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Drosophila melanogaster ADAM metallopeptidase with thrombospondin


LOCUS       NM_132019               3920 bp    mRNA    linear   INV 26-DEC-2023
            type 1 motif B (AdamTS-B), transcript variant B, mRNA.
ACCESSION   NM_132019
VERSION     NM_132019.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3920)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3920)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3920)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3920)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3920)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3920)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3920)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3920)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3920)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3920)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3920)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3920)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3920)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3920)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3920)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3920)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3920)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3920)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3920)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3920)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3920)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3920)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3920)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On May 8, 2012 this sequence version replaced NM_132019.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3920
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3920
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif B"
                     /map="5B1-5B1"
                     /db_xref="FLYBASE:FBgn0029791"
                     /db_xref="GeneID:31490"
     CDS             730..3801
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /EC_number="3.4.24.-"
                     /note="CG4096 gene product from transcript CG4096-RB;
                     CG4096-PB; AdamTS-B-PB"
                     /codon_start=1
                     /product="ADAM metallopeptidase with thrombospondin type 1
                     motif B, isoform B"
                     /protein_id="NP_572247.2"
                     /db_xref="FLYBASE:FBpp0290305"
                     /db_xref="GeneID:31490"
                     /db_xref="FLYBASE:FBgn0029791"
                     /translation="MTCSRMWIRSRWLGLLLHYWLVVVTQGGGVRPLYGLHSDELVAG
                     EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANE
                     TLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTC
                     AGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKS
                     GSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQ
                     QKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFHRDLNG
                     YLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQ
                     HKLNKGSEKDPHHHDVAILITRKNICANNCMTLGLANVGGMCKPKQSCSVNEDNGIML
                     SHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHF
                     LDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFC
                     STLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVRREELAAVNGGWGDWSEWSECS
                     RSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDN
                     VSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGIC
                     KKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARH
                     ILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITI
                     PQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQFQWRLSNWTACSASCGGGV
                     QHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCR
                     PVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPAEMEPCESSLPICRTK"
     misc_feature    868..1314
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    1669..2283
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...; Region:
                     ZnMc_ADAMTS_like; cd04273"
                     /db_xref="CDD:239801"
     misc_feature    order(2095..2100,2107..2109,2125..2127)
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="active site"
                     /db_xref="CDD:239801"
     misc_feature    2329..2535
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="ADAMTS cysteine-rich domain 2; Region: ADAMTS_CR_2;
                     pfam17771"
                     /db_xref="CDD:465496"
     misc_feature    2569..2727
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    2743..3033
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="ADAMTS cysteine-rich domain; Region: ADAMTS_CR_3;
                     pfam19236"
                     /db_xref="CDD:437068"
     misc_feature    3037..3387
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="ADAM-TS Spacer 1; Region: ADAMTS_spacer1;
                     pfam05986"
