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Drosophila melanogaster Tousled-like kinase (Tlk), transcript


LOCUS       NM_130717               5849 bp    mRNA    linear   INV 26-DEC-2023
            variant C, mRNA.
ACCESSION   NM_130717
VERSION     NM_130717.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5849)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5849)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5849)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5849)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5849)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5849)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5849)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5849)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5849)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5849)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5849)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5849)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5849)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5849)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5849)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5849)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5849)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5849)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5849)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5849)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5849)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5849)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5849)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_130717.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5849
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5849
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="Tousled-like kinase"
                     /map="3E6-3F1"
                     /db_xref="FLYBASE:FBgn0283657"
                     /db_xref="GeneID:318206"
     CDS             512..4276
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /EC_number="2.7.11.1"
                     /note="CG34412 gene product from transcript CG34412-RC;
                     CG34412-PC; Tlk-PC; BEST:GH17330; tousled-like kinase;
                     tousled like kinase"
                     /codon_start=1
                     /product="Tousled-like kinase, isoform C"
                     /protein_id="NP_570073.3"
                     /db_xref="FLYBASE:FBpp0099673"
                     /db_xref="GeneID:318206"
                     /db_xref="FLYBASE:FBgn0283657"
                     /translation="MCVQKNMRRLKKMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQ
                     QQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQ
                     QQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAA
                     AAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAER
                     KRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRL
                     GGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVG
                     VPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQ
                     TSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHV
                     VVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLG
                     VVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEH
                     ESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEAR
                     QKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMK
                     KRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSV
                     SVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNG
                     GGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYY
                     EYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDR
                     YLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHK
                     ALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSA
                     LKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTS
                     QGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEE
                     NTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRG
