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Drosophila melanogaster enhanced adult sensory threshold (east),


LOCUS       NM_080125               7368 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant B, mRNA.
ACCESSION   NM_080125
VERSION     NM_080125.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7368)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7368)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7368)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7368)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7368)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7368)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7368)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7368)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7368)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7368)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7368)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7368)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7368)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7368)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7368)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7368)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7368)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7368)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_080125.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7368
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7368
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="enhanced adult sensory threshold"
                     /map="2C2-2C4"
                     /db_xref="FLYBASE:FBgn0261954"
                     /db_xref="GeneID:46006"
     CDS             275..7180
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="CG4399 gene product from transcript CG4399-RB;
                     CG4399-PB; east-PB; enhanced adult salt tolerance;
                     suppressor of white-spotted"
                     /codon_start=1
                     /product="enhanced adult sensory threshold, isoform B"
                     /protein_id="NP_524864.2"
                     /db_xref="FLYBASE:FBpp0070312"
                     /db_xref="GeneID:46006"
                     /db_xref="FLYBASE:FBgn0261954"
                     /translation="MSSRKVPGGSGGADESTAAAAPLDDNANASVEIPDSSEEPAMGV
                     GEEMSIISKTRTSTLSVEPAKEPTVTAELEGEKELESNPVSKTPRSTPTPTLTPAVTP
                     TASDGVAAKSVRVTRHSSPLLLIISPTTSRREVGDGELDTEEPTGSGGQRKSSVERSL
                     APVIRGRKSIKDLKEAKEVKSEEPPAAASESRAASGVTPGQVKEQHVADGNEMESLPI
                     TDKKDHKDTKDKGDERETDQEEEKEKSADTEIIADTEKTSEKQKYTEKDKAADKDGGK
                     EKDIDANKDIDKEKEKVKEVLPPVVPIAPVTPTCNRVTRKSHAQEQAINTRVTRNRRQ
                     SSTVGANSTASLVAASSSVTEQPPPSRGRRKKPVVVAPPLEPAVKRKRSQDVEADSDA
                     NNSTKYSKVEVVKSEEAEAPEEDSSAVPIKQESVDGNEVSSISPTVTPTPTPAPTPAP
                     VPGSRRGRGRPQNRNSSSPATTTRATRLSKAGSPVILTPVAQEPAPPKRRRVGSSTRK
