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Drosophila melanogaster furrowed (fw), transcript variant A, mRNA.


LOCUS       NM_078581               4698 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_078581
VERSION     NM_078581.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4698)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4698)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4698)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4698)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4698)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4698)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4698)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4698)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4698)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4698)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4698)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4698)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4698)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4698)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4698)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4698)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4698)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4698)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4698)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4698)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4698)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4698)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4698)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_078581.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4698
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4698
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="furrowed"
                     /map="11A1-11A1"
                     /db_xref="FLYBASE:FBgn0001083"
                     /db_xref="GeneID:32162"
     CDS             592..4116
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="CG1500 gene product from transcript CG1500-RA;
                     CG1500-PA; fw-PA; furrowed; wrinkled"
                     /codon_start=1
                     /product="furrowed, isoform A"
                     /protein_id="NP_511136.2"
                     /db_xref="FLYBASE:FBpp0073424"
                     /db_xref="GeneID:32162"
                     /db_xref="FLYBASE:FBgn0001083"
                     /translation="MFCCNIPVDASVATSTSTSISTYPLQRATKRAMTPPNAMALIML
                     LLLALCAAGNGQICGPPAVPLNAKVRTITVDSQIAEAHYECDAGYELFGPSAVKCDRR
                     TGWDRDLPFCGVNVAYRKPVNQSSYTRSGPASYANDGKPGNKNPDGQECSETQKEPSP
                     WWRVDLLTPQAVHVVRITTRGCCGHQPLQDLEIRVGNSSADLQRNPLCAWYPGTLDEG
                     VVKTFTCARPLVGQYVAIQLVGVEGSLSLCEVETFTNDEFSVDRCLSPKIGVDTVVTT
                     FSKTCYDFHITKGESFDKAQAICKQTGGDLVHDFRGATSSYILSELERRKSELKPQLV
                     WIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVGC
                     NLDYLHFICQHSPLSCGSPDAQQNTTVMGKKFTLGEKIQYTCPKGHSLLGQTERECRL
                     DGTWSGSSPTCKYVDCGSLPELKFGSIHMSEERTSFGVVATYSCHENYTLIGNENRTC
                     AMDGWSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVGEAIISCG
                     LGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTTTVNSVVKYECDEDHWLDGQSELY
                     CTREGKWSGEAPVCELVTCETPSVPSGSFVIGYDYNVHSKIQYNCDPGHIMHGTPVLE
                     CLDSGEWSADAPYCEYIDCGTILPIPYGSHKYVTNTTYVGSEVVFSCSQSHKLSGVLK
                     RTCLESAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQT
                     YKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLAT
                     NATYYGAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEA
                     GPRAVGSVATFKCAKGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIV
                     VNDSTLYGGSAEYHCIPNYNRIGQYLRKCTEDGAWSGKQPRCELATAEGQETSELGTG
