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LOCUS NM_057814 1951 bp mRNA linear INV 26-DEC-2023 ACCESSION NM_057814 VERSION NM_057814.4 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 1951) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1951) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1951) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 1951) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 1951) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 1951) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 1951) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 1951) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 1951) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 1951) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 1951) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 1951) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 1951) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 1951) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 1951) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 1951) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 1951) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 1951) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 1951) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 1951) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 1951) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 1951) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 1951) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_057814.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..1951 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..1951 /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /note="licorne" /map="11D10-11D10" /db_xref="FLYBASE:FBgn0261524" /db_xref="GeneID:32257" CDS 339..1343 /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /EC_number="2.7.12.2" /note="CG12244 gene product from transcript CG12244-RA; CG12244-PA; lic-PA; drosophila MAP kinase kinase 3; p38 MAPK; MEK-kinase 3; Mkk3" /codon_start=1 /product="licorne" /protein_id="NP_477162.1" /db_xref="FLYBASE:FBpp0073551" /db_xref="GeneID:32257" /db_xref="FLYBASE:FBgn0261524" /translation="MSKRHRLTPFTIAKEPEAAIVPPRNLDSRATIQIGDRTFDIDAD SLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDC PYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALH YLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERI DPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTF SPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVARILDLPDAQPAQ " misc_feature 468..1316 /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /note="Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; Region: PKc_MKK3_6; cd06617" /db_xref="CDD:173729" misc_feature order(480..482,486..488,492..515,519..521,525..527, 561..566,570..578,672..674,678..683,687..689,693..695, 708..722,741..743,864..869,873..875,903..905,918..920, 927..938,1311..1316) /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:173729" misc_feature order(492..506,516..518,555..557,561..563,654..656, 702..713,717..722,729..731,852..854,858..869,873..875, 903..908,915..917,954..965,969..971,1062..1064,1089..1091) /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /note="active site" /db_xref="CDD:173729" misc_feature order(492..506,510..512,516..518,555..557,561..563, 654..656,702..713,717..722,726..731,858..860,864..869, 873..875,906..908) /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173729" misc_feature order(501..506,852..854,858..866,915..917,954..965, 969..971,1062..1064,1089..1091) /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:173729" misc_feature order(903..950,954..971) /gene="lic" /locus_tag="Dmel_CG12244" /gene_synonym="CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK" /note="activation loop (A-loop); other site" /db_xref="CDD:173729" ORIGIN 1 cgctagtgga aaagagagaa aaacgagaag agaagcgaaa agcgatcggt gaacagtgca 61 aaaagtgcgg aaaggaaagc aaaggcaata gcgaaaggtt gggcggcaaa acccgggcca 121 cacgatccac accgatccga tccccatatc accgacccgc atccgaatcc tgacctgacc 181 aaatgcggta aaaatagccg caccgcatcg catccgattc gcaccgaacc gccaagtctt 241 gcagaatccg ccagaaaaca ccaaggaaag tcgtggagag gagagggtat atatagcata 301 tagcatatag gatataggat atagaagggc ctaccaaaat gtccaaacgc caccgcctca 361 cgccctttac cattgccaag gagccagagg ccgccatagt cccgccacgc aacctggact 421 cgcgggccac catccaaatt ggcgaccgga cctttgacat cgatgcagat agtctcgaga 481 agatctgcga tctgggccgt ggcgcctatg gcatcgtgga taagatgcgc cataagcaaa 541 ccgatacggt cctggccgtc aaacgcatac ccatgaccgt aaatattcga gaacagcacc 601 gccttgtaat ggatttggac atatcgatga gatccagcga ctgcccctac accgtccact 661 tttatggtgc gatgtatcgc gagggcgatg tctggatttg catggaggtg atgagcacca 721 gcctggacaa gttctatccg aaggtcttcc ttcacgatct gcgaatggag gaaagcgtgc 781 tgggcaagat tgccatgagc gtggtcagtg cgctgcacta tctgcacgct caactgaaag 841 tcattcatcg ggacgtcaag ccctcgaaca tactgatcaa tcgggccggc caggtcaaga 901 tctgtgactt tggcatctca ggctacctcg tcgactccat tgccaaaacc attgatgccg 961 gttgcaagcc gtacatggcg ccggaacgga tcgatcccca aggaaatccg gcgcaatacg 1021 acatcaggtc ggatgtttgg tcgctgggca tcggcatgat cgaaatggcc acgggccgct 1081 acccatacga caattggcga acgccatttg agcaactgcg tcaggtggtt gaggacagtc 1141 cgccgcgcct gccggaggga acattttcgc cggaattcga ggacttcatc gccgtctgcc 1201 tgcagaagga gtatatggca aggcccaact acgagcagct gctcaagcac agcttcatcg 1261 tggagcacct gcagcgcaac acggacatct cggagttcgt ggccaggata ctggatctgc 1321 ccgacgcgca gccggcgcag taggttaatg gccgggtagc aggttaatgg ttaacccatg 1381 gcgccgcccc cttaacccct taagccgtgc ccgtgcccgt gtaaattgcc gccgtcttct 1441 tctagcatgc atttcgtaca tgttgtgtgt gtgtcccccg tctgtgtgac agcaaaagga 1501 ataaaacttt atttgaatgg agtccaagga aaccccaaaa acaaacccaa cagcaatcag 1561 caataagcgt cagctaatct aaagatacaa aatggaaagt gcataattat taatttaagt 1621 gagagaagca acagcaacat aaccgttact agcaaacctg caatatgcat aatgcaacaa 1681 tcgccttgca acgctcaaaa atggataacc gaaccgtgcc tcccagctgg cgatgctgct 1741 gatgtcttga agcataatac cattttaata tatattttta aatgagaata gcttagtcaa 1801 cgaaaaacaa gaacagaagc aagcaaagca ttgaatgtaa aaacgtacta aacttaaatg 1861 ataatttgtg aacttttgaa caccaaaata gtcgaaaaga aagtgtttat aattataatt 1921 gtttaacaaa tatatattac gtaaaatagc t