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Drosophila melanogaster Salt-inducible kinase 2 (Sik2), mRNA.


LOCUS       NM_130616               5230 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_130616
VERSION     NM_130616.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5230)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5230)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5230)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5230)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5230)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5230)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5230)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5230)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5230)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5230)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5230)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5230)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5230)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5230)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5230)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5230)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5230)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5230)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5230)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5230)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5230)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5230)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5230)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 31, 2011 this sequence version replaced NM_130616.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5230
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5230
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /note="Salt-inducible kinase 2"
                     /map="2C8-2C8"
                     /db_xref="FLYBASE:FBgn0025625"
                     /db_xref="GeneID:31170"
     CDS             426..4622
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /EC_number="2.7.11.1"
                     /note="CG4290 gene product from transcript CG4290-RA;
                     CG4290-PA; Sik2-PA; Salt-induced kinase 2"
                     /codon_start=1
                     /product="Salt-inducible kinase 2"
                     /protein_id="NP_569972.1"
                     /db_xref="FLYBASE:FBpp0070326"
                     /db_xref="GeneID:31170"
                     /db_xref="FLYBASE:FBgn0025625"
                     /translation="MSTCEAAAAGENGSQAKSEESQPPEDQKKKQPQHERNEKQLDKP
                     PENLPQNGKTEAKGAEGACSHPPLDALRSSVLLDAGAASPSIDAIVACKDALLAQKLF
                     ASGGGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARH
                     RITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSE
                     YASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMN
                     IKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCG
                     ALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM
                     CPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAA
                     IYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTS
                     SILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSH
                     LTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHR
                     PVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDC
                     RALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTI
                     KTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSG
                     GDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCETDQGNDPGSASQESKGSNGGGSG
                     NANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNLS
                     RGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASASPAGISSEHSSERS
                     LYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRR
                     ASDGLVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHSHPHA
                     HQHPHQHPHPHPQAYGLEELCQFPNGQFYALPGKHHPLLTLPHHHAHPAQHHHGHHSL
                     FHSGHQATPLLLEAAAGGDMYGHGCYAPPPPPPGLYTHHQLGVGMAVPMSPMQKPPLQ