                     TVSASSLAPSSQGGAGDEDSKDSMASSMDDLLMAAADIKQEKLTPDFDDSLMPEGLPS
                     TSGASSANGHSCTEPLTVDTEINVKPADSKVKPKESPVVAVEESPSQSETQSAKVSAH
                     AGKAPSLSPDMISEGVSAVSVRKFYKKPEFLENNLGIEKDPELGEIVQTVSNNDTETD
                     VEMAVDGEVNQPSTPKSQDKKKEEQEKNQKSGLKAAKKAPAKLEPKAEDISEILTDVP
                     VDISTEAVEIIEEAEEDTCSNSSIKPGELRLDESNDEPELLLEDALIVNGDENETPDQ
                     PEEKEDQVEFFHTGEYDDFEHEIMVELAKEGVLDASGNALSQQKVELEHPEDVTLHES
                     KNDIEAEESVERKPLKDPSVADEMEDMNEESYIDIKDQTNQLLVEHLAEEAMEADCGP
                     EDNKENLSTSASSTAADGLDIQLAIKEDDDEEKPLAVIADEQKPGLLLTNDMKVDEKP
                     NGKQESVCDEHVQLVPNLRQEQEIHLQNLGLLTHQAAEHRRKCLLEAQARQAQMQLQQ
                     HHHHQHKRQGARGGGSATHVESSGTLKTVIKLNRSSNGGVSGSGGLPTGTVIHGGCGS
                     SSASSTSSSSVGSATRKSSGTLGSGAGAGAGVRRQSLKMTFQKGRARGHGAADRSADQ
                     YGAHAEDSYYTIQNENEDSSHSESQGQTDHGFYQMVKKDEKEKILIPEKASSFKFHPG
                     RLCEDQCYYCSGKFGLYDTPCHVGQIKSVERQQKILANEEKLTVDNCLCDACFRHVDR
                     RANVPSYKKRLSASGHLEMGSAAGSALEKQFAGDSGVITESGGEAGSTAAVAVQQRSC
                     GVKDCVEAARHSLRRKCIRKRVKKYQLSLEIPAGSSNVGLCEAHYNTVIQFSGCVLCK
                     RRLGKNHMYNITTQDTIRLEKALSEMGIPVQLGMGTAVCKLCRYFANLLIKPPDSTKA
                     QKAEFVKNYRKRLLKVHNLQDGSHELSEADEEEAPNATETERPTSDGHEDPEMPMVAD
                     YDGPTDSNSSSSSTAALDTSKQMSKLQAILQQNVGADAAGAAGTGTVAASPGGSGSGA
                     DISNVLRGNPNISMRELFHGEEELGVQFKVPFGCSSSQRTPEGWTRVQTFLQYDEPTR
                     RLWEELQKPYGNQSSFLRHLILLEKYYRNGDLVLAPHASSNATVYTETVRQRLNSFDH
                     GHCGGLNIAGSPSSSGSGKRSGVPQPTGASVLATALTTPLTSHSSSSASISSEQHSSV
                     DPVIPLVDLNDDDEGEDGAGGAGERESTNRQQDVILECLRTASVDKLTKQLSSNAVTI
                     IARPKDKSQLSCNSGSSTSISSSSSAISSPEEVAVTKVTAVAPVQSKDAPPLAPASSG
                     VSNSRSILKTNLLGMNKAVELVPLTTAPHAYKPTGCHKPEKQQKILDVANKQPGSQGE
                     PVPSSALLGLQSKLKPPTHQQQVSGSGAGTSGSQKPSNVAQLLSSPPELISLHRRQTS
                     GAAAGSSSFLQGKRLQLPRSGAGPSGAGTGTGAGAAGSRSAGGPPPPNVVILPDALTP
                     QERHESKSWKPTLIPLEDQHKVPNKSHALYQTADGRRLPALVQVQSGGKPYLISIFDY
                     NRMCILRREKLMRDQLLKSNAKPKPQNQQQQQGQTHQQQQNSAASAAAFSNMVKLAQQ
                     HTARQQLQQLQQKPQQQQQLPTLQPGGVRLARLPQKLLMPPLTNPQIGSQAPNLQPLL
                     SSTLDNSNNCWLWKNFPDPNQYLLNGNGGGAGSSSSKLPHLTAKPATATSSSGAANKS
                     AGSLFTLKQQQHQQKLIDNAIMSKIPKSLTVIPQQMGGNTGGDMGGSSSSGKD"
ORIGIN      
        1 cgttatttcg cttcgcaccg tgtttgcgtt cacaactctt gttcgggttc tgcattttat
       61 tttattatta tttttttttg tttgttgcta ttcgatattc ttcacatcac agtcaaccaa
      121 tgggaccaaa tcactgcgac tcgaactgga cacaatcagc atcggatcgc agggaacaac
      181 aggaggtggt ggagcagcag cgccagaagg cgtcggggga gcggccatca taggagcagc
      241 aacgtcggca gcagctgccc agggcccctc gagaatgtct agccggaagg tgccaggagg
      301 ctctggagga gctgacgaat ccacagcagc agctgccccc ctggatgata atgccaatgc
