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Drosophila melanogaster Raf oncogene (Raf), transcript variant A,


LOCUS       NM_080308               3247 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_080308
VERSION     NM_080308.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3247)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3247)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3247)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3247)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3247)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3247)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3247)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3247)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3247)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_080308.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3247
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Raf oncogene"
                     /map="2F5-3A1"
                     /db_xref="FLYBASE:FBgn0003079"
                     /db_xref="GeneID:31221"
     CDS             589..2808
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.25"
                     /note="CG2845 gene product from transcript CG2845-RA;
                     CG2845-PA; Raf-PA; polehole; l(1)pole hole; pole-hole;
                     raf-like-oncogene-1"
                     /codon_start=1
                     /product="Raf oncogene, isoform A"
                     /protein_id="NP_525047.1"
                     /db_xref="FLYBASE:FBpp0070385"
                     /db_xref="GeneID:31221"
                     /db_xref="FLYBASE:FBgn0003079"
                     /translation="MSSESSTEGDSDLYDPLAEELHNVQLVKHVTRENIDALNAKFAN
                     LQEPPAMYLIEYQELTSKLHELEAKEQELMERLNSQDQQEDSSLVERFKEQPHYQNQT
                     QILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISG
                     VRLCDALMKALKLRQLTPDMCEVSTTHSGRHIIPWHTDIGTLHVEEIFVRLLDKFPIR
                     THIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLCQPFPMDSY
                     YQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGR
                     PPRISQDDRSNSAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTST
                     LKHNRPRARSADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHG
                     PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSS
                     LYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGD
                     FGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAE
                     CLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPL
                     LNMLENMLRTLPKIHRSASEPNLTQSQLQNDEFLYLPSPKTPVNFNNFQFFGSAGNI"
     misc_feature    1012..1224
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Ras-binding domain (RBD) found in RAF family
                     serine/threonine kinases; Region: RBD_RAF; cd01816"
                     /db_xref="CDD:340514"
     misc_feature    order(1012..1014,1018..1020,1033..1050,1054..1056,
                     1093..1095,1105..1113)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="RBD_Raf-Ras interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:340514"
     misc_feature    order(1012..1014,1033..1035,1039..1050,1093..1095,
                     1102..1113)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="RBD_Raf-KRas interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:340514"
     misc_feature    1204..1206
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Ca binding site [ion binding]; other site"
                     /db_xref="CDD:340514"
     misc_feature    1249..1395
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in the Raf (Rapidly Accelerated Fibrosarcoma) kinase
                     family; Region: C1_Raf; cd20811"
                     /db_xref="CDD:410361"
     misc_feature    1891..2649
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Raf (Rapidly Accelerated Fibrosarcoma) kinases; Region:
                     STKc_Raf; cd14062"
                     /db_xref="CDD:270964"
     misc_feature    order(1891..1905,1915..1917,1945..1947,1951..1953,
                     2044..2046,2089..2100,2110..2112,2116..2118,2230..2232,
                     2236..2238,2242..2247,2251..2253,2284..2286,2293..2295,
                     2347..2358)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="active site"
                     /db_xref="CDD:270964"
     misc_feature    order(1891..1905,1915..1917,1945..1947,1951..1953,
                     2044..2046,2089..2100,2110..2112,2230..2232,2236..2238,
                     2242..2247,2251..2253,2284..2286)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270964"
