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Drosophila melanogaster histone methyltransferase 4-20, transcript


LOCUS       NM_130497               6137 bp    mRNA    linear   INV 26-DEC-2023
            variant A (Hmt4-20), mRNA.
ACCESSION   NM_130497
VERSION     NM_130497.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6137)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6137)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6137)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6137)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6137)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6137)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6137)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6137)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6137)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6137)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6137)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6137)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6137)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6137)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6137)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6137)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6137)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6137)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6137)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6137)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6137)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6137)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6137)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_130497.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6137
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6137
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="Histone methyltransferase 4-20"
                     /map="1B13-1B14"
                     /db_xref="FLYBASE:FBgn0025639"
                     /db_xref="GeneID:31015"
     CDS             668..4570
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /EC_number="2.1.1.362"
                     /EC_number="2.1.1.372"
                     /note="CG13363 gene product from transcript CG13363-RA;
                     CG13363-PA; Hmt4-20-PA; histone methyltransferase 4-20;
                     Suv4-20"
                     /codon_start=1
                     /product="histone methyltransferase 4-20, isoform A"
                     /protein_id="NP_569853.1"
                     /db_xref="FLYBASE:FBpp0070146"
                     /db_xref="GeneID:31015"
                     /db_xref="FLYBASE:FBgn0025639"
                     /translation="MVVGSNHTRRGETGSRFTNSSSSSSTSGGPTASASSTTSVTSSL
                     ATNSTSTSTAAALLSSMSHKSHGPPPSAPPSAHHQTNQQHHQVAHSQPHATHYQQTNQ
                     HPSHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSAVSRLSQSTGMSPRELSEN
                     DDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYEGP
                     WIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRW
                     SKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCR
                     ANCKFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAG
                     KDDGLMLGLSMGLGLASSGPGNNGGYRLRETDNRINRIKSRANSTNSTSNSNSNTNDS
                     TGPSETSSTNGLVASGGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNVVVSP
                     LTMKELRQKGMTKYDAEMIMANAAYQQQHHHQHHFHHHHHHHHHHHNHGQHASTGAEA
                     TAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAGSEVNGGRSTSLRKSMRVNSTS
                     SSISTASADEVIAPVVAASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRRSERQ
                     KEKLTDGESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEPQPEKSEEKQQEQQKRVTRN
                     SAGRVGLVARLATAHNNNIATTTNSSSSSNKATTITNCNNHNSNNSSRINHNSNLSSR
                     LSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPSTQGI
                     KEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTT
                     SCSSTTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHRE
                     GTAGEGSVRSALNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEP
                     PPKEELQLVNKKQRKKQRSRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDIPP
