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Drosophila melanogaster uncharacterized protein, transcript variant


LOCUS       NM_130481               1492 bp    mRNA    linear   INV 26-DEC-2023
            A (CG13375), mRNA.
ACCESSION   NM_130481
VERSION     NM_130481.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1492)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1492)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1492)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1492)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1492)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1492)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1492)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1492)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1492)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1492)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1492)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1492)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1492)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1492)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1492)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1492)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1492)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1492)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_130481.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1492
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /map="1A1-1A1"
                     /db_xref="FLYBASE:FBgn0040370"
                     /db_xref="GeneID:30976"
     CDS             396..1316
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="CG13375 gene product from transcript CG13375-RA;
                     CG13375-PA"
                     /codon_start=1
                     /product="uncharacterized protein, isoform A"
                     /protein_id="NP_569837.2"
                     /db_xref="FLYBASE:FBpp0070098"
                     /db_xref="GeneID:30976"
                     /db_xref="FLYBASE:FBgn0040370"
                     /translation="MRGRHLRRRFSLQPSFMKDDNAEDKPKRDKVGRNNAVDDAIGPA
                     NARHKIVVMGSAKVGKTSIITQFLYNTFSTKYKRTIEEMHQGNFSIAGVSLTLDILDT
                     AGSYEFPAMRALSISSADAFILVYDVTDATTFEEVRTIRDQIHETKATTAVPIVVVGN
                     KIDLLADGETEREVEYATTESVVTVDWENGFVEASASSNENITQVFKELLAQAKITYN
                     LSPALRRRRQSLPQQIGNNGPSTPLHHHQHTQHHNSGGGTSASTSSAAAAASSSGGSG
                     SHAPTPAQLQHLQRIQERSLGAKRNSCIIS"
     misc_feature    540..1112
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="Ras - dorsal-ventral anterior localization
                     (Ras-dva) family; Region: Ras_dva; cd04147"
                     /db_xref="CDD:206714"
     misc_feature    555..578
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="G1 box; other site"
                     /db_xref="CDD:206714"
     misc_feature    order(558..563,702..707)
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="putative GDI interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:206714"
     misc_feature    order(561..581,696..698,705..707,873..878,882..884,
                     978..983)
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206714"
     misc_feature    order(576..581,618..620,624..626,645..650,687..692,
                     696..698,702..707,984..986)
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:206714"
     misc_feature    order(621..626,639..650)
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206714"
     misc_feature    621..647
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206714"
     misc_feature    627..629
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="G2 box; other site"
                     /db_xref="CDD:206714"
     misc_feature    696..707
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="G3 box; other site"
                     /db_xref="CDD:206714"
     misc_feature    order(702..743,753..758)
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206714"
     misc_feature    873..884
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="G4 box; other site"
                     /db_xref="CDD:206714"
     misc_feature    978..986
                     /gene="CG13375"
                     /locus_tag="Dmel_CG13375"
                     /gene_synonym="Dmel\CG13375; EG:BACR37P7.8"
                     /note="G5 box; other site"
                     /db_xref="CDD:206714"
ORIGIN      
        1 acgcagcgtg ttgttatatc gcatctgccc caaaacaatt ttcatctcaa cagctacaaa
       61 aacagaacac tcttagcaag aaatcaaata ccaccctaga taaaaaataa acggaaaatt
      121 tgttatttct ttcgtacatg gtgaacacag gaatacaacg cgaagattag catttttaat
      181 attctggtgg aaagacgaac cgcaaaggga aaaacgctaa agaataagca aagtacgatg
      241 gactaacagt ttgccagtga gcgctacatt ttcagctaag ctgcaaatat aaaacggcat
      301 acgaagcatg agcattaaat cttaggcgag ggtcgttgac ttatcagtag cctcaataat
      361 cagggagacc actcaggtat tccaaggatt acaatatgcg tggccgccac ttacgccgcc
      421 gattcagcct gcagccctcg tttatgaagg acgacaatgc cgaggataag ccaaagcgtg
      481 ataaggttgg tagaaacaac gcggtagatg atgccattgg accggccaac gcacgccaca
      541 aaatcgtcgt catgggctct gcaaaagtgg gaaaaacgtc aataatcacc cagtttctgt
      601 acaatacatt tagcaccaag tacaagcgga ccattgagga aatgcaccaa ggcaactttt
      661 ccatcgccgg cgtgagcctt acccttgata ttttggacac tgccggctca tacgagtttc
      721 cggcgatgcg agctctttcc atatcctcgg cggatgcttt tattctggtc tacgacgtaa
      781 ccgatgccac cactttcgag gaggtgcgca caattcgcga tcagatccac gagactaagg
      841 ccactaccgc tgttccaatt gtagttgtcg ggaacaagat cgatctctta gcagatggag
      901 aaactgagcg agaggttgag tacgccacca cagaatcggt tgttactgtg gactgggaga
      961 acggatttgt agaggcttca gcttccagta atgaaaacat tacccaggtg ttcaaggaac
     1021 tgctagccca ggcaaaaata acttacaatc tgagtccggc cctccgtcgt cgtcgacagt
     1081 cgttgccgca gcagattggt aacaatggac ccagcacccc gttacaccac caccagcaca
     1141 cccagcacca caattccgga ggtggtacct ccgcttctac ctcttcggca gctgcagctg
     1201 cgtcatcttc cgggggatcc ggatcccatg ctcctacacc tgcccagctg cagcacctcc
     1261 aaagaatcca ggagcgaagc ttgggcgcca aacgcaactc gtgcatcatt tcctaaacag
     1321 gccaaactga aagaggtcta atatataatg gttttcaaaa ccttttcaat agtctataat
     1381 aacatggggc gtttttctaa actcaaacaa cagaactaat attaacagaa gaggcagatt
     1441 aattctatta acatgagagt cttgtaaggg aagacaacat tctgggtgag ct