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Drosophila melanogaster hemipterous (hep), transcript variant C,


LOCUS       NM_078587               2738 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_078587
VERSION     NM_078587.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2738)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2738)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2738)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2738)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2738)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2738)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2738)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2738)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2738)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2738)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2738)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2738)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2738)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2738)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2738)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_078587.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2738
                     /gene="hep"
                     /locus_tag="Dmel_CG4353"
                     /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK;
                     DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK;
                     Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1;
                     l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7"
                     /note="hemipterous"
                     /map="11D10-11D10"
                     /db_xref="FLYBASE:FBgn0010303"
                     /db_xref="GeneID:32256"
     CDS             659..2137
                     /gene="hep"
                     /locus_tag="Dmel_CG4353"
                     /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK;
                     DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK;
                     Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1;
                     l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7"
                     /EC_number="2.7.12.2"
                     /note="CG4353 gene product from transcript CG4353-RC;
                     CG4353-PC; hep-PC; hemipterus; Mitogen-activated protein
                     kinase kinase 7; hempiterous; JNK kinase; hemipterous;
                     JNK-Kinase"
                     /codon_start=1
                     /product="hemipterous, isoform C"
                     /protein_id="NP_511142.2"
                     /db_xref="FLYBASE:FBpp0073579"
                     /db_xref="GeneID:32256"
                     /db_xref="FLYBASE:FBgn0010303"
                     /translation="MSTIEFETIGSRLQSLEAKLQAQNESHDQIVLSGARGPVVSGSV
                     PSARVPPLATSASAATSATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASASSS
                     SSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPT
                     PPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLS
                     SNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELM
                     SMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNI
                     KLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATA
                     RSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPEL
                     LAQPFIRIYESAKVDVPNWFQSIKDNRLRANGDPTLQRLPNS"
     misc_feature    1199..2086
                     /gene="hep"
                     /locus_tag="Dmel_CG4353"
                     /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK;
                     DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK;
                     Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1;
                     l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7"
                     /note="Catalytic domain of the dual-specificity Protein
                     Kinase, Mitogen-activated protein Kinase Kinase 7; Region:
                     PKc_MKK7; cd06618"
                     /db_xref="CDD:270791"
     misc_feature    order(1265..1279,1289..1291,1328..1330,1334..1336,
                     1427..1429,1475..1486,1490..1495,1502..1504,1616..1618,
                     1622..1633,1637..1639,1667..1672,1679..1681,1718..1729,
                     1733..1735,1820..1822,1847..1849)
                     /gene="hep"
                     /locus_tag="Dmel_CG4353"
                     /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK;
                     DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK;
                     Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1;
                     l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7"
                     /note="active site"
                     /db_xref="CDD:270791"
     misc_feature    order(1265..1279,1283..1285,1289..1291,1328..1330,
