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LOCUS NM_078510 2790 bp mRNA linear INV 26-DEC-2023 ACCESSION NM_078510 VERSION NM_078510.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 2790) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2790) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2790) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 2790) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 2790) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 2790) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 2790) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 2790) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 2790) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 2790) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 2790) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 2790) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 2790) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 2790) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 2790) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 2790) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 2790) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 2790) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 2790) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 2790) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 2790) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 2790) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 2790) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_078510.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..2790 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..2790 /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="Minichromosome maintenance 6" /map="6C4-6C5" /db_xref="FLYBASE:FBgn0025815" /db_xref="GeneID:31603" CDS 120..2573 /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="CG4039 gene product from transcript CG4039-RA; CG4039-PA; Mcm6-PA; female sterile(1)K1214" /codon_start=1 /product="minichromosome maintenance 6" /protein_id="NP_511065.1" /db_xref="FLYBASE:FBpp0070913" /db_xref="GeneID:31603" /db_xref="FLYBASE:FBgn0025815" /translation="MDVADAQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGEIKYTRPA ASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQK DCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIR NVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAV EIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGL KALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSK DRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPST AKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICC IDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSL QQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLR YVTFARQFKPVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMA KLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDEGLDMDDGIQHDIDMENNGAA ANVDENNGMDTSASGAVQKKKFTLSFEDYKNLSTMLVLHMRAEEARCEVEGNDTGIKR SNVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIYHDQVIIPLKTSTLKPRIQVQK DFVEEDDPLLVVHPNYVVE" misc_feature 183..446 /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="MCM N-terminal domain; Region: MCM_N; pfam14551" /db_xref="CDD:464206" misc_feature 456..2066 /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="MCM helicase family; Region: MCM; cl28901" /db_xref="CDD:475121" misc_feature order(1164..1172,1287..1304,1950..1952) /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:350663" misc_feature order(1230..1235,1251..1253,1287..1292,1314..1316, 1347..1355,1359..1370,1374..1379,1419..1421,1425..1430, 1434..1439,1443..1445,1452..1454,1473..1478,1485..1487, 1554..1565,1569..1577,1713..1715,1728..1730,1740..1742, 1749..1754,1758..1766,1866..1868,1878..1880,1887..1892, 1899..1904,1932..1940,1944..1949,1956..1961,1968..1970) /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="oligomer