                     AAAEGSGSGLDDLNSSGGGGDESFNASYASSTSLTVNTSSSSTSSSSGVGGATSTSAE
                     PVDSSTVGPPIAAQSPSSTTSSSFQSACTSTTNSNSYFPNGKQRAAGEDSYAMHYYQL
                     GKFAGTPSPGQGQAIVSSSSGSSGGGGSGAGFLSMPKHTFGTCALLAPTSFACLQNQP
                     QISQQKTSSGGGAGVVPTSTSTGAVTSHHHTNNHHGQK"
     misc_feature    1412..1837
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain superfamily; Region: SET; cl40432"
                     /db_xref="CDD:394802"
     misc_feature    order(1466..1471,1643..1660,1682..1690,1754..1765)
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="active site"
                     /db_xref="CDD:380914"
     misc_feature    order(1466..1471,1646..1660,1760..1762)
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="SAM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:380914"
ORIGIN      
        1 agtggtcgaa gcatcaacgt ctttttacat cactaatccg agtatcgcgg aaaaaaagca
       61 gccgcatttt gtaaactaag tccgaattag agctgataca agtcccgact tattcgtcaa
      121 gaggagcggc ggtagcaaat agcaacagcg acacttggtg caaagaacgc agaggagaaa
      181 gaagtgaaaa aagcatacat acatacgcac gtacacacgt ctcgctagta gagggaatat
      241 atgtatatgc atacggctgg gtttacgtgt gcttgtgtgt gctacagccg cttctaggcg
      301 tgaaagagcg agggatacat tctcttccca tactcgcgac ttttggagcg tctcgcgagc
      361 gaaagagaaa gcacgagcca tggacggcgg ttggaagttt ttgtggaaca aaggcgtcaa
      421 gaactaaaat gatttgggac tgcaagcgcg atttattttg ggtacgcagc caaagccaag
      481 ccatccaaaa cggagtccag ctccaatcca gtgtgtcgcc gtttgtatat gtgagtctcg
      541 acgaaaagcc gtggaaagag acggacacac gcacagagaa gcagcagaca aagcatcgtt
      601 ttgcgagatt gagcgagagg cacaatatcg ccttagttaa taaattcatt taagactgtc
      661 gtgcagaatg gtcgtcggct ctaaccacac gcggcgcggt gaaactggca gcagatttac
      721 aaacagcagc agctccagca gcacaagcgg tggccccacc gcttcggcca gtagcaccac
      781 cagcgtaacg tcttcactag ccaccaattc cacgtcgaca tcgacggctg cggctctgtt
      841 gtcgtccatg tcccacaaga gccatggccc tccgccatcc gcacctccat ctgcacacca
      901 ccagacgaac cagcagcacc accaggtggc ccacagccag ccacatgcca cccattacca
      961 acagacaaac cagcacccta gccaccatca ccagtcccat cagtcttcga acggcagtgg
     1021 cggaggatct gctggatcgg gatctggatc tggatcggtg gttagtggac tcaatggttg
     1081 caacggcagc gccgtcagcc gcctatcgca atccactggg atgtcgccgc gggaactgtc
     1141 cgagaacgat gacctggcca catcgctgat cctcgatccg catcttggat ttcagaccca
     1201 caagatgaac atacgctttc ggcctcttaa ggtggacacg caacaactga aagcgatcgt
     1261 ggacgacttt atccacacgc agaactacga tatagccatc cagcgcatat acgaggggcc
     1321 gtggataccg cgtcatctca agaacaagaa caagattgcc accaagcggc tccacgatca
     1381 tatcgtccga tacctgcgcg tctttgacaa ggatagcggc tttgcaatcg aggcctgcta
     1441 cagatacaca ctggaagagc aacggggcgc caagattagc tcgacgaagc gctggtcgaa
     1501 gaacgacaag atcgaatgcc tggttggctg catcgccgag ctgacagagg cggaggaggc
     1561 cgctctgctg cactctggca aaaatgactt ctcagtaatg tacagttgtc gcaagaactg
     1621 cgcccaattg tggctgggac cggctgccta tatcaaccac gattgtcgcg ccaactgcaa
     1681 gtttttggcc accggcaggg acacagcgtg tgtaaaggtc ctgcgcgaca ttgaggtagg
     1741 ggaggagata acctgcttct acggcgagga cttctttggg gattccaatc gctattgtga
     1801 gtgcgaaacg tgcgaacgcc gtgggactgg agccttcgcc gggaaagatg atggcctgat
     1861 gctggggctc agtatgggac tcggcttggc cagcagtgga cctggtaata atggcggcta
     1921 tcgtctgagg gagacagaca atcggattaa ccgcatcaag agccgagcca actccacaaa
     1981 cagcacctca aacagcaaca gtaatacaaa tgattccact ggccctagcg agactagtag
     2041 cacaaatgga ttggtggctt ctggcggagc aggaggagcc actggtgccg cgatgctgcc
     2101 cacaccctcg caacaatcaa ctggcggcaa ggaggccaca gccgccgtct ctttgctcga
     2161 aaagaaactt ccgaatgttg ttgtttcacc gctgaccatg aaggagctgc gccaaaaggg
     2221 aatgactaag tacgatgccg agatgatcat ggccaacgca gcttaccagc agcagcacca
     2281 tcatcagcat catttccatc accaccatca tcatcatcac catcaccaca atcatggcca
     2341 gcatgcaagt actggagccg aggctacagc ggctgtacag caaatggcgg ccatgcagaa
     2401 gccaggagtt ggcggaacag gagctgcagg aaatgctgga gcaacgacag tgagcagcgt
     2461 ggcagccgga gcgggctccg aggttaatgg tggtcgttcc accagtctac gcaagtctat
     2521 gcgcgttaac agcaccagca gcagcatttc caccgcctcc gcggacgagg tgatcgcacc
     2581 cgtggtcgcg gcgagcattt cgctgcccag caaggcaccg gtggttctta tgccgcgttg
     2641 caagccagct cagatggcca ttgctgcgct gcaccagagc cagcagcgcc agcttagacg
     2701 tagcgaacgc cagaaggaaa agctgacgga cggcgagagc agcgacacca gcagcgagca