                     QQLLQHRLLQQKRQLFQKQYALEAQLAGRHHHHQQHSHHHHHHFGHSLGPPPPPAPAP
                     EHHLADELYELALLDRPRSGTPRLQHSMTMPGAHAFSQMNLKTSYISQSDQVPGAAPN
                     GAGSGGSAAGVSCSAPPSTAPGTPTVKCKPTTPHGHSLDSDYHTSTPVLSLFTPNWQS
                     LVKPLSESPILEISEHLESV"
     misc_feature    843..1601
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Salt-Inducible kinases; Region: STKc_SIK; cd14071"
                     /db_xref="CDD:270973"
     misc_feature    order(864..878,888..890,927..929,933..935,1026..1028,
                     1074..1085,1095..1097,1101..1106,1110..1112,1209..1214,
                     1218..1220,1224..1229,1233..1235,1263..1268,1275..1277,
                     1314..1331,1335..1337,1425..1436,1440..1442)
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /note="active site"
                     /db_xref="CDD:270973"
     misc_feature    order(864..875,888..890,927..929,933..935,1026..1028,
                     1074..1085,1095..1097,1224..1229,1233..1235,1263..1268)
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270973"
     misc_feature    order(1095..1097,1101..1106,1110..1112,1212..1214,
                     1218..1220,1224..1226,1275..1277,1314..1331,1335..1337,
                     1425..1436,1440..1442)
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270973"
     misc_feature    1263..1331
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270973"
     misc_feature    1677..1799
                     /gene="Sik2"
                     /locus_tag="Dmel_CG4290"
                     /gene_synonym="CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2;
                     SIK2"
                     /note="UBA domain found in salt-inducible kinase SIK1,
                     SIK2, SIK3 and similar proteins; Region: UBA_SIK; cd14338"
                     /db_xref="CDD:270523"
ORIGIN      
        1 agttggacgc agctcgggat tggaggcagc cacgtttcct agccatctgc cgtgtgtgtc
       61 gcagcgactg tgtctgtgtg tgccgtgctg tgctgttccg agccgcatgt gtggcgctcc
      121 gcggacgcga tgtaaagcgg atcctcgcca gcgtttatcc tctcatagcc agtaaccgga
      181 ttcggattaa gctggcccag cctgtagcct attctcagtt tttgccaccg ctcctgctcg
      241 aaacttcttt gtcaaccggc gaggcttgtg cttttaacgc tttcaccaat aacgaagcgc
      301 tgtcatgaga caggaggtgt gtgtgagcat gtgcatcacc atctcgctgt cgatcgcgat
      361 ctcccactcc ctccgcctcg cgctctccgt gtgagatttc ccgcccaggg tggcgcagtt
      421 ggaaaatgag cacgtgcgag gcggcggccg ctggcgagaa tgggagccag gccaagtccg
      481 aggagagcca gccgccggag gatcagaaga agaagcagcc gcagcatgag aggaacgaga
      541 agcagctgga taagccgccg gagaatttgc cccaaaacgg gaaaaccgaa gcaaaaggag
      601 cagaaggagc gtgttcacac cccccactgg atgccctccg gagctcagtg ctcctggatg
      661 ccggtgctgc ttcgccctcg atagacgcaa tagtggcttg caaggatgca ctgctcgccc
      721 agaagctctt tgccagcggg ggtggctcca cgcccggtcc cagtcccaca tcctctgcgg
      781 tgggcgcggg cggtatcagt ggcaaggacc tgctcaaact caaggagccc atgcgcgtgg
      841 gcttctacga catcgagcgc accattggca agggaaattt tgcagtggtc aagctggccc
      901 ggcatcgaat caccaagaac gaggtggcta tcaagatcat tgacaagtcg cagctggacc
      961 agacaaacct acagaaagtc taccgcgaag tggagatcat gaagcgcctg aagcaccctc
     1021 acatcattaa gctctaccag gttatggaga ccaagaatat gatctacata gtgtcggagt
     1081 atgccagcca aggagagatc ttcgattaca ttgccaagta cgggcggatg tccgagtcgg
     1141 cggcgcgctt taagttctgg cagatcatat cggcggtgga gtactgtcac aagaagggca
     1201 tagtgcatcg ggatctcaag gcggagaacc tgctcctgga tttgaacatg aacatcaaaa
     1261 tagcggattt cgggttctcc aatcacttca agccgggaga attactggcc acctggtgcg
     1321 gatcaccgcc gtacgcagct cccgaggttt tcgagggaaa gcaatatacg ggtccagaga
     1381 ttgatatttg gtcactgggc gtcgtgcttt atgtgctggt atgtggggcc ctgcccttcg
     1441 acggatccac gctgcagagc ctccgggatc gggtgctttc cggtcgcttt cgcattccgt
     1501 tttttatgag ctccgagtgc gagcacctca ttcgccggat gctggtactg gagcccacaa
     1561 ggcggtacac catcgaccaa atcaaacgcc atcgctggat gtgccccgag ctgctggagc
     1621 acgtcctgat agccaagtac aatctgggcg ccgagcggca gacgtccgtg gaacccagcg
     1681 aggacattct tcgcatcatg gccgagtatg tcggcattgg gtcggacaag acgcgagcca
     1741 gtcttaagaa gaacacttac gaccatgtcg cggccatata tctgctcctg caggatcgag
     1801 ttagccacaa gaaggagcag agcaacggct taggcgccag cgcccttgcc tcgtcgacct
