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Drosophila melanogaster bifid (bi), transcript variant A, mRNA.


LOCUS       NM_080331               4048 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_080331
VERSION     NM_080331.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4048)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4048)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4048)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4048)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4048)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4048)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4048)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4048)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4048)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4048)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4048)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4048)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4048)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4048)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4048)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4048)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4048)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4048)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_080331.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4048
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4048
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="bifid"
                     /map="4C3-4C4"
                     /db_xref="FLYBASE:FBgn0000179"
                     /db_xref="GeneID:31379"
     CDS             303..3221
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="CG3578 gene product from transcript CG3578-RA;
                     CG3578-PA; bi-PA; opomoter-blind; quadroon; optomotor
                     blind; optomotor-blind; optimotor blind; optomer-blind;
                     optomotorblind; lethal(l)optomotor-blind; Optimotor-blind;
                     optomotor-blind gene; optomoter blind; optomoter-blind"
                     /codon_start=1
                     /product="bifid, isoform A"
                     /protein_id="NP_525070.2"
                     /db_xref="FLYBASE:FBpp0070640"
                     /db_xref="GeneID:31379"
                     /db_xref="FLYBASE:FBgn0000179"
                     /translation="MRYDVQELLFHQSAEDPFARFANGMAYHPFLQLTQRPTDFSVSS
                     LLTAGSNNNNSGNTNSGNNNSNSNNNTNSNTNNTNNLVAVSPTGGGAQLSPQSNHSSS
                     NTTTTSNTNNSSSNNNNNNSTHNNNNNHTNNNNNNNNNTSQKQGHHLSTTEEPPSPAG
                     TPPPTIVGLPPIPPPNNNSSSSSSNNSASAAAHPSHHPTAAHHSPSTGAAAPPAGATG
                     LPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPH
                     HPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEG
                     KDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHN
                     SRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTIL
                     NSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFA
                     KGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALL
                     DNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHA
                     AAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGA
                     AAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLPYLYPHGLYPPPHLGLLHNPAAAA
                     AMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGS
                     LGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHSPPTRPI
                     SMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSAAAAAAAL
                     QLAEEAAQHHHHTQAHHQQQQHQSHHQQQHHQQPAQPHPHHQTHLHSHHGATTGGTDQ
                     "
     misc_feature    <1080..1256
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="Optomotor-blind protein N-terminal region; Region:
                     Optomotor-blind; pfam11078"
                     /db_xref="CDD:337907"
     misc_feature    1278..1841
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="DNA-binding domain of T-box transcription factor 2
                     and 3, and related T-box proteins; Region:
                     T-box_TBX2_3-like; cd20188"
                     /db_xref="CDD:410314"
     misc_feature    order(1365..1370,1599..1601,1608..1610,1656..1661,
                     1770..1781,1794..1796,1803..1808,1815..1835)
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410314"
ORIGIN      
        1 tgttagtaaa cgtcgacact tcatatgaaa cgaagagcgg agatcacagc ggaaaatcca
       61 ggggtcaatg aaacatgaat ttttttgaaa caacaagaag agaaataaag tgtacaagtc
      121 agtgagtgtc ccaaacaaaa agttttaaaa aaaaagaaac aaaaacaagt acctgtagaa
      181 caaaaacaaa ataaagcatc taaaaatttc aaaagtcaaa ctagagagat cccttttttg
