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Drosophila melanogaster LIM domain kinase 1 (LIMK1), transcript


LOCUS       NM_078584               5627 bp    mRNA    linear   INV 26-DEC-2023
            variant C, mRNA.
ACCESSION   NM_078584
VERSION     NM_078584.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5627)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5627)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5627)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5627)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5627)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5627)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5627)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5627)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5627)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5627)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5627)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5627)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5627)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5627)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5627)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5627)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5627)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5627)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5627)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5627)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5627)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5627)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5627)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_078584.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5627
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5627
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="LIM domain kinase 1"
                     /map="11B2-11B2"
                     /db_xref="FLYBASE:FBgn0283712"
                     /db_xref="GeneID:32207"
     CDS             300..4073
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /EC_number="2.7.11.1"
                     /note="CG1848 gene product from transcript CG1848-RC;
                     CG1848-PC; LIMK1-PC; LIM kinase 1; LIM-kinase 1;
                     LIM-DOMAIN KINASE; LIM domain protein kinase; agnostic;
                     LIM-kinase1; Lim kinase; LIM Kinase1; im kinase"
                     /codon_start=1
                     /product="LIM domain kinase 1, isoform C"
                     /protein_id="NP_511139.2"
                     /db_xref="FLYBASE:FBpp0073493"
                     /db_xref="GeneID:32207"
                     /db_xref="FLYBASE:FBgn0283712"
                     /translation="MHHQQRLRANGGRGGTGLGAGSGPVSGGHSPLCAHCRGQLLPHP
                     EEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDYYGRFGDACQQCMAVI
                     TGPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQPADAKA
                     RITTAGKPMHSIRLVEIPKDATPGLRVDGVALDDGCPTVRITDLFCNFFLWLTSMAEQ
                     CCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQ
                     VCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNAS
                     TTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKP
                     QRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVL
                     RLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIAC
                     GMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGA
                     NSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCE
                     IIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETL
                     HVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAV
                     DSEISPVEKEKENMVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERR
                     NLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDT
                     SLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMRTRLNQCR
                     SKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRT
                     QRINQTPIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATPAPKRSKATATTKGG
                     QSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQ
                     QRTSSNHRLPMCNNKGKTLKPLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTA
                     ATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKVHRLGARLTDQKQKMREEAAATAS
                     SVGGAGCAAGTAAGSLNGHRTIGSSGTPNSAVGERRRRAAPSPPVRTHFNTRC"
     misc_feature    396..563
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="The first LIM domain of LIMK (LIM domain Kinase);
                     Region: LIM1_LIMK; cd09364"
                     /db_xref="CDD:188750"
     misc_feature    order(396..398,405..407,468..470,477..479,486..488,
                     495..497,546..548,555..557)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188750"
     misc_feature    582..743
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="The second LIM domain of LIMK (LIM domain Kinase);
                     Region: LIM2_LIMK; cd09365"
                     /db_xref="CDD:188751"
     misc_feature    order(582..584,591..593,642..644,651..653,660..662,
                     669..671,729..731,738..740)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188751"
     misc_feature    804..1121
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="PDZ domain of LIM Kinase (LIMK) family, and related
                     domains; Region: PDZ_LIMK-like; cd06754"
                     /db_xref="CDD:467236"
     misc_feature    order(852..872,903..905,963..965,1053..1055,1065..1067,
                     1074..1079)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467236"
     misc_feature    1518..2378
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     LIM domain kinase; Region: STKc_LIMK; cd14154"
                     /db_xref="CDD:271056"
     misc_feature    order(1518..1532,1542..1544,1581..1583,1587..1589,
                     1674..1676,1722..1733,1743..1745,1749..1751,1863..1865,
                     1869..1871,1875..1880,1884..1886,1917..1919,1926..1928,
                     2079..2090)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="active site"
                     /db_xref="CDD:271056"
     misc_feature    order(1518..1532,1542..1544,1581..1583,1587..1589,
                     1674..1676,1722..1733,1743..1745,1863..1865,1869..1871,
                     1875..1880,1884..1886,1917..1919)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271056"
     misc_feature    order(1530..1532,1743..1745,1749..1751,1863..1865,
                     1869..1871,1875..1877,1926..1928,2079..2090)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271056"
     misc_feature    order(1914..1946,2040..2090)
                     /gene="LIMK1"
                     /locus_tag="Dmel_CG1848"
                     /gene_synonym="ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK;
                     Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af;
                     LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1;
