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Drosophila melanogaster period (per), transcript variant A, mRNA.


LOCUS       NM_080317               4527 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_080317
VERSION     NM_080317.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4527)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4527)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4527)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4527)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4527)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4527)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4527)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4527)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4527)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4527)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4527)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4527)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4527)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4527)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4527)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4527)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4527)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4527)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4527)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4527)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4527)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4527)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4527)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Nov 6, 2002 this sequence version replaced NM_080317.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4527
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4527
                     /gene="per"
                     /locus_tag="Dmel_CG2647"
                     /gene_synonym="CG2647; Clk; clk-6; Dmel\CG2647; dmper;
                     dper; dPer; dPER; EG:155E2.4; mel_per; Per; PER; Per-2"
                     /note="period"
                     /map="3B1-3B2"
                     /db_xref="FLYBASE:FBgn0003068"
                     /db_xref="GeneID:31251"
     CDS             370..4026
                     /gene="per"
                     /locus_tag="Dmel_CG2647"
                     /gene_synonym="CG2647; Clk; clk-6; Dmel\CG2647; dmper;
                     dper; dPer; dPER; EG:155E2.4; mel_per; Per; PER; Per-2"
                     /note="CG2647 gene product from transcript CG2647-RA;
                     CG2647-PA; per-PA; dperiod; PERIOD; period clock protein;
                     clock-6"
                     /codon_start=1
                     /product="period, isoform A"
                     /protein_id="NP_525056.2"
                     /db_xref="FLYBASE:FBpp0070455"
                     /db_xref="GeneID:31251"
                     /db_xref="FLYBASE:FBgn0003068"
                     /translation="MEGGESTESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHS
                     SGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRD
                     EEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEG
                     VAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESM
                     TGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFID
                     FVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVS
                     YEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFA
                     IRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTA
                     GASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAA
                     PTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDE
                     VSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLL
                     RFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNI
                     HMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGT
                     NSGTGTGTASSSKGGSAAIPPVTLTESLLNKHNDEMEKFMLKKHRESRGRTGEKSKKS
                     ANDTLKMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTGG
                     VGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGS
                     STPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLT
                     PTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAA
                     AAATAMMYQPMPFPGMANALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHSVTT
                     PAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSNPAN
                     NKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESKI
                     MEHPEEDQTQHGDG"
     misc_feature    1081..1368
                     /gene="per"
                     /locus_tag="Dmel_CG2647"
                     /gene_synonym="CG2647; Clk; clk-6; Dmel\CG2647; dmper;
                     dper; dPer; dPER; EG:155E2.4; mel_per; Per; PER; Per-2"
                     /note="PAS fold; Region: PAS; pfam00989"
                     /db_xref="CDD:395786"
     misc_feature    1531..1854
                     /gene="per"
                     /locus_tag="Dmel_CG2647"
                     /gene_synonym="CG2647; Clk; clk-6; Dmel\CG2647; dmper;
                     dper; dPer; dPER; EG:155E2.4; mel_per; Per; PER; Per-2"
                     /note="PAS domain; PAS motifs appear in archaea,
                     eubacteria and eukarya. Probably the most surprising
                     identification of a PAS domain was that in EAG-like
                     K+-channels. PAS domains have been found to bind ligands,
                     and to act as sensors for light and oxygen in...; Region:
                     PAS; cd00130"
                     /db_xref="CDD:238075"
     misc_feature    order(1579..1581,1591..1593,1609..1611,1648..1659,
                     1750..1752,1765..1767)
                     /gene="per"
                     /locus_tag="Dmel_CG2647"
                     /gene_synonym="CG2647; Clk; clk-6; Dmel\CG2647; dmper;
                     dper; dPer; dPER; EG:155E2.4; mel_per; Per; PER; Per-2"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     misc_feature    order(1639..1641,1651..1653,1675..1677,1684..1689,
                     1786..1788,1792..1794)
                     /gene="per"
                     /locus_tag="Dmel_CG2647"
                     /gene_synonym="CG2647; Clk; clk-6; Dmel\CG2647; dmper;
                     dper; dPer; dPER; EG:155E2.4; mel_per; Per; PER; Per-2"
                     /note="heme pocket [chemical binding]; other site"
                     /db_xref="CDD:238075"
ORIGIN      
        1 agtgttcgtg cgaatttaga gccagaaggt cgacaacgcg ttcgtcgcac agtagaaagt
       61 attgccatat accaaataaa tcgcaacaac gacctgtcga atcacgcaaa caaacagctt
      121 cgtttttttt tttttaattt cgaccagaaa caaaccgtta ttctttggtg ccagtgttag
      181 tgtcaagtgt atcgagctga gtgacatata gccacagcca aaaagtgaga ccataagtga
      241 gattccaaac agaaggcagc agcagcctaa tcgcagccta atcgcaaaaa agtgcagctg
      301 ggtgagagcg agagcgagtg taatctcgca ctagtcaacc aactgggcaa gctggagaac
      361 ctaagcacca tggagggcgg cgagtccacg gagtccacac acaacaccaa ggtgtccgac
      421 tcggcctact cgaacagctg cagcaacagc cagtcgcagc gcagtggcag ctccaaatcc
      481 cgcctgagcg gcagccactc ctccggcagc agtggctatg ggggcaagcc ctcgacgcag
      541 gccagcagca gcgacatgat catcaagcgc aacaaggata agtcgcgcaa gaagaagaag
      601 aacaagggcg ccggccaggg ggcggggcag gcgcagaccc tgatctcggc gtcgacgagc
      661 ctagagggca gggacgagga gaagccgcgg cccagcggca ctgggtgcgt agaacagcag
      721 atctgccgag agctgcagga tcaacagcac ggcgaggatc acagcgagcc gcaggccata
      781 gagcagctgc agcaggagga ggaggaggat cagtccggct ccgagtcgga ggcggaccga
      841 gtcgagggcg tggccaagtc ggaggcggca cagagctttc cgattccctc gccgctatcc
      901 gtcaccattg tcccgccctc gatgggcggc tgcggcggag tgggccacgc agccggtctg
      961 gacagcgggc tggccaagtt cgacaagacc tgggaggcag gtccgggcaa gctggagtcc
     1021 atgaccgggg tgggcgcagc ggcggcgggc acagggcagc gcggggagcg ggtgaaggag
     1081 gacagcttct gctgcgtcat ctccatgcac gacggcatcg tcctgtacac gacgcccagc
     1141 atcaccgatg tcctgggcta cccgcgcgac atgtggctgg gcaggtcctt catcgatttt
     1201 gtgcacctta aggaccgcgc caccttcgcc agtcagatca ccacgggcat acccattgcg
