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Drosophila melanogaster hopscotch (hop), mRNA.


LOCUS       NM_078564               5055 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_078564
VERSION     NM_078564.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5055)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5055)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5055)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5055)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5055)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5055)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5055)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5055)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5055)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5055)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5055)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5055)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5055)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5055)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5055)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5055)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5055)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5055)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5055)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5055)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5055)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5055)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5055)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_078564.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5055
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5055
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="hopscotch"
                     /map="10B5-10B6"
                     /db_xref="FLYBASE:FBgn0004864"
                     /db_xref="GeneID:32080"
     CDS             637..4170
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /EC_number="2.7.10.2"
                     /note="CG1594 gene product from transcript CG1594-RA;
                     CG1594-PA; hop-PA; locus 18; hopskotch; tumorous;
                     Janus-family kinase; JAK kinase; Hop; janus kinase"
                     /codon_start=1
                     /product="hopscotch"
                     /protein_id="NP_511119.2"
                     /db_xref="FLYBASE:FBpp0073313"
                     /db_xref="GeneID:32080"
                     /db_xref="FLYBASE:FBgn0004864"
                     /translation="MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSIHTN
                     DGTIRVFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPL
                     VRLDLTWCLPGERLNCQLVYCFRMRFRVPELDSQLELIDGRSHKFLYRQMRYDMRTEQ
                     IPEIRYPEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPPSLWRAHSFFV
                     GSKIREVFRSLKANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSG
                     PIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRRSTSGGIDVYVRVFP
                     HDSLEPGLKVARVTSEATLKWILVGAVEGIFMISKINDTSVRLEIVGLPKGYEMQFQT
                     EKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLMKLHEN
                     GDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFRIVRKDSQWKLSYNNG
                     EHVLNSLHEVAHIIQADSPDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQLSEAELQ
                     RRNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPVKDVSVTMKMLKSDGNFM
                     EFFRLAQTWSLIQSPQFLKLYGLTLADPYTMVMEYSRYGPLNKFLHSMPNVTLHCLLD
                     LMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSP
                     WIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNIL
                     KMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNG
                     TGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFN
                     DKDQPREQVAIKMLNTMQVSTDFHREIGIMRTLSHPNIVKFKYWAEKSHCIIMEYLQS
                     GSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDC
                     VKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMF
                     SRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFAT
                     IVDIITREVATKVTHPTDGHQSPPNQPTDAE"
     misc_feature    751..1413
