Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS NM_078529 6934 bp mRNA linear INV 26-DEC-2023 (Trf2), transcript variant J, mRNA. ACCESSION NM_078529 VERSION NM_078529.4 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6934) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6934) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6934) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6934) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6934) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6934) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6934) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6934) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6934) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6934) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6934) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6934) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6934) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6934) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6934) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6934) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6934) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6934) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6934) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6934) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6934) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6934) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6934) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_078529.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6934 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6934 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TATA box binding protein-related factor 2" /map="7E7-7E9" /db_xref="FLYBASE:FBgn0261793" /db_xref="GeneID:31773" CDS 4016..5914 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="CG18009 gene product from transcript CG18009-RJ; CG18009-PJ; Trf2-PJ; lethal (1) G0295; lethal (1) G0425; TBP-related factor 2; lethal (1) G0039; TBP related factor 2; lethal (1) G0071; TATA box-binding protein related factor 2; TBP-like factor" /codon_start=1 /product="TATA box binding protein-related factor 2, isoform J" /protein_id="NP_511084.2" /db_xref="FLYBASE:FBpp0305945" /db_xref="GeneID:31773" /db_xref="FLYBASE:FBgn0261793" /translation="MQNDMVSIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLANAP RVYLTPSSTFMTNRQMAGVASTGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGP SLQRKLANGDTIVLATGSKNMFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSI TVIDDDDEEKKEVAEDEEESSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLK LREIALQGSNVEYRRENGMVTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYA RCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMR DPDPKATLKIFSTGSVTVTAASVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRL QAGGDPHELEKNVLADNKTASLDNIFVNTTAAHSKSSSNDQTSAPATILSSTVDSMPR LKQMVNYHQMMKQTQEERRHIMFNGEKANPASTSSAAAAPSTSSSSSSSGDNICANAR RRATECWATKLQNKRPRYNDPGTTGTINAASSTASAATSSLASQATHLRNPLKTAALA