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Drosophila melanogaster echinus (ec), transcript variant B, mRNA.


LOCUS       NM_130722               6863 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_130722
VERSION     NM_130722.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6863)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6863)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6863)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6863)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6863)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6863)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6863)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6863)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6863)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6863)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6863)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6863)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6863)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6863)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6863)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6863)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6863)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6863)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6863)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6863)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6863)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6863)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6863)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_130722.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6863
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6863
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="echinus"
                     /map="3F2-3F3"
                     /db_xref="FLYBASE:FBgn0000542"
                     /db_xref="GeneID:31339"
     CDS             587..5827
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="CG2904 gene product from transcript CG2904-RB;
                     CG2904-PB; ec-PB"
                     /codon_start=1
                     /product="echinus, isoform B"
                     /protein_id="NP_570078.2"
                     /db_xref="FLYBASE:FBpp0111713"
                     /db_xref="GeneID:31339"
                     /db_xref="FLYBASE:FBgn0000542"
                     /translation="MSAHSGRRMTTPGTLYRLASGSAATPATPTNSPYGQPAKPYAVG
                     SIQNGSERNRILELLRAPNSLTSPTLEPSSKGLLNGPGQNNCFLNCAVQVLWHLDAFR
                     RSFRGLNQHVCGGQDCIFCALKELFQQLQTSSEPALCPEPLRRALASGPLAGRRFPLG
                     CLGDAAECFELLLHRVHSHISPDDGDSCESSACIAHRRFAMRVIEQSVCKCGANSEQL
                     PFTQMVHYVSASALTSQKSLALQSHQQLSFGQLLRAAGNMGDIRDCPNTCGAKIGICR
                     ALLNRPEVVSIGIVWDSERPAADQVHAVLKAVGTSLRLGDVFHQVSEPRWAQQTQHEL
                     VGIVSYYGKHYTTFFFHTKLKVWVYFDDANVKEVGPSWEGVVDKCSRGRYQPLLLLYA
                     VPQQPTVGNGVGIGHVDVAMPASAPSIAGSVVRRAVTPSPEKPSLGNTRRAITPTPLR
                     TPPNDYQNLSVIQKNIFPSNLAMGTDETDAYISRKTVEHVLSAQYQNLSVIQDKIGGG
                     NGVGVGQQSVDKDGGFLSRKPIEAVLSAQLARRQHLQLQRSHSAESSSGHASSNGSSP
                     PSDGLTMPEHLNQPRRRDSGNWSGDRNSASSASSTTLDNPYLYMVAKRGVAAVPQSPT
                     RHGLPYDPGYDSFSLSSTDSYPPKHALNPQLAKIPEAAMGVVPNGGAMPHGHGNGQLA
                     LSGDCEKLCHEADQLLEKSRLVEESHDLETALVLCNAAAGRARAAMDAPYSNPHTMTF
                     ARMKHNTCVMRARSLHRRILVEKGAETEAMPELKHMREGSTSSVKHVRQNSKDRTLEK
