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Drosophila melanogaster Glutamate-cysteine ligase catalytic subunit


LOCUS       NM_080266               3426 bp    mRNA    linear   INV 26-DEC-2023
            (Gclc), transcript variant A, mRNA.
ACCESSION   NM_080266
VERSION     NM_080266.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3426)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3426)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3426)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3426)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3426)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3426)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3426)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3426)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3426)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3426)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3426)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3426)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3426)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_080266.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3426
                     /gene="Gclc"
                     /locus_tag="Dmel_CG2259"
                     /gene_synonym="2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS;
                     DmGCSh; GCL; gclc; gclC; GclC; GCLc; GCLC; Gcs; Gcsh;
                     GCSh; mTOR"
                     /note="Glutamate-cysteine ligase catalytic subunit"
                     /map="7D6-7D6"
                     /db_xref="FLYBASE:FBgn0040319"
                     /db_xref="GeneID:53581"
     CDS             323..2476
                     /gene="Gclc"
                     /locus_tag="Dmel_CG2259"
                     /gene_synonym="2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS;
                     DmGCSh; GCL; gclc; gclC; GclC; GCLc; GCLC; Gcs; Gcsh;
                     GCSh; mTOR"
                     /EC_number="6.3.2.2"
                     /note="CG2259 gene product from transcript CG2259-RA;
                     CG2259-PA; Gclc-PA; glutamate cysteine ligase;
                     glutamate-cysteine ligase; catalytic subunit of glutamate-
                     cysteine ligase; gamma-glutamylcysteine ligase;
                     gamma-Glutamylcysteine synthetase catalytic subunit"
                     /codon_start=1
                     /product="Glutamate-cysteine ligase catalytic subunit,
                     isoform A"
                     /protein_id="NP_525005.2"
                     /db_xref="FLYBASE:FBpp0071063"
                     /db_xref="GeneID:53581"
                     /db_xref="FLYBASE:FBgn0040319"
                     /translation="MGLLSEGSPLSWEETKALADHVREHGVNQFINLYHRLKDRQGDI
                     LKWGDEVEYIIVKFDDEQKVARVALRAQDLLAQLNEKELADPNGVKSLWRPEYGAYMI
                     EGTPGKPFGGLMAHFNLVEANMRYRREEVTELLAKDECVMSITNFPRLGAPNFTYPLA
                     QPRPEDPLSSARSLYFPDEAIFPGHPRFKTLTRNIRKRRGEKVSIKLKVFKDTKTKLP
                     VEGAPPGEPDVVLLDAMGFGMGCCCLQLTFQACNITEARRLYDQLAPLCPIMLALTAA
                     SPIYRGYLTESDCRWNVISSSVDCRTEEERGLAPLDQQKFRIAKSRYDSIDSYLSPEG
                     AKYNDVPLTYDEKVYQRLVEGGIDHLLAQHVAHLFIRDTVSLFSEKVHQNDNEDTDHF
                     ENIQSTNWQTMRFKPPPPNSSIGWRVEFRPCEAQISDFENAAIVCFVVLLTRVILSYQ
                     LNFLTPISKVDENMQTAQKRDACRKEKFWFRKSSKTTEQRAAKAQAQAQAQAKAQAQT
                     NGKATLNGNGLANGNGNGSENSDQEEQQPLTNGSAKMNGHGSGTTNGTNGSSNGSSNG
                     TDSDHTDTDDEENELFQLLSINEIFNGKPNVFPGLVPLIRSYLQSMEVDTDTHCTIEQ
                     YLRFIQKRAAGELITTATWMREQVLSHPDYKQDSVVSERINYDLLKRIQGIQEGKQVE
                     PALLGQDYHSKTKTKDFIPPALQKQLAKNGCCEEK"
     misc_feature    1016..2347
                     /gene="Gclc"
                     /locus_tag="Dmel_CG2259"
                     /gene_synonym="2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS;
                     DmGCSh; GCL; gclc; gclC; GclC; GCLc; GCLC; Gcs; Gcsh;
                     GCSh; mTOR"
                     /note="Glutamate-cysteine ligase; Region: GCS; pfam03074"
                     /db_xref="CDD:460796"
ORIGIN      
        1 cacattcaaa atttgtattt aaagtggagc gttttattgt tttgggcatt cgttagtgtt