NARMLGAKVTTCTRNSIIVQQPQRIQMQQQQQQLQPQQQQTSFSPSEFDVDDLIEEEE NNELDMPF" misc_feature 4613..5134 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; Region: TLF; cd04517" /db_xref="CDD:239953" misc_feature order(4628..4633,4637..4639,4715..4720,4730..4732, 4736..4738,4757..4759,4763..4765,4775..4777,4781..4783, 4787..4789,4793..4795,4883..4885,4898..4900,4904..4906, 4991..4996,5009..5011,5048..5050,5054..5056,5060..5062, 5072..5074) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative DNA interaction surface [nucleotide binding]; other site" /db_xref="CDD:239953" misc_feature order(4673..4675,4694..4702,4706..4708,4718..4720, 4736..4738,4742..4744) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIA interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" misc_feature order(4934..4939,4973..4987,4994..4996,5009..5011) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIB interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" ORIGIN 1 gtgagtgcgc acacacacgc acgcacgcgc gcacgcagca attgtgttgg tgcaagtgac 61 gtttcccatt tctttttgtt ttgcttcgtt tcgtttgctg attactattt acagaaaata 121 acggcaagtt gcgacgcgaa ttaactgtga tcctttacta aaagatgcag attctttgaa 181 aattcgtgaa taaaaaccaa gcgatcgaat tcaaagattc atccgcataa gttggtagta 241 aatagcggtg atccttctca aatgcaacga gaaattgtaa ctgttaaaca gactgctaaa 301 cggaacaact aaaaactaca agcaaattta accaggagaa aagaacggaa gactagacat 361 aatcataaac atagtagata gaattagaga accagcaaac ccaacaacta gaacactaag 421 aaaacattaa ttctaataca aaatcacaca taaaaaagta ttttttggcc ttaagtgcaa 481 acatactcac atacaaacac atacatacac atccacatga acgaaacaat ggaaagaatg 541 taatacaaca ccaaggaaga atcaccttta gccttatata caattaaata taattaagaa 601 gctagcaaga aaacgcagag caagagtcct atcaagaaac ccaaaaagat aacaagaaat 661 atttttttaa cgatgggcag tgcgtaagta ggcatacaga gaaaaaaaaa gaactattac 721 acgatataca gtagatataa agagccgcat atccacaccg ccacagtcac acaaacacgt 781 caaaaagggg gatggttccc cgactcgaat acttgaagaa taccaagtag ctagagactt 841 aaggaacgag gatttgtttc cggaacatcc ggttgaacat ccggacgaag attcggataa 901 ggagaaccaa tcgccgaatc aatcccccaa tccaagagcc atcggtgatt gtgagcaagg 961 acctgacatt ggtaaagata ctctaaatcc caacgaagct gaccagtttt cgagcgaaga 1021 agttgagaag aacgaagcca acagcagctg taacgagtcg ggcggggatg ctcgcaattc 1081 tagagatcgt ttaagttcct ctcatagcga ggacgaacag cttaaccaag aatattcaac 1141 ttcatcaagc ggaagcacca tcggaaatcg tgagcaaggc tctgacgttg gtaaagatac 1201 ttcaagtcgc aacgaagctg accagttttc gaacgaagaa gttgagaaga acgaagccaa 1261 cagcagcggt aacgagtcgt acggggatgc ctgcaattct agtgatcgct taagttcttc 1321 taatagcgag gacgaacagc tgcaccaaga atattcaact tcatcaagag gaagaacaag 1381 ggaatatgca caatctgact tgaatcccgg gtaccaggac ttgaatatcg gtaaccagga 1441 cttgaatcaa gttaatcgcg agtaccagga gtctaataac gagtaccagg tttcaaacca 1501 agagtaccag cacttgaata ccgagtacca ggagttgaat cacggcgatc aggactcaaa 1561 tgacgagtac caggagttga atcacggcaa ccaggactca aatgacgagt accaggaatc 1621 aaatcacggc aaccaggact caaatgacga gtaccaggag ttgaatcaca gcaaccagga 1681 ctcaaatgac gagtaccagg agttgaatca cggcgatcag gactcaagtg acgagtacca 1741 ggatttgaat cacgtcaacc aagactcaaa