                     SLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS"
     misc_feature    <2153..>2563
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="Family of unknown function (DUF5401); Region:
                     DUF5401; pfam17380"
                     /db_xref="CDD:375164"
     misc_feature    3287..4090
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Tousled-Like Kinase; Region: STKc_TLK; cd13990"
                     /db_xref="CDD:270892"
     misc_feature    order(3296..3298,3335..3337,3341..3343,3449..3451,
                     3500..3511,3521..3523,3527..3529,3644..3646,3650..3652,
                     3656..3661,3665..3667,3707..3709,3716..3718,3785..3796)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="active site"
                     /db_xref="CDD:270892"
     misc_feature    order(3521..3523,3527..3529,3644..3646,3650..3652,
                     3656..3658,3716..3718,3785..3796)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270892"
     misc_feature    order(3704..3742,3755..3796)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270892"
ORIGIN      
        1 aaagaccaaa taggaaaaaa aagcattcaa tatagtgtat aaagcaatcg tgataatttt
       61 aagtgtactt ttgtccgttt tcgtttcggt ttctttttcg ttttcgcaaa taagcgaata
      121 gttacactcg ctcttttgct cgttccgtcg cactctccct ctcgccgctc ttgttcttcc
      181 tcttcgtttg ctaactctct gtgtgtttgc accttcttct ttctttcgct ccgctcatta
      241 ccattttaca aacacacaag cgcacgatga gagcgactgc aaaaaaatcg gaataaacac
      301 ggttataata tataagtaca aataaaccat atatatgtgt ttatgttatg tatatataca
      361 taaaggaaaa taacaaggca aatgtgaaaa ttagtgcaaa ctgaacgaaa agacaaaaat
      421 aaaacaaaag gaaacccaaa tgtgataata ttgtaatata atgtgaaaag caaaacacac
      481 acaaatacac aactcacgca cttagccacg tatgtgtgtg cagaaaaata tgcggcgctt
      541 aaaaaagatg tcccccggcg cccatttgca gatgtccccg cagaacactt cgtccctaag
      601 tcaacaccat ccacatcaac agcaacagtt acaaccccca cagcagcaac aacagcattt
      661 ccctaaccat cacagcgccc agcaacagtc gcagcagcag cagcaacagg agcaacagaa
      721 tccccagcag caggcgcaac agcagcagca gatactccca catcaacatt tgcagcacct
      781 gcacaagcat ccgcatcagc tgcaactgca tcagcagcag caacaacaac tccaccagca
      841 acagcagcaa cacttccacc agcagtcgct gcaagggctg catcagggta gcagcaatcc
      901 ggattcgaat atgagcactg gctcctcgca tagcgagaag gatgtcaatg atatgctgag
      961 tggcggtgca gcaacgccag gagctgcagc agcagcgatt caacagcaac atcccgcctt
     1021 tgcgcccaca ctgggaatgc agcaaccacc gccgccccca cctcaacact ccaataatgg
     1081 aggcgagatg ggctacttgt cggcaggcac gaccacgacg acgtcggtgt taacggtagg
     1141 caagcctcgg acgccagcgg agcggaaacg gaagcgaaaa atgcctccat gtgccactag
     1201 tgcggatgag gcggggagtg gcggtggctc tggcggagca ggagcaaccg ttgttaacaa
     1261 cagcagcctg aagggcaaat cattggcctt tcgtgatatg cccaaggtaa acatgagcct
     1321 gaatctgggc gatcgtctgg gaggatctgc aggaagcgga gtaggagccg gtggcgccgg
     1381 aagcggggga ggtggcgctg gttccggttc tggaagcggt ggcggcaaaa gcgcccgcct
     1441 gatgctgcca gtcagcgaca acaagaagat caacgactat ttcaataagc agcaaacggg
     1501 cgtgggcgtc ggtgtgccag gtggtgcggg aggcaatacc gctggccttc gaggatcaca
     1561 tacgggaggt ggcagcaagt caccctcatc cgcccagcag cagcaaacgg cggcacagca
     1621 gcagggaagc ggtgttgcga cgggaggcag tgcaggcggt tccgctggca accaggtgca
     1681 agtgcaaacg agcagcgctt acgcccttta cccaccagct agtccccaaa cccagacgtc
     1741 acagcaacag cagcagcagc aaccgggatc agactttcac tatgtcaact ccagcaaggc
     1801 gcagcaacaa cagcagcgtc aacagcaaca gacttccaat caaatggttc ctccacacgt
     1861 ggtcgttggc cttggtggtc atccactgag cctcgcgtcc attcagcagc agacgccctt
     1921 atcccagcag caacagcagc aacaacagca gcagcaacag cagcaactgg gaccaccgac
     1981 cacatcgacg gcctccgtcg tgccaacgca tccgcatcaa ctcggatccc tgggagttgt
     2041 tgggatggtc ggtgtgggtg ttggcgtggg cgttggagta aatgtgggtg tgggaccacc
     2101 actgccacca ccaccgccga tggccatgcc agcggccatt atcacttata gtaaggccac
     2161 tcaaacggag gtgtcgctgc atgaattgca ggagcgcgaa gcggagcacg aatcgggcaa
     2221 ggtgaagcta gacgagatga cacggctgtc cgatgaacaa aagtcccaaa ttgttggcaa
     2281 ccagaagacg attgaccagc acaagtgcca catagccaag tgtattgatg tggtcaagaa
     2341 gctgttgaag gagaagagca gcatcgagaa gaaggaggcg cgacagaagt gcatgcagaa
     2401 tcgcctcagg ctcggacagt ttgttaccca acgagtgggc gccacattcc aggagaactg
