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Drosophila melanogaster corkscrew (csw), transcript variant B,


LOCUS       NM_057783               7664 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_057783
VERSION     NM_057783.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7664)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7664)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7664)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7664)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7664)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7664)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7664)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7664)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7664)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7664)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7664)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7664)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7664)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7664)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7664)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7664)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7664)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7664)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7664)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7664)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7664)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7664)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7664)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_057783.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7664
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7664
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="corkscrew"
                     /map="2D1-2D2"
                     /db_xref="FLYBASE:FBgn0000382"
                     /db_xref="GeneID:45278"
     CDS             859..3696
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /EC_number="3.1.3.-"
                     /EC_number="3.1.3.48"
                     /note="CG3954 gene product from transcript CG3954-RB;
                     CG3954-PB; csw-PB; enhancer of sevenless 1A; corkscrew"
                     /codon_start=1
                     /product="corkscrew, isoform B"
                     /protein_id="NP_477131.1"
                     /db_xref="FLYBASE:FBpp0070363"
                     /db_xref="GeneID:45278"
                     /db_xref="FLYBASE:FBgn0000382"
                     /translation="MLFNKCLEKLSSSLGNVVNHKLQEKQVYNNNNINNNNNNTLNNN
                     NAYNNQRNFEYERAIQAHYGSKGRRSEERERSGKFKASKGRKAKVTPPTETPEAQEPA
                     CKNCMTHDELAQIIKGVAKGADAQRNRDNRLQRRRRPLSAQPSAAASASTSTESLHRL
                     TPSPQASYPATPTSWTATPPQFPAAFGGASCSNSTLSLLATMRVQLHGYTWFHGNLSG
                     KEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESF
                     GTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESL
                     QQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLP
                     TDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSN
                     CATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTA
                     GCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNM
                     VWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFL
                     VSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVH
                     CSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
