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Drosophila melanogaster secretory 22, transcript variant A (Sec22),


LOCUS       NM_130507               1743 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_130507
VERSION     NM_130507.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1743)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1743)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1743)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1743)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1743)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1743)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1743)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1743)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1743)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1743)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1743)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1743)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1743)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_130507.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1743
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="Secretory 22"
                     /map="1C5-1C5"
                     /db_xref="FLYBASE:FBgn0260855"
                     /db_xref="GeneID:31030"
     CDS             410..1045
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="CG7359 gene product from transcript CG7359-RA;
                     CG7359-PA; Sec22-PA; Sec22 ortholog"
                     /codon_start=1
                     /product="secretory 22, isoform A"
                     /protein_id="NP_569863.1"
                     /db_xref="FLYBASE:FBpp0070136"
                     /db_xref="GeneID:31030"
                     /db_xref="FLYBASE:FBgn0260855"
                     /translation="MALLTMIARVIDGLPLVGTMQDDEQSGRSILDYQNQAKMLFRKL
                     GTHSPARCSIETGPYLFHYLIENDVCYLVMVDKMYSKRLAFNYLEDLAQEFHANYGRR
                     VNSVTRPYAFIEFDVYIQKAKKQLTDRRRNISNINTQLQDVQRIMVQNIDDVLQRGTV
                     LAELDTKTQNLSMMSQKYKKDAKLLNRKSMYVKAMALGMILLVFIMYFWVL"
     misc_feature    416..784
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="longin domain; Region: Longin; cd14824"
                     /db_xref="CDD:341428"
     misc_feature    order(416..418,506..508,515..517,575..577,584..586,
                     590..592)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="lipid binding site [chemical binding];
                     lipid-binding site"
                     /db_xref="CDD:341428"
     misc_feature    order(452..454,461..463,467..469,509..511,521..523,
                     758..760,770..772,779..781)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="Sec22 interface [polypeptide binding]; other site"
                     /db_xref="CDD:341428"
     misc_feature    order(572..574,581..583,641..643,653..655)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="VARP interface [polypeptide binding]; other site"
                     /db_xref="CDD:341428"
     misc_feature    797..988
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="SNARE motif of SEC22; Region: R-SNARE_SEC22;
                     cd15866"
                     /db_xref="CDD:277219"
     misc_feature    order(803..811,815..820,824..841,845..853,857..859,
                     866..871,875..883,887..904,908..925,929..946,950..967,
                     971..979)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="heterotetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:277219"
     misc_feature    878..880
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="zero layer; other site"
                     /db_xref="CDD:277219"
ORIGIN      
        1 cggtatattt acacggacat accggtgacg tggttacatt gcaacaaaca tccacagaaa
       61 cctccaatcc actccaatcc cagacacccg cccgccgcga cgttgcaaca cagttttcat
      121 ggtagcagcg aacgttcccg attcgaggca gagtccattt ggaagtcccg ggcatcgcag
      181 gagcactgcg gcaagcaccg accgatcggc tgagttgtga aatccaagaa gtggaagagg
      241 acgaccggac acaaacttca cacactggtg actggactgc agcggatcca catcggaata
      301 agtagcagcc agtggaagga ggcgacggca gagtgcagcc gtggccaaga agacttgaga
      361 cgcagccccg tagttccgcg agcaatcgta accaggaaca gcagaagcca tggcgctgct
      421 gaccatgata gccagggtca tcgatggcct tcctctggtg gggaccatgc aggatgacga
      481 gcagagcgga cgcagcatac tggactacca aaaccaggct aagatgctct tccgcaagct
      541 gggtacccac tccccggctc gatgcagtat cgagaccgga ccctacctat tccactacct
      601 aatcgagaac gacgtctgct acctggtgat ggtggacaag atgtactcaa agcgactggc
      661 cttcaattac ctggaggacc tggcccagga gttccatgct aactacggcc ggcgagtaaa
      721 ctcagtgact cgcccatacg cattcatcga gtttgacgtg tacatacaga aggcgaaaaa
      781 acagttgacg gaccgcagac gcaacatcag caacatcaac acacagctgc aggatgtgca
      841 gcgcatcatg gtgcaaaaca ttgacgacgt gctccaacgt ggcacagtgc tggcggaact
      901 cgacaccaag acccagaacc tatcgatgat gtcacagaag tacaagaagg acgccaagct
      961 gctcaaccga aagtccatgt acgtgaaggc gatggccttg ggcatgatac ttctagtgtt
     1021 catcatgtat ttctgggttc tgtaatatca agcagttcca tggccactcg gagcggcgcg
     1081 ttctttgttg gagtcaagcg tcaaggacgc aagaccaaaa gacatttaga ttacgcgtgc
     1141 acctgtactc cacgccacca accacaccat attcattcat atctatgaat cataggcaag
     1201 cgaaaagtga atagcgaaac cccctaccag catacgcatc gctcccgagg attgttttac
     1261 ttctaatatt aacttacctt tgcgttattt acggtctggg attccattaa ttattaactc
     1321 ccatttcatt tcgcctcgcg cttccgttgc gcaggttttc taaatatttg attacgaatc
     1381 gggtttagtt tagacgacct ttgagccaag tcggttgact acgacccaaa tctgtaaatt
     1441 atgagcgtcg atccgtgtgt gtgtgtataa atgtctagat tgtagatgga tcgctgcata
     1501 gcgaatccga atccggcgga gtgcttgata caagctgcaa aaacaccgca aaaaacaaaa
     1561 gaaaaagaaa agataacaag cgaaccgaaa gaaaagaaaa gaagagaaag ggaaataaac
     1621 aataacagtt ttaggcaatt tatatgtgta aaattaaggc aaataaataa atttatattg
     1681 tttaataaag agaaggcaaa actgtgttcg atgcactacc caagcccgaa agatagaaac
     1741 tgc