interface [polypeptide binding]; other site" /db_xref="CDD:350663" misc_feature order(1374..1376,1389..1394,1398..1400,1491..1493, 1551..1556) /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="nucleic acid binding site [nucleotide binding]; other site" /db_xref="CDD:350663" misc_feature 2223..2567 /gene="Mcm6" /locus_tag="Dmel_CG4039" /gene_synonym="CG4039; dMcm6; Dmel\CG4039; DmeMCM6; DmMCM6; fs(1)K1214; mcm6; McM6; MCM6" /note="MCM6 C-terminal winged-helix domain; Region: MCM6_C; pfam18263" /db_xref="CDD:465688" ORIGIN 1 ctgtcagaaa aaggcgccaa aaccgagcaa agcacgcagc tgtaaacatt cgcaagaaac 61 gaaagcaatc tcggaattta gcgcgcaatt caccagtttg aagcaagaag tgacccaaaa 121 tggatgtggc agatgctcag gttggccagc tgcgcgtaaa agacgaggtg ggcattcggg 181 cccagaagtt gtttcaggat ttcctcgagg aattcaagga ggatggcgag atcaagtaca 241 cgcgcccagc cgccagcttg gaatccccgg atcgctgcac cctggaggtc agcttcgagg 301 atgtggagaa atacgatcag aatctggcca ccgccattat cgaggagtac taccacatct 361 atccgttcct ttgccaatcc gtttcgaact acgttaagga ccggattgga ctgaagaccc 421 agaaggattg ctatgtggcc ttcacggagg tgccgacgcg tcacaaggtt cgcgatctga 481 ccacctccaa aatcggcacc ctcatccgca tctccggcca ggtggtgcgc acccatcccg 541 tacatccgga gcttgtttcc ggcgtcttca tgtgcctcga ttgccagacg gaaattcgga 601 acgtagagca gcagttcaag ttcaccaatc ccaccatttg ccgcaatccc gtgtgctcca 661 atcgcaagcg tttcatgctg gatgtggaga agagtctgtt cttggacttt caaaagattc 721 gcatccagga gacgcaagcc gagctgccgc gtggctgtat tccccgcgcg gtggagatta 781 tcctgcgctc ggagctggtg gagaccgttc aggctggcga tcgctatgat ttcacgggca 841 ctctgattgt ggtgcccgat gtgagtgtcc tggccggagt gggcacacgg gcggagaaca 901 gttcacgcca caagcccggc gagggcatgg atggcgtcac tggcctaaag gcactgggca 961 tgcgagagct caactatcgg atggccttcc ttgcctgcag tgttcaggca acgacagcac 1021 gttttggcgg caccgatctg cccatgtcgg aggtgacagc cgaggatatg aagaagcaga 1081 tgacagatgc cgagtggcac aagatctatg agatgtccaa ggatcgcaat ctctaccaga 1141 atctaattag cagcctcttt ccctcgatct acggcaacga tgaggtcaag cggggcattc 1201 ttctgcagca attcggtggc gttgcgaaga ccaccaccga aaagacatcg cttcgtggcg 1261 acatcaatgt gtgcatcgtt ggcgatccca gcacggccaa gtcacagttc ctcaagcagg 1321 tatccgactt ctcgccgcgt gcgatctaca cctcgggcaa ggcatcctcg gcagcgggct 1381 taaccgctgc ggttgtgcgc gacgaggagt cctttgactt tgtcatcgag gcgggcgccc 1441 tcatgttggc cgacaatggc atttgctgca ttgacgagtt cgataagatg gatcagcgcg 1501 atcaggtggc cattcacgag gccatggaac agcagaccat atcgattgca cgcgccggcg 1561 tacgagccac actcaatgcg cgcacttcga ttctggccgc cgccaatccc attaatggtc 1621 gctacgatcg ctccaagagt ttgcaacaaa atattcagct atcggcaccg attatgtcgc 1681 gattcgatct gttcttcatt ctcgtggacg aatgcaatga ggtggtggac tatgccattg 1741 ctcgcaagat cgttgatctg cactcgaaca tcgaggagtc cgtggagcgg gcatatacgc 1801 gcgaagaggt ccttcgctat gtgacatttg cgcggcaatt taagccggtt attagccagg 1861 aggccggaca catgctggtc gagaactatg gccatttgag gcagcgcgat acgggcacgt 1921 cgggcaggag cacctggagg ataacggtgc gtcagctgga gtccatgatt cgactgagcg 1981 aggccatggc caagctggag tgctcgaatc gcgtgctgga gcgacacgtc aaggaggcct 2041 tccgtttgct caacaagtcc atcattcgcg tggagcaacc ggatattcat ttagatgacg 2101 acgagggtct ggacatggac gatggcattc agcacgacat cgacatggag aacaatggag 2161 cagcggccaa tgtggatgag aacaatggta tggacacatc cgccagcggc gccgtgcaga 2221 agaagaagtt cacgctttcg ttcgaggatt acaagaatct gtccaccatg ctggtgttgc 2281 atatgcgcgc cgaggaggcg cgctgcgagg tggagggcaa cgatacgggc atcaagcgca 2341 gcaatgtggt cacctggtat ctggagcagg tggcggacca aatcgaatcc gaggatgagt 2401 taatttctcg caaaaatctc atcgagaagc ttatcgatcg cctcatctat cacgatcagg 2461 tcattattcc gctcaagaca tccacgctga agccgagaat tcaggtacaa aaggatttcg 2521 tggaggagga cgatcccctg ctggtggtgc atcccaacta cgttgtggag tgatcccagc 2581 cgatcaacag tttattacta tgccctaaat ctagctggtt aagtttctgt ttccgcgtct 2641 tgcttttttt tgctcaccca aacaaacaat gtatttaggc agtaagttta tagtttagag 2701 acattattga aatccattaa ggatttcttg gttcagttac gttccaaatc attcatgttt 2761 tcgccgaaat aaacgttcat ctcaagattc