /gene_synonym="Btd; BTD; CG3599; CT12113; Dmel\CG3599"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(529..540,544..546,568..576,634..636,640..654,
                     661..666,727..732,736..744,748..753,823..828)
                     /gene="Btnd"
                     /locus_tag="Dmel_CG3599"
                     /gene_synonym="Btd; BTD; CG3599; CT12113; Dmel\CG3599"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1006..1566
                     /gene="Btnd"
                     /locus_tag="Dmel_CG3599"
                     /gene_synonym="Btd; BTD; CG3599; CT12113; Dmel\CG3599"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
ORIGIN      
        1 ttttggcatt tggatttcgg ccgacgttcc attatgaagt cgattcaatt gagttttcta
       61 ctcttgtcag tgctcttcag cagttcgcat cagctttcca agccggaaga tccaacctat
      121 acggcagcag tggtggagca cagccagcca gtgggcgatt ctccgcgtgc acgcaccacc
      181 tcagcttcgg aatcctttca aaagatcatc cgtgaagtcg gcgatgtgga catcatagtg
      241 tttcccgagc acatactcaa tagtcaggcc acagccactt ttgtgcccca tgagtcgcag
      301 aacataacgc cctgctacca aacggactat gagctcttcc tcatcgagct atcctgctcg
      361 gcgagggcta accacctgta tgtggtcata aacgtggtgg agaaggaact gtgtgcccat
      421 ggagctggtt ctgacaccta caatccttgt ccatcgtctg gcgttcggta cttcaacaca
      481 aatgtcgtgt tcgatcgaag gggcaggatt gtctcgcgtt acagaaaaac ccatttgtgg
      541 cgacacgagt atgtctcgac atcagtgctc cgatctccgg atatatccat ctttaggaca
      601 gactttggcg taacctttgg tcatttcatc tgcttcgaca tgttgttcta tgatccggcg
      661 atgaaattgg tgaaggagca caagatcacg gacatcgtgt atccaaccta ttggttctcg
      721 gaattgccat tccttggcgc tgtacaactc caagagggtt gggcatttgg taatgatgtt
      781 aatgttctag ccgcagatgc cagtaatccc gatggacgca cttccggatc gggtatctat
      841 gcaggacgcg gtggccgatt ggtggcggag attttcgagc agcccaccac taagttgctg
      901 attgcggagg tgccgaagag ggaacatggc caactggcac ccacttttac gccgatcttc
      961 gagccgcaga ggaaaacgca aagattgact ggcctggcca cgtaccggga taataatgtg
     1021 gatatattcg aaagtgaatt gttggacgat gattttctga gtttcgaacg ccagttgtgc
     1081 catggcagct tttgctgtac cttctccatc gaacgaaagg tcaccagtgc cgcggagaac
     1141 gagttgccct ccagtggggc caagtcatat cgctatagga tcggcgtcta ctggggcaac
     1201 gagaccaccg tcattggcgt ggatcgcacg gagcaggcaa cttgtgcact ctttgcctgc
     1261 acggatgtgc gtctcgcgag ttgtggctac atctatccgg agaacgagga ggtcatcaat
     1321 acgcatcatt tcaccaagct gagtatctcg ggcaattttc cagctgctcc acgtggccga
     1381 cgattgatca tgcccagctc cttgaatgct ctatttctgc ccgtttcggt ttccgattat
     1441 gaatggattg aatcaccaga ggcggcgaat aatctagaca agacaatatt ggtcgatttg
     1501 aaactagcga aggcacagaa cgatctgcta acctttgcca tttgggccaa ctactacacc
     1561 gatataccca gcactcacaa cttggatcac atgcagccga atggaactca gtccaatcct
     1621 tcgacttccg catcctcgac agtttcggca ttctggattt tatgtgtcct caactgtttc
     1681 atcagcgtat tatagattac tagttggaaa tacgttagcc cgttcacttt ctgactcaaa
     1741 tgttatattt agtcagattt tttttttttt ttgcttatct gaacaccaaa ataaatgtag
     1801 agcaaccaaa attttataac tcctcataag aacgaaatgc ctcactaagc cagagtaata
     1861 aaagttttgt agattttaaa tttttcaaat ttaaagaaac tgaaggc