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LOCUS NM_131953 1760 bp mRNA linear INV 26-DEC-2023 transcript variant A (Pdha), mRNA. ACCESSION NM_131953 VERSION NM_131953.5 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 1760) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1760) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1760) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 1760) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 1760) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 1760) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 1760) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 1760) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 1760) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 1760) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 1760) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 1760) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 1760) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 1760) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 1760) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 1760) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 1760) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 1760) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 1760) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 1760) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 1760) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 1760) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 1760) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_131953.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..1760 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..1760 /gene="Pdha" /locus_tag="Dmel_CG7010" /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1" /note="Pyruvate dehydrogenase E1 alpha subunit" /map="4C14-4C14" /db_xref="FLYBASE:FBgn0028325" /db_xref="GeneID:31406" CDS 208..1407 /gene="Pdha" /locus_tag="Dmel_CG7010" /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1" /EC_number="1.2.4.-" /EC_number="1.2.4.1" /note="CG7010 gene product from transcript CG7010-RA; CG7010-PA; Pdha-PA; l(1)G0334; PDH complex; pyruvate dehydrogenase; lethal (1) G0334" /codon_start=1 /product="pyruvate dehydrogenase E1 alpha subunit, isoform A" /protein_id="NP_572181.4" /db_xref="FLYBASE:FBpp0070676" /db_xref="GeneID:31406" /db_xref="FLYBASE:FBgn0028325" /translation="MLRTLSRVSELPIIVKQLQKNAAQAGVSKTNNYATEATVQVNRP FKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETAAGNLYKEKIIRGFCHLYSGQE ACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMY APNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLW KLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINY VNTHGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLIT TDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRGTIAYDIDHIQ ERKGVNH" misc_feature 307..1353 /gene="Pdha" /locus_tag="Dmel_CG7010" /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1" /note="Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629" /db_xref="CDD:470272" misc_feature order(481..483,637..639,712..717,808..810,814..825, 832..834,844..846,856..858,901..912,952..954,1102..1104, 1114..1116) /gene="Pdha" /locus_tag="Dmel_CG7010" /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1" /note="tetramer interface [polypeptide binding]; other site" /db_xref="CDD:238958" misc_feature order(571..576,712..714,718..720,802..813,892..894, 898..900,1090..1092) /gene="Pdha" /locus_tag="Dmel_CG7010" /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1" /note="TPP-binding site [chemical binding]; other site" /db_xref="CDD:238958" misc_feature order(697..699,703..705,709..711,724..726,733..738, 745..750,754..759,766..768,823..828,844..849,856..858) /gene="Pdha" /locus_tag="Dmel_CG7010" /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1" /note="heterodimer interface [polypeptide binding]; other site" /db_xref="CDD:238958" misc_feature order(1075..1095,1099..1131,1156..1164) /gene="Pdha" /locus_tag="Dmel_CG7010" /gene_synonym="CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1" /note="phosphorylation loop region [posttranslational modification]" /db_xref="CDD:238958" ORIGIN 1 caaacggttg ttatagttgt gcaatatagt agttgataaa ctaatctcgc tacctttttt 61 tccgattgtt taacttacaa cgacgcgcgg cggtgcgact gagacaccag atatatagcg 121 tgcgattcta gatccggaca atccgcatat agaaagcccc cattcacatc caatttctgt 181 cagtcgaacg agaataacac agcgaaaatg ttgcgtactc tgtcacgcgt tagcgaattg 241 cccattattg ttaagcaact gcaaaaaaat gcagcccaag caggtgtttc gaaaaccaac 301 aattatgcca cggaggccac cgttcaagtg aatcggccct tcaagctgca ccgcctggac 361 gaaggacccg ccacggaagt gaagctgacc aaggatcagg ccctcaagta ctacacacag 421 atgcagacga tccgtcggtt ggagacggcc gccggtaatc tgtacaagga gaagatcatt 481 cgcggcttct gtcatctgta ttccggccag gaggcatgcg ccgttggcat gaaggcggcg 541 atgcgggatg tggacaacat catctcggcg taccgtgtcc acggatggac ctacctgatg 601 ggcgtctcac ccagcggcgt actggctgag ctcaccggtg tccagggtgg ctgtgcccgc 661 ggcaagggtg gctccatgca catgtacgca ccgaacttct acggaggcaa tggcatcgtg 721 ggtgctcaag ttcctttggg tgccggcgtt ggcttggcct gcaagtacaa gggcaatggc 781 ggcatgtgcc tggccctcta cggtgatggt gccgccaatc aaggacaggt gttcgaggct 841 tacaacatgg cctacctgtg gaaactgcct gtgatctttg tctgcgagaa caacaactac 901 ggaatgggca ccagttctga gcgtgcttcc tgcaacactg attactatac ccgcggcgac 961 gctctgcccg gaatctgggt ggacggcatg gatgtgctgg ccgtgcgcag cgccaccgag 1021 ttcgccatca actatgtgaa cactcacgga cctttggtga tggagacgaa cacgtaccga 1081 tactctggac actccatgtc cgatccgggc acatcgtacc gcacacgcga ggagatccag 1141 gaggtgcgcc agaagcgtga tcccatcacc tccttcaagg agctgtgcat cgagctgggt 1201 ctgattacca ccgatgaagt taaggccatc gatctgaagg tacgcaagga ggtcgacgag 1261 gccaccgcct tcgccaagtc cgatgccgag ctgggcgtga gccacctctg gacggacgtg 1321 tactccaaca atctggagcc caagctgcgc ggcaccatcg cctacgatat tgatcacatc 1381 caggagcgca agggcgtcaa tcactaagtc atcgggccaa cgaatctgat tcgggaactc 1441 acaagaacct taaacgaaac aagaaaaccg aacagcaaac acaaatcact gacagacaga 1501 caagaagaca caataactca gaaacttgga cacaagcgaa atctctagat cataagccga 1561 aagttgaacg atgagaaccc cgtagaacgg aacggatccg aagagaccca caaaaagctt 1621 agctaatcgg agcactccaa ccacacatcg tagcgcacca cataactctg gggtactgca 1681 ttggatatta tattgcgaac gtgttcaata aggataaagc gaggtgtaaa ttgttgaaaa 1741 tataaaaatc tagaaaaatt