      361 cagtgtggag attccagaca gcagcgagga gccagcaatg ggcgtcggcg aagagatgtc
      421 tatcataagc aaaacacgca cctcaacttt gtcagtggag cccgctaagg agccaacagt
      481 aacagcagag ctggaaggcg aaaaagagct ggaatcgaat ccagtctcca aaactcctag
      541 gtccacgcct acgccaaccc ttacgccagc cgtcacgcct accgccagtg atggagtggc
      601 ggccaagagc gtgagggtta cccggcactc gtcgccactg cttctgatca tctcgcccac
      661 gacaagtaga cgtgaggtcg gcgacggaga gctagacacc gaggaaccaa cgggatcggg
      721 tggccaaaga aagagctccg tggagcgatc tttggcgccc gttatacgcg gacgaaagtc
      781 catcaaggat ctgaaagaag ccaaagaagt caagtccgag gagccgcctg ccgcagcatc
      841 agagtcacga gctgcaagtg gagtgacgcc tggccaggtc aaggaacagc atgtcgcgga
      901 tggcaacgaa atggaatcct tgccaatcac agacaagaaa gaccacaaag acacaaaaga
      961 caagggagat gagcgggaaa ccgatcagga ggaagagaag gaaaaatcag ctgatacaga
     1021 aataattgca gatacagaaa aaacttcgga gaaacaaaag tatacagaga aggacaaagc
     1081 tgccgataaa gatggaggaa aagaaaaaga tattgatgca aataaggata tagataagga
     1141 gaaggaaaag gtcaaggaag tacttccgcc agtggtgcct atagcaccag tgacacccac
     1201 ttgtaaccgt gtcacacgta aatcacatgc ccaggagcag gcgattaaca cgcgggtcac
     1261 tcgcaatcgt cgccagtcct ctacagttgg agccaactcc accgcgtctt tggtagctgc
     1321 atcctcctca gtaacagagc aaccccctcc atctcgcggt cgacggaaga agccagtggt
     1381 ggtggctcct cccttggagc ctgcggtaaa acggaagcga tcgcaagatg ttgaagccga
     1441 ctcagacgcc aacaacagca cgaaatacag caaggtggaa gtggtaaagt ctgaggaagc
     1501 tgaggcacca gaggaggact ccagtgccgt gcccattaag caggaatctg ttgatggcaa
     1561 cgaggtcagt tctatttctc caacagtcac gcccacaccc acacctgcgc caacaccagc
     1621 tccagtcccg ggcagtcgac ggggtcgtgg gcgcccgcag aacaggaact cctcttcgcc
     1681 tgcaaccaca acgcgggcaa cgcggctaag caaggcggga tcaccggtta tcctgacgcc
     1741 agtagcccag gaaccggcgc caccgaaacg gcggcgagtc ggctccagca cacggaagac
     1801 tgtctcggcc agctcgctgg cacccagctc gcagggcggc gccggggatg aggactccaa
     1861 ggacagtatg gcctcgtcca tggacgacct gctgatggcc gcagcagata tcaagcagga
     1921 gaagctgacg cccgatttcg acgatagttt gatgccagaa ggcctgccct ctacttctgg
     1981 tgcgtcgagt gccaatggtc attcctgcac cgaaccgctt actgtggaca cggaaattaa
     2041 tgttaagccc gctgattcca aagtaaaacc aaaggagtca ccggtggtag cagtcgagga
     2101 atctccatca caatccgaaa cgcaatctgc aaaggtgtca gcgcatgcgg ggaaggctcc
     2161 atctcttagt ccagatatga taagtgaagg cgtgagcgcg gtcagtgttc gaaagtttta
     2221 taagaagcct gagttcctgg aaaacaatct gggcattgaa aaggatccgg agctaggtga
     2281 aatcgttcag acggttagta acaatgacac ggaaacagat gtggagatgg ctgttgatgg
     2341 cgaggtgaat caaccgtcaa ctcccaagtc gcaggataaa aagaaagagg agcaggaaaa
     2401 gaatcagaaa tcagggctaa aggcagcaaa gaaggctcct gctaagttag aacctaaagc
     2461 tgaagacatt tctgaaattc ttactgacgt tcctgttgat atttcgactg aggcagtaga
     2521 aattatagaa gaagcagagg aagacacttg ttcaaatagc tcaatcaaac caggtgagct
     2581 ccgactggac gagagcaacg atgaacctga actgcttctt gaagacgccc tcatagtcaa
     2641 tggtgatgag aatgagacac cagatcaacc ggaggaaaag gaggaccagg tggagttctt