                     EQQQLQFQQIQQIQQIHQIQQQIPASIEIYATLPKRKSPLKALASASACDDNAIEYEQ
                     EKQLATSPGKPERESRSLFGRKDKEKEKRSRSEDRNKLTREFSLTETLLVNAKDTLKK
                     HKEDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRKNRSMPDLTEAVDDSTANAGITHHP
                     HYPAQGVTTAGTLLGTSVDDSAVGLGKHGHGMSGYISEGHFDYSGSGSASNSGAGSNP
                     NPNLERSKLMRKSFHGSGRQLTMVPKVAPPPPMRTSSTLTPQQQQQQQQQFHHEANLS
                     NLSAMSSNTSISEDSCQTIITTCAQVHSEQSPLKDLQMLVAQDELPLPPPMELPPYPS
                     PPHSSCHSRQASEDFPPPPPPELDLEPLNQQLSQLQALEAASKQQRQQLESLEGTTSI
                     LAQLQQRQHLLKLRKEQANHPGAATTDATWLKELQAKQANDLRAMQRKLEASSPSSVR
                     DLTHRFEQTSIRSYASQELLSQPGQSQQLGQLRTQMNGLPNGNAKMDVDEVDAMPAVR
                     NSLPAALSAHQLLPKPKYEMTQSQIAEEIREVELLNTMVQQTLNQNGAAALPKRVKKK
                     SVSFCDQVILVATAGNEEDDDFIPNPILERVLRTAQHPNEKVTAQMIQQQQQNMMRLQ
                     TEAQPRQQQVQQLQQPSPMLGRPAGATADMQRYVQRMQQQQQQQQQQQQQQQQQQQQQ
                     QQQQQQQQQQQQQHQELYRQQQLHRTSMSGIASQQHLQQLDAQYTTMPRPLHHSQLGS
                     YSVTLQKHQQLQQQQQQQQQQQAPQQLSLGYFSNGSVATSEQVPLPSPYQRVPLPHGY
                     QPAAAGPYYPLPNAQQHLQQQQLMAKPVQKKVSFEPGTKGEADCLPPPPPPPQKNGLP
                     ETGSAGSGHPGAAPGASGAGGTTSAGITAIPTRVYNNAIVKASAKAVECNLCRKRHVI
                     APAVYCTNCEYYLQMLNQRR"
     misc_feature    812..1699
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    <5735..>5803
                     /gene="ec"
                     /locus_tag="Dmel_CG2904"
                     /gene_synonym="CG2904; Dmel\CG2904; Ec; EG:EG0002.3;
                     Q1W9Q0"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; Region: C1; cl00040"
                     /db_xref="CDD:412127"
ORIGIN      
        1 ggtttgtttt gattcatagc ggctgccctg actttgtttg catttgctga cagtgtcttt
       61 gcatttgcat ttgcgcagtt gccacacagt tgtgtttttg ttgacgtgcg cgtgtgtctt
      121 tgatagtttg tttgtctttg cgaggccaaa ccactagttg ctggatggct tttgcctgtt
      181 ttgccaaaaa aaaaaaaacc aaaccgcgat tgcaaacctg aataatgaag atgaagatga
      241 aaaataaata gtggccgagt tgagtttgtt tttgtgtgtt tgctgagttt tttgagtttt
      301 tgttcaagtg aaagcgtgtg aaaagtggcc aactctcggt ccaaagccct ctcgcactct
      361 cttttggctc tcttttggca agggaattta taatatacaa taaactcaag accagacatc
      421 caccgatatc cagcgatatc cagcgatatc catatcctgc cttgcggcca gccgaaaact
      481 tccggtcaac atgcaaccgc aattgttgca tagccgcagc ctccgccctt cattgccacg
      541 atctccatca tcatattagc cacaggtgta gccagctcag tttttgatgt cagcccacag
      601 tggacgcaga atgaccacgc cgggcacact ttatcggttg gccagtggct cagctgccac
      661 accagccacc cccacaaaca gcccttatgg gcagccggca aagccatatg cggtgggttc
      721 aatccagaac ggatcggagc ggaatcgcat tctggagttg ctgagagcac ccaatagctt
      781 gacctcgccc acgctggagc cctcctctaa gggactactc aatggacccg ggcagaacaa
      841 ctgctttctc aattgtgccg tacaggtctt gtggcacttg gacgcctttc gacgatcgtt
      901 tcgcggccta aatcagcacg tatgcggtgg ccaagactgt atcttttgcg ctctaaagga
      961 acttttccag cagctgcaga ccagttctga gcccgccttg tgcccggagc cactgcgtcg
     1021 ggctttggcc agtggtccat tggctggacg gcgattccca ctcggctgct tgggcgatgc
     1081 agccgaatgc ttcgagctcc ttctccaccg cgtccactcg cacatttcgc cggatgacgg
     1141 cgactcctgc gaatcctccg cctgcattgc ccaccgaaga ttcgccatgc gcgtcatcga
     1201 gcagagcgtc tgcaagtgcg gagccaattc ggagcagctg cccttcaccc agatggtgca
     1261 ctacgtctct gcctcggctc tgacctccca gaaaagtctg gcactgcagt cccatcagca