     1261 gaatccaggg gcagcgtgcc caaggacgcc aagagcacct tctgcgtgat gctgcgtcgc
     1321 taccggggac tcaagtccgg cggattcggc gtcatcggca ggcccgtcag ctacgaaccc
     1381 ttccgcctgg ggctcacctt cagggaggct ccggaggagg cgcgaccgga caactacatg
     1441 gtctccaatg gcaccaacat gctgctcgtc atctgcgcca ctccgatcaa gagcagctac
     1501 aaggttcccg acgagattct ctcacagaag agccccaagt tcgccatacg ccacacggcc
     1561 accgggatca tatcgcacgt ggacagcgcg gcggtcagtg cactgggcta tctgccgcag
     1621 gacctgattg gccgcagcat catggacttc taccaccacg aggacctctc agtcatgaag
     1681 gagacctacg agacggtaat gaagaagggt cagacggcgg gcgcctcctt ctgcagcaag
     1741 ccataccgct tcctcatcca gaacggttgc tacgtccttc tggagaccga atggaccagc
     1801 ttcgtcaatc catggtcccg caagctggaa tttgtcgtcg gacaccatcg cgtctttcag
     1861 ggacccaagc agtgcaacgt cttcgaggcg gcgcccacat gtaagctgaa gatatcggag
     1921 gaggcacaga gccggaacac gcgaatcaag gaggatatcg tgaagcgcct ggcggagacg
     1981 gtgtcccgtc cgtcggacac ggtcaagcag gaggtttccc gccgctgcca ggcgctggcc
     2041 agcttcatgg aaacgctcat ggacgaggtg tcccgggcgg atctcaagct ggagctgccg
     2101 cacgagaacg agttgaccgt ctcggagcgg gacagcgtga tgctcggcga gatttcgccg
     2161 caccacgact actatgacag taagagttcc accgagacgc cgcccagcta caaccagcta
     2221 aactataacg agaacctgct gcgttttttc aacagcaagc cggtcacggc gccggcggag
     2281 ctcgatccgc ccaaaacgga gccgccggag ccgcgcggca cgtgtgtcag tggcgccagt
     2341 ggtccgatga gtcccgtcca cgagggcagc gggggcagtg gctcctcggg caacttcacc
     2401 accgccagta acatacacat gagcagtgtg acaaatacga gcattgccgg cactggtggc
     2461 acgggcactg gtacaggtac aggtactgga actggaactg gaaccgggac aggaactgga
     2521 accgggacag gaactggaac gggaacaggt acaggcacag gcacaggcac tggaacaggc
     2581 aatggaacaa attccggcac cggaaccggc accgccagct catccaaagg cggaagcgcc
     2641 gccataccgc cagtcacgct gaccgaatcc ctgctcaata agcacaacga cgagatggag
     2701 aagttcatgc tgaagaagca ccgcgagtcg cgcggacgga cgggtgagaa gagcaagaag
     2761 tccgccaatg acacccttaa gatgctggag tacagcggtc caggccacgg gataaaaaga
     2821 ggaggctccc attcctggga gggagaggcc aacaagccca agcagcagct aaccctggga
     2881 acagatgcga tcaagggagc ggcaggaagt gcgggcggag cagtcggcac tggcggtgtg
     2941 ggatcaggag gagccggtgt ggcgggcgga ggaggatccg gaacaggcgt agcaggcaca
     3001 ccagaaggca gagccacaac gacctcggga acggggacac caggtggagc cggaggcgga
     3061 ggcggagcag gagcggcagc agcggctgga gcgtcctcct ccgtgggcag ttccacgcca
     3121 ggaccctcgt cctatcccac ctgcacgcaa aacataaacc tctggccacc gttctcggtg
     3181 ggcatcacac cgcccgttca ctccacgcac acggccatgg cccagagcag cttctcctcc
     3241 gccggcctct tcccgacctt ctactacatc cccgcctcct tgacgcccac cagtcccacg
     3301 cgctctcccc ggatgcacaa gcatccgcac aagggtggca cggacatgcc caccacctcg
     3361 cagcaggcgg ctgccgcggc cgcccaggcc atgccgctgc agtacatggc cggcgtgatg
     3421 tacccgcatc cttcgctttt ctacacacac ccggcggcgg ccgcggccac ggccatgatg
     3481 taccagccga tgccctttcc gggaatggcc aacgctctcc agattcccga acgtccgttg
     3541 ggctcccaat ccgcgtacaa caagtcggtg tacacgacca cgccggcgtc catgacgaag
     3601 aaggtgccgg gtgcattcca ctcggtcacc actcctgccc aggtgcagcg tccctcctcg
     3661 cagagcgcat ccgtcaagac ggagccgggc tccagtgcag cggtatccga tccctgcaag
     3721 aaggaggtgc cggactcctc gcccattccc tccgtgatgg gcgactacaa ctccgacccg
     3781 ccctgcagca gcagcaatcc cgccaacaac aagaaataca cggacagcaa tgggaatagc
     3841 gacgacatgg atggctccag cttctcctcc ttctactcgt ccttcatcaa gaccacggac
     3901 ggatcggaga gtccgccgga caccgaaaag gaccccaagc accgaaagct gaagagcatg
     3961 agcacatctg agagcaagat catggagcac ccggaggagg accagacaca gcacggggat
     4021 gggtagtagc cacacccgca gttgctgctg accgacgtac acaaccgagt gcacaatgtc
     4081 gatccctggg atgatccgag cagcagacac cgaggagcag cagggtcctg gaaacgagtg
     4141 agcaattgcc tccggtctgg gcaccgagta ccagccagtc ccaccagttc ctattcctaa
     4201 ctcccccttc cattcccttc aagttcttcg aatcaacgcg aacgcttccg tgggatgtca
     4261 ccattcagta tccgaacaag taacgaaagc atcagacgaa ctgacgtgga aggatgccca
     4321 gaacccatgc aagccgagga taatgtagat ctcaagccaa gcaaagcttt tagatgatat
     4381 ctatcctatg tttaatcaga atattaagtg aattgaaaac tagagagggt tcgaacatcg
     4441 aaccaccctt ctcagcccta aggtttatat atccgaatct tttttagtta tttattgtac
     4501 aataaatatc gaaaagccaa cgccaac