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Drosophila melanogaster integrator 6, transcript variant A (IntS6),


LOCUS       NM_132025               5733 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_132025
VERSION     NM_132025.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5733)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5733)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5733)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5733)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5733)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5733)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5733)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5733)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5733)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5733)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5733)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5733)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5733)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5733)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5733)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5733)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5733)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5733)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5733)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5733)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5733)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5733)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5733)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_132025.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5733
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5733
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="Integrator 6"
                     /map="5B4-5B6"
                     /db_xref="FLYBASE:FBgn0261383"
                     /db_xref="GeneID:31496"
     CDS             560..4414
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="CG3125 gene product from transcript CG3125-RA;
                     CG3125-PA; IntS6-PA"
                     /codon_start=1
                     /product="integrator 6, isoform A"
                     /protein_id="NP_572253.2"
                     /db_xref="FLYBASE:FBpp0070806"
                     /db_xref="GeneID:31496"
                     /db_xref="FLYBASE:FBgn0261383"
                     /translation="MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQR
                     TQDCLGDRYMLLTFEEPPANVKAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLL
                     NLNRMQSGIDTYGQGRCPFYLEPSVIIVITDGGRYSYRNGVHQEIILPLSNQIPGTKF
                     TKEPFRWDQRLFSLVLRMPGNKIDERVDGKVPHDDSPIERMCEVTGGRSYRVRSHYVL
                     NQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTISGMGISSTSGAGPAPDI
                     VFQPVKKMIYVQKHITQKTFPIGYWPLPEPYWPDSKAITLPPRDAHPKLKVLTPAVDE
                     PQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFELPFGYLKAAPNFS
                     QVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALVN
                     INVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYR
                     QVETGKLFTGAPLRRDLVRHPLLRDIFSKLHGEIDPVENYTIVVPQPTHQSSAKSHRN
                     PFDIPRRDLVEEIAKMRETLLRPVSLVAKDSGHCLPIAEMGNYQEYLKNKDNPLREIE
                     PTNVRQHMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGP
                     GPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPL
                     PRSFEFRRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADGGPSSSCF
                     DEDSNSNSSFVSSTSEASASDSGMSNSHLDPLRISFVFIEEETSDQDTPLNGYVHNFI
                     NGISDDAETGETEAVPGGASLPGASSANEPSSIGASPAVSATPATSVIPASNGSEVCS
                     AVAAGSSSSISSSASSPGVLYVPLNGLTTHAAYSSNLGGPSSPLDNLSSLGGAAGGGG
                     SGLLGVSKPGSLPLANGYGHGHSSAISPPSPLSLVPLSPLGTSTPAASSSGLSSSSAY
                     FSHNDINDASEISRILQTCHNGTSSGSSVGAGASNSNLNGNGSTESGGGVSSDDHASL