                     AVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKT
                     PLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGS
                     STTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQQQREEQAPAGAGKMQQ
                     PAPPLRPRPGILKLLTSPVIFQQNSKTFPKT"
     misc_feature    1489..1779
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="C-terminal Src homology 2 (C-SH2) domain found in
                     SH2 domain Phosphatases (SHP) proteins; Region:
                     SH2_C-SH2_SHP_like; cd09931"
                     /db_xref="CDD:198185"
     misc_feature    order(1570..1572,1576..1578,1591..1596)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198185"
     misc_feature    order(1633..1635,1714..1716)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198185"
     misc_feature    1912..3102
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 11 and type 6; Region: PTPc-N11_6;
                     cd14544"
                     /db_xref="CDD:350392"
ORIGIN      
        1 attcattcat accccagcgc ttagaacacc accaggccac agctcccgtc cgagagatat
       61 agccactaag agagagcgga agaatcgaat cgcaaagaga ggagccgcgc tgagacaacg
      121 tcaagaatcc gatttcgatt ccgattgcga tttcgaatcc gaggcaaaaa gcttcagact
      181 cggcagcagg cgcttcattc tcgagttgtg atccaacggg ttagcagctc agctcgcaag
      241 cagtcgccgt tcgtcgtcga gcggcaagca gttcgtttca tttctactgg gcgccagtac
      301 aagttccatc gagtgttttt gttattcgaa ggcaaagcgc gaaaattatg ccttcagcca
      361 catttgtcct ggagcatttg atggcggcac aatcgcgact cgacgagcag gccgcatccc
      421 cagcagaggt caaacccacc agcaccatca acagcagcag caccaccgtg gccaaggcca
      481 tcaatgtcaa gtcgtacgaa aagaagctgt tgctggctct caagaagatt gtgcaataat
      541 aaacgaatgc ggggtaaaca gcactctatt tgacaaactg tagacatttc ccctaatcga
      601 gctgactaag atcaataaaa agcaaacaga gaagcacaac aaacagcggc aaaaaacaaa
      661 aaccaagaat tctagttttt gtgctttcag tgtgtgttcg tgtgtgtggg caagttgtta
      721 cataaaacaa aaacaataac aaaataaaaa aaaaataata aaaaaacacc ccagccgaga
      781 cgcatttttc cgcagtggaa tactactatc taagcttctt tttgttttgg tgtgtgcgag
      841 aaaacgagtg tgaagaaaat gctgttcaac aaatgtctgg aaaagttgtc cagctcgctg
      901 ggcaatgtgg tcaatcacaa gctgcaagag aaacaagtct acaacaacaa caatatcaac
      961 aataacaata acaatacgct aaacaacaac aatgcctaca acaatcagcg aaactttgag
     1021 tacgaaagag ccatacaggc gcactacgga agcaagggaa gacgctcgga ggagcgcgaa
     1081 aggagcggca agttcaaggc cagcaagggt cggaaagcaa aggtcacccc accaacggag
     1141 acacccgagg cccaggagcc ggcctgcaag aactgtatga cccacgacga gctggcccag
     1201 atcataaagg gcgtggccaa gggcgctgac gcgcaacgta atcgagacaa ccgactgcag
     1261 cgcagacgtc gtcctctctc cgcccaaccc tccgccgctg cctccgcctc cacatcgacg
     1321 gaatctctgc accgtcttac acccagcccg caggcttcct acccggccac gcccacctcc
     1381 tggacagcca caccgcccca gttcccagcc gccttcggcg gcgccagctg ctccaacagc
     1441 acactgtccc tcttggccac catgcgcgtc cagctccatg gttacacatg gtttcatggc
     1501 aatctttccg gaaaggaagc ggaaaaattg atcctggagc ggggcaagaa tggttcgttt
     1561 ctcgtccgtg aatctcagag caagcctggc gacttcgtcc tttccgtgcg cacggacgac
     1621 aaagtaacgc atgtcatgat tcgatggcag gacaagaagt acgacgtcgg cggcggggaa
     1681 tcctttggca ccttgtcgga actgatcgat cactacaagc gtaatcccat ggtggagacg
     1741 tgcggaaccg tggtgcatct gcgacagcca ttcaacgcca cacgaatcac ggcggccggc
     1801 atcaatgccc gggtggaaca gctggtcaag ggaggtttct gggaggaatt cgaatcgctg
     1861 caacaggaca gtcgggacac attctcgcgc aacgagggct acaaacagga gaaccgcctc
     1921 aagaatcgct accgcaacat attgccatac gaccacacgc gcgtcaagct gctggacgtg
     1981 gagcatagcg tggccggagc cgagtacatc aatgccaact acatacggct gcccaccgac