                     limK1; Limk1; LimK1; ts398"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271056"
ORIGIN      
        1 atgacagtcc tacggtcaca ctggctgaat tgtattttat tttgtgtagt tttgttgttg
       61 ttttgtttat tatgcatttc ttttttattg tttgagttag cgagctgtgc gtcgcgtcgg
      121 catttaaaca aaatccgcgg catttcggta gttgcgatta ataattgctt ggcgggaatt
      181 acagtcgaat aagaaattgg cgaggaaaaa ccaacaaatg tgcaatgtgc gtcaagtcaa
      241 tagcaataca aacgaacaat tattgctaac gtgatcgggc caaggcacaa aaacattcca
      301 tgcatcatca gcagcgcctg cgggcaaatg gcggacgagg aggcactgga ttgggcgcag
      361 gatcaggacc tgtgtccgga ggacactcac cattgtgcgc ccattgtcgg ggtcaactac
      421 tgccacatcc agaggagcca atcgtgatgg ctctcggcca gcaatggcac tgcgattgct
      481 ttcgctgctc cgtttgcgag ggccatctgc ataactggta cttcgaacgg gagggcttac
      541 tgtactgtcg tgaggattac tacggccgat tcggcgatgc ctgtcagcag tgtatggccg
      601 ttatcaccgg acccgtaatg gtcgccggcg agcacaaatt ccatccggag tgcttctgct
      661 gcacggcatg cggctccttc atcggcgagg gcgaatcgta cgcccttgtc gagcgttcga
      721 agctctattg tggccagtgc tatggcaaac gttcctgcca gccggcggat gcgaaggcgc
      781 ggatcacaac ggccggcaag ccgatgcact ccatccgtct ggtcgagata cccaaggacg
      841 ccacgcccgg cctgagggtc gacggagtgg ccctcgacga tggttgtccc acggtccgca
      901 ttacagactt gttctgtaac ttcttcttgt ggctaacctc gatggcggaa cagtgctgtg
      961 gggcgcctta tagaattgat gtgaatctta caaatctgca tattggagat aggatattgg
     1021 aggtgaacgg cacaccagtt agtgattcgt ccgtggaaca gatcgacaaa ttgatacgga
     1081 gtaatgagaa gatgcttcag ctgaccgtgg agcatgatcc ggtgcaagtg tgccgctcct
     1141 gcagccaagc ggacatccag cgggccatgt cagcgtccac gttaatcctg ccgctcagca
     1201 catcggcctc cagtgtcgag gtgggcaggg agcgtctgta caagacaccc ggcgaacagg
     1261 gcacgaaggc caggaaactg cgacaagcca ccaatgcctc tacgacaata ccaccggcag
     1321 ctggagccac cgcaatgacg caactaaagg agaaggagcg ttgttccagt ctgtccaagt
     1381 tgctggatga acagcatcag gcacaacagc attcggcgca tcctcagctc tatgatctgt
     1441 ccaggacgca atcctgccgt gtcgtccaaa agccacaacg aatctttcgt gcaactgatc
     1501 tggttatagg agagaagcta ggcgagggct tctttggcaa ggttttcaag gtgacccacc
     1561 gtcagagcgg cgaggtgatg gtcctcaaag aactgcatcg tgcggatgag gaagcgcaaa
     1621 ggaatttcat caaggaagtg gccgttctcc gtttgctgga ccatcggcat gtgctcaaat
     1681 tcattggtgt tctgtacaag gataagaaac tgcacatggt cacggagtac gtggccggtg
     1741 gttgtctcaa ggagctgatc cacgatccag cccaagtact cccttggccc cagcgcgtcc
     1801 gcttggccag ggatattgcg tgcggcatga gctatctgca ctcgatgaac atcatccatc
     1861 gcgatttgaa ctcaatgaat tgcctggtcc gtgaagatcg ctcggtcata gtggcggatt
     1921 ttggactagc tcgcagtgtg gatgcgccgc ggctgccaag tggcaatatg acgccaggcg
     1981 gctatggatc aggcgctaac agcgatgcgc ccatgtcacc gagtggaaca ctaaggcgca
     2041 gcaagagcag gcagcgaagg caacgttaca cggtggtcgg gaatccctac tggatggcac
     2101 ccgagatgat gaaaggtctc aaatacgacg aaaaggtgga tgtcttctcc tttggcatta
     2161 tgttgtgtga gatcattgga cgcgtggaag ccgatccgga ttttatgcct cgcaattcgg
     2221 acttcagtct caatcagcag gagtttcgcg agaagttctg cgctcagtgt ccagagcctt
     2281 tcgttaaagt ggccttcgtg tgctgtgatc ttaatcccga tatgcgtccg tgtttcgaaa
     2341 ctctgcacgt ttggctgcag cgtctcgccg atgatctggc cgccgatcgt gtgccgccag
     2401 agcgtctgct gcacgagatt gagacctttc aggaatggta cgccagctct gaggacgcct
     2461 tgtcacccac ctcccagcgc agcttaaata atctcgatga gttggtcaag agtgcggtgg
     2521 attcggaaat ttcgccggta gaaaaagaga aggagaatat ggtgattaag ccccaggata
     2581 taccgaaatc tccgcatctc ggcaaggatt tctcgcccag cggcgagaga ctgcgtgaca
     2641 gtatgcgggc caggcgtcgc caacgtttct tgggcgccca ggaggagcgt cgtaatctca
     2701 cgcccgacac ggagtccaag gaaagggctt tgaagaaggc gctgaagaaa tgtcgtccgt
