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Drosophila melanogaster frizzled 4 (fz4), transcript variant A,


LOCUS       NM_078513               3927 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_078513
VERSION     NM_078513.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3927)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3927)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3927)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3927)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3927)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3927)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3927)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3927)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3927)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3927)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3927)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3927)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3927)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3927)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3927)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3927)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3927)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3927)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3927)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3927)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3927)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3927)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3927)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_078513.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3927
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3927
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="frizzled 4"
                     /map="6F5-6F5"
                     /db_xref="FLYBASE:FBgn0027342"
                     /db_xref="GeneID:31659"
     CDS             701..2818
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="CG4626 gene product from transcript CG4626-RA;
                     CG4626-PA; fz4-PA; Frizzled4; frizzled 4"
                     /codon_start=1
                     /product="frizzled 4, isoform A"
                     /protein_id="NP_511068.2"
                     /db_xref="FLYBASE:FBpp0070977"
                     /db_xref="GeneID:31659"
                     /db_xref="FLYBASE:FBgn0027342"
                     /translation="MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFR
                     QCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAA
                     YVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMC
                     MEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLC
                     EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW
                     CHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAA
                     CAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFV
                     AWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLIS
                     GYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFA
                     NIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKHT
                     SAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSIS
                     LNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQFHPHHNHQHHSTSSHRLYYPPGSYA
                     SQKYSQHGSYYPHLQQYGNETLL"
     misc_feature    827..1207
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="Cysteine-rich Wnt-binding domain of the frizzled 4
                     (Fz4) receptor; Region: CRD_FZ4; cd07448"
                     /db_xref="CDD:143557"
     misc_feature    order(857..859,863..871,875..883)
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="putative Wnt binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:143557"
     misc_feature    1364..2371
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="class F frizzled/smoothened family, member of the
                     7-transmembrane G protein-coupled receptor superfamily;
                     Region: 7tmF_Frizzled_SMO; cd13951"
                     /db_xref="CDD:320089"
     misc_feature    order(1367..1369,1394..1396,1553..1555,1937..1939,
                     1952..1954,1958..1960,1985..1987,2228..2230,2237..2242,
                     2261..2263,2276..2278,2285..2290)
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:320089"
     misc_feature    1391..1468
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320089"
     misc_feature    1502..1567
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320089"
     misc_feature    1661..1741
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320089"
     misc_feature    1862..1912
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320089"
     misc_feature    1976..2065
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320089"
     misc_feature    2141..2224
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320089"
     misc_feature    2255..2332
                     /gene="fz4"
                     /locus_tag="Dmel_CG4626"