     1861 ccgccagtcg gatgatctac agctccagaa atgaccacca accgacgcag caacaatcgc
     1921 agcagcagtc caagacaata tccaccagct cgatcctggc caaggatcag tgccacaaaa
     1981 gacttagccg ccatcagacg gtactcatga gtgagcgtaa cgcccacgcc ggcgcgacac
     2041 ccacagttcc agatcccggt cccggatact acgccaagta tggcccactg caactgccac
     2101 tgcctctgac gggccactcc cacctgactg ggtatctgaa tggaggaggc gtcgaggtgg
     2161 atgccagcgg cattccgctg cccatgcggt acaccccgct gccgacagcc gcgtcgcccg
     2221 ctccctctaa ctgctcatcc acatcctcga gggtaggacg acacagtcta agctccagct
     2281 cgccgcgaag ccatcgaccg gtggccattt cgctcagcat cgacaacaac ccctcgctgg
     2341 ccaacctgcg gtgcagggag atgatggagg ctggaggagg acccgttgga gcagtgggtg
     2401 tgcctctagc gtccaagcag cttcatcaga ccatcagcga gttcatcatc aaacagagca
     2461 ccgaagactg tcgtgcgctg ctgcagcagt ccacagcagt ggctgagggt aaagatgatc
     2521 cgccaaaggc ggaatcaagc gtaggaggcg ttcctccgcc cgcctctacc acacccacat
     2581 ccagtacagc gggaccggaa tcgggatcgg ctccctgccc tggtgagatt aacggcaaga
     2641 caataaagac tatgtccagc tcgagcagct tcgattctaa ggccaatttg ggccaaagct
     2701 ttcgctacaa gatgtccgcc gaggccagca agcttttcca gactctccag gaaagcccac
     2761 tgcccgtgga gcaaaggact aagcgtcgtg tgcacgtggg cagcaccaat ggcagcggcg
     2821 gtgactccgg ccaggaaacg aatgatgcga aatcgaatgg cgacagccgc tcggagaaga
     2881 aagttctggc ccaaggcagc tccagcacag atgagggctg cgagacagac cagggcaacg
     2941 atccgggctc tgcttcccag gagtcaaagg gcagcaatgg cggcggtagc ggtaacgcca
     3001 acggcggacc cacctcgcac tccagcagcg atctgacgcg gctcgttgga accactacct
     3061 ctggacagag tcacaagatg cgctcgtatg ccagtagtag ctcgtccagt ggcgttctcg
     3121 ccgggagcgc tggtagctac tccaaaagtc tgagccagaa cctgagccgc ggctcgtcca
     3181 agagcaattg cagcggtccc tacgatagct tggactttgc cttgccttct ggcaagggca
     3241 gtctaccctc gtgcatgggc tcaagttcga tgctggccac gcccactccg gcctcggcat
     3301 cgccagcggg aatctcatcg gagcattcat cggaaagatc gctgtacggg agccacaact
     3361 cctgcatcca tatgccagga gctctgccgt tgggcttggg ccttcctcag agttcagcct
     3421 ccacgcccac gccgaatcct acgcctccgc caaatggcgg tggtgtcacg ttcctggaca
     3481 agcgttcacc catacacttt cgcgaaggaa gacgggcgag tgatggcctg gtggcccagg
     3541 gcctgcttag ctctggttcc ttgctgggca ccagtcgtgt gtacggaagt tatcgctacg
     3601 agcaggccaa gcgtcacggt tggctggaga tccagcagct gcagcagctg cagcaggagg
     3661 cggctgtggg gcattcacac ccacatgccc atcaacatcc gcatcagcat ccgcatcctc
     3721 atccccaagc gtacggcttg gaagaactct gtcaatttcc aaatggtcaa ttctatgctc
     3781 tgccgggcaa gcatcatccg ctgctgactt tgccccatca tcatgcgcat cctgcgcagc
     3841 atcaccatgg ccatcattcg ctgttccatt caggccacca agccacacct ctgctcctgg
     3901 aagccgctgc tggtggggat atgtatggtc atggatgcta tgctccgcca ccgccgccac
     3961 cagggctata cacgcaccat cagttgggcg tgggtatggc cgtgcccatg tccccgatgc
     4021 aaaagccacc gctgcagcag cagctactgc agcaccgcct gcttcagcag aagcgtcagt
     4081 tgttccagaa gcagtacgca ctggaggcgc agctagccgg tcgacatcac caccatcagc
     4141 agcacagcca tcaccaccat caccactttg gccacagcct gggtccgcca ccgccgccgg
     4201 ctccggctcc ggaacatcac ctggccgacg agttgtacga gttggccttg cttgatcggc
     4261 ccaggagcgg aactcctagg cttcagcact ccatgaccat gcccggagct catgccttca
     4321 gtcagatgaa cctcaagact tcctacatca gccaatcgga ccaggtgcct ggtgcggcgc
     4381 ctaatggagc tggttccgga ggatcagctg ctggggtatc atgctcagct ccaccgtcca
     4441 cggcgccggg tacgcccacg gtcaagtgca agcctaccac gccccacggt cacagcctgg
     4501 actccgacta tcatacatcg acgccggtgc tcagcctttt cacgcccaat tggcagtcgc
     4561 tggtaaagcc gctcagcgag agccccatcc tggagatatc ggagcacctt gagtcagtct
     4621 gaggccgtgt gtgatgttat tcggtggagg ggttggggca attcgaatgg gagtagattt
     4681 gtaagtggaa gtcggtggga aaggaaaagg ggtaggactg gacatcgaac tataatgggg
     4741 gctggaccgg gaccggggcc acctttttat taagctcgca atcgcaatta tgaattattt
     4801 gatccatata cgatatacac ccatacatac atataaatag cctatataga tatgaatgcg
     4861 ggtcggaatc ggaatcggag ttacatcgat tcacgtttat tggaaccgat agaatcatta
     4921 ccgaaccggg cgaagcagta atattgaatg atttagttgt gttactagtc ttaagtagtc
     4981 caagtttcgt acgcatatac gcagacatat acaatatgta tattgataat aatagcgtta
     5041 agctatagct ctacttatga ttacactata cactattgta ttgcccccac gacagtggac
     5101 gagaacaacg taactacata tatcaattat tcgaagcatt tattgggggc atagaaaggg
     5161 cgtatccata taaggatata tctattatgt attggtacaa taattagcga caagcaaaga
     5221 aaaaaaaaac