     2761 ttggcgaaag aggttacctg gtggatctgc gtgccggtgc cgaattgcag ctagaggatg
     2821 tcagggattt gaacacctat tccgatgtgg actccagttg cgatactagc ctaaattacc
     2881 atgatgtaaa taatctgcca gcagcgcaag aggatgagaa tacagtgaaa ccgggcaagg
     2941 aagaactgtt ggaggagagc acaaataaac ccagcaacca ggagtcacaa caccatcgtc
     3001 tggccatcga tgatatgcgc acccgcctga atcagtgccg cagcaaattc gagcatttgg
     3061 aggaggctag tcggcggaac ttcaaccagt cgcagcactc catgaagaac tttttcaaaa
     3121 ccccaccggt ggcccttaag atgtttcagc gcctggagca cgaggctgca gccctgaatg
     3181 gtggcaacaa ttgcccaccg ccaccaccac gtacgcagcg catcaatcag acgcccattt
     3241 tcggtcgaaa gaatccgcca gtggcaatcg tcgggcaaaa actacagcat gctgagtccc
     3301 tagaggacct ggcctccagc ggagttgcca aacagctggc cacaccagca cccaaacgca
     3361 gcaaagccac agcaacgacc aaaggcggcc agagcagcaa tccgccactt ttcctgccgc
     3421 ctagccttaa cataagtgtc gcattaaata gcaatggaaa tgtgaccaca acgaccaata
     3481 ccaatagtag ttgtccacca tccgcatcag actggctgcc gaagaagcac aagctaactt
     3541 tgccacttcc gtcggcccaa cagcagcgaa cgagcagcaa tcatcgcctg ccaatgtgca
     3601 ataacaaagg gaagacactg aagccactgc caagtcgcac gggcagtcaa ggcattcccg
     3661 caagcaattg cgtctcgccg acgaggagca gcaggcccgg atcacccacc aagcatctgg
     3721 cccagaggca cacagccgcc acggcgcagc gactgacaaa tgcggccgcc actcaccagc
     3781 agcagcatca gcaacaatcc tcgaagacga cgcgcctgaa tatcctgagt ccggaaaagg
     3841 tgcatcgcct gggcgctcga ctcaccgatc agaagcagaa aatgcgcgag gaggccgcag
     3901 cgacggcctc gtccgtcgga ggagccggtt gtgcggcagg aacagcggct ggaagcttaa
     3961 atggtcatcg gaccatcgga tcctccggca caccgaattc ggcggtcggt gaacggagga
     4021 ggcgagcagc tccatcgccg ccagttcgca cgcatttcaa tacgcgctgc tagctagacg
     4081 aagtagccat actctctatt aacgattgtc aagtgttgtg cgcagtttgt tgtggttcca
     4141 ctcaggaagc tgttgtaagc agcttaatgt tctacaaaca aactgtcgta attagcgtaa
     4201 atctttgaag gatataactg ttgtaacttc tataaccaac cattcgccat ttgtatcgta
     4261 cggaattaaa tttccacgac atgtagaggc actttttttt ttaaatacat aatgactttt
     4321 aaagtgtaat gtaacattaa gaaccagtga actgtgccgc tgttataaac gcaactgtta
     4381 tacgcacata acaagatcaa cattccgacg aaagtgttta tttttttttt gattccaaca
     4441 tttgatttta agtttcaact gaacgaaggt taagtgcctg ataggaatga aaaaccaata
     4501 agttgcaata tttacacgga ttgtataaac caagcgaata attatagtat gtaagattac
     4561 agggtaacaa ctgtctcgac taacctaaaa aaaaaaactg aactagaagc aaagctaagc
     4621 aaatacttgt ttaacccact attgtctgac ataaagttat attgcgaaag agatagcgaa
     4681 agacggataa agagagaagg aagaaacttg tgccatgatg ttgatgcgaa aaacgaacga
     4741 atctgaagaa tcctcgagag agggagatcc cacccgcaaa aaaaagacaa aaggaacgaa
     4801 aagaacttta actagaaaaa ttgtggttta aatatttttt gataaacagc gtatataaat
     4861 gtatttgtat atctattcca taattatata gataaacgta ttccatgtta gtgcttaaat
     4921 ctaatttatt atttatcgat tctcgaccca ttcaccccgt cccctcattc caagaacaat
     4981 aattaacaat gctaagaaac aaactttttt gtattgacga gaataagtct aactcctata
     5041 actaaatata taagaatgtt tttgctcaaa ggcaatttta gttgtaattg atacgaacag
     5101 acatacaaac acacacacac gctaactgtt atacaaatga aacgcacacg ctcaagccta
     5161 atactgttat actgtgtact ttatatagcc attatatacc taaacctata tacatatagg
     5221 atcgaaacgc ttgcaattaa ctgcttacat aagacatttg agtcgggccc ttgttatacg
     5281 gacgtatgcc agtagaacag tggccgcgcc gaaccgatct agcatttaac tatctatata
     5341 caacaaatat gtgcgatatt ttttatatgc agctaattta atgtgttgta ttttgacccc
     5401 acaccacctt gtaactacgt ttatacgcct gcttttcgaa aattgagtaa cgcttataga
     5461 attttcgatt caattcttta tgccttttaa cagttgaaca tatataatca gtatagcaac
     5521 attttctacc cacttgtaaa taagtttata actaatgcag tttttgttgc ctacttattc
     5581 gggagtcgaa aggtctgtaa ttacaaataa agcttgtgta taaacgt