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LOCUS NM_078571 3756 bp mRNA linear INV 26-DEC-2023 variant A, mRNA. ACCESSION NM_078571 VERSION NM_078571.4 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 3756) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 3756) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 3756) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 3756) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 3756) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 3756) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 3756) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 3756) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 3756) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 3756) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 3756) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 3756) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 3756) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 3756) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 3756) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 3756) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 3756) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 3756) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 3756) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 3756) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 3756) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 3756) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 3756) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_078571.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..3756 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..3756 /gene="Met" /locus_tag="Dmel_CG1705" /gene_synonym="bHLHe59; CG1705; Dmel\CG1705; DmMet; met; MET; Met/Met1; Mett; Rst(1)JH" /note="Methoprene-tolerant" /map="10D1-10D1" /db_xref="FLYBASE:FBgn0002723" /db_xref="GeneID:32114" CDS 745..2895 /gene="Met" /locus_tag="Dmel_CG1705" /gene_synonym="bHLHe59; CG1705; Dmel\CG1705; DmMet; met; MET; Met/Met1; Mett; Rst(1)JH" /note="CG1705 gene product from transcript CG1705-RA; CG1705-PA; Met-PA; methoprene tolerant; resistance to juvenile hormone; Methoprene-tolerant protein; juvenile hormone resistance; resistance (1) juvenile H; methoprene-tolerant" /codon_start=1 /product="Methoprene-tolerant, isoform A" /protein_id="NP_511126.2" /db_xref="FLYBASE:FBpp0073368" /db_xref="GeneID:32114" /db_xref="FLYBASE:FBgn0002723" /translation="MAAPETGNTGSTGSAGSTGSGSGSGSGSGSSSDPANGREARNLA EKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHC QSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSAST SGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRC FTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNML AAAAAVAAEAATVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLT IYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVI VALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEE AGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAE TVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVSVVNV TAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCILSPASSLSAS EAPDTPDPHSNTSPPPSLHTRPSVLHRTLTSTLR" misc_feature 856..1011 /gene="Met" /locus_tag="Dmel_CG1705" /gene_synonym="bHLHe59; CG1705; Dmel\CG1705; DmMet; met; MET; Met/Met1; Mett; Rst(1)JH" /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; Region: bHLH_PAS; cd11391" /db_xref="CDD:381397" misc_feature order(856..858,865..870,877..882,886..891,901..903, 964..969) /gene="Met" /locus_tag="Dmel_CG1705" /gene_synonym="bHLHe59; CG1705; Dmel\CG1705; DmMet; met; MET; Met/Met1; Mett; Rst(1)JH" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:381397" misc_feature order(886..888,895..900,907..912,916..921,928..936, 964..972,979..984,991..993,1000..1005,1009..1011) /gene="Met" /locus_tag="Dmel_CG1705" /gene_synonym="bHLHe59; CG1705; Dmel\CG1705; DmMet; met; MET; Met/Met1; Mett; Rst(1)JH" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:381397" misc_feature 1153..