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Drosophila melanogaster downstream of raf1, transcript variant A


LOCUS       NM_078543               1799 bp    mRNA    linear   INV 26-DEC-2023
            (Dsor1), mRNA.
ACCESSION   NM_078543
VERSION     NM_078543.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1799)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1799)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1799)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1799)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1799)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1799)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1799)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1799)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1799)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1799)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1799)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1799)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1799)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1799)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1799)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1799)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1799)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1799)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1799)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1799)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1799)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1799)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1799)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On May 8, 2012 this sequence version replaced NM_078543.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1799
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1799
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="Downstream of raf1"
                     /map="8D2-8D3"
                     /db_xref="FLYBASE:FBgn0010269"
                     /db_xref="GeneID:31872"
     CDS             458..1648
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /EC_number="2.7.12.2"
                     /note="CG15793 gene product from transcript CG15793-RA;
                     CG15793-PA; Dsor1-PA; downstream of Raf1; downstream
                     suppressor of Raf 1; Map kinase kinase; mitogen-activated
                     protein kinase kinase; MAPK kinase; dSor1; drosophila MEK"
                     /codon_start=1
                     /product="downstream of raf1, isoform A"
                     /protein_id="NP_511098.1"
                     /db_xref="FLYBASE:FBpp0071248"
                     /db_xref="GeneID:31872"
                     /db_xref="FLYBASE:FBgn0010269"
                     /translation="MSKNKLNLVLPPVNTEATVAAATVAPTPPFKTPSGTDTHSLLGK
                     PKTSIDALTETLEGLDMGDTERKRIKMFLSQKEKIGELSDEDLEKLGELGSGNGGVVM
                     KVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISI
                     CMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVN
                     SSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMA
                     IGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFS
                     TEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGWVCKTMDLPPSTPKRN
                     TSPN"
     misc_feature    710..1603
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="Catalytic domain of the dual-specificity Protein
                     Kinase, Mitogen-Activated Protein (MAP)/Extracellular
                     signal-Regulated Kinase (ERK) Kinase; Region: PKc_MEK;
                     cd06615"
                     /db_xref="CDD:132946"
     misc_feature    order(734..748,758..760,797..799,803..805,893..895,
                     941..952,959..964,971..973,1082..1084,1088..1099,
                     1103..1105,1133..1138,1145..1147,1181..1192,1196..1198,
                     1277..1279,1304..1306)
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="active site"
                     /db_xref="CDD:132946"
     misc_feature    order(734..748,752..754,758..760,797..799,803..805,
                     893..895,941..952,959..964,968..973,1088..1090,1094..1099,
                     1103..1105,1136..1138)
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:132946"
     misc_feature    order(743..748,1082..1084,1088..1096,1145..1147,
                     1181..1192,1196..1198,1277..1279,1304..1306)
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:132946"
     misc_feature    order(746..748,803..805,857..859,866..868,893..895,
                     935..937,941..943,1136..1150,1157..1159,1169..1171)
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="noncompetitive inhibitor binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:132946"
     misc_feature    order(755..757,815..820,923..925,1202..1204,1214..1225,
                     1397..1399,1406..1411,1418..1423)
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:132946"
     misc_feature    1133..1198
                     /gene="Dsor1"
                     /locus_tag="Dmel_CG15793"
                     /gene_synonym="CG15793; D-mek; D-Mek; D-MEK; D-MEK/Dsor;
                     D-sor; D-Sor; D-SOR; D-sor-1; dMek; dMEK; Dmek; DMEK-1;
                     Dmel\CG15793; DRODSOR1; dsor; dSor; Dsor; DSor; DSOR;
                     dsor1; dSor1; DSor1; DSOR1; DSORT; EK1-1; MAPKK; mek; Mek;
                     MEK; MEK/Dsor1; Mek1/2; MEK1/2; sor; Sor; SOR; sor/MEK1;
                     Su(Raf)34B"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:132946"
ORIGIN      
        1 ttagtcgtag gagtgtatta acggtatttg gtaatcgcga catctggcca taccgcaccg
       61 tctgcgaaaa aaacccaaaa gtcgccgatt ttggctgatt attgcaaaaa taatattaac
      121 tatccgtttg ctgttcgtgt gctcggttcg ggtgtgttaa agttaagcgc aacgcgagga
      181 attggtgcaa atttaccagc ggctggacac acaaaacgaa acattcgcac ttggcctccc
      241 ttcgcacgcc ccctcgccga cgcccctcgc ccctcacacc cttcagccgt tcgtcggacg
      301 ccgctgttcg tagtgcgttt tgttgttgtt tccactggaa cactctctat ttgtattgtt
      361 tcatttatta gttttttttt gttgttgtta ttgttgtgtg ctttaactta tcggtaacgg
      421 ataacggtat cgagagatat atattatata tagtaagatg tcgaagaaca agctgaatct
      481 ggtgctgccg ccggtaaata cggaggcaac tgttgccgcc gccacagtgg cgccgacgcc
      541 gccattcaaa accccctcgg gcacagacac acacagtttg ctggggaagc ccaagacgag
      601 catcgatgcg ctgacagaga cgctggaggg tctggacatg ggcgacacgg aacgcaagcg
      661 gatcaagatg ttcctcagcc agaaggagaa gatcggcgag ctgtccgacg aggatctgga
      721 gaagctgggc gagctcggat cgggcaatgg cggcgtggtg atgaaggtcc ggcacacgca
      781 cacacacctg atcatggcca ggaaactgat ccatctggag gtgaagccgg cgatcaagaa
      841 acagatcctg cgcgaactga aagtcctgca cgaatgtaat ttcccgcaca ttgtcggttt
      901 ctacggcgcc ttctacagcg acggcgagat cagtatctgc atggagtata tggacggtgg
      961 atcacttgac ctgatcctca agcgggccgg tcgaatacca gagtccattc tcggcaggat
     1021 cacgctggcg gtgctcaagg gcttgagcta tctgcgcgac aatcacgcca tcatccaccg
     1081 tgacgtgaag ccgagcaata tcctcgtcaa tagcagcggc gagatcaaga tctgtgattt
     1141 cggcgtctcc ggtcaactga tcgactcgat ggccaactcc tttgtgggca cccgtagcta
     1201 tatgtcgccg gagcgattgc agggcaccca ctactccgtg cagtcggaca tctggtcgtt
     1261 gggtctgtcg ctggtggaga tggccatcgg catgtacccc atcccgccgc caaacaccgc
     1321 caccctggag tcgatattcg ccgacaatgc ggaggagagc ggccagccga cggacgagcc
     1381 cagggcaatg gccatcttcg agctgctgga ttatattgta aacgaaccgc cgcccaagct
     1441 agagcacaag atcttctcca ccgagttcaa ggacttcgtg gacatctgcc tgaagaaaca
     1501 gcccgacgag cgggcagatc tcaagaccct gctgagtcat ccgtggatac gcaaggcgga
     1561 attggaggag gtggatatat ccggctgggt gtgcaagaca atggacctgc cgccatcgac
     1621 gccaaagcgt aatacgtcgc ccaactagac gcctctgcgt tccggccccc attttctcta
     1681 tcctcccata tccacacttg ctctttgttc aatagagcgt tgacgctggg caaaaacaac
     1741 tgaactatta ttattattat tattaaatcg aaaataaaga aatcgaagtc ataccatgt