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Drosophila melanogaster alpha-Mannosidase class I a (alpha-Man-Ia),


LOCUS       NM_078550               3710 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant K, mRNA.
ACCESSION   NM_078550
VERSION     NM_078550.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3710)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3710)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3710)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3710)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3710)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3710)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3710)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3710)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3710)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3710)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3710)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3710)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3710)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3710)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3710)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3710)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3710)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3710)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3710)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3710)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3710)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3710)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3710)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_078550.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3710
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3710
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="alpha-Mannosidase class I a"
                     /map="9B5-9B7"
                     /db_xref="FLYBASE:FBgn0259170"
                     /db_xref="GeneID:31957"
     CDS             112..2043
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /EC_number="3.2.1.113"
                     /note="CG42275 gene product from transcript CG42275-RK;
                     CG42275-PK; alpha-Man-Ia-PK; alpha mannosidase I;
                     alpha-D-mannosidase; alpha 1,2 mannosidase; mannosidase 1;
                     alpha-1,2-mannosidase I; alpha1,2-,mannosidase;
                     alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-Mannosidase class I a, isoform K"
                     /protein_id="NP_511105.2"
                     /db_xref="FLYBASE:FBpp0289739"
                     /db_xref="GeneID:31957"
                     /db_xref="FLYBASE:FBgn0259170"
                     /translation="MCPKTSKTTPLLLIGGICFVIVLVGITGITLINNINLSNIIRLN
                     EKVASDSVSNNENQIKELNYVNNHPRNVYLKLNASSRDDEDDEQMQKEQEQLELPKIS
                     AVIGGSKPKVEDNQVKESSEVISPSTSTFSMRSSAGELTSTSAPLSSIVSVTAPPMPF
                     GGVKYNQSSGLIDYEKRNQVVKMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYD
                     LGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLY
                     AFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFG
                     TLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLG
                     ALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRL
                     EHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFR
                     FSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAH
                     GYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIK
                     GANAYYRQAPVTLPVSNAS"
     misc_feature    634..1980
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="Cyclases involved in the biosynthesis of
                     lantibiotics, and similar proteins; Region: LanC_like;
                     cl04955"
                     /db_xref="CDD:471159"
ORIGIN      
        1 gatttttcat ttgaatattt tttagtcaag aaacggttag cttaaatcaa aagaaatatg
       61 acaacataat ttccaatcaa aactaaagtg catgcaaatc aaaaagtgaa aatgtgtccg
      121 aaaacgtcga aaaccacgcc gctcctgctg attggcggaa tttgctttgt gatcgttctg
      181 gtcgggatta ccggcataac gctgatcaac aacatcaatt tgtcgaacat cattcgactg
      241 aacgagaagg tagccagcga tagtgttagc aacaatgaga atcagatcaa agagttgaac