                     GGNSFDALKRTAGTAGSTAAGNPHYYWASGLNHHNNNNSSAAGAASGSTLSNNHNHRG
                     HNNSSPNKLEVKINSSCGSSPTHNNGGMGSPGQSLPLIFTEEQREAARLHNVELRLQI
                     FRDIRRPGRDYSQLLEHLNLVKGDQDMQSDFVDMCIVESLRFRRHRMASSIQEWWDRK
                     QQLTAVGTNEATPSAEQAVAKS"
     misc_feature    569..952
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="von Willebrand factor type A domain; Region: VWA_2;
                     pfam13519"
                     /db_xref="CDD:463909"
     misc_feature    4145..4327
                     /gene="IntS6"
                     /locus_tag="Dmel_CG3125"
                     /gene_synonym="CG3125; Dmel\CG3125; Int6; l(1)G0060"
                     /note="INTS6/SAGE1/DDX26B/CT45 C-terminus; Region:
                     INT_SG_DDX_CT_C; pfam15300"
                     /db_xref="CDD:464626"
ORIGIN      
        1 caaatcattc gaactttgag aacggtagtg ttgtgttgtt attgctcggc agcaaagtaa
       61 aatccgaaga gaagcgagtc gaacaagaga agaagaagcg caggagtgga cgacagcaat
      121 gcaacaacag tgacgaggcg ccagtgtgca aaagtatgtg tgcgagtgcg tgtaagcaac
      181 aactccccga tacaaaccta cgagcgagag ggggacggcg atagcgacgg tcgttcggtc
      241 ggtcggtccg accgctagtc gcgtctgtcg gtcgttctcg cctatgcacc tcggcggcag
      301 agcgaaagag agcgcactct ggctgtgtgt gtgcgtgtgt gttctcgctc tctcgcgcgg
      361 tggtgataaa tttctgttgg cacaaagtaa aaatataaca gaataaaaaa tcgtggcgcg
      421 gcatatagaa gctaatcgaa aattattgcg agtattgggt ggaggagaaa cattcctctt
      481 cttgatatca gagagagacg gaaagacacg caaattggga agaggaagag gtccctcgaa
      541 cgcaggatca atcatcgcca tgacaatcat actcttcctg gtggacactt cgtcgtccat
      601 gtgccagaag gcgtatgtga atggggtaca gaaaacgtat ctggacattg ccaagggagc
      661 cgtggagacg tttctcaagt atcgccagcg tacgcaggat tgcctgggag atcgctacat
      721 gctgctcaca ttcgaggagc caccggcaaa cgtgaaagct ggatggaagg agaaccatgc
      781 caccttcatg aacgagctga agaacctaca gagtcacggc ctcacctcga tgggtgaatc
      841 gctgcgcaat gcgttcgatt tgttaaatct gaatcgcatg cagtcgggca tcgatacgta
      901 cgggcagggc aggtgcccgt tttatctgga gccatcggtc atcattgtga ttacggacgg
      961 cggtcgctat tcgtaccgga atggtgtcca tcaggagatc atactgccgc taagtaacca
     1021 aataccgggc acaaagttta ctaaggagcc atttcgctgg gatcagcgct tgttttcgct
     1081 tgtcctccgc atgccgggca acaagattga cgagcgagtg gacggcaagg tgccgcatga
     1141 cgattctccc atcgaacgga tgtgcgaggt aaccggcgga cgttcatatc gagtgcgaag
     1201 ccactacgta ctcaaccagt gcattgaaag tcttgtccaa aaggttcagc ctggtgtggt
     1261 gctgcagttc gagcctatgc tgcccaagga ggctacttcc gctaccgctg gcgaagcggc
     1321 gggtgcgagc acgatatccg gcatgggaat atcctcaacg tccggagcgg gtcccgctcc
     1381 cgatattgtc ttccagccgg taaagaagat gatctacgtg cagaagcaca tcacgcagaa
     1441 aacctttccc atcggctatt ggccactgcc ggagccctat tggccggact ccaaggcgat
     1501 tacattgccg cctcgcgacg cacatcccaa gctgaaggtc ctgacgccgg cggtggacga
     1561 gccacagctg gtgcgcagct tccccgtcga caagtacgag attgaaggct gtccgttaac
     1621 gctgcagatt ctcaacaagc gcgagatgaa caagtgctgg caggtgattg tgaccaatgg
     1681 catgcatgga ttcgagctgc cctttggcta cctaaaagcg gcgcctaact tttcgcaggt
     1741 acacctctat gtactggcct acaattatcc agcgttgctg cccattctgc atgacctcat
     1801 tcacaagtac aatatgagtc cgccgagcga tctgatgtac aaattcaacg cctatgtgcg
     1861 ttcaataccg ccgtattact gcccgttcct gcgcaaggcg ctggtcaaca tcaatgtgcc
     1921 gtatcagctg ctgcagtttc tgctgccgga gaatgtggac aactatctgt cgccaacgat
     1981 cgccaatcag ctgaagcaca tcaagaatac ggccaagcag gatcaggaga atctttgcat
     2041 gaaggtgtac aagcagctga agcagccgaa gccaccatat cgccaagtgg agacgggcaa
     2101 actgttcaca ggtgcgccgt tgcgcagaga tttggtgcgg catccactgc tccgggatat
     2161 attttccaag ttgcatgggg aaatagatcc cgtggagaat tatacgattg tggtgccgca
     2221 gccaacgcat cagtcgtcgg ccaagtcgca tcgcaatccc ttcgatatac cgcggcggga
     2281 tttggtggag gaaatagcca agatgcgtga gaccttactg cgacccgtct cgctggtggc
     2341 caaggactcg ggccattgcc tgcccatcgc cgagatgggc aactaccagg agtacctcaa
     2401 gaacaaggac aatccgctgc gtgaaatcga gccgacgaat gtgcggcagc acatgttcgg
     2461 taatccgtac aagaaggaca agcacatggt gatggtggac gaggcggatc tgagcgatgt
