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Drosophila melanogaster Protostome-specific GEF (PsGEF), transcript


LOCUS       NM_130646               6966 bp    mRNA    linear   INV 26-DEC-2023
            variant A, mRNA.
ACCESSION   NM_130646
VERSION     NM_130646.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6966)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6966)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6966)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6966)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6966)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6966)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6966)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6966)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6966)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6966)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6966)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6966)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6966)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6966)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6966)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6966)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6966)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6966)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6966)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6966)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6966)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6966)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6966)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_130646.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6966
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6966
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="Protostome-specific GEF"
                     /map="3A2-3A2"
                     /db_xref="FLYBASE:FBgn0264598"
                     /db_xref="GeneID:31224"
     CDS             260..4849
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="CG43947 gene product from transcript CG43947-RA;
                     CG43947-PA; PsGEF-PA; protostome-specific GEF"
                     /codon_start=1
                     /product="Protostome-specific GEF, isoform A"
                     /protein_id="NP_570002.1"
                     /db_xref="FLYBASE:FBpp0305706"
                     /db_xref="GeneID:31224"
                     /db_xref="FLYBASE:FBgn0264598"
                     /translation="MPTMTRMHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHF
                     MSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQATPQLAALRCLPRTTGGAVAL
                     EDSQLSSSRMGDTTLDRMLDAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETS
                     VHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSS
                     SASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSID
                     VSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGS
                     MSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLNSVPVTQSE
                     WQARVKSGTERRTAERLAKLENAGNEAKRSEFLGCSTFPLNELVHPDSGVSAGSYKLH
                     AQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATG
                     SGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLR
                     FLELDPPADGNANSTTTQAQATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGS
                     SVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRVEKIEAGLSADRCGILPG
                     DYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHIS
                     TRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSI
                     EAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGER
                     KDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQDQEPQMNFASRVYLSKTTAICA
                     AYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAVPRKRPDLTMFIHRPLQHFREIL
                     KLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITVSSGLMEPLGEGRPLLTLQDLES
                     RMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKVSRDRVLFI
                     TEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKS
                     LILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTA
                     SMGSMKLPSLDSIHLKQQQKQQVRLFRSKRLDSGDSYENLQRLASAVRHHCASTTTSS
                     ATQTQSHPQPPLCTTSLPSRTNSPARNQRHPNGQGHVGGSVPNGVGGVSFGGCNTNSS
                     CLSSSASLTQTQTQVHTQTLNHSQTHSQTQTSVLSLSSCKCLTVIPEVTSEPPVNQHA
                     SQKLLEFSLSSVGRSFIDESGGVVGGQVSLTTPETPTPNISPTTSQPCNSDAFSNDFV
                     ATSTTGKGPNIPLAEFGGSWDLLELDLQLHEVNLDPSYDTDVEECIFLGDEEDREGTE
                     GHGHDEDSDEDDSVVVDDPFGMLPTRPTPPDSLDL"
     misc_feature    <494..886
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="Domain of unknown function (DUF4799); Region:
                     DUF4799; pfam16056"
                     /db_xref="CDD:318308"
     misc_feature    1115..>1402
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="C2 domain; Region: C2; pfam00168"
                     /db_xref="CDD:425499"
     misc_feature    2192..2407
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="canonical PDZ domain; Region: PDZ_canonical;
                     cl49608"
                     /db_xref="CDD:483948"
     misc_feature    2762..3280
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571"
                     /db_xref="CDD:470622"
ORIGIN      
        1 atttccgttt ctgagctcgt gctaagcaga cacgtgaact tcatagcaga aaagaacgaa
       61 aatacctttg gcttgaagaa attagttggc ttattttttt tttcgtgtaa aagatctatc
      121 aaaatttgtg tgccgccgac gcgcaaggat cacattttta aacaaaatca gtgctgttaa
      181 tcaagttgaa cctaagctaa atcgagttgc agttcgccag gcgacgtagt cgcaaaaaga
      241 tcaagttacc agtagggaca tgccaaccat gacacggatg catcgccact ccagttccag
      301 tgccgtggtg gaggagtcgc gtggccggcg ccgtggagtg ggcgtgccag gagtcggaga
      361 cgcgaacaag gagaatttcg gggtgcactt catgagcagt cccttcggca atgccagttt
      421 gattgccctg caggatttga gcaacgtgca cggaaagagt ccgcagcgca ggagtttcag
      481 cgagggcagt ggtccgcggc aggccacgcc acaattggcg gcactgcgct gcttgccacg
      541 caccaccggt ggtgcagttg ctctggagga ttctcagctc tcctcatcgc gaatgggcga
      601 taccacactg gaccgcatgc tggatgccat catagagtcg gccaggaagg aggtgaggtg
      661 tacgaagaca ctgccaggcg ccggcgccac cacttcgacc accattttgg cggataatgc
      721 cgagtggagc gagaccagtg tccacgaaat ggaggtgcgc acgcccaccc acttgaagcg
      781 gcagcgggtg gtgcggcgca agaacccaca caagactacc accattaacc aaacgcaaag
      841 tcaccaagcc aagaagttgg agccactgca gttggttccc agcaccaaac gctgcctgag
      901 cttctcatcc agttccgcct cgagtgattt ggacgaggat gagcagcagg tggccaagag
      961 gagttcgctg gcctccccca ccaccacacc tccctcccac tgcaccacca ccaccagcag
     1021 catcagcagc agcagcagca gtaatggtgg tgcggacatg gaggccagtc agcggggcag
     1081 catcgatgtg agcatcgcat tcgatgccaa ggagcagcaa cttaatgtac atgtgattcg
     1141 ctgtcgcgac ttgcagcgct cccatggcag tggaaacggc agcatcaacg cctacgtcaa
     1201 ggtggccctg tccggaggag cccagccacc cggatacggt ggccactcgt cggggggaag
     1261 catgagttcc gggtaccaac gcaccgccgt ccatcggcac tcgggccgcc cgtacttcga