     2041 ggcgacctgt acaacatgag cagctcgtcg gagagcctga acagctcggt gccctcgtgc
     2101 cccgcctgca cggctgccca gacacagcgg aactgctcca actgccagct gcaaaacaag
     2161 acgtgcgtgc agtgcgccgt gaagagcgcc attctgccgt atagcaactg tgccacctgc
     2221 agccgcaagt cagactccct gagcaagcac aagcggagcg aatcctcggc ctcttcatcg
     2281 ccctcctccg gctctgggtc cggaccagga tcgtcgggca ccagcggagt gagcagcgtc
     2341 aatggacccg gcacacccac caatctcacg agcggcacag ccggatgtct ggtcggcctg
     2401 ctgaagagac actcgaacga ctcgtccgga gctgtttcta tatcgatggc cgaacgggaa
     2461 cgcgagaggg agcgcgagat gtttaagacc tacatcgcca cccagggctg tctgctcacc
     2521 cagcaagtga acacggtgac ggacttctgg aacatggtct ggcaggagaa cacgcgggtg
     2581 atcgtcatga ccaccaagga gtacgagcgc ggcaaagaaa agtgcgcccg ctactggccg
     2641 gacgagggta gatcggagca gttcggccac gcgcggatac agtgcgtctc ggagaactcg
     2701 accagtgact atacgctgcg cgagttcctc gtctcgtggc gggatcagcc ggcgcgccgg
     2761 atctttcact accatttcca ggtgtggccg gatcacggag tgcccgccga tccgggctgt
     2821 gtgctcaact tcctgcaaga tgtcaacacg cgtcagagtc acctggctca agcgggcgag
     2881 aagccgggtc cgatctgcgt gcactgctct gcgggcatcg gtcgcactgg cacctttatt
     2941 gtgatcgata tgattctcga tcagattgtg cgcaatggat tggatactga aatcgacatc
     3001 cagcgcacca ttcagatggt ccgatcgcag cgttccggtc ttgtgcaaac cgaggcgcaa
     3061 tacaagttcg tctactatgc ggtgcagcac tatatacaga ccctgatcgc ccggaaacga
     3121 gctgaggagc agagcctgca ggttggccgc gagtacacca atataaagta cacgggcgaa
     3181 attggaaacg attcacaaag atctccatta ccaccagcaa tttctagcat aagtttagtt
     3241 ccgagtaaga cgccactgac gccgacatcg gcggatttgg gcactgggat gggcctaagc
     3301 atgggcgtgg gcatgggcgt cggcaacaag cacgcatcga agcagcagcc gccgttgccg
     3361 gtggtcaact gcaacaataa taacaacggc attggcaata gcggctgcag caacggcggc
     3421 gggagcagca ccaccagcag cagcaacggc agcagcaacg gtaacatcaa cgccctactg
     3481 ggcggcatcg gcttggggct gggcggcaat atgcgcaagt cgaactttta cagcgactcg
     3541 ctgaagcagc aacagcagcg cgaggagcag gctccggcgg gagcaggtaa gatgcagcag
     3601 ccggcgccgc cgctgcgacc gcgtcctgga atactcaagt tgctcaccag tcccgtcatc
     3661 tttcagcaaa attcaaaaac attcccaaag acatgatcgg cttgcgaccg ccaagccatg
     3721 cgcctgcgtt gccgccgcca ccgacaccgc cgcgcaaaac atgacaaatg aatttctaag
     3781 tcgcgacgcc cccttgacac gcccccttga cacgcccccc tgacacccac ctccctccac
     3841 acgcacacag accacatatg gttttcattt taaatgtcac ccagccgccg ccccaaaccc
     3901 aaaacccaat ccctcgacta tgttttactg ttgtaccacg ttctacgttt tttttttttt
     3961 tttataattg taatctatat acttttttgt aattgtgtgt aatgtaatgt ttagttttat
     4021 gttattgtct cgctttatgt tgtaagtgtt ccctgcacac gaaaagcagt aaccccacca
     4081 ccaccccaaa acccaaaacc cagcatattt atgtagtagt attgtaagaa tccccgaacc
     4141 ggtagttgag gatacaatct gggcggaact gcagcagatc cgccaaaaaa caaaaacaca
     4201 tttttaagca gaatcgcagc aacaaaatat aacacccgtt ccctgttcca aaccgcttga
     4261 atttggtgga atcggccttg atagtatttc actttcttga aaatattcgc tttagataag
     4321 aaaattgact tgtgacaaat atttacatgt attgcgctgg ttacaaacca caaaagttgc
     4381 ttaactttaa attttacgaa tcgacattta tgatatttcg catgcttgaa aatagttgta
     4441 gtttcctatt tgggaatcat tgaaaaatcc atttataaag cgaaatccag ttctggcacg
     4501 ttcaatttga atcggttaat ttctaatcta gttggcgaaa aagtgaagaa aagtgaagtc
     4561 cacctcctcc aaattcaact tgaaacggaa acgggttacc ggttggagtg caaataaagt
     4621 ttttagtgta gtaagtgttg acaaaatcga tagagaagaa attagaggag taactgaggc
     4681 agtaagcacg taacgataat gatacaaaaa gcgttgattg tgattcgagt gacagcgaga
     4741 acagaaactg aaacagtaac agtaacagta acagatgaga acagatgcga atgggatcag
     4801 tacagaacag aacagaacag cggagacgcc aaccgaacag aacagaaatg aacagaagag