tcacgagtac caggcttgga atcacgaata 1801 ccaggactca aatcacgagt atcaggcctt gaatcgagag taccaatatc ctgaatctga 1861 tgaggaagag gccgctagaa aaagaaacat atatacccgt ttacgatcct acgcttgtca 1921 ggtacatctc cctcgtttag gagaatcaga agttgatagc gacgatcgtc gccataaccc 1981 aatcaatcag ccattcaatc agccaatcaa taggccaaat caaaaatcgg attcatcttt 2041 agagtcatct tcgccggaga gacaagactc tgaaagcgag tcgcgacaag cttcagatga 2101 ggaatcgtct tctggggact cggactactt aatcgatcca gttactgggt ggctatcgcg 2161 ccggcgagaa acttctaccg aacgcgagga aaaaagcgac caaagccaac aggagtcgtc 2221 agaggaaatt acagacgaac agaaggaaga aagcgacgac gtcgaacaac agtcgccggc 2281 tgaacatact tcttctgata gacgcgatca ttcgccagac aagcaacaga ataagcgaaa 2341 atcgttaggc actgggaatt cttcgtattc gaagaaacca ttattggacg gtgacaaagg 2401 agacccacgt tcacatttat cgtctctggg aagtcgcaga tccttaaagc gtaaatggcc 2461 ttttgattgt acagactcta agaaatttaa accaaacttg cagagtgagg aagacaaatc 2521 tgaggaggaa aaacgtgaag atacggaaag cgaatgctct gacgaagaag actcagatag 2581 ttcaagtttc gatacagatt caaattcaga ttcagattca aatttagatt tagattccga 2641 ttccgattcc cattccgatt tcgaatcatc ttcaagttct gaggaatctg cccaggatcc 2701 agctcctgaa ggcgaaaccg atcaagatcc agctcctgaa ggcgaagccg atcaagatcc 2761 agctcctgaa ggcggagtcg atcaagatcc agctcctgaa ggcggagtcg atcaagatcc 2821 agctcctgaa ggcgaagtcg atcaagatcc agctcctgaa ggcgaatccg atcaagatct 2881 agctcctgaa ggcggagtcg atcaagatcc agctcctgaa ttcggaaccg atcaagatcc 2941 acatccttat tacaacgatc aggatccagc tccttattac gacgatcagg atccagcttc 3001 ttattacgac gatcacattt gtgattctga ggaggattat aaaccattta tcttctcaaa 3061 ggaaaggaag ttcttgaaat tcgtaacaaa tcctttaggg gatgataaat ctagtttgga 3121 ccttagcata cagctctata aggtatttgg agcttacaaa ctggaagacg tatacagcag 3181 tattgatgag gaaggccaac cagaacagga cctgcaactg aagcagcaac agaaacattt 3241 aaaaaaatat caaaagttgc aactggtggt attctggcac caggagaaat tcttttcaaa 3301 ggagcaactg ttgctatatg agtatctgaa actacttttg cagaaattct ttccacaaga 3361 gcaacaggag aaacggttgc aacaggagaa acttttgcaa caggagaaac tcttgcaaca 3421 ggagaaacgg ttgcaacagg agaaacggtt gcaacaggag aaacggttgc aacaggagaa 3481 acggttgcaa caggagaaac ggttgcaaca gcagaaactc ttgcaacagc agaaactctt 3541 gcaacaggag aaactcttgc aacagcagaa actcttgcaa caggagaaac tcttgcaaca 3601 ggagaaactc ttgcaacagg agaaacaatt gcaacaggag aaacacttgc cacaggagcg 3661 acagttgcaa caggataaag tcttcctaca gctacgacag ttgcaacaga agaaagaact 3721 ggaggagcag cgagagcgaa agcgccacct ctttgagcaa cagaaacagt ttgtcctaga 3781 aaaattgcgc caacagaagg agcagcatcg tcgtcagcaa aatcgcgtaa aacgcgaacg 3841 taaattgcgc cagaaaaagg agaaacagcg cttggaatac gaacgattct tgaaggaata 3901 tagggaggac tgtaaacgtc agttgcgttt gcagcgcgag cattatctga tcaagattaa 3961 gcagctggag aaggccagtc agcgctcgtt gaaggggaat cgaaagcaca agctgatgca 4021 aaacgatatg gtcagcatac cggtggccaa tttgaacggc ggccttaaag cggccagcag 4081 cggttccgga gttggtgtag tgacctccgg cggcgtcgta tcctcggcgg tgctggccaa 4141 tgccccacgt gtatacctaa cgccctcctc cacattcatg accaatcgcc aaatggcggg 4201 agtggcgtcc accggaagaa tgagcggaca agtcgtcggt ggttcatctg gcacagcctc 4261 aacagccggt accgttcgct atttttcgca attcagcaaa atgcaaacgg ccggcggacc 4321 cagtttgcaa aggaaacttg ccaacgggga