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Drosophila melanogaster polyhomeotic distal (ph-d), transcript


LOCUS       NM_080055               5821 bp    mRNA    linear   INV 26-DEC-2023
            variant A, mRNA.
ACCESSION   NM_080055
VERSION     NM_080055.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5821)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5821)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5821)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5821)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5821)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5821)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5821)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5821)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5821)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5821)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5821)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5821)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5821)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5821)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5821)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5821)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5821)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5821)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5821)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5821)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5821)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5821)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5821)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_080055.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5821
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5821
                     /gene="ph-d"
                     /locus_tag="Dmel_CG3895"
                     /gene_synonym="CG3895; Dmel\CG3895; DROZFP;
                     EG:BACN25G24.3; ph; Ph; PH; ph-D; Ph-d; PH-d; phd; PhD;
                     PHD; phm; ph[d]; ph[D]"
                     /note="polyhomeotic distal"
                     /map="2D2-2D2"
                     /db_xref="FLYBASE:FBgn0004860"
                     /db_xref="GeneID:44889"
     CDS             69..4682
                     /gene="ph-d"
                     /locus_tag="Dmel_CG3895"
                     /gene_synonym="CG3895; Dmel\CG3895; DROZFP;
                     EG:BACN25G24.3; ph; Ph; PH; ph-D; Ph-d; PH-d; phd; PhD;
                     PHD; phm; ph[d]; ph[D]"
                     /note="CG3895 gene product from transcript CG3895-RA;
                     CG3895-PA; ph-d-PA; polyhomeotic; polyhomeotic-distal;
                     polyhomeotic proximal"
                     /codon_start=1
                     /product="polyhomeotic distal, isoform A"
                     /protein_id="NP_524794.2"
                     /db_xref="FLYBASE:FBpp0070417"
                     /db_xref="GeneID:44889"
                     /db_xref="FLYBASE:FBgn0004860"
                     /translation="MPHGFGAAPSVSVSGDTESESATTIRTPPPSPEATTSVKVNSTT
                     RVDPQRPLRCLETLAQKAGISFDEDFAKSPSQSPSSKAARGSVGTPSIRRRHPLLPLS
                     SRSPSAPDSKTTGRKLEKSQSPAQQVAAATNVPLQISPEQLQQLYANNPYAIQVKQEF
                     PTHTTSGSGTELKHATNIMEVQQQLQLQQQLSEANGGGAASAGAGGAASPANSQQSQQ
                     QQHSTAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLHPGGL
                     GQQPIQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFAGGNYATCIPSNHNQSPQT
                     VLISPVNVISHSPQQQQNLLQSMAAAAQQQQLTQQQQQQLNQQQQQLNQQQQQQQLTA
                     ALAKVGVDAQGKLAQKVVQKVTTTSSTVQAATGPGSTGSTQTQQVQQVQQQQQQTTQT
                     TQQCVQVSQSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFWQNAAGLQPFGSNQIILR
                     NQPDGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVG
                     TTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQ
                     SLLKAKMRNKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAG
                     NKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQHILQQQMLQQQIAAIQ
                     MQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQA
                     QHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQA
                     QQQQQQREQQQNIIQQIVVQQSTGATSQQQQQQPQQQSGQLQLSSVPFSVSPSMTAED
                     IAGITSSALQEALSVSGAIFQTTKPITCSSSTLPTSSVVTITSQSSTPLVTSSTVASM
                     QQAQTQGTQIHQHQQLISATIAGGSQQQQQQQQLGLPSLTPTTPSPTTNPILAMTSMM
                     NATVGHLSTAPPVSVSSTAVTPSSGQLVTLSSASSGGGAGFPATPTKETPSKGPTATL
                     VPIDSPKTPVSGKDTCTTPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGAT
                     TPTSKQSNAAVQPPSSTIPNSVSGKEEPKLTTCGSLTSATSTSTTTTITNGIGVARTT
                     ASTAVSTASTTTTSSGTFTTSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFI
                     IQEANEPFPVTRQRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKME
                     HKAKLKRKRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEE
                     KMQTESYQTVSDALPIQAATPEVPPISMPVLAAMSTSSPLSLPLTLPLPIAIAPTVSL
                     PVVSAGVVAPVLAIPSSNINGSDRPPISSWSVEEVSNFIRELPGCQDYVDDFIQQEID
                     GQALLLLKENHLVNAMGMKLGPALKIVAKVESIKEVPPGDVKD"
     misc_feature    4449..4655
                     /gene="ph-d"
                     /locus_tag="Dmel_CG3895"
                     /gene_synonym="CG3895; Dmel\CG3895; DROZFP;
                     EG:BACN25G24.3; ph; Ph; PH; ph-D; Ph-d; PH-d; phd; PhD;
                     PHD; phm; ph[d]; ph[D]"
                     /note="SAM domain of Ph (polyhomeotic) proteins of
                     Polycomb group; Region: SAM_Ph1,2,3; cd09577"
                     /db_xref="CDD:188976"
     misc_feature    order(4503..4508,4608..4613,4620..4625,4632..4634)
                     /gene="ph-d"
                     /locus_tag="Dmel_CG3895"
                     /gene_synonym="CG3895; Dmel\CG3895; DROZFP;
                     EG:BACN25G24.3; ph; Ph; PH; ph-D; Ph-d; PH-d; phd; PhD;
                     PHD; phm; ph[d]; ph[D]"
                     /note="oligomer interface EH [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
     misc_feature    order(4536..4550,4554..4559,4566..4571,4581..4583,
                     4596..4598)
                     /gene="ph-d"
                     /locus_tag="Dmel_CG3895"
                     /gene_synonym="CG3895; Dmel\CG3895; DROZFP;
                     EG:BACN25G24.3; ph; Ph; PH; ph-D; Ph-d; PH-d; phd; PhD;
                     PHD; phm; ph[d]; ph[D]"
                     /note="oligomer interface ML [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
ORIGIN      
        1 tttgttcgtc aagcgctaag agaatatgaa taagaatata aatataaatt taaacatgaa
       61 tatgaagcat gccccacgga ttcggagccg cgccaagtgt gtccgtcagt ggggacaccg
      121 aaagtgaatc agcaacaaca atacgtacac caccaccttc cccggaagcc accacatctg
      181 taaaggtcaa ctccaccact cgcgtggacc cccagcggcc actaaggtgc ctggaaacac