                     /db_xref="CDD:461796"
     misc_feature    3430..3597
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    3604..3789
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
ORIGIN      
        1 tgtatttgca cgatatcttt tcacccgcgc tgcttgtgcc tcgcttccca cagagagccg
       61 ctgtgaaaat acatattagg gaaaacgctg caaagccggg aaaaacggaa acgccagttg
      121 aaagtgtgga caatacgaca gttttcctta gatccttacc agcaccagtt acagacttcg
      181 ctgcaataca gctagagcaa aaaaaaagaa actcggcttg tgagtgtgtg tgtgtgccag
      241 tgcgtgtgtg attgactcga atttcaaatc gtaatattgg agttttcgaa aacgcgtctt
      301 ttgctttttt tactgccctg ttttgggtat ttatatatat atattttttt tttacctgtg
      361 cctgcgaacc tcggttcgcg acttgtgaaa tcatcggcca tcggccattg ttgtgaaaga
      421 gcggctgtct gggcctgggt tctcctacct ggcgctataa tcgccgcccc taaatgaaat
      481 aataaaaaaa taaataagaa taacaataaa gctaaactgc tgccgacggg cttttgcttt
      541 tgtttgcggt taaaatattt gcgggcttca ccagcggcgc ctctcggaat tggattccag
      601 ttcgaattcg gaatcgcgag cgctgatctc ctgaccagcc caagatccgt attatgcgac
      661 cgctgccatg ctgctgagac aacgcctgga taacggctag ggctgtggac taggatcggg
      721 ttgaggagca tgacgtgcag caggatgtgg atcaggagtc gctggctggg cctgctgctc
      781 cactattggc tggtcgtggt tacgcaaggc ggtggcgtac gtccgcttta cggactccat
      841 tccgacgaac tggtggcggg tgaggggcag ttggtggtgc cacgacgcgt tcatcccgat
      901 ggtgcgttta tgacccacca attggagtac gcacacgaac tggatcatcg gcggcatcgg
      961 cagaggcgca gcctgaactc ggaacacgat acccaggcgg cggacctgca tctgctgttg
     1021 ccgctggcga acgagacact gcatctggag cttatggcgc acagctactt tctggccccg
     1081 aatctggtgg tggagcgcca ccggcgggat ctgcgcactc ggtcaccgtt gacaacgcgg
     1141 cacctcaact gtcacttcca tggaaaggtg cgcggccaac cggccaccaa tgtggccatc
     1201 tccacatgcg ccggactggt gggtcacatc cggacggcag gcaatgagta cttcattgag
     1261 ccctcgaagg agcacgagcc gcatccggtc aacgggcatc cgcacgtggt cttccagcgc
     1321 tcctccgtca aaccgaagca ttcgttgcga aagcgaaaca agcgcaagcg gggcggcaaa
     1381 tcgggatccg gagccgaggt cagcaattgc ggcacgcggg agccacgccg tcgaatggag
     1441 acgagactgg agtggcaggc caggggcaag gtgaaggtcc agggaggccg tcaaattagg
     1501 cgccaccatc accaccacca ccatcatcat cacaagcaca agtaccgcca tcatcagcag
     1561 aaaatcagca gagttccgca caccaagttc aagtacgaga cgcagttcca aacggagccg
     1621 gatcacgcag agattccccg gcgcaggcga tccatcagca gtccacggca tgtggagacg
     1681 ctcatcgtgg ccgatgccac catgtcggcg tttcacaggg acctcaacgg ctatctgctg
     1741 accatcatga acatggtgtc cgcattgtac aaggatccca gcattggcaa ctccatcgag
     1801 atcgttgtgg tgcgcattat ccaactggac gaggaggagt cccagctcca gctgaatctc
     1861 acgcagaatg cgcagaagaa cttggatcgg ttctgcagtt ggcagcacaa actgaacaag
     1921 ggcagcgaaa aggatccgca tcaccatgac gtggccattc tcatcacgcg gaagaacatc
     1981 tgcgccaaca actgcatgac tctcggcctg gccaacgtgg gtggcatgtg caagccgaag
     2041 caatcgtgca gcgtgaacga ggacaatggc atcatgctct cgcacaccat cacccatgaa
     2101 ctgggccaca acttcgggat gttccacgat acggcgaaga tcggctgcca tccgcgcgtg
     2161 ggtcccattg tgcacatcat gacgcccact tttggggcgg acaccctgca ggtttgctgg
     2221 tcgaactgca gccgcaagta tatcacacat ttcctggatc agggattggg cgagtgcctg
     2281 gacgatccgc cgacgccctt ggatgagtac aactacacgg gcgagctgcc gggcatgcga
     2341 tacaatgcga ggggccagtg ccgcctgcag ttcaacttga ccacggacag cgaggtgggc
     2401 gcctgttccg ccccccacga attctgctcg acgctgtggt gcaaggtcaa cggcgagtgc
     2461 gtcacccaca tgcggcccac agcgccgggc acattgtgcg gtcggaacaa gtggtgccag
     2521 aacggcaagt gcgtccgacg cgaggagctg gcggcggtca acgggggatg gggcgattgg
     2581 agcgagtgga gcgagtgctc gcgaagctgc ggcggcggcg tgtccacgca gcagcgggaa
     2641 tgcgacaatc cggtgccggc caatggcggt gtcttctgca ttggcgaacg gaagcggtac
     2701 aagatttgcc ggaagcggcc gtgtccggcg gaggagccca gtttccgggc gcagcaatgc
     2761 gctcggttcg ataatgtcag ctaccagggt gccacctaca agtggctgcc cttcttcgat
     2821 aagaataatc cctgcaagct gttctgcagc gatgtggacg acacgataat cgccaactgg
     2881 ggcgccacgg tgctggacgg gacaccctgc accttgggca cgaacaacat gtgcatcgac
     2941 ggcatctgca agaaagttgg ttgcgattgg atcgtcgact cggaggtgca ggacgatcgg
     3001 tgcggtgtct gcggcggttc tggcgatcag tgccagccgg tgagggagac ctacacggat
     3061 ccgtttgccg ccaaggatgg cgcctatgtg gaaatcgtca ccataccggc acgggcgcgg
     3121 cacattctca tccgcgagct ggccaattcg ccgcactttc ttgccattgc cacgggcgac
     3181 ggcggggatc gattctattt gaacggggat agcctcatct ccatgcccgg cgagtttgag
     3241 atcgctggcg ccgagagcct ctacgatcgc gtcgacgagc aggagaccat cacaatacct
     3301 cagcccatcc agcattccat atcgttatat gcgattgtgc gcggcaatga gagcaacgct
     3361 ggcattttct acgagttcac cctgcccgca ctgaatgtga ccgctggcag gcagttccag
     3421 tggcgcctga gcaactggac cgcctgctcc gccagctgcg gcggtggcgt gcagcaccgt
     3481 gagcccatct gccaggagaa cggcaaggcc ttgggtgata cgctgccctg ctggacgcac
     3541 gccaagaaca agagaccggc ccggcaatcg cgaggatgtg gcgaccagcc atgtcctgcc
     3601 cactggtggc caggtccttg gcaattttgt ccggtcacct gtcgtccagt tggatttgtg
     3661 gcgccacctc agcgccggcg atccgtcgtc tgtctggacg aacacgatgt ggtggtggcc
     3721 gatgccgaat gtggtcacct gcagaagccg gcggaaatgg agccctgcga atcctcgctg
     3781 ccgatctgca ggaccaagta gcacaggaca cactccctat ttattgacgc caccgaagga
     3841 tcagtgcgtt gttatggaac atatttattc agcgagtaag cgatcatccc agatgtactt
     3901 aactaactat acgcacgcac