     1321 tcagcgattc aacttccaga tttccagtgg cgaggagacc gctggacagt atcttcagtt
     1381 ggccgtgtgg catcgggatc gccatttaaa ctcagttccc gttactcagt ccgagtggca
     1441 agctcgcgtg aaaagcggca cagaacggcg aacggcagaa cggctggcga agctcgaaaa
     1501 cgcaggaaac gaggcaaaac gcagcgagtt cctgggctgc agcacttttc cactgaatga
     1561 gttagtgcat ccggattcgg gcgtctcggc aggatcctac aagctgcatg cacaggcatg
     1621 tcctccgcct actagccgcc atagccaacc aaaagccaac gcaggccagg atcaaaagca
     1681 ggaaacggaa gcggcgaagg atcaggataa acagcaggac gattcccccg cagaaatggc
     1741 agcagccgtc acagtcacgc cccaaaaacc ggttgccact ggatccggtt cgggatcgaa
     1801 ttccgcagcg atggcactga acgacgaggt gatcagcatt agcatcgata gcatgggcaa
     1861 agaggatcct ctgctacccc agcagcccca gcagcccatg aagctcagca agaaggcact
     1921 ccaccagcga gatgccgacg agaatctctt tttaagattc ctggagctgg atccgccagc
     1981 ggatggcaat gcaaacagta ccaccaccca ggcacaagcg acgggctccc agtcctcggc
     2041 gtcgaaggcc aacgaaagca atgccaacca cttgaacaat gggacatccg gtggacgcag
     2101 acagtccacc atgccaaata gcggaggatc tagcgtagga ggcgctgtcc gccagcagca
     2161 gggacgtacc ccattcacca tgacgaaaag acttacgcga accgaggaac ggggctttgg
     2221 attctctatt gtctggacgc atccgccacg ggtggagaaa atcgaggcgg gactctcggc
     2281 cgatcggtgt ggcattttgc ccggcgacta tgtgatcttt gtggacaagc ataacgtcgt
     2341 cacgatgccc gaggctgatg ttctgaattt gatacgatcg cagggctcgt ccttgacgtt
     2401 ggagatattc agaaggtcag gcgcgggcgc cacaacaatc acgtcgacgg acttgggcca
     2461 gaacaatgta cacataagca ccagattggg cgcggcagtg ggcttgggca gcgaggagca
     2521 caccctggcc accaccgcaa caggaacgac caccgtaatg agtctgcaaa ggaccaccag
     2581 tacgaggatc cagccattgg caaatagcat gagccggccg gctaccgcat gctcgggaac
     2641 cacctcctcc atcgaggcgg ccaaaaggag gcttcacctg ccacaggtca ccttcagcaa
     2701 ggagtcgatt gtgcctgtca cggacaaccg taggcgcttc ctgctccagc tgattagtcg
     2761 ggagcagaac ttcacggctg ccctgcactt cggagtggac cgctttgtgc agccgcttgg
     2821 cgaacgaaag gatctgatct cgccgaacga tcatcgcact ttgttccaga acatcgacga
     2881 gctgctcagg attgccgagg acatcctgga gcagttgtgc agcagcgatc agcaggacca
     2941 ggagccacaa atgaactttg cctcgcgggt ctacctatca aaaactacag cgatctgtgc
     3001 ggcatacaag aagtactgca atggaattaa gcgggccgac tgtgttttgg tcaataagtc
     3061 ccgacagact ggctccgagt ttatagcctt cattacggaa ccggccgttc cacgtaaaag
     3121 acccgatctc accatgttca tccatcgacc actgcagcat tttcgtgaaa tccttaaact
     3181 gatgcagttg ctcgctggaa attgccatgt ggatacggag gagcacaaga actttagcac
     3241 ggttatcaac gaactgcagg ctgcctatcg ggagatcact gtgagcagtg gtctgatgga
     3301 accactggga gaaggtcgcc ccctgctcac cctccaggat ctggagtccc ggatggtctt
     3361 taccaaatgc aagcctttta cgttggccgt tcaggggcgc cagtggatct ttggcggcga
     3421 tttgtcccgg gtcgaaggtc gctccgttaa gccctattgg acactactat tcagtgatat
     3481 catcgttttt gccaaggtca gccgtgatcg agtcctgttt atcacagagg agcccattcc
     3541 catcgccaat gtggttgact cttgtttcca tatgcgcaag aaaaccaccg agtttcgtct
     3601 cacagtggat cccaatggac gcctggcgga gagtccgacg ggttactgtg ctcccgatct
     3661 cacccgcact ccaaagcgag gagcccgccg caagagcctt attttaaggg caccttcgct
     3721 ggaacttaag gccgtttggc agaatcttct ccagcggcag atctttctag ttaacgccgc
     3781 ccttggctcc acgcccttgt ccagtccctt ggactcgccg gatgttctca acaccctggt
     3841 gccgctgagt gatattggtc tgaccaccgc ctccatgggg tcgatgaagt taccatcgct
     3901 ggacagcatc cacctgaagc agcagcagaa acagcaggtg cgtctctttc gcagcaagcg
     3961 tttggacagc ggtgattcct acgagaatct tcagcgtctg gccagtgcgg ttcgacacca
     4021 ctgtgccagc accaccacga gcagcgccac ccagacgcag tcccatccgc agccacctct
     4081 ctgcaccacc tcgctgccct cgcgcaccaa ctcgcccgcc cggaaccaac gccatccgaa