      241 tcgcccagaa ggcaggcatc agcttcgacg aggactttgc caagagtcca tcccaatcgc
      301 ccagctctaa ggcagcacgt gggtcagtcg gaacgccatc aatcagacgg cgccacccac
      361 tactaccgct cagcagcaga tcgccaagcg cacccgactc aaagacaacc ggccgcaaac
      421 tggagaagtc acagagtcca gctcaacagg tggcggccgc caccaatgtg ccgctgcaga
      481 tctcccccga gcagctgcag cagttatatg caaacaatcc ctacgccatt caggtgaagc
      541 aagagtttcc cacgcacacg accagtggca gtggaactga actaaagcat gcaaccaaca
      601 ttatggaagt tcagcagcag ttgcagctgc agcagcagct gtcggaagcc aacggtggag
      661 gagcagcctc ggccggagcc ggaggagcag ctagtccggc caactcgcag caaagccagc
      721 aacagcagca ctccacagcc atcagcacca tgtcgccgat gcaattggca gcggccactg
      781 gaggagttgg cggggattgg acacagggaa ggacggtgca gctaatgcaa ccctccacca
      841 gtttcctgta tccccaaatg attgtgtcgg gaaatctgtt gcatccagga ggcctcggtc
      901 agcagccaat ccaggtgatc accgccggca agccattcca aggcaacggc ccccagatgc
      961 ttaccaccac gactcaaaac gccaagcaaa tgatcggtgg ccaagcggga ttcgctggcg
     1021 gaaattacgc gacctgcatt ccttcgaacc acaatcagtc gcctcagacg gtgctcatct
     1081 cgccggtgaa tgtcatctcc cactcgccac agcagcagca aaaccttctg caatcaatgg
     1141 ccgccgcagc tcaacaacag caacttaccc aacagcagca gcaacagctt aaccagcagc
     1201 aacagcagct caaccagcag cagcaacagc aacagctgac tgccgctctg gccaaggtgg
     1261 gagtggatgc gcagggcaag ctggcccaga aagtggttca gaaggtgacc accaccagca
     1321 gcacggtgca ggcggcgacg ggtcctggat ctactgggtc aacacagacc cagcaggtgc
     1381 agcaggttca gcaacagcag cagcagacca cccaaaccac tcagcagtgc gtgcaggttt
     1441 cacagtcgac tttgccagtc ggtgtgggtg gacagtctgt tcagactgcc caacttttga
     1501 acgctggcca agcgcaacaa atgcagatcc cttggttctg gcagaatgcg gcgggcctgc
     1561 aacccttcgg ctccaatcag atcatcctgc gaaaccagcc agacggaacc caaggcatgt
     1621 tcattcaaca gcaaccggcg acgcagactt tgcagaccca gcaaaaccag attattcaat
     1681 gcaacgtgac gcagacgccc actaaggcac gcactcaact ggatgcactt gctcccaagc
     1741 agcaacagca gcagcagcag gttggcacta ccaaccagac gcagcagcag caactagcgg
     1801 tggctactgc ccagttgcag caacagcagc agcaactcac tgcagccgct ctgcagcgac
     1861 caggagcccc tgtcatgccc cacaatggaa ctcaagtgcg tccggccagt tccgtatcca
     1921 cacagactgc ccagaaccag agcctgctga aggccaaaat gcgcaacaag cagcagccgg
     1981 tgcgccccgc tttagccaca ttgaaaaccg aaatcggtca agtcgcagga caaaataagg
     2041 tagtaggcca cctgaccacc gtgcagcagc agcaacaggc gacgaatctc cagcaggtgg
     2101 ttaatgcggc gggcaacaaa atggttgtga tgagcacaac gggcactccg atcaccctgc
     2161 agaatggaca gacccttcat gcagccactg cggcaggagt cgacaagcag caacagcagc
     2221 tacaactgtt tcagaaacag cacatccttc aacaacaaat gttgcaacag caaattgctg
     2281 ccattcaaat gcagcagcag caagcggctg ttcaggccca gcaacaacag cagcaacagg
     2341 tctctcagca gcagcaggtt aacgcccagc aacagcaagc ggtggcgcaa caacaacagg
     2401 cagtcgcgca ggctcagcaa cagcagaggg agcaacagca gcaagttgcc caagcccagg
     2461 cgcagcatca acaggctctc gcgaatgcca ctcagcaaat ccttcaggtg gcgccaaatc
     2521 aattcatcac gtcccaccag caacagcagc agcagcaact tcacaaccaa ctgatacagc
     2581 agcagctaca gcaacaggcg caggcacaag ttcaagccca agtgcaggct caagcgcaac
     2641 agcaacaaca gcagcgagag cagcagcaga atattatcca gcagattgtg gtgcaacagt
     2701 caactggagc gacttctcaa cagcagcagc agcaaccgca acagcagtct ggacagttgc
     2761 agcttagcag cgtgccgttt tcggtttcac catcgatgac ggcggaagat attgccggaa
     2821 taacatccag tgccctacaa gaagctctct cggtgtctgg cgccatcttt cagacaacca
     2881 aaccgattac ttgcagttcc tctacgctcc ccacaagcag tgtggtcaca attaccagcc
     2941 agagcagcac tcctctggtc accagcagta cggtggccag tatgcagcag gctcagacgc
     3001 aaggtactca gatccatcaa catcagcagc taatcagcgc cactattgcc ggagggtctc