     misc_feature    order(1903..1905,2110..2112,2116..2118,2230..2232,
                     2236..2238,2242..2244,2293..2295,2347..2358)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270964"
     misc_feature    order(1927..1929,1933..1938,2017..2037,2047..2055,
                     2188..2190,2197..2202,2209..2214,2260..2262,2266..2268,
                     2647..2649)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270964"
     misc_feature    order(2281..2322,2338..2358)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270964"
ORIGIN      
        1 cgattggtac agccgaatca cgcctcctga taacgattaa acaaaaagtc gaaatgtagt
       61 aaaattcgcg gaaagtaaat aaattgttat agccaaggtg aaataacgag cggccagcta
      121 gtggcgatac tgatactgtt gcgaacgttg ggcagccacc gacggtgccg gctggtcagg
      181 ttgttatcgg gtaattggca gctcctttgg aaaatcctca agttcagctg cttctgcaca
      241 cactgacctt cattatacat acataccgta tatacgagct gtttgtgtgc gtgtgtgtgt
      301 gtgcgcttgc aagtgtgtgg gtgcactgaa aaaaggttgg aaaggataca agccagaaat
      361 cagtgaaaac cgggaatatt gcatcccgga gacggcggaa aagccgaaaa agcccattaa
      421 aagtcaagga cgacatgctg ccctccgccc acagaagtgg atgtgggtgg ctcacccatt
      481 agaactccac caaaacgcaa gcgcaggagt ttttccttca agaagtcaag gcttcttcgt
      541 tttcggggtc atggtcacag cgcatagtat ataggataaa gcaacaccat gtccagcgag
      601 tcctccaccg aaggcgacag cgatctatac gatcctttgg ccgaggagct gcacaacgtc
      661 cagttggtca aacatgtgac ccgcgagaat attgatgccc tgaatgccaa gtttgccaac
      721 ctgcaggagc caccagccat gtacttaata gaataccagg agttgacctc caagctccac
      781 gaactggagg ccaaggagca ggaactaatg gagcgactga actcgcagga ccagcaggag
      841 gactcctcct tggtcgagcg gttcaaggag cagccccact atcaaaatca aactcaaatc
      901 ctgcagcaac aacggcaatt ggcgcgagtg caccacggca acgatctaac cgatagcttg
      961 ggctctcagc cgggcagcca atgtggaact ttgacccgtc agcccaagat ccttttgcga
     1021 gcccacctgc ccaatcaaca gcgcacttca gtggaggtaa tttcgggagt acgactatgt
     1081 gatgccctca tgaaggccct gaaactccgg caactaacgc cggatatgtg cgaagtaagc
     1141 acaactcatt ccggaagaca tatcataccc tggcacacgg atatcggcac tctgcatgtg
     1201 gaggagatct ttgtcaggct gctggataag tttcccatta ggacacacat caagcaccag
     1261 atcatacgga agaccttctt ctcgttggta ttctgcgagg gctgtcgaag gcttctgttc
     1321 accgggttct actgtagcca gtgtaatttt cgattccatc agaggtgtgc caatagagtg
     1381 ccgatgctgt gccagccctt tcccatggat agctactatc agctactgct ggccgagaat
     1441 ccggataatg gcgttggttt ccccggcaga ggcactgctg tccgcttcaa tatgagcagc
     1501 cggagtcgca gtcgtcgttg cagcagcagt ggcagcagca gcagctcgaa gccaccatct
     1561 tcatcctccg gcaatcatcg acagggtcgt ccgccgagga tcagccaaga cgatcgatcc
     1621 aattccgcgc caaatgtgtg catcaacaac attcgatcgg tcacaagcga agtgcagcgc
     1681 agtttgataa tgcaggccag acctcctttg ccgcatccgt gcacagatca ctccaactcc
     1741 acgcaagcgt cgcccacgag caccttgaaa cacaatcgtc ccagggccag gtccgccgat
     1801 gagagcaata aaaatctgct tttaagagac gccaaaagtt ccgaggaaaa ctggaatatt
     1861 ctggcggagg agattttaat tgggccgcgc atcggatcgg gttcctttgg aaccgtttat
     1921 cgcgcccatt ggcacggtcc cgtggccgta aagacactca acgtgaagac accgagtccc
     1981 gcccagttgc aggcgtttaa gaacgaggtg gccatgctga aaaagacgcg ccactgcaat
     2041 atcctcctct tcatgggctg tgtatccaaa ccatctctag cgattgtgac ccagtggtgc
     2101 gagggcagca gtctctacaa gcacgtccat gtcagcgaaa ccaagtttaa attgaacacg
     2161 ctcatcgata tcggacgtca ggtggcccag ggcatggatt acctgcatgc caagaatatc
     2221 attcatagag acctcaagtc aaacaacatc tttttgcacg aggatctttc cgtgaagata
     2281 ggcgacttcg gattggccac tgcgaaaact cgatggtcgg gtgaaaagca agccaatcaa
     2341 cccacgggca gtattttatg gatggctcca gaggtgattc gcatgcagga gctaaacccc
     2401 tactccttcc agtcggacgt ttatgccttt ggtatcgtga tgtacgaact gttggcggag
     2461 tgcttgccct acggtcatat tagcaacaag gatcagatcc tgtttatggt ggggcgagga
     2521 cttctgcgtc cggacatgag tcaagtgcgc tcggatgcgc cgcaggcatt gaagcgcttg
     2581 gccgaggatt gcattaagta tacccccaag gatcgaccgc tctttaggcc gctgctcaat
     2641 atgctggaga acatgctgcg cactttgccc aaaattcatc gcagtgccag tgaaccaaac
     2701 ttgacgcaat cgcagctgca gaacgatgag tttctgtatc tgcccagccc gaaaacgccg
     2761 gtgaacttca acaactttca gttcttcggc agcgctggga atatctagac agcgacctgt
     2821 acctgtactt acatatatcc tgcgtgatca acgtgatcct acatctatat actttttgtt
     2881 cttgtccctc tgtacataag cgattcgcga aggggacggc tttggttgtc caccaaagtg
     2941 aaagagagag agagagagag aaagagagag agatgggttg cctgccgacc cgggagcgaa
     3001 acttgcttct ttccttggaa ctgacaaagt gcatttctgt taccacacac aaaacgacta
     3061 caaactgtaa actaaactgc aacgcccatg tgtacataac tgcatcataa cttatatacg
     3121 ttaggcaaga ctactgaaac taaactaaac taaactaaac tagctgatcg caattacatt
     3181 atacacatta tacttatact acaagagatg gtgttgtttc tggagtcgag cacgatgaag
     3241 aacattt