                     1334..1336,1427..1429,1475..1486,1490..1495,1499..1504,
                     1622..1624,1628..1633,1637..1639,1670..1672)
                     /gene="hep"
                     /locus_tag="Dmel_CG4353"
                     /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK;
                     DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK;
                     Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1;
                     l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270791"
     misc_feature    order(1274..1279,1616..1618,1622..1630,1679..1681,
                     1718..1729,1733..1735,1820..1822,1847..1849)
                     /gene="hep"
                     /locus_tag="Dmel_CG4353"
                     /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK;
                     DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK;
                     Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1;
                     l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270791"
     misc_feature    1667..1735
                     /gene="hep"
                     /locus_tag="Dmel_CG4353"
                     /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK;
                     DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK;
                     Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1;
                     l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270791"
ORIGIN      
        1 ggctgatgca tcgatgtttt tttacatcac tattgtacac gcgatttagg cagcaaaaac
       61 gtacaaaagc gagtgatcaa attgtgccag tgataccgcc gcccgcggtc gcgaaacgaa
      121 tcgattgcag aagtgcgaca aacagcgccg cgaaaggaaa acaaccgatg aaatattctc
      181 ccaaaaaagg aggaaaaaat cgcaagttgt tgttgccgtt gctgctgaaa aagaaagaga
      241 gagagggcgc tgcgtgtatg cctgtgtgtg tgcgtgtgtg ggggtgagga tgtctctctc
      301 taatgcacag tgactgtgtt ttcctttttt cgattttgtt tttgtgcccc cccttggcaa
      361 acaacaaaag tccaagcaat cctttatttt tgcaagtgta aagtttacag tgtatgtgtg
      421 ccgccgaaca acaacaacat cagcgacaaa acaaacaggg cgcacagcaa aacaattcac
      481 acacacacgc accctccccc gcctgcgcgc gcttgtgtgt gtgtgagaga gagggagtga
      541 gtgagaggaa aatcgaagaa gtgctggcca aaaaacggcg aaaaaaattt aataaatacc
      601 aaaatccaac gatactagca actaactata aaaaatcgaa ccaaatcgac tcgatataat
      661 gtccaccatt gagttcgaaa cgatcggcag tcggctgcaa tccttggagg caaagctcca
      721 ggcgcagaat gagtcccacg accagatcgt cctctccggt gcgcgcggcc ctgtcgtttc
      781 cggttccgtt ccatctgccc gcgtcccgcc cctggcgaca tccgcatccg cagccacatc
      841 cgccacccac gcaccttcct tgggcgcagg ttccgtttcc ggatcgggta tcagcatagc
      901 ccagcgtcca gcacctccag ttcctcatgc gacgcccttc ggcagcgcca gcgcctcgtc
      961 atcatcctca tccgcatccg catttgcatc cgcagcaccg gcgacgggca ccttcggtgg
     1021 aacatacacc ccgccgacaa ctagagtgtc gcgagccacg cccacactgc ccatgctttc
     1081 tagtggtccc ggtggtggac tgaatcgtac gcggccggtg atacttccgc tgcccacgcc
     1141 gccacatcct ccagtttcgg aaacggacat gaagctgaag atcatcatgg agcagaccgg
     1201 caagctgaac atcaacgggc ggcagtatcc gacggacatc aatgacctca agcacctggg
     1261 cgacctgggc aatgggacta gcggcaatgt ggtgaagatg atgcacctgt ccagcaacac
     1321 gatcatcgcc gtgaagcaga tgcgacgcac tggcaacgcg gaggagaaca aacgcatcct
     1381 gatggatctg gatgttgtgc tcaaatcgca cgactgcaag tacattgtca agtgccttgg
     1441 ctgcttcgtt cgcgatccgg atgtgtggat ctgcatggag ctgatgtcca tgtgctttga
     1501 caagctgctc aagctgtcca agaagccggt gccggaacag atcctgggca aggtcacagt
     1561 ggcgacggtc aacgcattgt cctacttgaa ggacaagcac ggagtcatcc atcgagatgt
     1621 gaagccctcg aacattctga tcgatgagcg cgggaacatc aagctctgtg atttcgggat
     1681 cagcggacgc ctggtggact ccaaggccaa cactcgatcc gccggctgtg cagcttatat
     1741 ggcgccggag cgcatcgacc ccaagaaacc aaagtacgac attcgcgcag atgtgtggtc
     1801 actgggcata acgctggtgg agctggccac agcgcgatcc ccgtacgagg gatgcaacac
     1861 ggacttcgag gtgctcacca aggtgcttga ctcggagccg ccgtgtttgc catacggcga
     1921 gggttacaac tttagtcagc agttccgcga tttcgtcatc aagtgcctca caaagaacca
     1981 tcaggatcga cccaagtatc cggagctttt ggcccagccc ttcatccgga tttatgaatc
     2041 agccaaagta gatgtgccca attggtttca gagcatcaag gataaccgac tgcgcgccaa
     2101 tggcgatcca acgctccaga ggttacctaa ttcctaatac catttcttaa acaataatga
     2161 caaacaatga agaaatccaa taaacataat ctaacaaaaa ataaaagcaa acgaaaaaga
     2221 agaagacaaa ctataaacaa aaaccaaaca ttaaaaacta tcgacataaa ctgaaaaaca
     2281 aaacaaaagc attcaagtaa accttgcaac catcaactct atatacagat atataaacct
     2341 aaaaatatat ttacctatat ataatgataa tgccaaccaa acataactac tcaaaaaaaa
     2401 aaaaaaaaaa cgataaaaac tcctcccaat taaaaaagta aaattcaggc aacggcgact
     2461 ggaagtgcga tcggttctgg ggccggatct ctcgcaggat caggatcagg atccgcaggt
     2521 ggagctgtaa aatatggtag ggcgacaacg tatgcggggc agagtcccac aaatccgcag
     2581 aagacaataa aacccactca gataccgagt taccagcagc aacagtcgca gtttttcatg
     2641 caatcagcca cacaactacc tcaaacaaca accacaacac cgacggcaac gacaaactgt
     2701 ttcggcggca gcggaaacgg aaatggaaga ggaaacgg