       61 aataacactg tttacgtcga cggagaattt ggcggcaaag gaaacgcaat accaaagtcg
      121 cgtttaaaga aattacaaat atacaaaata aatacgaaac acacacacac caacacacat
      181 cgcaacacca aaaacataat aaggaaatag tgagagcgca aaaacagcgg taaattcggc
      241 aaataacgtt acacaaccca ccaaaactgc agcgagagag cggcagagag cgaaacagag
      301 tgacgaagaa caaaaagcag caatgggtct actgagcgag ggcagtccac tctcctggga
      361 ggagaccaag gcgctggctg atcatgtgcg tgagcatggc gtcaatcagt tcatcaactt
      421 gtaccacaga ctcaaggatc gccagggtga catattgaaa tggggcgacg aggtggagta
      481 cattattgtc aagttcgacg atgaacagaa ggtggcacgt gtggcgctgc gcgcccagga
      541 tctgctggca cagctcaatg agaaggaact ggccgatccc aatggtgtca agtcgctgtg
      601 gcgtccggaa tacggagcct acatgattga gggcacaccg ggcaaaccct ttggcggtct
      661 gatggcacac ttcaatctgg ttgaggccaa tatgcgctat cgtcgcgaag aggtcaccga
      721 gctgctggcc aaggacgagt gcgttatgtc cattacgaat ttcccacgac tcggcgcacc
      781 aaatttcact tatccgcttg cccagccgcg tcccgaggat cctctcagtt cagcccgctc
      841 gctctacttc ccggatgagg ccatctttcc gggtcacccg cgtttcaaga cactcacgcg
      901 taacattcgc aagcgacgcg gcgagaaggt gtccatcaag ctaaaagttt tcaaggacac
      961 aaagacgaag ctaccggtgg agggtgctcc gcctggcgaa ccggatgtgg tgctcctgga
     1021 cgccatgggc ttcggcatgg gctgctgttg cttgcagctc accttccagg cctgtaacat
     1081 tacggaggcg cgtcgcctct acgatcagct ggctcccctc tgtccgatca tgttggctct
     1141 gacggccgct tcgcccattt acaggggcta tctaaccgaa tcggattgtc gatggaatgt
     1201 gattagctcc tcggtggatt gccgcacgga agaggaacgc ggactggcgc cgctggatca
     1261 gcaaaagttc aggatagcca agtcgcgata cgattcgatt gactcgtatt tgtcgcccga
     1321 gggagccaaa tataacgatg taccgctcac atacgatgag aaggtctatc agcgtctggt
     1381 ggagggcggt atcgatcatc tgttggccca gcatgttgcc catttgttta tacgcgacac
     1441 cgtgtcgctg ttcagcgaga aggtgcatca aaacgacaac gaggatacgg atcatttcga
     1501 gaacattcag tccaccaatt ggcagaccat gcgcttcaag ccgccgccac cgaacagctc
     1561 cattggctgg cgtgtcgagt ttcgaccttg cgaggcgcag atcagtgatt tcgagaatgc
     1621 ggccatcgtg tgctttgtgg tgctgctcac ccgtgtgatt ctctcctacc agctgaactt
     1681 cctaacgccg atcagcaagg tggacgagaa catgcagacg gcccagaagc gagatgcttg
     1741 tcgcaaggag aagttttggt tccgcaaatc ctcgaagacc accgagcaga gggcggccaa
     1801 ggcgcaggca caagctcaag cgcaagctaa agcccaggcc cagacgaatg gcaaggccac
     1861 tttgaatggc aatggactgg cgaatggaaa tgggaatggc agcgagaaca gtgaccagga
     1921 agagcagcag cctctgacca acggttcggc caagatgaat ggccacggaa gtggcaccac
     1981 taacggcact aatggctcct ccaatggatc atcgaatggc accgatagcg atcacaccga
     2041 caccgatgac gaggagaatg agctgttcca gctgctgtcc atcaatgaga tcttcaatgg
     2101 aaagcccaac gtttttccgg gtctggtgcc attgatccgc agctatttgc agtccatgga
     2161 ggtggacacc gatacgcatt gcaccattga acagtatctt cgctttatcc agaagcgtgc
     2221 cgccggcgag ctaatcacca cggccacctg gatgcgcgaa caggtgctta gccacccgga
     2281 ttacaagcag gattccgtgg tgagcgagcg catcaactac gatttgctga agcgcatcca
     2341 aggcatccag gagggcaagc aggtggagcc agcgctgctc ggacaagact atcattccaa
     2401 gacgaagacg aaagacttca ttccgccggc cttgcagaag cagttagcca agaacggctg
     2461 ctgcgaggag aaatgatcga ggagcgcgct gcggacgcgt tcagcgcagc tggccgccgg
     2521 tggccggcgc atgtgattcg ggttttgtgg gtccgttcgg atggagtgcg gcatatatgt
     2581 tgagggcaaa ggcaaaggcg aaggcgaagg caacggcaaa acgaaacgga atggatacgt
     2641 tacggatacg gagcaacatt tatcaatatt atttttaata gcataatttc aaacggatta
     2701 acaattagcg tgcaccaaga tcctaattgt ggacaaatgt tttgcggccg tgcgtgacct
     2761 tttggaaatg aaagtcaagc agaccaggaa ggaggaggcg acggagaagg agaggatgga
     2821 ttaaggaatg gttatggggc acatgaggat ccacgtgccg taggatcctc cgccagccac
     2881 gatatcctcc aggaagtcac catgctctcg tcatcgtttc gatggaactt cgagttcctc
     2941 gaaccgtcga tcgcagccga tttgccatag ttatatagag agctaaatgc taaaccaact
     3001 atataccagc gtcaagaact acaacggcaa cataaatctc aactaagtgc cgttccacga
     3061 gacctacaaa aatatgaata catatagttc aaaacgaggc aaggttaaaa gtgtatttct
     3121 gtttgttttc gtttatatca tatatattta ttatactatt cctattctta taaatgcaag
     3181 tacaatgaaa agttgtttat tttttttaat agatatattt acacacacac acacacatac
     3241 acacgcaaat acacatttgt ttaaaagtgg cctgctgtta ttaaactaga tatgataagt
     3301 acacatataa cgaaaaaaac aacactgtgc tattataatt tattgtgtat gtgattgttt
     3361 ccccattatg atacgattat gatttattgt gaccacaagc aagcaaataa acggaaaata
     3421 ttgttg