                     VGIGATVIVALLVIFGLIFLYRNKARPVKNTENVQAAETKDERNAAVMSYSTLEANNR
                     MHMDNNPSATFNTFHGGAGGRSNGGGNPDANSNGERLNNNRSENIYDQIPNEQFYDAP
                     YEMRTNDEVYEPEPVASNVITINGISVR"
     misc_feature    763..927
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     Region: CCP; cd00033"
                     /db_xref="CDD:153056"
     misc_feature    order(793..795,847..849)
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     misc_feature    928..1374
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain;
                     Region: FTP; smart00607"
                     /db_xref="CDD:128870"
     misc_feature    1432..1800
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cd00037"
                     /db_xref="CDD:153057"
     misc_feature    order(1708..1710,1723..1725,1729..1731,1747..1749,
                     1753..1764,1774..1782)
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153057"
     misc_feature    <1813..2325
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="secreted complement-binding protein; Provisional;
                     Region: PHA02927"
                     /db_xref="CDD:222943"
     misc_feature    <2113..2679
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="secreted complement-binding protein; Provisional;
                     Region: PHA02927"
                     /db_xref="CDD:222943"
     misc_feature    2518..>3102
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="EEV host range protein; Provisional; Region:
                     PHA02639"
                     /db_xref="CDD:165022"
     misc_feature    2983..3633
                     /gene="fw"
                     /locus_tag="Dmel_CG1500"
                     /gene_synonym="CG1500; CT3745; Dmel\CG1500; Fw; fw-like;
                     wr"
                     /note="secreted complement-binding protein; Provisional;
                     Region: PHA02927"
                     /db_xref="CDD:222943"
ORIGIN      
        1 aaccagttat aagccaactt tcattccaag cagacgtgct gggagtttcg catcggaaag
       61 cggcggtttt ttgtttcgcc gttgcagtag caacagcaac agcagcagcg ttaactcgtg
      121 caaatgcagc caggtcgccc aaaacgagaa ataagttcac gttcatagta tccaatgcta
      181 tatgtaatat acataaaaca tcataattag ccagtggaaa ttcagtgtga atgcaaagtg
      241 aaaccttaat gaacgcatca cgatcgctca cgccatctat gtgttatgtt tatgtgcaag
      301 ttttaaaaca gcaaaaaatt attaaaaaaa tagcgagata aatatatata catatgaata
      361 atcgacaagt gtatgcataa attaatcgct gctgatgccg caacaacaac aacaacaaaa
      421 aacaccccaa ctgaaaacaa caaaagctaa agctatatag ccaaagctaa tgctaatcgg
      481 cagccaacga acggcatcgg gcattataat catcaacttc aacttcaaca tcagcatccc
      541 gggcattgga aacaacaata ccaacacacc tgccaccagc agacagacac aatgttttgc
      601 tgcaacatac cggtggatgc atccgtggcc acatccacat ccacatccat atccacatat
      661 ccattgcaac gggcaacaaa aagagccatg actcctccaa atgcaatggc actcattatg
      721 ctactgctgc ttgcactgtg cgcagctggg aatggccaaa tctgcggtcc gccggcggtg
      781 ccgctgaatg ccaaggtgcg aaccatcacc gttgactccc agatcgcgga ggcgcactac
      841 gagtgcgacg ctggctacga gctcttcggg ccatcggcgg tcaagtgtga ccggcggacg
      901 ggctgggatc gggacctgcc cttctgcggg gtaaatgtgg cgtaccgcaa gccggtcaac
      961 cagagctcct atacgcgcag cggtcctgcc agctatgcga acgatggcaa gccgggcaac
     1021 aagaatcccg atggccagga gtgctccgag acgcagaagg agccatcgcc gtggtggcgc
     1081 gtcgaccttc tcactccgca ggcggtgcac gtggtgcgga taacgacgcg cggctgctgc
     1141 ggccatcagc cactgcagga tctggagatc cgtgtgggca acagcagtgc ggatctgcag
     1201 cgaaatccgt tgtgcgcctg gtatccgggc accctggacg agggcgtggt gaagaccttc
     1261 acgtgcgcgc gcccattggt cggccagtat gtggccattc agctggtggg tgtggagggc
     1321 agcctcagtt tgtgcgaggt ggagaccttc accaacgacg agttctccgt ggatcgatgc
     1381 ctgagtccga aaatcggtgt ggacactgtg gtaacgacat tctcgaaaac ctgctacgac
     1441 tttcatatca caaaaggaga aagcttcgac aaggcgcaag ccatttgcaa gcaaactggt
     1501 ggcgacttgg tacacgactt tcgtggcgcc accagttcgt acatcttgtc cgagctggaa