     2521 ggcgccaatg aagtcgccaa atggcaatgg accgggtgga gcgccgcccg gctcaccttc
     2581 cggatcgggc tcgcccactg gaccgggtcc ctcatccccg ggctcttcgc ccggcggtgg
     2641 ttcgggtccc gggatgcccg gaatgccggg aatggggggt ggaatgtcag gactgatgct
     2701 gggcgcaggt ggcagtggcg gatcctctaa aaaactggac ggaacgtctc gtgggcgaaa
     2761 gaggaaagca ggaccgctgc cacgtagctt tgaattccgt cgatcatcta cggactcgcg
     2821 atcttcgagc tccggctccg aatcatcaac aacgggtagt gcaccaggat caccgatacc
     2881 aggcgccacg tcatccatat ccggctgcga ttccgccatg ggcgctgatg gcggtcccag
     2941 ttccagctgt ttcgacgagg acagcaatag caacagcagc tttgtgagct ccacatcgga
     3001 ggcctcggcc agtgattcag ggatgtcaaa ctcgcatttg gatcccttgc gaatcagttt
     3061 cgttttcatc gaggaggaga ccagcgatca ggatacgccg ctcaatggtt atgtgcacaa
     3121 tttcatcaat ggcatcagcg acgatgcaga aacgggcgaa acggaagcag ttccaggcgg
     3181 ggcatccctg ccgggtgcgt cttcagctaa cgaaccgtcg tcaattggag catcaccagc
     3241 agtttcagcc acgccagcaa catctgtgat ccccgccagc aatggcagcg aagtttgctc
     3301 cgccgtcgcg gccggcagca gcagttccat cagctccagc gccagttccc cgggcgttct
     3361 ctacgtgccc ctcaacggac tgaccaccca tgcggcctac agcagtaatc tgggtggtcc
     3421 gagctcgccg ttggacaacc ttagctccct gggtggagcg gcgggtggcg gaggatcggg
     3481 actactcggt gtcagcaagc cgggatcgct gccactggcc aatggttatg gacacggtca
     3541 tagttcagcc atttccccac cttcgccatt gtccttggtg cctctatcac cattgggaac
     3601 aagtacgccc gctgccagca gctcgggact atcgtctagt tccgcctact tcagccacaa
     3661 tgacatcaac gatgcctcgg agatctcgcg catactgcag acctgtcaca atggaaccag
     3721 cagtggctcc tcggtcggag cgggcgcaag caacagcaat ttgaatggca atggcagcac
     3781 ggagagtggc ggaggagtct catccgacga tcatgcctcg ctgggtggca acagtttcga
     3841 tgccctgaaa cggacagcgg gtactgcggg cagcactgca gcgggaaatc cccactacta
     3901 ctgggccagt ggtctcaatc atcacaacaa taacaacagc agcgccgctg gagcagctag
     3961 cggttcgacg ttgagcaaca atcacaacca ccggggtcac aacaacagca gccccaacaa
     4021 actggaggtg aagatcaact ccagctgcgg ctcctcaccg acgcacaaca acgggggcat
     4081 gggctcaccg ggacagagcc tgccgctcat tttcaccgag gagcagcgcg aagcggcccg
     4141 gttgcacaac gtcgaactac gattgcagat cttccgtgat atacggcgac ccggccgaga
     4201 ctacagccag ctgctggagc acctgaatct ggtcaagggc gaccaggata tgcagtcgga
     4261 tttcgtggac atgtgtatcg tggaatcgct gcgcttccgc cgccatcgca tggcgtccag
     4321 catacaggag tggtgggatc gcaagcagca gttaactgcc gtgggaacca atgaagcgac
     4381 ccccagcgcg gagcaggccg tcgccaagag ttaacgatgg ctcatgtggc accactgagc
     4441 ccgcggggtc atccaatcca tctgtctgtg atgtcaacaa aatcgaaatc gaaatctaaa
     4501 ccgaaactgg gaaggggaag agcagccgcg gaagccaaga attctcgtca atttccatat
     4561 actgtaaata attgccagga caggtagccc acaggatctg gatggggatc aacgcatacc
     4621 aaacaagcaa caataatatt aacaatttcc atatactgta aataattgcc aggacaggta
     4681 gcccacagga tctggatggg gatcaacgca taccaaacaa gcaacaataa tattaacaac
     4741 aaaaccaaca agcagccaca attctaaatg agagaaaaca ccacattttt agggcaagct
     4801 agctacatgt aattataaca tatatataaa taaatactta agctagccgt tagttagcaa
     4861 tagaatataa agtataaagc gaagggattt tgtagcagcc gtttcagttg tagttttttt
     4921 tttacttagt ataaatatgt aagcgtaaat taaaatttac tcttgagctt aggaataatt
     4981 ttaaatagac ttagataaat taagataaat ctaagtgtag tgtatgtgta taaaaaaaaa
     5041 gggaaaagtt taggaaaagc ttgagcttaa tgagccccac acgttttagc caattttttg
     5101 ttggacctgt ttcaagaaca ctttgctttg attttagcca aaacgaatag agaacgtaaa
     5161 aaacaaaagc gatgaccctt caaaaacaga tatatatgtg tatgtttata tacatatatg
     5221 tatatagagg atattacata aatcgggtca gcgttttatt attaaaaaga attgtattac
     5281 cttgtatttc cttgaatcct ccaatatatt atttgctatt atgttatgtt tattttataa
     5341 aatatttatg cgaattgtaa tgtgagcata gcctgtagaa aggcagacaa aacgataagc
     5401 gaaaacgtac agtttgttat atacatatag aaaaacaaga aaaaagtaat acatttttgc
     5461 actatttttt tacgtgtatg tttgtatgca tggcctgtga gtaattgaga tataacaaaa
     5521 acgaaaaaca caaagagaaa acgtttacta gtagttaggc ggcgggcagt gttttagaac
     5581 tgcttcatta ttaaataatg atgtacaatt tagagtctgc gtatttaaca aatttcataa
     5641 gacaaccacc acaacagaat caacagagca gcagcaaagc aaactgaaat caatacgaaa
     5701 tcaaacgaaa ataaaaagag gagcattgca ttc