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LOCUS NM_078590 5001 bp mRNA linear INV 26-DEC-2023 variant B, mRNA. ACCESSION NM_078590 VERSION NM_078590.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5001) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5001) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5001) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5001) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5001) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5001) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5001) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5001) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5001) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5001) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5001) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5001) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5001) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5001) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5001) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5001) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5001) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5001) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5001) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5001) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5001) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5001) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5001) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_078590.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5001 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5001 /gene="mew" /locus_tag="Dmel_CG1771" /gene_synonym="alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1" /note="multiple edematous wings" /map="11E3-11E8" /db_xref="FLYBASE:FBgn0004456" /db_xref="GeneID:32275" CDS 353..3793 /gene="mew" /locus_tag="Dmel_CG1771" /gene_synonym="alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1" /note="CG1771 gene product from transcript CG1771-RB; CG1771-PB; mew-PB; alpha1 integrin; multiple edematous wings; alphaPS integrin; PS1-Integrin; alphaPS1 integrin; integrin alphaPS1; integrin alpha PS1; integrin alphaPS1 subunit; integrin PSII alpha subunit; PS I alpha; alpha-PS1-integrin; Position-specific-1 antigen; alpha[[PS1]] subunit of integrin; PS1 integrin; Position-specific-antigen-1alpha; alpha integrin; alpha1 integrin subunit" /codon_start=1 /product="multiple edematous wings, isoform B" /protein_id="NP_511145.2" /db_xref="FLYBASE:FBpp0073563" /db_xref="GeneID:32275" /db_xref="FLYBASE:FBgn0004456" /translation="MLELPFTTIRPNCRLRQNLGILIILQCVLTCYNFNLEQRLPIVK YGHPHSHFGYSVATHTIGEANGPNKTNCVLVGAPLDQNRQPNTTHSGALWRCPMTQRF DDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTVRSNPLQANGSGGKVIVCAHRY MYIVRENRYGQGLCYLLTNDLQFEEVHEPCKGRPVQRQHEDYGLCQAGTSAALLDDDT MVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTGGRF FGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDH RPDLIVAAPLYFTKTEGGAVYVYQNIQDTLPMKYTLKLTGPLESRFGLALANIGDLNK DNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISI SGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDP ASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVL SRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILD QTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVS NLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPMLRDTTTFVTI RFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSF YSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPY SLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPA QMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERL MYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTL VSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLII ILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPSKNTHHVF " misc_feature 494..685 /gene="mew" /locus_tag="Dmel_CG1771" /gene_synonym="alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1" /note="Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191" /db_xref="CDD:214549" misc_feature 1301..1456 /gene="mew" /locus_tag="Dmel_CG1771" /gene_synonym="alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1" /note="Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191" /db_xref="CDD:214549" misc_feature 1484..1636 /gene="mew" /locus_tag="Dmel_CG1771" /gene_synonym="alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1" /note="Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191" /db_xref="CDD:214549" misc_feature 1688..1825 /gene="mew" /locus_tag="Dmel_CG1771" /gene_synonym="alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1" /note="Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191" /db_xref="CDD:214549" misc_feature 1790..3370 /gene="mew" /locus_tag="Dmel_CG1771" /gene_synonym="alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1" /note="Integrin alpha; Region: Integrin_alpha2; pfam08441" /db_xref="CDD:462478" ORIGIN 1 cattttattt ttcgtttgcc cgtcgaagaa ggcgaagcga agagaaaata tctgccgctt 61 cgaacgcacg ctatcaatgt ctaattcttt acgtaataat catttttttt tttgctgtgt 121 gactgaaacg aagaaatata cgagcaaaag tgaaaaatac gtggactacc tgttgatcca 181 aagatctcaa cggatttagt gtgtgtgtgt gtgtgtgcgt gcgtgttttt tttcggttca 241 ttgttttgtt tgcaatagtg caaaggaaaa agtaatcact ttgccgtgtt cggtgcacgt 301 gcacgaaata tttataaaat atatattaaa aaaaaaaaac ataaaattaa cgatgttgga 361 gctaccgttt accaccatac ggcccaactg ccggctaaga cagaatcttg gtattctgat 421 aatcctgcaa tgcgttctca cttgctacaa tttcaaccta gaacagcgat tgcccattgt 481 gaagtacgga catccgcatt cgcatttcgg ctactcggtg gccacccaca ctattggcga 541 ggccaatggg cccaacaaga ccaactgtgt tttagtggga gctccattgg atcaaaatcg 601 acagccgaac accacacact ctggcgccct ctggcggtgt ccaatgacac agcgtttcga 661 tgactgcgaa caagtgatca ccgatggcag gcgaaacttc gacagcgaaa tcctttcacc 721 gcccggcaat gacgaaatca aggaggatca atggatgggc gttacggtgc gttcgaatcc 781 cctacaggcc aacggatccg gcggaaaggt aatcgtctgc gcccatcgct atatgtacat 841 cgtccgagag aatcgttatg gacagggtct ctgctatctc ctaacgaacg atctgcaatt 901 cgaagaggtc cacgagccct gcaaaggacg acctgtgcaa aggcaacacg aagattatgg 961 actgtgccag gcgggcacat cggctgccct actggacgat gacaccatgg tgttgggttc 1021 ccctggaccg tacacatggc gcggatccat ttgggtgact caggtgggcg gggagtacct 1081 gcagcgcgac aagacgacct actacagtga tcattcggac ttgaattcgc cggtggacaa 1141 gtacagctat cttggtatgt cggtgaccgg tggcagattc tttggtcaca tgtcatatgc 1201 ggctggagct ccacgatccg agggtcatgg acaggtggtg attttcgaca agtccaccga 1261 taatccaata ccggtgcact cgatcctgga tggtgagcaa ttcggttcga gttttggcta 1321 tgaactggca accgccgata taaacggaga tcacaggccg gatttaatag tggcagctcc 1381 tttgtacttc acaaaaacgg aaggtggagc tgtgtatgtg taccagaata tccaggatac 1441 gttgcccatg aagtacacac tcaagttgac gggacctctg gagagtcgtt tcggtctggc 1501 gttggccaat atcggagatc tgaacaagga taactgcgag gatctggccg tgggagcacc 1561 atacgagggc aacggcgtag tctacatcta cttgggctcg agtcagggcc tgaattccaa 1621 gcccgcccag aagatccagg cctcggaact gggtggaacc atacccaatg gtcaaccgat 1681 tcgtaccttt ggcatctcta tatccggcaa cacggacttg gatgataact cctatccgga 1741 tgtggtaatc ggagcattca actcctcggc agccgtaatc ctgctggcca gacctatcat 1801 cagcattcag acgagtgtac agcgcaagga gctgcataac atggatccca atacgcccgg 1861 ctgtttggac gatccggcca gtaatctaac atgtttcacg ttcagagcat gttgcagcat 1921 tgaaccgtac gatgagaaga acaaggaact