     1561 cgccggaaga gcgaactgaa accgcagctt gtgtggattg gcgcccaaaa ggagccgggc
     1621 attacatcgc gcacctggaa atgggtgaac ggcgatgtgg ttcaaaagcc aacatggggc
     1681 aaggaccagc cgaacaacta caatggcgag cagaattgcg tggtcctcga tggaggtcgc
     1741 aattggctgt ggaatgatgt gggctgcaat ctggactatt tgcacttcat ctgccagcac
     1801 tcgccattgt cttgcggctc gccggatgcc cagcaaaaca ccactgtcat gggcaaaaag
     1861 ttcactctgg gcgagaagat tcagtacacc tgtcccaagg gccattcgct gctcggtcag
     1921 acggaacggg agtgtagact tgatggcact tggagtggct cctcgccgac ctgcaaatat
     1981 gtggactgcg gcagtctgcc ggagctgaag tttggatcca tccacatgtc ggaggagcgg
     2041 actagcttcg gcgtggtggc cacatacagt tgccacgaga actacacgct aatcgggaat
     2101 gagaatcgca cgtgcgccat ggacggctgg agcggcaagc agccggaatg cctggtggac
     2161 tggtgtccag atccgcagcc catagccggt ggcgatgtgc gattcaatga caagcgtgcc
     2221 ggttccacgg ccacgtatgt ttgtgagccg ggctatgtgc tagttggcga ggcgatcatc
     2281 tcgtgcggtt tgggcggcga gtggtccagc aagacgccct cgtgcagatt cgtcgattgt
     2341 ggtgcaccgg cacgaccaaa tcgtggcatt gccatcctgc tgaacggcac caccaccgtc
     2401 aattcggtgg ttaaatacga gtgcgacgag gatcattggc tggacgggca gtcggagctc
     2461 tattgcaccc gggaagggaa gtggtcgggt gaggcgcccg tctgtgaact ggtcacctgc
     2521 gagacgccat cggtgccatc cggttcgttt gtcattggct acgattacaa tgtccattcg
     2581 aagatccagt acaactgcga tcccggtcac attatgcacg gcactccggt gctcgagtgc
     2641 ctggactccg gggaatggag tgccgatgcg ccctactgcg aatatatcga ctgcggcaca
     2701 atcctgccca ttccctatgg cagccacaag tacgtgacga ataccaccta tgtgggctcc
     2761 gaagtggtct tcagctgctc ccaatcgcac aaactgagcg gagtcctcaa gcgcacgtgc
     2821 ctggaatcgg ctgtctggag cgatgcgtcg cccaagtgcg aggagattcg ctgtccggaa
     2881 ccgaaactgg ctgcgcacag tctgctctcc gtcaccggaa atgatcgcat gtatggaagg
     2941 acacttatcc gcacctccga atcctcgcag aacacagctc aaacctataa gattggagca
     3001 ctggccaagt accgatgcga acggggctac aagatggtgg gcgaggcact ggccacctgc
     3061 acggatagtg gacaatggag cggcaccatt ccggaatgtg tgtatgtgga gtgcggtgct
     3121 ccggagggca tcaacaatgg caaggtggtc ctggccacaa atgccacgta ctacggcgcc
     3181 gctgtcctct atgagtgcaa tgtgaacttc aagctaaacg gagtatcccg acgcctgtgc
     3241 acggagcacg gcaactggag ccacgaggca ccggaatgcg tggaggtggt ctgcgatacg
     3301 cccaacatca atgagaatct gatcgtggag gcgggtccgc gtgctgtggg ctccgtggcc
     3361 accttcaagt gcgccaaggg caggatcatg atgggaaacg atacgcgtgt gtgtcagaaa
     3421 aatggcaaat ggactggcaa gagtcccacc tgcagacccg tcgactgtgg tcgtcctctg
     3481 gccatcgaga atggtcgcgt gattgtggtc aacgattcca cgttgtacgg cggatcggcg
     3541 gagtatcact gcataccgaa ctacaatcgg attggccagt atttgcgcaa gtgcaccgag
     3601 gatggagcct ggagcggcaa gcagccgcgc tgcgaattgg ccacggcgga gggtcaggag
     3661 acttcggagc tgggcacggg cgttggcatt ggtgccaccg tgatcgtcgc cctgctggtg
     3721 atctttggtc tgatcttcct atatcgcaac aaggcgagac ccgtcaaaaa tacggagaat
     3781 gtgcaggcgg cggagacgaa ggacgaacgc aatgccgccg taatgtccta ctcgacgctg
     3841 gaggccaaca atcggatgca catggacaac aatccgtcgg cgacgttcaa cacgttccat
     3901 ggcggagccg gcggaaggag caacggcggc ggtaatccgg atgcaaacag caatggtgaa
     3961 agactgaaca acaatcggtc ggaaaacatt tacgatcaaa taccaaacga gcaattctac
     4021 gacgctccct atgagatgcg caccaatgat gaggtttacg aaccggaacc ggtggccagt
     4081 aatgtcatca ccatcaatgg gatttccgtc agatagagat cgatatctat atcgatatcg
     4141 atatctatat caatacaact ttgtgttgat atcgaaatcc aaagggatgg cagaattaat
     4201 tgacaaacgt taaacgttag ttttgtgtta ataactgtac atattaattg tttaagggag
     4261 gttttgagtt actcgtagtt cgcctaaatt ttaaaacttg ctcaccctgc gcacatgtac
     4321 actgtagccc ctacgcatga cataggtcta tccatatacc gcataatcta ttattattat
     4381 tattattatt attattatta ctattattat aattataatt attatatgaa cctaacatat
     4441 ccaaatcgat gtacctactc tgcagtccat gtactgaaat cgtgacttgt cgcgtaggaa
     4501 ttttggatca cgagccgaaa gatatgcact ccatattcat actcgtattt ttgtttgttt
     4561 atattgttta aattatttga attgtattgt agcgtgagga gtgaacaatt tttttgttat
     4621 gcaatgtgta agaactcgcc aatgtgtgta atgtaaaaag cgttaatttt acgaacaatt
     4681 aaacgattgt ggttgact