>1302 /gene="Met" /locus_tag="Dmel_CG1705" /gene_synonym="bHLHe59; CG1705; Dmel\CG1705; DmMet; met; MET; Met/Met1; Mett; Rst(1)JH" /note="PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130" /db_xref="CDD:238075" misc_feature 1945..2274 /gene="Met" /locus_tag="Dmel_CG1705" /gene_synonym="bHLHe59; CG1705; Dmel\CG1705; DmMet; met; MET; Met/Met1; Mett; Rst(1)JH" /note="PAS domain; Region: PAS_11; pfam14598" /db_xref="CDD:464214" ORIGIN 1 ccagttacat cgatgtatcg atagttttta gactggccaa tgtttattgt tataaaataa 61 atgttacaaa taaacaatta atcacttagt ataaacaaaa ataagtgcaa gcagcaagtg 121 cgttgttaaa acgaccgccg ccctccgaat ttccttattg cgggcattaa atcgcaacaa 181 caacaacgcc accagcaaca gcaacaacaa taagcaggag attcagattc gcaacgcaat 241 caaaacgtaa aaaaaaaacg aaaaataaaa aactacaagg cgaaacgcat aaataaatag 301 ggaagcaaat aatagtaata ataagactaa aagcaagtgg aaaagtacga aagcgaaaag 361 agaaaacata tgtacgttgc gtgagagtga cgtgtgtgtg tgtgtgtcag tgagcgaagg 421 agagtgagcg agagagggga ggcgagcaaa aacaaaaaca acagcacagc ataagcgaga 481 ccttgaaaac tttaaaagca gcaaaaaaaa caagacaaca gccaaaaata agaaactaaa 541 agctgcaaaa gtaataaaaa atatatttta gccgaaaaat ttccataata acaattctag 601 aagtgcggag cgtacaccct gttatggaga gtgacgattt tcatttaccg caaggcgcca 661 attaaagggg aaaatccata aatcgaggat tacaagtgga aaacaaggag gcagtaactc 721 cagaaaacgc ccaaaaagtc caaaatggca gcaccagaga cgggcaacac gggctccaca 781 ggatccgctg gctcgacagg atcgggatcg ggatcgggat cgggaagtgg gagctcctca 841 gatccagcga atggacggga ggcccgtaac cttgccgaaa aacagcgacg ggataagctt 901 aatgccagca tccaggagct ggccaccatg gtaccacatg cagccgaatc ctcccgtcgc 961 ctggacaaaa ccgccgtcct tagattcgcc acccatggcc tgagacttca gtatgtcttt 1021 ggcaagtccg cttccagacg tcgcaagaaa accggcctca agggaacggg tatgtctgcc 1081 tcacctgtcg gagatctacc caatcccagt ctgcatctaa cggacactct aatgcaactg 1141 ctggactgct gcttcctcac cctaacctgc agtggccaaa tcgttttggt atccaccagc 1201 gtggagcagc tattgggtca ctgtcagtcc gatttgtatg gccagaatct actgcagatc 1261 acgcatcccg atgatcagga tctgttaaga cagcagctaa tacccaggga tatagagacc 1321 ctgttctatc agcatcagca ccaccagcag caggggcaca atccccagca gcactccact 1381 tccacgtcgg cctcaacttc gggcagtgat ctggaggagg aggaaatgga gacggaggaa 1441 caccgtctgg gtcggcagca gggagaggcg gacgatgacg aggatcaccc gtacaaccga 1501 cgaacaccca gcccgcggag aatggcccat ttggcgacca ttgatgaccg actacgcatg 1561 gatcggcgct gctttaccgt ccgcttggct agggcttcca cgcgagcgga ggccacgcgt 1621 cattacgagc gggttaagat cgatggctgc tttcgtcgca gtgactcctc cttaaccgga 1681 ggtgccgctg ccaactatcc gattgtctcc cagctgatac gacgctcgag aaacaacaat 1741 atgctggctg ctgctgcagc agtggcagca gaagcggcga cggtgccgcc ccagcacgat 1801 gccattgccc aggcggcgct gcacgggatt agcggcaatg atattgtcct ggtggccatg 1861 gccagggtgc tgcgagagga acggccgcct gaggagacgg agggtacagt gggcttgacc 1921 atttacagac agccagaacc ctatcagttg gagtaccata cgaggcatct aatcgacggc 1981 agcatcatcg actgtgatca aaggattggt ctggtggcgg gatatatgaa ggatgaggtg 2041 cgcaacctta gtcccttctg tttcatgcac ctggacgacg ttcgctgggt gattgtggcc 2101 cttcgacaaa tgtacgattg caacagtgac tacggcgaga gctgctaccg tctgctgtcc 2161 cgcaacgggc gcttcattta cctgcacacc aagggatttc tggaggtcga ccgtggcagt 2221 aataaggtgc attcctttct gtgcgtcaac acgctgctcg atgaggaggc gggccggcaa 2281 aaggtgcagg agatgaagga gaaattctcg acaatcatca aggcggagat gcccacgcag 2341 agcagcagtc ccgatttgcc cgcctcgcag gcaccgcagc aacttgagag aattgtcctc 2401 tatctaatag agaacctaca gaagagtgtg gattcagcag agacggttgg cggccagggc 2461 atggaaagcc taatggacga tggctacagt tcgccagcaa ataccttaac tctcgaggag 2521 ttagctccct cgcccacgcc cgccttggcc ttggtgccgc cggctccctc atcggtcaag 2581 agctccatct ccaagtcggt gagtgtggtc aatgtgacgg cggccagaaa gtttcagcag 2641 gagcatcaga agcagcgtga acgtgaccgt gagcagctta aggagcgcac caactccacg 2701 cagggcgtga tccggcaact gagcagctgc ctaagcgagg cggaaacggc atcctgtatc 2761 ctatcaccag ccagtagctt gagtgccagc gaagcaccgg acacgcccga tccgcacagc 2821 aacacatcac cgccaccgtc gctccacaca cgtcccagtg tcctgcatcg aaccctgacc 2881 agcacgctgc gatgacgggc tgatggaacc tggtttgcct tctaattggg tgtgtggaaa 2941 tggacgtcat tggtagctca cgtgcccaca aacgaattag tatcggtaat ataatcctgg 3001 ccaatcgcaa aatgaaaacc caaaatgtat cagaaaaaaa cgagcattat tcaaatagtt 3061 taaaaattca gccaaaaaac ttaaaaacga aaaaaaagag cgtgggttga aaaacctttt 3121 gttttcatat tcacatttcc aagctttgag caatcaaaca attttaattt tcagtataca 3181 catatgtata atgagttggc tttacaaaag ctattaacaa atcaagcaat tgtgtaattt 3241 aatatgagac tttccgtgat tttcgctttc tacgtacttt tcgacttcaa ttgatctata 3301 gggtttccgt attaaaaacg aaattaacgt ggtttcattt gatgaaaatg caatatgagc 3361 tcgcatttat tttgatatta tgacagtaat aatgatctga tcacgataat cgttttctca 3421 aaacataagc gatacatttt gggtacattt ggccattact gtttctgtgt gtgatttcgg 3481 tataaaatag tagtttgatt acatgttata ttgatgaatg gcgatcggtg ggtgctgcta 3541 aatgcgttcc attatcaata attttcgtta tgtaattacg tttaatttgt aaatatgtat 3601 gagtgcgagc gtgagtgagt ttgtgatcgt gtcagcatgg gtgtgaatga acattagatc 3661 agtgctcgga tttggtttta gttgaaattt aaaccccatt tccccgattt cccagttatc 3721 accttccgcc ccaaaacacc agtgtaaaaa gagtac