     3061 aacagcagca gcagcagcag caactgggac taccttcact tacacccacc acgccctcac
     3121 ctacaacaaa tcccattctg gccatgacct cgatgatgaa tgccaccgtg ggtcacctat
     3181 ccactgcccc acccgttagt gtttctagca ccgctgtcac tccatcgtct ggacagctgg
     3241 tcacactaag cagtgctagt agcggtggag gagcaggctt tccagccacg cccaccaaag
     3301 agacaccttc aaaagggccc accgcaaccc tggtgcccat tgattcgccc aagactcctg
     3361 tatcaggaaa ggacacctgc actaccccca aatcatctac tcctgccact gttagcgcat
     3421 ccgtagaggc cagtagttcc acaggcgaag ccctgtccaa tggagatgcc tcagataggt
     3481 cttccacgcc gtcaaagggc gctaccactc ccaccagcaa gcaaagcaat gcagcagtgc
     3541 agccaccgag tagcaccatt cccaacagtg tcagtgggaa agaagagccg aagctgacaa
     3601 cctgcggcag tttaacgtcc gcaacatcaa catcaaccac gacaacgatc accaatggga
     3661 ttggagtagc cagaacgaca gccagcacgg ctgtctcaac cgctagcaca accactacca
     3721 gttctggcac ctttaccaca agttgcacca gcacaaccac aaccaccacg tcgagtatca
     3781 gtaatggatc gaaggatctc cccaaggcga tgattaagcc gaacgtctta actcacgtca
     3841 tcgatggctt catcatccag gaggccaacg agccatttcc cgtcaccaga cagcgatatg
     3901 cagacaaaga cgtcagcgat gagccgccaa agaaaaaggc aaccatgcag gaggacatca
     3961 agctaagtgg aatagcatca gctccaggct cggatatggt tgcttgcgag cagtgtggaa
     4021 agatggagca caaagcaaag ctgaaacgga agcgctactg ttcgccagga tgctcgaggc
     4081 aggcaaagaa cggcatcggt ggagttggat caggagagac gaacggcctg gggacaggtg
     4141 gtatagttgg ggtggacgca atggcattgg tggacagact ggatgaagcc atggctgagg
     4201 agaagatgca gacagaatca taccagacag tatcggacgc tttgccaatt caagcggcta
     4261 cgccggaggt cccaccgatt tcgatgccag tgctggcggc tatgtcgaca tcttcaccac
     4321 tttcgttgcc cctgacattg cccttgccaa ttgcaatagc tcccactgtg tcactgccag
     4381 tggtttcagc tggagtggtt gcgccggtcc tagcaatacc atcctcgaat ataaatggat
     4441 ccgatcgccc tcccatcagc agttggagtg tggaagaagt tagcaatttc atccgagaac
     4501 tgcctggttg ccaggactac gtggacgact ttatacagca ggagatcgac ggccaagcgc
     4561 tgctgctgct caaagaaaac catttggtta acgccatggg catgaagctg ggtccagctc
     4621 tcaaaattgt ggccaaggtg gagtccatta aggaggtccc gccaggcgat gtaaaggatt
     4681 aaaaacacgc aacaaagtca aggtttcaaa agaccgcttt ctttagtttc ccgcgtttca
     4741 cctaaatgta acgacattta cttcgtgagc gaatgtgatc agacagaaca aagtgaatca
     4801 cgttccgact caccacttct cacagcacgt acaccctaat catcagctac atgcacctaa
     4861 tctacaaagg gaactcccca gagagcaacc ggtgcctgga atcactgact ctgttgcgag
     4921 gcccatccca tccagaatct atgcgagaaa tccataatta ggtgatgtag ttgtttttcc
     4981 cgcacatgac gaaagcaagg aatatgaccc tccttcggcg ccgaagctgc agctagttta
     5041 agcaccccga tcagacccca agattgtggc aatagtagag tccatgactc tgtgcgacga
     5101 aaaggacggg gaggttatag gaccgctggc gccaccgccg ttggatcaac agtcttcagc
     5161 agtctaccag agtctgagga taggagcggg cagtatcctg agcttctatt tgaccatgct
     5221 gatctcccac gacctttgca tggacctttg cctacctgtg gaccgggtcc aaccgggtct
     5281 gccacccaag ctgaatttga ttcacttgaa gcggactttc aatccttttg tacgtaatct
     5341 aaacatagca agaggggtaa tatcgtagct caaatgacag gacgccacat gtatgataga
     5401 gcatagactg ccatcccagt catcaattca tcactttgta tagaagttca caattactca
     5461 taatcactaa cgtatttatt tgaacgttgt taatcatttc acaacaccct atgcaaagaa
     5521 catgaaaaaa tcatttgaac tagaggtaat ctgggattat atttacgtag ttagaattaa
     5581 aacttaagcc tgaagtaatt cctaagtgaa actgaattga atccaactaa acctttaatt
     5641 tattgataaa cttaggtcgt aatgagtaac gtctgaagaa tttttgcctt tattgcaagg
     5701 ttccgaaaac gctgtccaac ttttatagat caaatcagtg gtcggagttt aatttttttt
     5761 ttagttttac gaaacctttt tttcctactg ctgaagtaaa taaaactgta aagtgattaa
     5821 t