ccggttggct tatagcgtcg aagcggaaac 1981 cttcgatcac ctaaagaaat tctctcgcgt cttcttcttc gatcgggaaa ataagcggac 2041 gaatgtgctc agtcgcgtgg tgagagtgca tacgaatgga aggacagaat gccaggcagt 2101 cacgggctac atcaaggcca atacccggga tatccagact cccgtgcgtt tccgcttgaa 2161 gtactcgctg gtggaacccc cattggcgga ttctgctttg gtacgcctca atccgatatt 2221 ggatcagacc caggcgcatg tcgatttcga gggcaccttc cagaaagact gtggcgatga 2281 cgatctctgt gagagcaatc tgattatccg ggtggagccg aacatcactg agtcctcagg 2341 caacgaatac acactgattc tggatgaaac ggaactggag gtccgcatca atgttagcaa 2401 tctggcggat tctgcttacg aagctcaact attcatcgcc catcaggcgg gtgtttcata 2461 tgtggcaacc aagaagccga cgaatgccac gtgcaatagc tacaatacca ccctggttgc 2521 ctgcagtctt ggtaatccca tgctgcgcga caccaccaca tttgtgacca tccgattcca 2581 gcccaaagga ttggagccaa gtgagaagat catgctattc cacatattcg caaataccac 2641 ctccaagctg gtgggacccg aacgtcccga gcgggatctt cgcgtgaatg tggtgcgtcg 2701 ggcgaagctc aacttccgag gttgggccat acccgagcag agtttctaca gtggatcgag 2761 tgtggctaat tcggttgcaa atactgccgc caccgatata gaaggacatg gtccgatggg 2821 tatggacgat gtgggctccc aagttcatca catgttcacc attttcaatg agggaccatc 2881 cacggcgccg aaggtacaaa tggtcatcca ttggccatac tcactgtaca gtgatccaca 2941 gagcggtcga ccggttcagt atctactcta tctggagcaa gtacccactg tggaagttag 3001 ccagggcgaa tgccatgtgg ccaaagaata tgtcaatccg ctgaatttgg ccagcggttc 3061 tagggaaaat ccagcctact tgagtgctcc cgcccagatg agaatgttcc cctcgcagtc 3121 gcgtcattcg ttcaacaaga gcttgatcca ctcgcagaga agctactact ccagcagcca 3181 ccgggatgat cattcggatg acactcaatc gaaccgcaat cgtgtccgtc gcagtttcct 3241 agaacgggtg acgcgcctgg agaggttaat gtacgatccc gagagtagca atgcggcgaa 3301 tggcaagaag caggacatcg tcgagctgga ctgcaataag ggcgcgacca actgcgtgcg 3361 catcgagtgt gacatcctaa acatgcccgc tttgtccgag gcccaggtgg tggtcaaggc 3421 gcgcctgtgg aactcgacgc tggtcagtga gtatcctcgg gtggaaaggg tcaggatttt 3481 ctcgacagcc acggctcaaa tacccgagag ctatggcgtc gaggtgatgg atcacaataa 3541 catagaggtg gagacgcggg cctatccgga gttaaggaac caacagcgcg acacatcgat 3601 accgtggctg attatcatcc tgggcatcgt tggtggcctg ctcctccttg cgctggtcac 3661 ctatgtgctg tggaaggtag gcttctttaa gcgcatccga cccaccgatc cgacgttaag 3721 cggcaatctg gagaaaatga acgaggagaa gcccttcctg gcgccatcaa agaatacgca 3781 tcacgttttc taacaagagg gcaccgttgg ctgggatttg gtgcgccgtc ggaggcgtcg 3841 acgtcgtcta aagctgcgac ttcctgttac cgctcagcca cgacatggtt ggcgaaaaac 3901 tacggataag tccattaaca acaataataa caacaatcac aacaacaaca gcagcaacag 3961 tagaaacgac agcgatgtgg acgtactttc gctgacacca ccgccgcccc ctcttagcat 4021 ctttagctgg ggaaacgatg gctattacca agccagcgca gcctggtggg gtcaccacat 4081 gtgatcaaat gggtcaccgt ggatcaagtg ggtcatgtgg gttgtggttc aatgtgccat 4141 ttcacttact taatacaaat gggttaagtt cagttcggtg gatgcgatcg gatggaattg 4201 atagcccgga ttccgtcact ggaatcagct aaatataaat tcaagttcaa tcctaattcc 4261 cttaaagtaa aaagtatatt tagacaaccc cttttcctaa tggtgctttt aaaacatctg 4321 caactaatta aagaatgcta aacacttaag aattagaccc aacaaaacaa aacaaaaaat 4381 aatgctgggg attgcctttt gattgtaatg tcttgaaacc caaaaaaaat ataaagaacc 4441 tactttatat ctagctgatg tcagtactga gcttagattt aaagatttag ctaagcccaa 4501 aacgttgata atctttgtga aaaatgttat tgtcatatat agatttaagc cttacaggct 4561 aagttgtagg gaacgacgag aaaattccga atatagaata tatacttaac cactgccaac 4621 aacaaattaa aagtgcctcg aaatcgaatc gaaagtccaa tttaccggac acgagttagg 4681 atcaaaagaa aataattaaa taaaaaaaaa agaaatcgaa agtattagca ctaacttaat 4741 gcattactat aaataatcca cgcaactaaa tttagcacac accagcaaga atattcttat 4801 tttgtttgtt ttccgtcagc tattctaagt gatagttttt aaaattgtga gaaaaaaact 4861 agagatgtta gttttttatg tatgtttttg tatgtatggg gtcgagatgt agttaaatta 4921 gttgtaaata taaattcgat agtactagct gtaaatagta attatgttct tgatttattc 4981 aatatacact tccttttttt t