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Drosophila melanogaster frizzled 3 (fz3), transcript variant A,


LOCUS       NM_080296               2249 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_080296
VERSION     NM_080296.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2249)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2249)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2249)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2249)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2249)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2249)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2249)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2249)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2249)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2249)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2249)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2249)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2249)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2249)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2249)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2249)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2249)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2249)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2249)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2249)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2249)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2249)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2249)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_080296.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2249
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2249
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="frizzled 3"
                     /map="1C4-1C4"
                     /db_xref="FLYBASE:FBgn0027343"
                     /db_xref="GeneID:31023"
     CDS             204..1949
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="CG16785 gene product from transcript CG16785-RA;
                     CG16785-PA; fz3-PA; Dfrizzled-3; dFrizzled3; frizzled 3;
                     frizzled3"
                     /codon_start=1
                     /product="frizzled 3, isoform A"
                     /protein_id="NP_525035.2"
                     /db_xref="FLYBASE:FBpp0070133"
                     /db_xref="GeneID:31023"
                     /db_xref="FLYBASE:FBgn0027343"
                     /translation="MYAASILILHLTWAVATIAANGAGHNGPVASGAGPNGLQCQPIA
                     VSACQGLGYNMTALPNLAGHTNQLEAELQIAKLVPLIESGCSRRARFLLCSSLFPLCT
                     PDVPRPVAACKLLCETVRGECMENAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEV
                     AVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPTSDLAGVLCPQNFSGSPFNPEECV
                     PQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCL
                     CYNLFSVCYLERIVFHNQARMHDVELQWRLMRPGCLLTPPCLASYITTSYLSLCAASW
                     WLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMC
                     YAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHRFGQIRKRFVLFSLLY
                     FAPTTAGVVAALCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWV
                     WSRKTCESYRNRLGASGTPTSSLMNQSKAAGALPKKHLYTSGKSMLPTGGITPLYAGI
                     SFHNVPVYNPNQSRV"
     misc_feature    312..680
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="CRD_domain cysteine-rich domain, also known as Fz
                     (frizzled) domain; Region: CRD_FZ; cl02447"
                     /db_xref="CDD:470581"
     misc_feature    order(342..344,348..353,360..368)
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="putative Wnt binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:143549"
     misc_feature    876..1769
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="class F insect frizzled subfamily 3, member of
                     7-transmembrane G protein-coupled receptors; Region:
                     7tmF_FZD3_insect; cd15031"
                     /db_xref="CDD:320159"
     misc_feature    order(879..881,906..908,1056..1058,1359..1361,1374..1376,
                     1380..1382,1389..1394,1422..1424,1641..1646,1656..1658,
                     1671..1673,1680..1685)
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320159"
     misc_feature    903..980
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320159"
     misc_feature    1005..1070
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320159"
     misc_feature    1155..1235
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320159"
     misc_feature    1284..1334
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320159"
     misc_feature    1413..1487
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320159"
     misc_feature    1545..1628
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320159"
     misc_feature    1650..1727
                     /gene="fz3"
                     /locus_tag="Dmel_CG16785"
                     /gene_synonym="CG16785; dfz3; dFz3; Dfz3; DFz3; Dm Fz3;
                     Dmel\CG16785; EG:34F3.6; Fz3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320159"
ORIGIN      
        1 tcagtttgtt ggaaacagtg aagagtagtg gtcgcgtttc gcagttcttg gagtggagac
       61 tttccaaacc ggagaaatac gtaaaccact gagagtcgca cagtaatata aacacaaaca
      121 ttttttttac gtgccgcgag tgacgtttga acagaaaccc tggagtggca aacatgacct
      181 cctgaaaccc actaagcatc gcaatgtatg ccgcctcgat cctgatcctg cacctgactt
      241 gggccgtggc cacgatcgcg gccaacggtg ccggccataa tggcccggtg gcatccggag
      301 cagggcctaa cggattgcag tgccagccca tcgccgtgtc cgcctgccaa ggcctcggct
      361 acaacatgac cgcactgccc aacctggcag gtcacaccaa tcagctggag gctgagctcc
      421 agattgccaa actggtgcca ctaatagaat ccggctgctc gcgtcgcgcc cgctttttgc
      481 tctgctcgtc tctgtttccg ctgtgcacgc cggatgtgcc acgccccgtt gccgcctgca
      541 aattgctgtg cgagactgtt aggggcgagt gtatggaaaa cgctccgccg gaactgatgg
      601 agctgtggcc ttcgttcctt aactgcgacg gactgccgca gccggagaag cacgagttgt
      661 gcatgcagat tccacaggag gtggctgtgc caggcgggag tccaagtggt ccgcccacca
      721 ctggttcacc tggcgtcgaa gatcacccgc agacgtaccg cttttggaaa agcggagcat
      781 ctcccacctc tgacttggct ggcgtcttgt gcccgcaaaa ctttagcggc agtcccttta
      841 atccggagga gtgcgtgccc cagtgtcagc gggacgcctt ccacacgagc tctcagaaga
      901 agacgtctga gaccctcatt ctaggcctct cggccgtctg cttcgtcctg acactgttcg
      961 ccttggtgac cttctgggcg gagcccacca ggtttggcta ccccgagaga ccagtgctct
     1021 tcctgtgcct gtgctacaac ctcttcagcg tgtgctatct ggagcgaatc gtgttccaca
     1081 atcaagcaag gatgcatgac gtcgagctgc aatggcggct gatgcgaccg ggttgcttgc
     1141 tgacgccccc ttgcctggcc tcctacataa ccacctccta tttaagcctg tgtgcagcca
     1201 gctggtggct gatatttgcc ctgtgcttct acctgtcctc ccacaaaaag tggtccagcg
     1261 aggcgctgga aaagaggtcc gggctgttcc acgttctggc ctgggtgcca ccgctggcgc
     1321 cccccattgc cgccctgctg ctggagaagg tgcgtccgag tgagctgact gggatgtgct
     1381 acgcaccggg atttgtggag ctgccagcac tggtcctgct cctgcttggg ctgtacttca
     1441 ccctgagagc ctccaggtct ctgctctccc tgcagcaaca gttgcagccc accctggccc
     1501 accaccgatt cgggcagatc cggaagcgct ttgtgctctt ctccctgctg tacttcgcac
     1561 ccacgaccgc cggcgtcgtg gcggctcttt gcgagcggta cgcggattca gtgcccagct
     1621 gctccacacc cgatgactgc ctctcaccca ctccgctcag tgcctggcca gcgttggtcc
     1681 ggatcttctt ccagctggtg ggcggaacgt tgacagggtt gtgggtgtgg tcgcgcaaaa
     1741 cctgcgagag ctacagaaat cggctgggtg ccagcggcac acccacctca tccctgatga
     1801 atcaaagcaa ggcggccggg gctttgccca aaaagcattt gtatacgagt gggaaatcca
     1861 tgctgcccac ggggggaatc actcctctat atgctggtat tagttttcac aatgtgcccg
     1921 tctacaaccc caaccaatcg agagtttagg ggatctttta gcccacatgg ggggctctag
     1981 aaaaatctcg aactctacta ttgtacatat aacatataca tacatcatag aaggctttga
     2041 gccgcggtga gagaacatga tcgaacatac gcctagtttt taagcccgaa aaggagaaac
     2101 tgaaatgtgt taatagcttt atagatcgcg ctcccccaag tacccatcac ctccagtttt
     2161 tattagtagt tctctagcta gtcctaagcc tgtaaatagt aaaacgtttt attcatagta
     2221 gaatgaattg taaataaatt atatgaatc