     2761 gcaaaagaaa gagcagaagc agcaggatca ccaactgccg caaaaaatgt tcagcctggc
     2821 ggaggaacca caaccagaga agtcggagga gaagcaacag gagcagcaga agcgtgtgac
     2881 gcgaaatagt gcgggaagag taggattggt agccagatta gccactgccc ataacaataa
     2941 cattgcaacc acaacaaata gcagcagcag cagcaacaaa gcaacaacga ttacaaattg
     3001 taataatcat aatagtaata atagcagtag aattaatcat aattcaaatc ttagcagtag
     3061 acttagtgtt aaatcgagga agccagcacc aagtgaggcc tcgtccatac cctcatccac
     3121 atcatcagaa aatcagcagc agcaggcaac gcgtcgcagc tgcagcccga ctcccgcgta
     3181 caagaagaac cttttggcca gctttgatcc cgatcctccc tccacccaag gaatcaagga
     3241 gcagctaaag gacgaatcag ttacttattc gccggtcaag cagaaacgta gcagaagggc
     3301 cgctgctctg gcggcagcgc aaagtatcca ctgcgaagcg ttgggcggat tccctaccgg
     3361 ttcaactggt agccagcgaa agagggccca ggccggagaa cctaccacct catgctcctc
     3421 tacaaccatc agcaatgttg agcccctact gaagactcct gagcgcaggc tgaagctaac
     3481 gttgcgcatg aaacgctcac caatcctaga cgaagtaatt gagctcggaa cgagtctgag
     3541 caacggagga gctggtcgag gtgcaccagg ctcccatcgg gaagggacag caggagaggg
     3601 gtcagttaga agtgcgctaa acctaaccgg cagcagctca aatggtattg aatacgagat
     3661 actgcgcatg gagggtattt cagagcacgg caacgatgac gatgaggacg aggaagaaga
     3721 tgatgaagag ccagctgccg aggaagagga ggagccgccg ccgaaggagg agctgcagct
     3781 ggtgaacaag aagcagagaa agaagcagcg cagccggagc aggagcagcc aacgcagatc
     3841 gccggcccca agcagtgtat atggaacacc gcagaagaag cgactccgct tgatctttgg
     3901 caacgaatcc cacaccatag acattccacc agcagcagca gagggatcgg gcagcggctt
     3961 ggatgaccta aacagcagtg gaggcggtgg cgacgagtcc ttcaatgcct cctacgccag
     4021 cagcaccagt ctgacagtta atacatcctc aagcagtacc agctcatcca gtggagtggg
     4081 aggagctacg tccacctctg cagagccagt ggattcgtcc acggttggac cgcccattgc
     4141 tgcccaatca ccttcatcga cgaccagcag ctcctttcaa tcggcctgca catcgaccac
     4201 caacagcaac agctactttc ccaatggcaa gcaacgagct gctggcgagg actcctatgc
     4261 gatgcactac taccagctgg gcaaatttgc tggaacacca agtccgggac agggtcaggc
     4321 catcgtgagc agcagcagtg gttcgtcagg aggaggagga tctggagctg gctttctgag
     4381 catgcccaag cacacattcg gcacctgtgc tctcctggcc cccaccagtt tcgcctgcct
     4441 acagaatcag ccgcagatta gccagcagaa gaccagcagc ggcggaggag caggagtggt
     4501 gcccacctcc acttcaacgg gcgcagttac atctcaccat catacaaaca accatcacgg
     4561 ccagaaataa ccaacgactg atctccaagc aaattgacta agcacagttg ccatttccat
     4621 gagaagagga ggagcgcgta gggggagagt accgggcgag gacatggtga agcaccaggt
     4681 gcagagaagc aggaataaca agggatggag actgagaatg gctgcgctgc tggcgtcgtt
     4741 gcctttgctg ctgctgattc caagcacctt atagaaaccg taggcttaga tcttagtcca
     4801 agtagatgat ccctgatata cccgccctgg gttttcatat tcgggaagca aagcaacagg
     4861 ctgaccaatt tgttaatgcg aatccggata tataccagat tgtaacttgt tttgtttttg
     4921 ctttcttttc catttctctc tttctctttg tgatcacttc ccgtttctcc caaccctttt
     4981 actttgtgtc cgcgttgcat gtggcgcgtg tgtgtgtggt gtgcttttat tttgcaggtg
     5041 gcagtctgaa tcgtagaagt aggaaaaggt cgcagcaaag ggcagcgtgt tgcaatcaca
     5101 acaaaagcag cagcgggagc aaccggagca gcggcaacat cggcagcagc aacagcagca
     5161 gcagcaccac caccaccacc accaccagca atttgatagt taaacggcta agaatagagt
     5221 taaatcgcat tcaaatcatg tacagttgag aactaaccga cctaaacagc ggacgagcag
     5281 cccaggagcc actgtgaatc agaatgggag gatttaggac gcaattagca gaggttttag
     5341 acgccttgca tccgaaaccc aacttagctt tacaccaagc aagcccctct gtttgttgca
     5401 agataatgaa acaaccacat attcgaggat acttgggact cccaccccac aatagccaac
     5461 aagaaaacaa tagcgcagca gcggcaacca gaacagcaat atataaataa taacatatat
     5521 gcatggtgta tatacaagat atacgagaca aacttaatgt taattactac aaagcgagct
     5581 ggttgaagag accgaaagga ggaggagctt acactttcac atacatataa caataacaat
     5641 gtatataaac caaaaagcgg gaaatttaat tataaagcaa gcgaaaacaa ttgaacagaa
     5701 gattcaaata aaacgctaaa tacaactcga tacaagtggt ggttcaagtg gttcgacgga
     5761 ccatgcaatc tggtttaatt cacatgaatc tgaatccaaa acaactcgca ctccctgccc
     5821 ttcgttttat tgccagctta ttgtttattt tgttctctgt gaaatttggt ttttaaaagg
     5881 cgacagatag aaaactacaa ctaaaccatc acaaccacac acacacacga agcaaattcg
     5941 atgatttttt aacgacataa ttattttttg tttacctata agtttagtta gtagcttatg
     6001 caattaaaca ttaatcatat ttgatatata ccatatactt tattcatatc tgtaactaat
     6061 gtgtattatt ttctaagctg ccgcggccgc aaaacattca taataaacta aaaagaacat
     6121 ttagttttta caaacgc