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Drosophila melanogaster NFAT nuclear factor (NFAT), transcript


LOCUS       NM_078592               5870 bp    mRNA    linear   INV 26-DEC-2023
            variant A, mRNA.
ACCESSION   NM_078592
VERSION     NM_078592.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5870)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5870)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5870)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5870)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5870)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5870)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5870)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5870)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5870)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5870)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5870)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5870)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5870)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5870)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5870)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5870)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5870)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5870)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5870)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5870)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5870)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5870)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5870)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_078592.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5870
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5870
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="NFAT nuclear factor"
                     /map="12A9-12B2"
                     /db_xref="FLYBASE:FBgn0030505"
                     /db_xref="GeneID:32321"
     CDS             713..4972
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="CG11172 gene product from transcript CG11172-RA;
                     CG11172-PA; NFAT-PA; NFAT homolog; Rel domain protein;
                     drosophila TonEBP; misexpression suppressor of Ras 1"
                     /codon_start=1
                     /product="NFAT nuclear factor, isoform A"
                     /protein_id="NP_511147.2"
                     /db_xref="FLYBASE:FBpp0073639"
                     /db_xref="GeneID:32321"
                     /db_xref="FLYBASE:FBgn0030505"
                     /translation="MLLKFTKTSGAGPSAVPLLTTAPATVTSSASMQATTTSYAARGT
                     GMRMTMSTNSTMSARIHRKGFRIPSKRQPGKGLPGKLHTITRTGPGKMVPGKRIPQRP
                     HPPPCDNSNDSGLGFDQHTELRSSAGAGGVTDPAANGGSGSNSGQRSSLLVNSALTNT
                     VAAAAAAAAAAVASNTLQQHQQHHQQQQQQQQQQQQQQQQQQQQQQQQQHSPQQHLIR
                     AIPVSRSRNNTKVMAHCLEDLDLISASSEDSSTIATPAGLDEDTGFVNDTKTTTTGGN
                     SSSDPFGGVFQATEAAVAAAVNAFNLQQQQHSVQQQQHQLFQYNGLLLQPQQQLQQQQ
                     SHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDDACSEDEFIRKIASSVTMSPTLEA
                     TPSPPPIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKFISARNVTRVANKRQPT
                     TPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDKV
                     AVLQVFIGTDIGRVAPHMFYQACKVAGKNSTQCNEKKVDGTMVIEIDFKPETDMTITC
                     DCVGILKERNVDVEHRFPEHLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPII
                     CTQPPGVPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDDPATEIA
                     VRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVSSGKKS
                     EPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGGSGNN
                     TSTGDNVEAKHEIDSGMMPPPITTQIPMGVRRSSLPSVTPMITDQQLVHLNAVAASAE
                     ALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIMYDQSNSLPGFPTVVA
                     PATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVVQQHQQMQEQMHEQQQQQQQQQQQ
                     QQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSAVIDHALTDILQA
                     KVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALAGAAAL
                     GGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNILAPHQVTMANSILNDI
                     AMQPEPTQQDAAVAALALSNIMMSPPTAASGVGVGDTLPPTPATMQPEVAATATSTAV
                     SNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQAAVGVSGNPAETASDPLVDLLLNH
                     SNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGHHGHSHGHGHSRVTGHVSGHVTSHH
                     RGHHLPVVPPTPQESLIVALASENALQKSVATAAVTTNGAVMTQQASAPNTAGSILPA
                     AVGAVAAAAAVAVQPPIPQELTTMSDQDLISYINPSTFDQL"
     misc_feature    2102..2593
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of tonicity-responsive enhancer binding protein
                     (TonEBP); Region: RHD-n_TonEBP; cd07882"
                     /db_xref="CDD:143642"
     misc_feature    order(2141..2143,2150..2152,2156..2173,2429..2431,
                     2435..2440,2492..2494,2498..2500,2591..2593)
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143642"
     misc_feature    2603..2959
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="Immunoglobulin-like fold, Plexins, Transcription
                     factors (IPT). IPTs are also known as Transcription factor
                     ImmunoGlobin (TIG) domains. They are present in
                     intracellular transcription factors, cell surface
                     receptors (such as plexins and scatter factor...; Region:
                     IPT; cl15674"
                     /db_xref="CDD:472823"
ORIGIN      
        1 gcagctctgt gcaacaagtt gaaaaataga agaagcaaat agaaacagcg tccgcaaata
       61 gtgcgcaaaa tagtgttttt ttgttaacgt gcaacagtga cattgttaag ccattgaatg
      121 caagtgacag tgggaccaga aaaacaatgc aaaacacttg gccacgcaac aataacaatt
      181 gagcaaggcg cacacacaca cacatgtgca ggcacccact cgtgtaagag aaaaaaagag
      241 atagcgcgag tgtgtgagtg agcgagaggc aagaactgta actgtaatat aattgataaa
      301 acaaaaaacg tcaggagcag gaatccagtg aaagagcggc tgtggctgag ggaaagagag
      361 agagagagag agagagcgag taagaggaca gcgaaaaaga gctgaaaaag gaggaggaat
      421 tgttgttgct aaaaatagca acaaatagac agggcacgaa gaagaagaag acgacggcaa
      481 ataagagcaa gaagaagaag cgttgacgca ggcaaaagtc gcagccttgt tggccacttg
      541 gactcttact ttgtcccgtt agccagctaa cgctctcccg gcgagcaaca acaacaacaa
      601 caaacatcga tagcagcaat aacaataacg atatcaagga atacgagatc agcatcatca