      301 tatgtgaaca atcatccgcg aaatgtgtat ctcaagttga atgccagcag cagggatgac
      361 gaggatgatg agcaaatgca aaaagagcag gagcagttgg agctacccaa gatatctgct
      421 gttattggtg gcagtaagcc aaaagtcgag gataatcaag tgaaggagtc gtcggaagtc
      481 atttccccat ctacatcaac tttctccatg cgctcgtctg ccggagaatt aacctcaacc
      541 tctgcaccct tgtcctcaat tgtatccgtg accgctccac ctatgccctt cggcggggtc
      601 aagtacaacc aatccagcgg tttgattgat tacgaaaaac gtaaccaagt cgtcaagatg
      661 atggaacatg cgtggcacaa ttacaaattg tatgcgtggg gcaaaaacga gctgcgtccg
      721 ctttcgcagc gaccccattc ggccagtatt tttggatcat acgatctggg tgctacaatc
      781 gtcgacggtc tggataccct gtacattatg ggactggaga aggaatatcg cgagggtcgc
      841 gattggatcg agcgaaaatt ctcactggac aatatcagcg cagagttgag tgttttcgaa
      901 acgaacattc gttttgttgg cggcatgctg acgctgtacg cctttacggg cgatccactg
      961 tacaaggaga aggcccagca cgttgccgac aagctgctgc ccgccttcca aacaccaacg
     1021 ggtattccct acgcgctggt caacaccaag accggtgtgg ccaagaacta cggctgggca
     1081 tccggcggca gttctatcct atccgaattt ggcacactgc atctggaatt tgcctatctg
     1141 agcgacatta ccgggaatcc actgtatcgg gaacgagtcc agaccattcg ccaagtgctc
     1201 aaggagatcg agaaaccaaa gggcctctat cccaacttcc ttaatcccaa gacaggcaaa
     1261 tgggggcaac ttcacatgtc attgggcgct ctgggcgaca gctactacga gtacttgctg
     1321 aaggcctggc tgcaatccgg ccaaacggat gaggaagccc gcgagatgtt cgacgaggca
     1381 atgctggcca ttctggataa gatggtccgc acaagtcccg gcggactgac atacgtctct
     1441 gatctcaagt tcgacaggct ggagcataag atggaccatt tggcttgctt ctcgggtggc
     1501 ctcttcgctt tgggagcggc tacacgtcaa aatgactata cggacaagta catggaggtg
     1561 ggcaagggca ttacgaatac ctgccacgag agctacatca gagcacccac tcagctggga
     1621 cccgaggcct ttagattcag cgaagctgtg gaggcgcgag cactgagatc gcaggagaag
     1681 tactacattc tacggccaga gactttcgag agctactttg tgctgtggcg actcacgcac
     1741 gaccagaaat accgcgactg gggctgggag gcggtcctcg ccctggagaa gcactgccgc
     1801 acggcgcacg gatattgtgg cctgcgcaac gtctaccagc aggagccgca aaaggacgac
     1861 gttcagcaaa gcttcttcct cgccgaaacg cttaagtacc tgtacttgct gttctcggac
     1921 gattcggtgc tgccgctgga cgaatgggtg ttcaacacgg aggcccatcc gctgccgatc
     1981 aagggtgcga atgcgtacta tagacaggcg cccgtaacgc ttccggtttc gaacgcatcg
     2041 taaacgggcg ccatgttgcg ccgctggcta ttcggcctgt ccctagcaat gcaccttact
     2101 tagctcgcga tatttggata tctacacatg tgtgtaccag atcgtaacat tttttttttt
     2161 ttttgttttg tttaagttat tagttagatt acgtgaggat gacaactgcg tacgaaagat
     2221 attgtatgtt tacaatcaat ccaggcacac acacacacac actcgagaaa ctgtcaatgt
     2281 aacatattta taaagcttgc acatatatag gaacgtaaac ttaaacggat atatcgtagt
     2341 ttagttctta actgtttgca caagtttctc caagtctctc ttcttgattt atcttatgga
     2401 attaatagca atccaaatag ttgacagagg tggatggtgg gaagacctca atttccattt
     2461 aaatgcgaat gacgtagacg taggcaaaaa ctcttgatat taattatgat atgatatata
     2521 atatgatata cgtgtaaatg taaaactcag gtgttcttat tatgattttc cttgcgctca
     2581 cacaaggcac tttttcaact aaaccagcta cgtaactatc tctacaagca ttctatacgc
     2641 aattctcgat ctgcgactat atctctgtgt ggatttatgg ccacttggcg ggcatttcgt
     2701 tagatctact ctgctaattt ccaattcgaa tctttgacca ctttattttg tatataattt
     2761 ctactgactt tcctcgcaaa atgaaggcag aagaaaatcg aattgatatt tatacaaata
     2821 tattcttaca caatattgtt tactttgtag cctaaatatt taaatataaa tctaatatag
     2881 agtctagctt actgtatgtg acgaaagaaa tgtaacgcaa attaccttaa atcgagaaca
     2941 tcaagcgaaa agaacgcaaa tgaatatata taaagtaaaa taaataaata tatatttgta
     3001 tttaattaaa tcaaataaaa cgtaggcaat tgttaaaata aattaattat acgatggcac
     3061 gagccgagcg aatggtaatt taatttttaa caactgtaaa ggttttttat aataataata
     3121 ccagcagtaa tcatatttat aattctattt ataactgtaa tccatagtct aagccacaag
     3181 gatcgcatga taaaagaaat atagaagtta tttaattgtt tttttttttt tttttgtaac
     3241 atacacagct tgttctgtgt aaagtgattt aacaaacgta aaaataacat aaaacataag
     3301 ctaagaccct aatgtaaaac aaaagaattt taaagaaaca ttttaacaaa ataaaataat
     3361 atcaaaatga tttaacccga taaatgaaga aatctaataa acccaagcta acaaacgtta
     3421 aacgagctaa atgcttaaaa agaataggaa gaaaagaatg aattcgatac taattaagca
     3481 taaatttagt ctctagagca aacctttttt tgtttagatc aaattagaaa ttgaggccaa
     3541 tagcgagata tataatatat ccgattataa tgccgaacac acagattcga atggcagttt
     3601 gtaaatgcat cagacacaat acattcatca atagcagtcc ctgagctgct ggagatgtca
     3661 cgtgtatttt gcctaaatca taagtttaat aaagatctaa taattaactt