     1321 actgagtttt ggccagcttt taagggccgc cggcaacatg ggcgacatac gcgattgtcc
     1381 gaacacctgc ggcgccaaga ttggaatttg tcgtgcgctg cttaaccgac cagaagtggt
     1441 gtccattggc atcgtttggg actctgagcg accggcggcg gatcaggttc atgccgtcct
     1501 aaaggcagtg ggcaccagcc tgcgtctggg tgacgttttt caccaggtca gcgagccacg
     1561 atgggcccag cagacccagc acgagctggt tggcatcgtt tcctactacg gcaaacacta
     1621 caccaccttc ttcttccaca cgaagctcaa ggtgtgggtc tacttcgatg atgcgaacgt
     1681 taaggaggtg gggcccagtt gggagggcgt ggtggacaaa tgcagccggg gaagatatca
     1741 gccactcctg ctgctgtacg ccgttcccca gcagcctacg gtgggcaacg gcgtaggtat
     1801 cggtcacgtg gatgtggcca tgccggcgag tgctccatcg atagctggct cagtggttcg
     1861 cagggcagtt acgcccagtc cggagaagcc cagcttgggc aacacaagga gggccatcac
     1921 ccccactccg ctgaggacac cacccaacga ctatcagaac ctgagtgtga ttcaaaagaa
     1981 tatctttccg agcaatctgg caatgggtac ggatgaaacg gatgcctaca ttagccgcaa
     2041 gacggttgaa catgtgctga gtgcccagta ccagaatttg agcgtaatcc aggacaagat
     2101 tggaggcggc aatggagtcg gtgtcggcca acagagtgtg gataaggatg gaggctttct
     2161 gagccgaaag cccattgagg cagtgctgag tgcccaactg gcgcggaggc agcacctcca
     2221 gcttcaacgc agccacagtg cggagtcaag ctccggccac gcctcctcca acggcagttc
     2281 tccgcccagc gatggactga ccatgccgga gcacctgaat cagccacgtc gtcgcgactc
     2341 gggcaattgg tcaggcgatc gaaacagcgc tagttcggcc agttccacga cgctggataa
     2401 tccctacctg tacatggtgg ccaagcgggg tgtggcagca gtgccacaga gccccacgcg
     2461 acatggtttg ccatatgacc cgggctacga ttcgttttcg ctaagctcca cggactcata
     2521 tccgccgaag catgcgctaa atccacagct ggctaaaatc ccggaagcag ccatgggcgt
     2581 cgttccaaac ggaggagcaa tgccccatgg acatggcaac ggacagctgg ccttgtctgg
     2641 ggactgcgag aagctgtgcc acgaggcgga ccagttgctg gaaaagtccc gactggtgga
     2701 ggagtcacat gatctggaaa cagccctggt gctctgcaat gcggctgctg ggcgggcacg
     2761 agccgctatg gatgccccgt atagcaatcc gcacacgatg acctttgccc ggatgaagca
     2821 caatacttgc gtgatgcggg cccgtagtct gcaccggcgg attctggtgg agaagggagc
     2881 tgaaacagag gctatgcccg aactgaagca catgcgcgaa ggaagcacga gtagtgtgaa
     2941 gcatgtgcgc cagaatagca aggatcgcac gttagagaag gagcagcagc agctgcagtt
     3001 ccagcaaata cagcagatcc agcagattca tcagatccag cagcagatcc cagccagcat
     3061 cgaaatatat gccacgctcc cgaagcgcaa gagtcctctg aaggccttgg cctctgcgtc
     3121 tgcgtgcgat gacaacgcaa tcgagtacga gcaggagaag caactggcca ccagtccggg
     3181 aaaaccggag cgcgagagtc gctcgctgtt cgggcgcaag gacaaagaga aggagaagcg
     3241 gagtcgcagc gaggatcgca acaagctaac ccgtgagttc tcgctcaccg aaacgcttct
     3301 agtgaatgcc aaggatacgc tgaagaagca taaggaggac aaggacgaga agaaggagaa
     3361 ggacaagagc ggcaaaaagc agcacaaaat cagacgcaag ctgttaatgg gcgggctcat
     3421 tcgtcgcaag aatcgctcca tgccggatct cacagaggcg gtggatgact cgacggccaa
     3481 tgccggcata acgcaccatc cacattatcc tgcacagggc gtaactacgg cgggcactct
     3541 cttgggtacc tccgtagacg acagtgccgt tggattgggc aaacacggcc acggcatgag
     3601 cggctacatc tctgagggac acttcgacta ctcgggttcc gggtcggcct caaattcggg
     3661 agccggcagc aatccaaatc cgaatctgga gaggagcaag ctgatgcgca agagcttcca
     3721 cggcagcggc aggcagttga caatggtacc gaaagtggct ccaccgccgc ccatgcgaac
     3781 cagctccact ttgaccccac agcagcaaca acaacaacaa cagcaatttc accatgaggc
     3841 caacttgtcc aacctctcgg ccatgagttc aaacacctcg attagcgagg attcctgcca
     3901 gacgatcatc accacttgcg cacaggtgca ctcggagcag agtccactaa aggatctgca
     3961 aatgctggtc gctcaggacg agctgccact gccgccgcca atggaacttc ctccgtaccc
     4021 aagtccaccg cactcctcct gccattcgcg gcaggctagc gaagatttcc cgccgccacc