      661 acacaaaaca aaacaaaaac aacaacaaca agtacgacga cggaccaaaa ctatgctttt
      721 gaaattcaca aaaaccagtg gcgctggacc ctcggccgta ccgctactga ccaccgcccc
      781 cgcgacagtc accagttcgg cgtccatgca ggcaacaaca acaagttacg cggcccgtgg
      841 aacaggcatg agaatgacca tgtccaccaa ttccacaatg agtgcgcgta tacatcgaaa
      901 aggatttcgc ataccatcga aaagacagcc gggtaaggga ttgcccggca agttgcacac
      961 cataaccagg acgggtcctg gcaaaatggt tcctgggaag cgaataccac agcgacccca
     1021 tccgccgccc tgcgacaact cgaacgacag tgggctgggt ttcgatcagc acacggagct
     1081 gagatcctcg gcaggagctg ggggcgttac tgatccggcg gccaatggag gcagtggctc
     1141 caactctggc cagcgatcca gtttgctggt caatagcgct ttaaccaaca cagtggctgc
     1201 tgcagcagcc gcagcagctg ccgcggtggc cagcaacacg ttgcagcagc atcagcagca
     1261 ccatcaacag cagcagcagc aacagcagca acaacagcag cagcagcagc aacaacaaca
     1321 acagcagcag cagcaacaac attcaccgca gcagcattta atcagagcga tacctgtatc
     1381 aagatcgcgg aacaacacga aagtgatggc tcactgtctg gaggatctgg acctaatatc
     1441 ggcgtcctcg gaggacagct cgaccatcgc aacgccggcc ggtttggacg aggacacggg
     1501 ctttgtgaac gacaccaaaa cgacgacaac cggtggcaat agtagttcgg atccatttgg
     1561 aggcgtcttt caggcaaccg aggcagccgt ggcagcagcc gttaatgcct tcaacttgca
     1621 acagcagcag cattcggtgc aacagcaaca gcatcaactc tttcagtaca acggattgct
     1681 gttgcagccg cagcagcaat tgcagcagca acagtcgcat caccaacaac aacaacaaca
     1741 gcaacagcat caccgccatg gcaagcatat caaacgcaag aagctcgagt gcaaccaagt
     1801 ggaactggac aacgatgatg cctgcagcga ggatgagttc attcgcaaga ttgccagttc
     1861 ggtaacgatg tcacccacgc ttgaggccac gccctcgccg ccgcccattg tcgcctccgt
     1921 tgcacctgcc acgaccattg ttagccttct gccgctcatc agcagcggca acagcaacaa
     1981 caacaacaac aacaacaaca ttgagacaaa attcatatcg gccaggaatg tcacgcgtgt
     2041 ggcgaacaaa cgtcaaccca ctacaccgct gaacagcgtc gccagctcca acgatggcca
     2101 ggtgcagctg gagattttgt cgcagccgga gcaacagcac cgggcacgct atcaaacgga
     2161 gggcagccgc ggtgccgtca aggatcgcag cggcaatgga ttcccgatcg tccgactgac
     2221 cggatacgat aaggttgccg tcctccaggt cttcatcggc acggacattg gacgcgtggc
     2281 accgcacatg ttctatcagg cctgcaaggt tgccggcaag aactcgacgc agtgcaacga
     2341 gaagaaggtc gacggcacca tggtcattga gatcgatttc aagcccgaaa cggacatgac
     2401 catcacatgc gattgcgttg gaatcttgaa ggaacgcaat gtggatgtgg agcaccgatt
     2461 tcccgagcat ctggcgcaaa agaacaagaa gaaatcgact cgctgccgga tggtgttccg
     2521 cacccagctg acccgtgacg atggcaccac cgagaccctc caggtctgct cgaatccaat
     2581 catctgcact caaccacctg gcgtgccgga aatatgcaag aaatccttaa actcatgtcc
     2641 cgttgatggc ggcctcgagc ttttcattat cggcaagaac tttctgaagg acacacacgt
     2701 ggtgtttcag gagacatacg acagcgtcaa cggtgacgat ccggccacgg aaattgcagt
     2761 gcgccagcag ctcatcggcg gtacagccgc tctttgggaa cagagtgttc tgccggataa
     2821 ggagtacctt caccagactc atctgatatg cacggtgcca ccgtatctgc accagaacat
     2881 cctgaaaccg gtccaggttc aagtgtcgat cgtctccagc ggcaagaaga gcgaaccgca
     2941 tacgttcacc tacacggcca agggacagta cacgacgctg gcggcggcca gcacgttaag
     3001 taacacaatc cacgcccaag atgtgagcgg tttcatggac accacatcag cgtccaatgc
     3061 gagtggctcc agtggttgga gtgcggcagg cggttccggc aacaatacat ctacaggcga
     3121 taatgtggag gccaaacacg agatcgattc gggcatgatg cctccgccca ttaccaccca
     3181 aataccgatg ggcgttcgac gctcctcgct gcccagtgtc acacccatga tcacggacca
     3241 acagctggtc catctcaacg cagtggcggc cagtgccgag gccctgaaga cggaactcga