     2461 gacggacggc tatgcgttcc aggagctgag tcggcggcaa gaagaaataa ccgctgagcg
     2521 tgaagagata gatcggcaga aaaagcagct gatgaaaaag cgtccggcgg agtccggacg
     2581 caagcgcaac aacaacagta accagaacaa ccagcagcag cagcaacagc aacaccagca
     2641 acagcagcag caacaaaatt ccaactcgaa cgattccacg cagctgacga gcggagttgt
     2701 taccggtcca ggcagtgatc gtgtgagcgt aagcgtcgac agcggattgg gtggcaataa
     2761 tgcgggcgcg atcggtggcg gaaccgttgg tggtggcgtt ggaggtggtg gtgttggagg
     2821 cggtggtgtc ggaggcggcg gtggacgtgg actttctcgc agcaattcga cgcaggccaa
     2881 tcaggctcaa ttgctgcaca acggcggtgg tggttcgggc ggcaatgtcg gcaactcggg
     2941 cggcgttggc gaccgcttgt cagatcgagg aggaggaggt ggcggcatcg gcggaaacga
     3001 tagcggcagc tgctcggact cgggcacttt cctgaagcca gaccccgtat cgggtgccta
     3061 cacagcgcag gagtattacg agtacgatga gatcctcaag ttgcgacaaa atgccctcaa
     3121 aaaggaggac gccgacctgc agctggagat ggagaagctg gagcgggagc gcaatctgca
     3181 catccgagag ctcaagcgga ttcttaacga ggatcagtcc cgctttaaca atcatcccgt
     3241 gctgaatgat cgctatcttc tgttgatgct cctgggcaag ggcggcttct cagaggtcca
     3301 caaggccttc gacctgaagg agcaacgcta tgtcgcatgt aaggtgcacc aattaaacaa
     3361 ggattggaag gaggataaga aagctaatta tatcaaacac gctttgcggg aatacaacat
     3421 tcacaaggca ctggatcatc cgcgggtcgt caagctatac gatgtcttcg agatcgatgc
     3481 gaattccttt tgcacagtgc tcgaatactg tgatggccac gatctggact tctatttgaa
     3541 gcaacataag actatacccg agcgtgaagc gcgctcgata ataatgcagg ttgtatctgc
     3601 actcaagtat ctaaatgaga ttaagcctcc agttatccac tacgatctga agcccggcaa
     3661 cattctgctt accgagggca acgtctgcgg cgagattaag atcaccgact tcggtctgtc
     3721 aaaggtgatg gacgacgaga attacaatcc cgatcacggc atggatctga cctctcaggg
     3781 ggcgggaacc tactggtatc tgccacccga gtgctttgtc gtgggcaaaa atccgccgaa
     3841 aatctcctcc aaagtggacg tatggagtgt gggtgttatc ttctaccagt gtctgtacgg
     3901 caaaaagccc ttcggtcaca atcagtcgca ggccacgatt ctcgaggaga atacgatcct
     3961 gaaggccacc gaagtgcagt tctccaacaa gccaaccgtt tctaacgagg ccaagagttt
     4021 cattcgggga tgcttggcct atcgcaagga ggatcgcatg gatgtgttcg cactggccag
     4081 gcacgagtac attcagccac cgataccgaa acatgggcgc ggttcgctca atcagcaaca
     4141 gcaggcgcaa caacagcagc agcaacaaca gcaacagcag cagcaacagt cgtcgacgtc
     4201 acaggccaat tctacaggcc agacatcttt ctctgcccac atgtttggca atatgaatca
     4261 gtcgagttcg tcctagctgc caaccaagcg caattcgaac tcataattcg ccgccgccgc
     4321 agtagcagca gctacattag ctgccagtag tcaacagcaa cttcaacacc agcaacagca
     4381 actccaaatc cagcaatacc agcagaatca gcaacttcat ttgcaaaaca gcagtagcaa
     4441 ttatgcggcc acgcttctag atgcagcggc cttttgctac gaaaccgtga tggatgcagc
     4501 ccacttccaa aacaacaata ataacagcac catcatcaag aacaatatgc agacaatgcc
     4561 ggcaaacgct gccaatgctg ctgcagctgc agggggaggg ggaacaccga cctatcaggg
     4621 gaaatacaag cgctggcagc agcaacagtt acaacagcag gcgcaactcc aacagcagca
     4681 gcacaagctg ctgttgcagc aagagctgct ctaaaatatg aagggaatga tgacaagcga
     4741 gtttaagaga acgaggagct gcctgccaca ctgccgccgt cagcaataac aacatcccaa
     4801 gaaaattcac agcgagtcgc aaaagcatca acaaacaaag caaaaaacgc aaaaaaggat
     4861 tacaaagacg cagagaatag gggacatttg caatgggaaa taacaaatta ttgcattatc
     4921 tgctggattg tgattgtggt tcaaacatta aaaatacact tactcataca cacaaggtag
     4981 acactgcaga ctaattttgc cttaaaagaa acaaaacgaa taatgttaac tgtaaatttt
     5041 cactttgtgt ccatgcatag ttactagtaa tgatgatata aatatataaa tatatataaa
     5101 atataaaaat tatataaatg tataaattta tatttatata tatatatata tatatatata
     5161 tatatctgca taaacattga agcatactag taaatcttta taaatatatt tatatatata
     5221 tttatctctt ccttttaacg cttttaatcg gaaaaaacat cccaattata ttttaattca
     5281 atttgaaata taaaagtcat ttttgtttgt tttgtatcaa aatccaaaaa aaattgattt
     5341 aaatataaaa ataccataaa cattaacacc acacacacac acacacacac atatatatat
     5401 atatatatat atatatatat atatacatat atatatacat ttgtatatag tcgtatctga
     5461 accacaaaca aatccacaga taaaaaaaac tgaaaaattc atagaatcaa accatttttt
     5521 tatatgccac aaagaaaaga aaataagtag aaatgcaaga aaaatcgaga aaaagcgtaa
     5581 ttcatgagat cagatcggat cagaaaaatc aacagaaaat aaacctattt gaagtaaaat
     5641 acttctaaat acatagtaaa ctaatgtaat agtttttatt aaaattacac atatatgtat
     5701 cgatatatat acatgttttt ttttttttaa ttttaaaatt ataattgtaa tgcactatgc
     5761 gtaaattgta ttaaatatta atatccaagg catattaata gaaatatata tacatatata
     5821 aaacctgcaa aaaaaaaaca tgaactacc