     2701 ccatacagga gaatacgacg actttgagca cgagattatg gtggagctgg cgaaggaggg
     2761 ggtgctagat gccagcggca atgcattaag tcagcaaaag gtagaacttg agcatcccga
     2821 ggatgtaact ctacacgaat caaaaaatga catagaagcc gaagaatcgg ttgaacgtaa
     2881 gcctcttaag gacccgtcgg ttgcggacga aatggaggac atgaatgagg aatcctatat
     2941 tgacattaag gaccagacaa atcaactgtt agttgaacac ttggcagaag aggccatgga
     3001 agcggactgc ggtcccgagg ataacaagga gaacttgtcc acgtctgctt cgagcaccgc
     3061 tgccgatggt ctagatattc agttggccat caaggaggat gacgacgagg agaaaccgct
     3121 tgcagttatc gctgacgaac agaagcctgg gctgctgttg accaatgaca tgaaagtgga
     3181 tgagaaacca aatggcaagc aggaatcggt ctgtgatgag cacgttcagc tggtgccaaa
     3241 ccttcgtcaa gaacaggaaa ttcacttaca aaatctgggc ctactcacgc accaggccgc
     3301 tgaacatagg cgcaagtgtc tgcttgaggc acaggcccgc caggcgcaaa tgcagctcca
     3361 gcaacatcac caccatcagc acaagcgaca aggagcgcgc ggaggaggca gtgccactca
     3421 tgtggaatcc agcggtactt tgaagacagt catcaagctg aacaggagca gcaacggagg
     3481 agtaagcggt agtggcggcc tgcctactgg tacagttatc catggaggct gtggctcctc
     3541 ttcagcttct tccacgtcct cctcctcggt gggcagtgcc acacgtaagt caagcgggac
     3601 cttgggctca ggagcgggag caggagctgg cgttcgccgg cagtcgctta agatgacatt
     3661 ccagaagggt cgggctcgtg gtcacggtgc tgcggatcga tccgccgatc agtatggcgc
     3721 ccacgccgag gactcctact acaccattca aaacgagaac gaagattcgt cccactcgga
     3781 aagtcaggga cagacggacc acggcttcta tcagatggtc aaaaaggacg aaaaggagaa
     3841 gatcctcatt ccggaaaagg cctcctcgtt taagtttcac ccagggagac tgtgcgaaga
     3901 ccagtgctac tactgtagcg gaaagtttgg cctctatgac accccctgcc atgttggaca
     3961 aataaagtcc gtggagcgcc agcagaagat cctagccaac gaggagaagc tcaccgtgga
     4021 taactgcttg tgcgacgcat gttttcgaca cgtggaccgc cgggcaaatg tgccatccta
     4081 taagaagcgt ctttccgctt caggtcactt ggagatgggg tctgcagcgg gatctgcact
     4141 agagaaacag tttgctggcg acagcggcgt cattacggaa tcgggtggcg aagctggttc
     4201 tacggcagct gtggccgtgc agcaacgatc ttgtggcgtg aaggactgcg tcgaagcggc
     4261 acgacactcg ctgcggcgca agtgcatacg caagagagta aagaagtatc agctcagcct
     4321 ggagattccc gcaggctcgt cgaacgtggg gctgtgtgag gcacattaca atacggtcat
     4381 ccaattttcc ggctgcgttc tttgcaagcg tagattaggc aagaaccata tgtacaacat
     4441 aaccacgcag gacacaattc gactggaaaa ggcgctgtcc gagatgggca tcccagttca
     4501 gcttggcatg ggcactgcag tctgcaagct gtgtcgctat tttgccaacc ttttgataaa
     4561 gccaccggat agcaccaagg cacaaaaggc ggaattcgtg aagaactaca gaaagaggct
     4621 cctcaaggtg cataatctgc aggatggcag tcatgagctg tccgaagcgg atgaagaaga
     4681 ggcacctaat gcaacggaga cagaaaggcc aacctcagac ggacacgaag atcccgagat
     4741 gcccatggta gcggactatg atggacctac cgactccaat tccagtagtt cttcgactgc
     4801 agccctggac accagcaaac aaatgtccaa gcttcaggcc atcctgcagc aaaatgtggg
     4861 agcggatgcg gcaggagctg cgggaacagg aactgttgca gcaagtcccg gaggaagcgg
     4921 atctggggca gatatctcta acgtattgcg agggaatccg aacatttcca tgcgcgaact
     4981 tttccacggc gaggaagagc tgggtgtgca gttcaaggtg ccgttcggat gcagcagcag