     4081 accgccggaa ctggatctgg agccactcaa ccagcaactg agccagctgc aggcactgga
     4141 ggcggccagt aagcagcagc gccagcaact cgagtccctc gagggcacca ccagcatttt
     4201 ggcccagctg cagcagcgcc agcacctgct caagctgaga aaggagcagg ccaatcaccc
     4261 gggagcagcc accacggatg ccacctggct gaaggagctg caggcgaaac aggcaaacga
     4321 tttgagagcc atgcaacgta agctggaggc ctcgtcgcca tcaagtgtca gggacttgac
     4381 tcatcgtttc gagcaaacct ccattcgatc ctacgcctcg caggagctat tgtcccagcc
     4441 gggacagagt cagcagctgg ggcagctgcg cacccagatg aatgggctgc caaacggcaa
     4501 tgcaaaaatg gatgtagatg aggtggacgc tatgccagcg gtgagaaact ctctgcccgc
     4561 cgcactcagc gcccaccaat tgctgcccaa gcctaagtac gaaatgaccc aatcgcagat
     4621 tgcagaggag attcgcgaag tggagttgct gaacacgatg gtacagcaga cactgaatca
     4681 gaacggagct gccgcactac ctaagcgggt aaagaaaaag agcgtctcct tttgcgacca
     4741 ggtgatcctg gttgccacag ccggaaacga ggaggacgat gactttatac ccaatcccat
     4801 actggagcgg gtcctgcgga ctgcccagca tcccaacgaa aaagtcactg ctcaaatgat
     4861 ccagcagcag cagcagaaca tgatgcgatt gcaaacagaa gcgcagccgc ggcaacagca
     4921 ggtgcagcag ctgcaacaac catcacccat gttgggcaga ccagcaggag ccacagcaga
     4981 tatgcagcga tacgtccaga ggatgcagca acaacagcag cagcagcaac aacagcagca
     5041 gcaacaacag cagcagcagc aacaacagca gcaacaacag cagcagcaac agcagcagca
     5101 gcagcaacac caggagttgt accgccagca gcagctacat cgcactagta tgagcggcat
     5161 agccagccag caacacttgc agcaattgga tgcacagtac accaccatgc cgcgtccctt
     5221 gcatcattca cagcttggta gctactctgt gaccttgcag aaacaccagc aacttcagca
     5281 gcaacagcaa cagcagcaac agcagcaggc cccgcagcag ctcagcttgg gctactttag
     5341 caatggcagt gttgcgactt cagagcaagt cccgctgcct tcgccctacc agcgggtgcc
     5401 cctgccacat ggataccagc ctgcagcagc aggaccctac tacccgctac ccaatgccca
     5461 gcaacatctg cagcagcaac agctgatggc taagcccgtg cagaaaaagg tgagctttga
     5521 gccaggaact aaaggcgaag ccgattgctt gcccccacca ccgccgccgc cgcaaaagaa
     5581 cggcttgccc gagacgggat ctgcaggatc aggacaccct ggagcagcac ccggggcaag
     5641 tggagcgggc ggcaccacat cggccggcat caccgccatt cccacccgcg tctacaacaa
     5701 tgccattgta aaggcttcgg ccaaagccgt tgagtgcaat ttgtgccgca agcggcatgt
     5761 gatcgcaccg gcggtatatt gcaccaactg cgagtactac ctgcagatgc tgaaccagcg
     5821 cagatgatga tgattcgaca ctcgaccatc gaccatctct agtgcaactt tctagccgta
     5881 catggaaccc gttaatctca agcattaaaa tgctgccacg tcgccaataa ggagccgcca
     5941 aggatgtaca tagcatgctt acaaatacat agataggtgt aaggatataa agtggtgcca
     6001 gctaacaggc gaattgcatg gacccggact caaggatcag gcggaatgcg gaaacggagg
     6061 ggaaacacag tccttctatg gttctacatg agaagttccc gctgtgacac ataacccacc
     6121 cactaaccca cccatcacca cccacatcaa tgccaatgtt cccaagcaca cgcacacaag
     6181 catattgtac acgcccattc atacctacac atatacttgc ccaggaatcg tgctaaagct
     6241 tagcgatgca gcggcaccac cgaatgggat tgcagtgaag tccagccgct gcaacgctta
     6301 cgaactgcac agtgccaccc gtcgccccat tggacatcga tcgcttgact aactccacat
     6361 tttttaaaca cccaaagcct gaccagtcgt ccgcctccat aaaccacatt agtgcttttt
     6421 gtttcgacat cgaattttat ttacattttt ttacctaagc taactaaata cgatttattt
     6481 ctctgtgtga gacgccagca gtttgaaact tggtcgttga gcttccttgt gcgtgctgtt
     6541 gtccaacgac actcgcactt ccattttttt tacatatttt ttttttgtat aatttttaat
     6601 tttactctaa atcagttaag gcatttattt ttgtattgtc gtacttaatt atgttaagaa
     6661 tattttttgt gtcttgcatt taaacgaata cgtgtatttt tagtgttaat atagctctta
     6721 catataacat aaatttttta cgattttatt ttgctataac attattaaaa gatactttgc
     6781 agcatatgaa caacgaaata agagatgtcg agcatccaca agaatgggaa gaaagtaata
     6841 tttctaaata aatgcataga aac