     4141 tggccaagga catgtgggtg ggtcggtgcc gaacggagtg ggtggtgtga gtttcggtgg
     4201 ctgcaataca aacagctctt gcttgagcag cagcgctagc ttgactcaaa cccagacgca
     4261 ggtccacacc cagactctaa accattcaca gacccactcg cagacccaaa cctctgtgct
     4321 gtccctctcc agttgcaagt gcttaaccgt cattccggag gttactagtg aaccgccagt
     4381 caatcaacat gcctcgcaga aactcttgga gtttagcttg agctcagtgg gtcgatcgtt
     4441 catcgatgag tctggcggtg tggttggtgg tcaggtctcc ctgactacgc cagagacacc
     4501 cacacccaac atttcaccca ccacttcgca gccctgcaac tcggacgcct tttccaatga
     4561 cttcgtggca acatccacga ccgggaaagg accgaatata ccgctagctg aatttggtgg
     4621 ctcctgggat ctattggagc tcgatctcca gctgcacgag gtcaatttag atcccagcta
     4681 cgacacggat gtggaggagt gcatcttttt gggcgacgag gaggacagag agggcactga
     4741 gggacacgga cacgacgagg acagtgacga ggacgatagc gtggtagtgg acgatccctt
     4801 cggcatgcta ccaaccagac caacgccacc ggactcgctg gacctgtgat ttgacttctg
     4861 gctgcagtca gaccccgcta acagcccctt gccgcacaat ctttgaatct cgacgagctt
     4921 actcaactat gttaccactg aactacccag aaacctctgc tctatatctc taaatattta
     4981 gctcaatcgc cgttttgctc tgcttttgtg tcagctttgg ccaagttttc catcactcac
     5041 aatcaaaact ttgtagtgta gtggcagcct gtctttggaa gattggggat tgactttgcc
     5101 aggatatcag aatcaggaac cgaacagtga gattaaaacg agtgacaccc gaataagata
     5161 ctagaaacaa catttaagaa cctatcacct ggatatgagc cattttaaaa atccgctgtg
     5221 tttcacagat ttcttttcca atttgcatcg taagatagct agctgacttc acatgtatat
     5281 tcaactgtta tataatagct ctagtgattt cttaaggcag aaacacttaa agggccaaag
     5341 attttaagat ccaggtgaaa agcatatgtg tttagctgac tctaatttcg agtgagaagt
     5401 gacaattatc cgtggaaaat tgtacataga catatattat tcatcgctct ctaagtgtat
     5461 gtatctctgt tgtgcattgt atatactcgt gtattgacat ccgtaccata tatcccattg
     5521 agtaaccctc cctttatatg gtattcgttc catccaagtc gattttgaat cgggtgtaaa
     5581 tagcaataaa cagttgaacg agggcagaga ttaacgttcg atgatgattg tatgtgttta
     5641 acgctagtat ttagctgttt ttagtaatgt atgtgagtat acatagtata cccaccttag
     5701 atatagccat atatatatgt atattagcta gtcaaatata caccaaacag atgcacaatc
     5761 tgctacgcga aaccccaacg gggtttacgt tttacaagag tttttagctt atggatatat
     5821 acatatatct acatagaata tgcatatata tatatcacac tctattcgta ctaaccattc
     5881 gattgaaact tttttgccaa tccaacaaaa acaaaaaaca aagaaacaag ataacctact
     5941 tgaaattata ctaatgttaa taatgcttcc attttgtagc caaattgaaa acctattgat
     6001 tactgttatt gctgttgtta tcctacatta gcctagtcct agtttctcct aacttccccg
     6061 aaattctcgc ctcggatcgg atcctcctcg tatgctaagt tgacccatta gccaaatttc
     6121 ttgtagaatc gctcgattaa tcgactaact tagttaagtt tacctcgatt ggccagttca
     6181 aattttaatc aaaatcgaaa tcaaaatctt agttgtatat atactacttt cctattaaca
     6241 tgattcagta tgcgttttta tcatctgtaa taaaatgttg ctcagtcgaa tgacttttgg
     6301 ctggatggca aaatacacgt gctatataca tatatgtatc tgatctagcc atcgatgtca
     6361 attagctatg acaagcaatt tgttgcctta aaaatatatc ttcacgctaa ccacttacat
     6421 aaatgtatta cccagcacta gtctgccttt gcacagtggt acaaaattct aaaggaagtt
     6481 aaattgatta aatgctaaac ttctaagatt tggtccctca gtgcggattc agtttggtca
     6541 aatttccacc cagccagaag tttaaacaga cagtttagca tacaaacaga cacacacaca
     6601 ccaataaaca cccactcact ctacgcacac agacaactat tgcaaattga aactgattgt
     6661 gaaatatcaa gcatacgccg ctttgtcttt tgcggttcgg ttttgagtgt gccttgagca
     6721 gtaaacaaga aacttctata cacagtatat atatatacat acaaactatt tagattcata
     6781 ttcatattct gtaaacttta tgtacgtcta gatattttcc atttatggtt tttcgacatt
     6841 ttacataaaa cgagaggatc gagaatcgac tatcgatata tcgatcgagt cgattgcgat
     6901 tgagattaag aatgcgaaga gaaacgatga attcaaataa taataaaacc aaatgattct
     6961 ttgact