     4861 aagagaacag attagaggta aaagaaaaag ctaagaagcg cttaagcgtg tcgtccctag
     4921 aataagaaaa ctaatattac agctccacag atccagattc agatccagat ctatatctct
     4981 agcagccaat ttctgatttc cccttccctc ttagttttcc cattaattta gtgattgtgt
     5041 gtatattttt aattgtatat tgaagattat ttatagcgat tgtccattgt gttacatttc
     5101 aaatgttcga aagaattgta tttagaaagt ttgtacttta gaaattatgc attaattgtg
     5161 tgtctgtgtc tctctaccca gtctccctat ctctgtctct ctctctctct ctccctcact
     5221 gtctatgcac gagtgttttc ttaactaagt ttattatttc aacgctgaag cgtaatcaaa
     5281 ctatatatgc aatatttaag cacagtacct tgggcgctgc aaagaaatta aaaaatttta
     5341 aaataaaaac aaactgctaa atcataaata caaaatatat acaggaagga ataatagcag
     5401 cgaaatgtaa atcaattaga ttattgtgca aatttgagta atatatttaa aacataccct
     5461 tattttatct tatttaactt tatgcttttg taagtgcttt aaattgttat tcatcttgat
     5521 cttgcaaaaa aatgaaaaaa ccacaaaact gaaaaacgaa tacaaaacta aaaaacaaca
     5581 caaattatat ttgtatttat acagaaaaat aaaacatttt atatgcgata cacgatagca
     5641 cattattttt tattttccct gcatgtttgt tgaacgcttt tccctttttg gttctcaact
     5701 tcagttatgt taccacacat caccaacgaa ctgaaagaaa cccgaacact ttggaacata
     5761 gccttatata aaacgcctcg acgaccaaga cggaaagttg aatcacacca cggagaagag
     5821 ggagacatct cccctctccc agttagaaca ataagtaatc atgtgttcac ccccaccacc
     5881 cacacgaatc taaactgacc cctgaccttc caccaaagac actagaataa tattattcta
     5941 atgtctttgc ttccacccac catctgagca ctagcgggtg atcccgatcg gacgacaaac
     6001 gtgtgtgtaa gtgcgtgatc tagtacttta tatagttagc ctataatacg attattcaaa
     6061 cggaatatgt cgaagcctgg cttcgactgg gcggcgacct agtggccccc aaaaaacgaa
     6121 ggtgaatccg aatatgaatc ccactgggga tacgatatgt tttgatcttg gagcgcgggg
     6181 cgaacaaagt cgcgcgcttc ttgtgttgaa tttttatagc atatagaaag aggtggatat
     6241 cggatatgga tattgaagaa cgcagtccaa tggagcagcc ggcggaggga gagatgaatg
     6301 ccaaagcaca aaagccaaca gcaacaaaac accaataggc ctcatcgcag tcatttgacc
     6361 acaaatctga caaacaacga tgttataatc aataagagcg aaccaaaatc aaaataacga
     6421 cgtgaatatt gagggaggga tcgatggaga cccaaacacc aaaacaaaaa aaaaaaaaaa
     6481 caaaaaaaac aagagcaagg aaacgcttta aacttaaata attctaaaat tgtatctagg
     6541 caatatcgaa atgtaaacca cacaccaact atccatagta gacaaacaaa caaacaccaa
     6601 gaaaaaattg cttgagtgac ttactttaga taacgatatt ctcgggtagg acctcgaaac
     6661 cccagcaacc tcggacctca accgatttcc tcgtgccctc gacccgaatc caacccaacg
     6721 tcccctcctc cagtacgtct ataagctaac cacgcgatcc aacctcaacc cgtgttcata
     6781 atccgatgag aagttgtgcg atttttagtg aaacctcggt gcggtttcga tgttgcaaga
     6841 attaaaacca aatagagacg acgttttctt tgttcaaatg ttgccaattt gcaaaataca
     6901 agtgttaaac taccatatag tatatggagt atgaataata tatatttaga tgcgaaatac
     6961 agctcagtac tcagctcaga agcattttca ttgagcccaa aacgagacgg cgaggcaaac
     7021 gtttatgtat cggtatacaa gaagcagctg agaggtagtt ctcctgccat ataaaatatt
     7081 aatcgaccca aaaacattag aaatccgtgt agaatactgc gatttgattg aaactataga
     7141 taacaatcga gaacaaaatg gtaaacgagc ccacgacgaa acgcgattga cgcaataaac
     7201 aaagttttcg tagctctaga tcgtaagata aacaaattaa tgaaacgcaa caaaacgatc
     7261 gcgaaatcga gacaaaaggc aacaccaaat aaattgtaaa caaaaccaaa gtcgttgtaa
     7321 tgttgaagca aatctatatg taaatcaatc tgcaagcgct aactaaacgt aacaaacata
     7381 aaaattaaac acagccacaa aatattatta tgaaattaaa ttgaaacctt aagatgcata
     7441 gctgttcgaa acattatacc gataacaata ttgaagatat attctacatt tttatgtgtc
     7501 tgcatatttg aaagaaaaat atatataatt gaataaacca tatttcaaat aacctttcgg
     7561 aaaattacca tgtgttttta gaatgagtga ctactaccca catatttgtt tcaatatcca
     7621 catatttggc aagaaggtac gaaatgaaca attccaataa aact