      241 gagagatcgc cgtgggaaac cctttctgca tgacgcactt ggttgtttga aacggttatg
      301 tgatgagata cgacgtccag gagctgctat ttcatcagtc tgctgaggat ccattcgcca
      361 ggttcgccaa tgggatggca tatcatccat ttctgcagct aacgcaacga cccactgact
      421 tcagcgtttc ctcgctgttg acggcgggta gcaacaataa caacagcggc aacaccaaca
      481 gcggaaacaa caactccaat tccaacaaca acaccaattc aaacaccaat aacaccaaca
      541 atctcgtggc cgtttcacca acgggtggtg gtgcgcagtt atcgccgcaa agcaaccaca
      601 gcagcagcaa caccaccacc accagcaaca ccaacaactc cagttccaat aacaacaata
      661 ataacagtac ccataataat aacaacaacc acacgaataa caacaacaat aataataata
      721 acacaagtca aaagcaagga caccacttga gcaccaccga ggaaccgcca tcgcccgctg
      781 gcacaccacc gcccacaatt gttggtctac cgccaatacc accgcccaac aacaacagca
      841 gtagcagcag cagcaacaac tcagcttcag ccgccgccca tccgtcgcac cacccaaccg
      901 ccgcacatca ctcacccagt acgggtgccg ccgcaccgcc cgccggcgcc acaggcttgc
      961 cgccacccac accgccgcac cacctgcaac aacaacagca gcaacaacag cacccggccc
     1021 caccaccacc accgtacttt ccagctgcgg cactggccgc tctagctgga agtccggccg
     1081 gaccgcatcc gggtctgtat cccggcggtg gattgcgctt cccgccgcac cacccaggtg
     1141 cccatccgca cgcccatcat ctgggcagcg cctatactac cgccgaggac gtcgtccttg
     1201 cctcggccgt cgcccatcag ctgcatccgg cgatgcgacc gctgcgggcg cttcagcccg
     1261 aggacgatgg cgtcgtcgat gatcccaagg tcacgctgga gggcaaagac ctgtgggaga
     1321 agttccacaa actgggcacg gaaatggtca tcaccaagag cggcagacaa atgtttccgc
     1381 aaatgaaatt tcgtgtttcg ggactggatg ccaaggctaa atacatcttg ctactggaca
     1441 ttgtggcggc ggacgattat cgttataaat ttcataatag tcgctggatg gtggctggca
     1501 aagcggatcc cgagatgcca aaacgcatgt atatccatcc agattcgccc acaacgggtg
     1561 agcaatggat gcagaaagtt gtttcatttc acaaattaaa attgaccaac aatattagtg
     1621 ataaacatgg atttgtaagt actacgatcc tgaactcgat gcacaagtac cagccgcgtt
     1681 tccacctggt gcgagccaat gacatcctga agctgccgta ctccacgttt cgcacgtacg
     1741 tcttcaagga gaccgagttc atcgccgtca cagcatatca aaatgagaag ataactcaat
     1801 tgaaaatcga taacaatccg tttgcgaagg gctttcgtga tactggtgcc ggcaagcggg
     1861 aaaagaagca ggcactgatg tcgaaccgag ggtccgattc ggacaagttg aatccgacgc
     1921 atgtgagcag ctcgcgggca ccgctccacc tgggccacgc cggccgtccg cctcatctgc
     1981 atccccatgc cgccctgctt gataatcagc aggacgacga cgacaagctc ctggacgtgg
     2041 tgggtccgcc acagagtccg ctactcccgc tcagccactc gctgcagcag atgcacgccc
     2101 accagcactc cgcagctctg gctgcctggt ttaatcactt ggctggcgct ggagccggag
     2161 cctccgaaca tgcagctgcg gcggcggcca atgccagtgc ggaggatgca ctgcgtcgtc
     2221 gcttgcaggc ggacgcggat gtggagcggg atggcagcga ttcgagttgc tcggaaagcg
     2281 tcggcggcag taccggcggt gcctttaggc ccacctcgac gggcagtccc aaggaggcgg
     2341 tgggcgcggc tgcagctgcc gcagcggctg gcttgaatcc cggtggcggt agctatccgt
     2401 caccgaatat atcggtgggt ccgcccattc acccgtcgcc gcatttgttg ccttacctgt
     2461 atccacatgg cctgtatcca ccgccgcatc tgggcctgct gcacaatccc gctgcagcgg
     2521 cggccatgag tccggctggc ctgaatccgg gtctgctctt caatgcccaa ctggcgctgg
     2581 ccgcccagca tccggctttg tttggccacg cctacgcggc ggcgggtcac acaccggtat
     2641 caccattaca aggcctaaag agccatcgct tttcgccgta cagtttgccc ggcagtttgg
     2701 gctccgcctt cgatgcagtg actcctggat cgaacgcaaa tcgctcggga gatcctccag
     2761 gcggcggcgg cggcggcctg ggtggtggtg tggtggagaa tggtcccagg agtctgagtt
     2821 ccagccctcg tccccgacct gcctcccact cgccgcccac tcgaccgatt tcgatgtcac
     2881 ccacaacgcc gccatccctg atgaagcaac cacgtggcgg tggtgctggc gccggtgtgg
     2941 cccaatcgca gcactcgcct tcggaactta agagcatgga gaagatggtc aacggactgg
     3001 aggttcaaca caatggcagt gcggcggcag cagcggcggc tcttcagctg gccgaggaag
     3061 ctgcccagca tcatcatcac acccaggcgc accaccagca gcagcagcat cagtcgcacc
     3121 accagcaaca gcaccaccag caaccggcac aaccacatcc gcaccaccag acccatctac
     3181 actcgcacca tggggcgaca acgggcggta cggatcagtg acaattactg gacggccgct
     3241 ccgattgtga ggatgccggt ctcgaattgg aactagagtt ggaggaggat gtcgaggatc
     3301 tggatcagga tccggatgag caggacgagg atcgcagctc ggtcatcgat cttgatctgg
     3361 acgtcgacgt ctgaccgcga acggatcagc gacattgcct ctagcctctg aactacacgg
     3421 ccaccgtctt tgtggtttag cgtagtgtat atgtacatat atatatcgga cgatttggac
     3481 cctagactat aggcatttgt agcatatata gtgtgtattc ctctctcgtt gcgaactcac
     3541 tctgcccgtt tatcgccagt gttaagtaac atcttttttt ttttttgtct cgtttctaag
     3601 caaagcctag cccctagaaa tcgctggcga ttcgctggca aagtgatgga gaggtctaat
     3661 tgaagacaga aggtagcaaa aacagaagaa aaaaaaaaaa taacacaaaa aggaaacaaa
     3721 aaacaggaaa aagttaaggc gacgtggcaa gagaatcgtc gtaactttta gcgccttgaa
     3781 ggttccagac ttcaagatca aacagacgga ataaaatgag aagtaagggc aaggggctat
     3841 cctcagacaa atttatgtat cacccatata tgtatattga ttggattgaa aatagcaaca
     3901 tcaaagatgg cgcctcttta tatacatcta gaacacgcat atatatatat ataaatatat
     3961 atatatagta tatatagaag ctggtatata tacagaatgt aaccttagta aaacatacaa
     4021 gaaaaaacaa agaaaaacaa aaacccac