taccattgtt ctggcaaccg gcagtaaaaa 4381 tatgttcctt actagcagcg aaaataaggc taatctgccg accgtcgcca gcaatggcaa 4441 tggtctgatc acagccaaaa tggatctatt ggaggaggag gtcatgcagt cgataactgt 4501 gattgatgac gatgacgagg agaaaaagga agtcgctgaa gacgaagaag agagcagcaa 4561 taatgccaaa cccattgacc ttcaccagcc aattgctgat aatgagcacg agctggacat 4621 tgtgataaac aatgtggtct gctcgtttag cgtcggctgt cacctgaagc tgcgcgaaat 4681 tgcgctgcag ggatcaaatg tggagtaccg tcgcgagaac ggaatggtga caatgaagct 4741 ccgccatcca tacaccactg cctcgatttg gtcgtcgggg aggattacct gcactggtgc 4801 cacttccgag tcaatggcca aggtcgctgc acgccgctat gccagatgcc ttggcaagct 4861 gggatttccc actcgtttcc tcaactttcg cattgtcaac gtactgggca cctgcagcat 4921 gccgtgggcc atcaagatcg tcaacttttc ggagcgccat cgcgagaacg ccagctacga 4981 gcccgagctg catcctggag tgacttacaa gatgcgcgat cccgatccaa aggccaccct 5041 gaagatcttc tccaccggca gcgtaacagt caccgcggct agcgtaaacc acgttgaatc 5101 ggctatccag cacatatacc cgctggtctt tgatttccgc aagcaacgtt cggcggagga 5161 gctgcagcat ctgcgtcaaa agcagcgtct gcaagccggc ggtgatcccc acgaactgga 5221 gaaaaatgtc ttggccgata acaagactgc ttcccttgat aatatctttg ttaatacaac 5281 agcggcgcac tctaaatcat cgtcgaatga ccaaacatca gcacccgcga ccatcttgtc 5341 cagcacagtt gatagtatgc ctcgtctgaa acagatggtc aactatcacc agatgatgaa 5401 gcaaacccag gaagagcgcc gccatataat gtttaatggg gagaaggcca atccggcctc 5461 cacctcatcg gcggcagcag ctccctccac ctcctcctca tcgtcctcat ccggggataa 5521 tatctgtgcc aatgcccgtc gccgggccac cgaatgctgg gcaaccaagc tgcagaataa 5581 gcgtccacgt tacaatgatc ccggtaccac gggcacaatt aacgccgcat cgtccacagc 5641 atcagccgcc acatcttcgt tagcctccca ggcgacacat ctgcgtaatc ctctcaagac 5701 ggccgcgttg gccaatgcac gtatgttagg cgccaaggtg acaacatgca cacgcaacag 5761 cataatcgtg cagcagccgc aacgtatcca aatgcagcag cagcagcaac agctgcaacc 5821 gcagcagcaa cagaccagct tctcgcccag cgaattcgat gttgatgact tgatcgagga 5881 ggaggagaac aacgaattgg atatgccctt ctaagctagc gctgcccgtg ccaaaaaaaa 5941 atttcaacta aaatggttca aatcgatgat gaaacactac aacactaaac acgccacact 6001 cacaaatagc cacgagcttc ttttcgaatt tgttggttat tcgttcaagt catttttcat 6061 cacatttatt ttcgtgtgct tgccgcattt aaactaaact cgagaaagcc tggacaccga 6121 agcgaaaagc acccacagcg aagcaacaac aacaaacaac aaacaaaaca ccgcagcaac 6181 aacaaaatca agagccaaat atttaaaata taagatttac gtttaaacta ctttgtaagt 6241 taagcgagca caccagaaac aaacaagcag agatagcgaa tagatgattt cgatcccgaa 6301 gtatcccaga aacctcaata acatctagat ggtaagcaag ggagcttacc acacggtaaa 6361 cataagttta gacttaaaga aaatacgtat gcgacagcgt tttacgtata taaccgaaat 6421 ctgtggatag cctggatgag tcaccatcaa tcatcgcaat tgcaatcaat tgtggtgaaa 6481 gtaagagaac acacatgtag aactaatcac caggacagga agaggacgat acgagcaagg 6541 tgcccaggcg gatcggatct cgcagcttcc tatcttattt taaatttttt tttgaagctg 6601 aactccaatt cagttctggc caagcaaact acaattctca agtaaaaatc cgtggagagg 6661 aggtggggcc agagaaaagc ccactaggat agttatcaat tatctgaaga acaactgatt 6721 aatttcttgt atattcatag gaaatttttt ttgttttcgc tataagtcct acataataaa 6781 tgctatacat aagtgctgcg tgtgggcgca taacaaacga aacgaaatgc gtttgaatgc 6841 gattataata ttaatattat tatgcatata tacaacacac acaaatacct atatctggtc 6901 acttctaacc aattataaac aaaactggaa aagc