                     /gene_synonym="anon-WO0170980.10; anon-WO0170980.11;
                     CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320089"
ORIGIN      
        1 gacgcagagc catctctagc tcagagtgac cagtatgcgt tgaattttac cacgaaaaca
       61 aaataaaata tataaacgtt cgatgttaat accaattaga ttagaataca ttcgctaagg
      121 ctacaaactg actgcgccat tcgtttaagc acatcgaaac aaatacacta ttcgttcact
      181 gagatgtgtg aaagattcga tggtttgcta gatcgttttc gggttaatcc ctgaggaaaa
      241 acccgtttat cgacgtcgat cagcgggttg ggcggcgtgc ggtggagaaa ggggagtggt
      301 tggggctgaa gaacgagtgg gggaaggagg agaagcgata acaagaacga cgccgaaaaa
      361 aaagaggtag ttaacgagtt gacaagccaa aagcaacaat aacaagctgg aaagaaggag
      421 agctggaagt tgttggaacg agtgagaggg tgcgagcgag agagggcgaa cgcacctgga
      481 acaggttacc ccttccagcg ttcgttccac cgaagaacga agaatctgca tatagttcgg
      541 attctttgga aagaaaagag ggaacccagc gcgaagaaaa ccccgaaatc tgatcttttc
      601 cacatttcga ttcctttaga gaaacggaaa tcggaacacc aagcgaagaa acgtatcgaa
      661 ttcgtattct tcggaacgaa agaacaacaa atcagccgca atgaagccaa cctgcatatt
      721 gtgtctcctg gtggtgatcc tcctgcatcc gcgcatctca aaatcctcaa cgagcggcaa
      781 ccccagtgcc agttccagtt ccagttctcc gccagaaatc cccgccttcc ggcaatgcga
      841 aaccattcgc attgagatgt gccgcaagat cggctacaat gagacctcca tgccaaatct
      901 ggtgggtaac gaaatgcaaa cggacgtgga gtacacactg caaacctttg caccactgat
      961 cgaatacgac tgcagttccc agttgaagct gttcctgtgc gccgcctacg tgcccatgtg
     1021 cacgcccaaa gctccagtcc atgccatcgg tccgtgccgg agtctctgtg agtccgtgcg
     1081 aatacgttgt catccagttt tgcagggatt cggatttcca tggccaccgg ctctcgactg
     1141 cgataaattt ccgcgagaga acaaccacga gacgatgtgt atggaaggtc ccggtgaatt
     1201 gcatcagccg cagcaggagc aggatttgta tgggctaccg ggccaaggaa tacccggtgg
     1261 attgggcggt aaactgccca tggattgctc gggactggcc aaatcgcatc tgtacgtaag
     1321 gctacccaga tctggacgct gtgcaccact ctgcgaggcg gacatactgt tcacaccggc
     1381 ggagaagcat ctggcagaga tctgggtctc cacatgggcc tatgccgctt tgggtttggc
     1441 cctggtagcc accgtgtgtc ttttggccag cgatggcagt cgtttggcca gcgccaagtg
     1501 gtccagattg ttgtcgccgc tgatttggtg ccacaacatg gtcaccttgg gctgggcagt
     1561 gcgctttatg gtgggaagaa cgggaactgc gtgcggcacg gatccccagg cgcccaatga
     1621 atccctactc accgtggacg gactgtccaa tgcctcctgc gctagtgtct tccttatgcg
     1681 ctactatttt ggaatggccg cctgcgcttg gtgggctgtg ctctgtttgg gctggcaccg
     1741 cgacattcgt cggcacagtc cggactccaa gggccatgtg gtcattccct cgaactttgg
     1801 aggcagtccg gcgaagagga acagtgccaa gacggctcag caggatctaa cgcaaaacaa
     1861 ctttgtgtgc ttcgtggcct ggggattgcc ggcctttcaa acgtcagcag tgatcgttgc
     1921 ccgtttcgtg gatgctgacg agttgcttgg cgcctgtttc gtaggcaatc agtcggataa
     1981 ggcgctacag atattggtgg ctacgcccgt tttttgctac tggatctttg gctcgatgaa
     2041 tctgatctcc ggctatttgg tacactgtcg caccaaggag atcctgagga atagcaatgc
     2101 actcagcgtg caacagcaac tgcaacagct aagcgcacac agtagttccg gcattggcat
     2161 attccttttc atctatggac ttgcatgtgc catgcttctg ttggctgtca tttacgagtt
     2221 tgccaacatc gatgtctggc tgggatcggg tgataccaat acgccacttt ggccattttt
     2281 gttgcgcgcc ttcatggaac tgatgctggg catttgctgt tttgcctggg tacttggacc
     2341 aagcatttcc actctctaca agaggcaagt cagcaatggc aaaatggtga agcatacgtc
     2401 tgccggagca gcaactggac acctggacgg gcatagtagc tcgcgtggat cgcatgcggc
     2461 ttgcaatagc acggtggtct cctaccattc ggtgcgaact tctatggcca gtgttccgtt
     2521 gccgccaagt ccgtacaaac tgaagacttc gcctggtacc ggctctatat cgctgaatca
     2581 gatgtccaac tattcgctgg gcaggagcgt gcatcaccag cagcgccatt cgccgcatca
     2641 tcatcatcac cagcagcagc agcatcatca gttccatccc caccacaatc accagcatca
     2701 ctccacatcc tcgcatcggc tgtattatcc gccaggtagc tatgcctcgc aaaagtacag
     2761 ccagcacggc agctactatc cccacttgca gcagtatggc aatgagacgc tactctagac
     2821 ggaattggat taggtaccat ttcagggcag gaaatgcttc ctgcttccag tcaatgttcc
     2881 tgcagcagct gctgtgccaa agtcaatcct ctactataac ttaatgcggt ttcgggtatc
     2941 gaaagaggca aagcaactta aatgggtggg gaaacggtcc aatttgtttg tcataaaacg
     3001 atcgtgagat aacgatatcg ttatttcgat tttagttgct ttgcctgtcc atagaacaca
     3061 atggggtaaa ccgatctatg tactgtgtat ataaccccgg aaatgtgctc ttagtgcttt
     3121 agtttgggcc tttatcgcga ggtcataggt catctacaat gtatttgtaa ttgccctaga
     3181 tgggcttcat atcctatttt cctgtgtgta cttaatgttg ctcctaatta gttgcccctt
     3241 gcgttgcctt tttaccattt tggtgtaacc aaattcaata atcgctcttg ccttttagac
     3301 attaggactt aatgtgtgtc gcctttgcgt acataacaca tatatacata tatatattta
     3361 gcatttttat ataaattctt tttttttgag ttagagagag agagaaacgc gcagcaacca
     3421 aatactgtga tacgcatgtt catgtcttca aaaacaaaaa aataaaaatg ggaaccagaa
     3481 actaggtttc caactttgct gtcttctccc gatgccgaaa caagtgtact taacaatcga
     3541 aaaaaaaaaa cgcaattgca atcgtagccg taatgcctaa ttgtattcag tgtgccatta
     3601 gctttaggga cttaactgaa acgagtcaat atcatgaaat taccttaaaa gagtcctttt
     3661 ccagcaacga actttggcgg aattactgag ggttttcctt caacttctgc tgattttcgc
     3721 acagaaaaag tcctacttct aaatgtccaa ctaactagct aagaaactaa ctaaccttta
     3781 tacaattgcg ggctaatacg aatcgtatgg agcccgcgac taacagtata tgtattgtat
     3841 tgtattgtat tttatatgtg tatttttttt attatcatat atgtatatgt ataacttatt
     3901 tgctagcgaa taaagtgtcg aaaagtt