     5041 ccagcgtact ccggagggct ggacacgagt gcagactttc ctacaatacg atgagccgac
     5101 gcgccgcctc tgggaggagt tgcaaaagcc gtacggaaat cagagctcat ttctgcgcca
     5161 cttgatacta ttagagaagt actaccgaaa cggagatctc gtcctagcac cgcatgcttc
     5221 ctccaatgcc acggtttaca cagagactgt tcgtcagcgg ctgaattcgt ttgatcacgg
     5281 tcactgcggt ggattgaaca tcgcaggcag cccttcttct tcgggttccg gcaagcgcag
     5341 tggagttcct caacctacgg gtgccagtgt gctggccacc gccctcacaa cacccttgac
     5401 aagccattca tcctcctctg catccatttc ctccgaacag cattcgtcgg ttgatcctgt
     5461 cattccgctg gtagacctca atgatgacga tgaaggcgaa gatggggcag gaggagcggg
     5521 cgaaagggag tcgacaaata ggcagcagga cgtaatcttg gaatgcctta gaactgcctc
     5581 tgtggacaag ctgactaagc agctcagctc gaatgcggtg acgattatcg cccggcccaa
     5641 agacaaatcg cagctctcct gcaacagcgg atcctccacg tccatttcca gctcctcgtc
     5701 cgctatttcc tcgccggagg aagtggccgt cactaaggtt acagcagtcg caccagtcca
     5761 gtccaaggat gcaccgccac tggcgccagc aagtagcggt gttagcaaca gtcgtagtat
     5821 ccttaaaacc aacctcttgg gcatgaacaa ggccgtggaa ctcgtgccct taacgactgc
     5881 cccccacgct tacaagccaa ctggatgcca taagcctgag aaacagcaaa agattcttga
     5941 cgtggccaat aagcagcccg gtagccaggg ggaaccggta ccatcaagcg ccttgcttgg
     6001 cctgcagtca aagctaaagc ctccaacgca tcagcagcag gtcagcggat caggagcggg
     6061 aactagtggt tctcagaagc catctaatgt ggcgcaattg cttagctctc caccggagct
     6121 aatcagcttg catcgacggc agaccagcgg agcagcagcg gggtccagca gcttccttca
     6181 gggcaagagg cttcaacttc cacgatctgg agcagggcct tcaggagcgg gaacgggaac
     6241 aggcgctgga gcagcaggaa gccgcagtgc gggtggacca ccaccgccca atgtggtcat
     6301 actgccggac gccttaaccc cccaggagcg acacgagagc aagagctgga agccaacgct
     6361 gataccgctg gaggatcagc acaaggtgcc gaacaaatca catgctcttt atcagaccgc
     6421 cgacggtcga aggttgcccg ccctggtgca agtgcagtct ggtggcaagc catacctcat
     6481 ctctatcttc gactataacc gcatgtgcat cttgcgaagg gaaaagctga tgcgggacca
     6541 gttgctcaag agtaacgcca agccaaagcc gcagaaccag caacagcagc agggccaaac
     6601 gcaccagcag cagcagaatt ccgccgcatc ggcggctgcc ttctccaaca tggtgaagtt
     6661 ggcccagcaa cacacggcgc gacagcagct tcagcagctg caacagaagc cacaacagca
     6721 gcaacaattg cccactttgc agccaggtgg ggtgcgactt gcccggctgc cgcaaaaact
     6781 actgatgcca ccactgacta atccgcagat tggcagtcaa gcacccaact tacagccgtt
     6841 gctgtctagt acgctggata acagcaacaa ctgctggctg tggaaaaact ttcctgatcc
     6901 caatcagtat ctgctaaatg gaaacggagg gggtgccggg agctcctcca gcaagttgcc
     6961 acatctcacg gccaaaccag ccacggcaac tagtagctcc ggagcggcca acaaatcagc
     7021 aggaagccta tttaccctca agcagcagca gcaccagcag aaactcatcg acaacgctat
     7081 catgtcaaag atacccaaaa gtctgacagt aataccgcag cagatgggtg gtaataccgg
     7141 tggcgatatg gggggcagca gctcctccgg caaggactga tgacggcgaa ggagggcgcc
     7201 atggccatta gccgtagcgc cggaggtaac ccggcgaagt agtaggatca acaagcaggc
     7261 gacgtgcagc ttaagcggcg atcttcagaa caagaggtga ccagcggcgg ctccatggat
     7321 atcacaaact ccacaattcc atggctgcag tagaataagt gatacact