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    1894..2184
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="Src homology 2 (SH2) domain in the Janus kinase
                     (Jak) family; Region: SH2_Jak_family; cd09921"
                     /db_xref="CDD:198177"
     misc_feature    order(1954..1956,2014..2016,2107..2109,2113..2115)
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198177"
     misc_feature    order(2110..2112,2179..2181)
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198177"
     misc_feature    2386..3144
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="Pseudokinase (repeat 1) domain of the Protein
                     Tyrosine Kinases, Janus kinases; Region: PTK_Jak_rpt1;
                     cd05037"
                     /db_xref="CDD:270633"
     misc_feature    3292..4101
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="Catalytic (repeat 2) domain of the Protein Tyrosine
                     Kinases, Janus kinases; Region: PTKc_Jak_rpt2; cd05038"
                     /db_xref="CDD:270634"
     misc_feature    order(3328..3336,3352..3354,3406..3408,3412..3414,
                     3493..3495,3535..3546,3553..3558,3676..3678,3688..3693,
                     3697..3699,3736..3741,3793..3807,3832..3834,3943..3945)
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="active site"
                     /db_xref="CDD:270634"
     misc_feature    order(3328..3336,3352..3354,3406..3408,3412..3414,
                     3493..3495,3535..3546,3553..3558,3688..3693,3697..3699,
                     3736..3741)
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270634"
     misc_feature    order(3676..3678,3688..3690,3793..3807,3832..3834,
                     3943..3945)
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270634"
     misc_feature    order(3736..3765,3769..3771,3772..3789,3793..3813)
                     /gene="hop"
                     /locus_tag="Dmel_CG1594"
                     /gene_synonym="4; CG1594; d-jak; Dm JAK; Dmel\CG1594;
                     DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak;
                     Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl;
                     Tum; Tum-1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270634"
ORIGIN      
        1 caatcgatat cgtgaggtgc aaattgtccg atgaatttca ctgaaattcg tggcttgtat
       61 tgtagcttcg caattgcagc ttcgtttcga cagcaggccc actttcagat cgaaggcgtc
      121 tataatcgcc atccagtccc gtcgccctgt tcccacaacg ccccacaaat ttcgggatct
      181 agctggcgtt tcgggtgtct aatttcggac cagtgcactg tgatttccga tttccagttt
      241 actttgctga cggatcgccc aagtggcgaa gtggttcttg ctcggaaagt tggcgcttgc
      301 taaaagaagg agcagtccag gtggttcccc gccagtggca tcaatggaac tcgcgctgga
      361 gtttggggca accttgcaac tgcaagggta agagcatcgc cgattccagg agcattcgca
      421 gtaagcccaa aaatagcaac tcaagtcagt cgcggtggtc attgttattg gcaagaagaa
      481 gaggaaacgg atagaacgcg gcaaattcct aggaaagctc ccatgatcta gcttcagtgc
      541 ggccgcgtaa ggaaactgct ccagccaagg aactgggctt gcaggagcag cagatagcac
      601 ccagcccaca agggaccact caccgacaat cctctcatgg ccctggccaa cgggggagag
      661 gatagaatgg acgacagcag cagcggacgc acttcgctgg cggacagcgc cagcctgacg
      721 aactcctcgc tgcgcagcgg cacctcctcg cagagcatcc acaccaacga tggcacaatc
      781 cgtgtgttca acttcaccac cggcgaattt gagcgtttcc atcccaacat gctgtgcgag
      841 gagatctgca atacgatgtg ccgccagctg ggcattgcac caattgccca gctgctctac
      901 ggaatacggg agcactcgac atcgcgacgt ccctcgccgc tggtgcgttt ggatctgacg
      961 tggtgcctgc ccggcgagcg actcaactgc cagctggtct attgctttcg gatgcgtttc
     1021 cgtgtgcccg aattggatag ccagctggag ttgatcgatg gacggagcca caagttcctc
     1081 taccgccaaa tgcgctacga tatgcggacc gagcaaatcc cggagattcg ctatccggag
     1141 cacaaggaca aatcaacggg actggccgtg atggatatgc taatcgacga tcaggaacag
     1201 tcggaggatc agcaggcgat gcgctccatc gagaagcttt acaaactgta tttgccaccg
     1261 agcttgtggc gcgcccacag cttctttgtg ggctccaaga tacgtgaggt tttccgcagt
     1321 ctaaaagcga attcgctgag tgtggagcgt ttgaagtggc actatgtgca tcaggtatcc
     1381 catttggcgc ccacctatat gaccgaacag ttcacctgca ccgttcagta tctgcccaac
     1441 gaggaggtgg cccgcggtag cggacccatc ggcaccagtc tggcccactc gacgtcgacg
     1501 ctggccagtt ctggatcgac caacactctg tccacgctca ccaccaacac caattccgtt
     1561 gcactcggcg gcagtggcaa gaaggccaaa cgacgttcca ccagcggtgg aatcgatgtc