     3301 cgacagcaac tcgcatagcc cactgaccgg tgaatccaca ccggatagcc ccaacgcagc
     3361 cttgcagtat catcgctttg cacgaaagcc cagcctggac accattatgt acgatcagtc
     3421 gaacagtctg cccggtttcc cgaccgttgt ggcgccggct acagctgccg ccgtggccgc
     3481 tgcagttgat attgatccga cggcggtggc cgtggcggtg gaactggccg taaaaaatga
     3541 gattgtcaag catgtcgtac agcagcacca gcagatgcag gagcaaatgc acgagcagca
     3601 gcagcagcaa cagcagcagc aacaacaaca acaacagcag caacaacaac aaccccaaca
     3661 gcagcagcag caacaggtgc acaagtttat tgacgagctg accaaatcca catcggtggt
     3721 ttccagcaat ggtaccaccg aaccagctct gttcaccacc tcggcggtga tcgatcatgc
     3781 cctgaccgat attctgcagg ccaaagttgg cattgcgccg cccaatgtgg tgctggaaag
     3841 gagtttgtcc ctaagctcca caaattccag cagctccatg agcggcagtg agagttcgcc
     3901 gaatagttca cctttgacgc aggatatcat actcaattca gaaccggcag cagctctggc
     3961 cggagctgct gccttgggtg gcccggcgcc tgtcgatgtc accggtggtc tgtccaccga
     4021 tatcattatg aatcccgccg tttcaccatc gactattttg tgctccgcaa atggagcggc
     4081 cactgccgta gtgccgaata tactcgcacc tcaccaagtg accatggcca actccatttt
     4141 gaacgatatt gccatgcagc cggaaccaac acagcaggat gcagcagtag cagccttggc
     4201 gttgagcaac atcatgatga gtccacccac cgcggcatcg ggtgtgggag ttggtgacac
     4261 actgccacca acaccagcta ctatgcagcc agaggtcgca gccactgcca catccactgc
     4321 ggtcagcaac atgattatta aggcggcggc ggactttata accacccagg agcaggagca
     4381 acaccactac catcaccacg gtcgcatcca ctcccattcg ccacaggcag ctgtcggagt
     4441 gagcggtaat cctgccgaga cggcatcgga tccattggtt gacctgctat tgaaccactc
     4501 aaacacacca gaaacagcgg ctgctgccgc tgccgcagta gctgtagaag cagccaactt
     4561 ccagtcgatg aatcacagtc accacagcca tcatggtcat catggtcaca gtcacggcca
     4621 cggccatagt cgcgtcacag gacacgtatc cgggcatgtg accagccacc atcgtggtca
     4681 ccacttgccg gtggtgccgc cgacaccaca agaatctctg atcgttgcgc tggccagcga
     4741 gaatgctctg caaaagtcgg tggccaccgc cgcagtgacc accaatggag cagtgatgac
     4801 gcaacaggca tctgccccga acacagcggg tagcatactt ccggcagcgg ttggagcggt
     4861 agctgcggcg gccgccgtgg cggtgcagcc gcccattccc caggagctga ccacgatgtc
     4921 ggatcaggat ctgatcagct acatcaaccc gagcaccttt gatcagcttt aaacggcttc
     4981 agatcaacaa attaaactat gtggacttgc tttttttttt atcaactata aatgtcactc
     5041 ctacacaggc ttaggcttaa gtatatatgt agtatataga gacatacaca aacaaacgat
     5101 aagacggaat aaaggtttca tgtggaccaa ctttttgacc aagagaaagg agtaaaaacg
     5161 ggatcagaga ataaaaacca caaacacaaa cagatttgta gctttagatt tgcttacgtt
     5221 taggcataaa ccctatttaa tataattacc taaatttaat gttttttttt tttttgattt
     5281 tttttgctat tttaatattg atttaaaaaa caaatgatga acttatctca aaaggttaaa
     5341 ttaaaacaat gataacgact gccatatacc tatgaaatat gaagtgaaat cccgaaagtg
     5401 aagaatgaaa accgaaaatg aaaaattcag ttatcaacct tgaaaatcga taattataga
     5461 aagaaccaac tttcataaaa caaatgttga ttacgctctt tgctggaaga cctattttta
     5521 taattaagtc tgatttgaaa acttcctttt tatttgtttg agaattttag gtatatttta
     5581 caattaaagc ctaactaaat gttttggcag taaaattaag cttatttaat tttgggtcaa
     5641 aagaaaacca cgaaaagaaa ttattattat acagttaata atttataaaa aaaaaataca
     5701 tattatgtgt agctacgaat ataatgaata tgcgagaaat tccaaaagac ttttgattta
     5761 aagaaaatgc aattattatt ttgtttatgg tttaatcatt tttattttca attatattga
     5821 aggaacgacg aacacacaca aataaagttg taactgatgt tattactatt