     1621 tatgtgcgag tctttccaca cgattccctg gagcctggac tcaaggtggc cagggtcacc
     1681 tccgaggcca cactcaagtg gatccttgtt ggcgccgtgg aaggaatttt tatgatctcc
     1741 aaaatcaacg acacctctgt gcggctggaa atcgttggtc tgcccaaggg ctacgagatg
     1801 cagtttcaga cggagaagga gatgaagtcc ttcatctcct acctgggtat ctacatcaga
     1861 ttgtcgagca aatggatgca ggatctgtgc cattcgtacc gcacgccctc cctggaggag
     1921 ctgagctccc tccactgcca tggtccaatc ggcggtgcct actcgctgat gaagctgcac
     1981 gagaacggtg acaagtgcgg cagctatatt gtgcgtgaat gcgatcgaga atacaacata
     2041 tactacatcg atatcaacac caaaatcatg gccaagaaaa ccgatcagga acgctgcaag
     2101 acggagacat ttaggatcgt gcgcaaggac tcgcaatgga agctaagcta caacaacggc
     2161 gagcatgtac taaactcact gcacgaagtg gcgcacatca ttcaagcgga tagtcccgat
     2221 cgctatcgca tacccgcctc caaatatgac aagccgccgc tgctgctact gctgctgcca
     2281 aagaacctca aggccaaaaa gactgacctc cagctgagcg aggcggagct gcagcgccgc
     2341 aatccgcaga tcttcaatcc ccgaacggat ctgcagtggt atccagattc gatatcgctt
     2401 agcgacgatg gcatgatgtt tacgatgcgc ggcgattgga tccaacagag tcccgtcaag
     2461 gatgtgtccg tgacgatgaa aatgctaaag agcgatggca atttcatgga gttctttcgc
     2521 ttggcacaga cctggagcct catccagtcg ccgcagttcc tcaagctgta cggcctaacg
     2581 ctcgccgatc cgtacacaat ggtcatggag tattcgcggt atggtccgct caataagttc
     2641 ctgcactcga tgcccaatgt aacactgcat tgtctactgg atctgatgca tggattggtg
     2701 cgcggcatgc actatttgga ggacaacaag attatccaca attacatacg atgcagtaat
     2761 ctgtacgtga ccaagtacga tccgaattcg tacgtgctag acgcgaaaat tagcgatccc
     2821 ggctatccgc gtccctaccg agaatccgac tcgccatgga tacctgttaa gtattatcgc
     2881 aatttgcaag cagccaaaac ggatcagttt gcccagctgt gggccttcgc taccaccata
     2941 tacgagatct tctcgcgctg caaggaagat ctgagcacac tgcgccagga gcagctactc
     3001 aggcagaaaa atctcgatgg caacatactc aagatgctcg atcaggacat ctgtccggcg
     3061 ccgatattcg agacaatcat ggatggatgg tccgatgatg agaccaagcg cttcagtcac
     3121 cacgacattt tctcgcgtct caacacgatc aaggcggaaa ttctgcccaa ttatatgccg
     3181 ccacccgaga tcgcaacgaa tggaactgga gacgagaccg tgatcgatag aagcgacata
     3241 ccctttctac cctttccgcg ttcgaatatg ttgatggtca taccgctgac cagcgaatgt
     3301 cgagtgatct acaacatgga gaacatgatc gggcgcggtc attatggcac tgtctacaag
     3361 ggtcatctgg agttcaacga caaggatcag ccgcgcgagc aggttgccat caagatgctg
     3421 aacaccatgc aggtgtcgac cgattttcat cgcgagatcg gcatcatgcg caccctcagt
     3481 catccgaaca tagtcaagtt caagtattgg gctgagaagt cgcactgcat cattatggaa
     3541 tatctgcaat ctggttcctt cgacatttac ctgcgtttca cggcacccaa tctcaataat
     3601 ccacggctcg tcagcttcgc tttagatatt gcaaatggca tgaaatactt gtccgacatg
     3661 ggactcatcc accgcgacct ggccgcccgc aacattttgg tggaccacaa cggcgatggt
     3721 gactgcgtca aaatctcaga cttcggcctg gcgcaattcg ccaattccga tggatattac
     3781 tatgcgaaaa gcaagcgtga tattcccatt agatggtact ctccggaggc catctccacc
     3841 tgcagattct catcgtattc ggatgtttgg agctatggcg tgacgctctt cgaaatgttt
     3901 tcgcgcggcg aggagcccaa tttggtgccg atccagacat cgcaggagga tttcctcaat
     3961 cgccttcaga gcggcgaacg cttaaatcgt ccggccagtt gtcccgattt catttacgac
     4021 ctgatgcagc tgtgctggca tgccacgccc cgttcgcgac ccagtttcgc gaccattgtg
     4081 gacatcatca caagggaggt ggccaccaag gtgacgcacc cgacagatgg acaccagtcg
     4141 ccgccgaatc agccgacgga tgccgagtga ctgttgacaa ctgaatgaaa tcgatataca
     4201 cacacaatta ggcataaggt cttttaagat gttagcattt aaactgtacg tttttaaaac
     4261 aacacaagcc agaccccaaa aaccacttga cgcaatcctt ggcttaaagc gctatcggaa
     4321 gaatcacatt gacccccaac caatcaatca ttcatccata ccaaatccgg atacacttac
     4381 gccatcgcaa gcatttttgg attctcgcca gatcttagtt ttatttgatt gtgcttacca
     4441 ctggccacgc ccccctacct ccaatgtcat taagcccacc cctcctcccc cctcttgaca
     4501 aagcgaaagt ccacacttta tatgatatat gtatatgtat aaacaaattc tcaacctact
     4561 ttgtgttata cattttagac aactttgtta aatattgtta agcttgagct tcaatttttt
     4621 ttttgtaatg cccacaccac gcataaacac tgaactaaac taaactaaat taatcataac
     4681 gtgtaaataa taattaaatt agttaagggt ttaatcgcga aacggcaaca cacggtaatt
     4741 tacaaaatga atggacgtcg acagaatcga aaggatgctg ctgcgatctg ttctgttcgg
     4801 cgactaagtc gaaccgccta atctacgcaa aaaaaaaaaa gtaacatgtg cacatatagt
     4861 cgtaaggtat gtcaattaat gttgatcaaa tgccatttta acctacaata cttcgaaaca
     4921 gaaacgaatt atatatttac aagctataca agccactata caagccggta tatgcacaac
     4981 cacacacccg caggcacaat aacttattat tgctgttaac gagaaaggat atttccgaaa
     5041 taaatcaatt ttctt