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Drosophila melanogaster corkscrew (csw), transcript variant A,


LOCUS       NM_057782               4560 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_057782
VERSION     NM_057782.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4560)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4560)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4560)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4560)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4560)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4560)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4560)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4560)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4560)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4560)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4560)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4560)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4560)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4560)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4560)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4560)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4560)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4560)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4560)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4560)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4560)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4560)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4560)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_057782.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4560
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4560
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="corkscrew"
                     /map="2D1-2D2"
                     /db_xref="FLYBASE:FBgn0000382"
                     /db_xref="GeneID:45278"
     CDS             172..2697
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /EC_number="3.1.3.-"
                     /EC_number="3.1.3.48"
                     /note="CG3954 gene product from transcript CG3954-RA;
                     CG3954-PA; csw-PA; enhancer of sevenless 1A; corkscrew"
                     /codon_start=1
                     /product="corkscrew, isoform A"
                     /protein_id="NP_477130.1"
                     /db_xref="FLYBASE:FBpp0070362"
                     /db_xref="GeneID:45278"
                     /db_xref="FLYBASE:FBgn0000382"
                     /translation="MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLS
                     VRRGNEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLI
                     CAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVM
                     IRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINAR
                     VEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEH
                     SVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNK
                     TCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVS
                     SVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQG
                     CLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQ
                     CVSENSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQ
                     SHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQ
                     RSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRS
                     PLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNCNN
                     NNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQ
                     QQREEQAPAGAAKFKNIPKDMIGLRPPSHAPALPPPPTPPRKT"
     misc_feature    184..477
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="N-terminal Src homology 2 (N-SH2) domain found in
                     SH2 domain Phosphatases (SHP) proteins; Region:
                     SH2_N-SH2_SHP_like; cd10340"
                     /db_xref="CDD:198203"
     misc_feature    order(208..210,265..267,328..330,334..336)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198203"
     misc_feature    order(325..333,373..375,430..441,445..447)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198203"
     misc_feature    499..792
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="C-terminal Src homology 2 (C-SH2) domain found in
                     SH2 domain Phosphatases (SHP) proteins; Region:
                     SH2_C-SH2_SHP_like; cd09931"
                     /db_xref="CDD:198185"
     misc_feature    order(583..585,589..591,604..609)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198185"
     misc_feature    order(646..648,727..729)
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198185"
     misc_feature    925..2115
                     /gene="csw"
                     /locus_tag="Dmel_CG3954"
                     /gene_synonym="19-106; anon-WO03040301.207;
                     anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw;
                     CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A;
                     EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170;
                     l(1)GA114; Shp-2; SHP-2; Shp2/csw"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 11 and type 6; Region: PTPc-N11_6;
                     cd14544"
                     /db_xref="CDD:350392"
ORIGIN      
        1 ttcttaaatc gactggccac accgcacagc ccagtaaaaa aatagttttt tttttgtatc
       61 caaccaacca actgtaaaaa taagtttaaa caaagcatct actcataagt ttcatttttt
      121 tccgttaagt gtcaacatta tttatttttt aagtgtgcat tcaataagaa aatgtcatcg
      181 cgaagatggt tccacccaac gatatctggc atcgaagctg agaaactgct gcaggagcag
      241 ggattcgacg gctccttcct cgcccgcctc tcctcctcga atccgggcgc cttcacgctc
      301 tccgtgcgcc gcggcaacga ggtgacccac atcaaaatcc aaaacaatgg cgacttcttt
      361 gatctctacg gtggtgaaaa gttcgccaca ctgccggaac tggtacaata ctacatggag
      421 aatggcgagc taaaggagaa gaacggccag gccatcgaac tcaagcagcc gctgatctgc
      481 gccgagccca ccacggaaag atggtttcat ggcaatcttt ccggaaagga agcggaaaaa
      541 ttgatcctgg agcggggcaa gaatggttcg tttctcgtcc gtgaatctca gagcaagcct
      601 ggcgacttcg tcctttccgt gcgcacggac gacaaagtaa cgcatgtcat gattcgatgg
      661 caggacaaga agtacgacgt cggcggcggg gaatcctttg gcaccttgtc ggaactgatc
      721 gatcactaca agcgtaatcc catggtggag acgtgcggaa ccgtggtgca tctgcgacag
      781 ccattcaacg ccacacgaat cacggcggcc ggcatcaatg cccgggtgga acagctggtc
      841 aagggaggtt tctgggagga attcgaatcg ctgcaacagg acagtcggga cacattctcg
      901 cgcaacgagg gctacaaaca ggagaaccgc ctcaagaatc gctaccgcaa catattgcca
      961 tacgaccaca cgcgcgtcaa gctgctggac gtggagcata gcgtggccgg agccgagtac
     1021 atcaatgcca actacatacg gctgcccacc gacggcgacc tgtacaacat gagcagctcg
     1081 tcggagagcc tgaacagctc ggtgccctcg tgccccgcct gcacggctgc ccagacacag
     1141 cggaactgct ccaactgcca gctgcaaaac aagacgtgcg tgcagtgcgc cgtgaagagc
     1201 gccattctgc cgtatagcaa ctgtgccacc tgcagccgca agtcagactc cctgagcaag
     1261 cacaagcgga gcgaatcctc ggcctcttca tcgccctcct ccggctctgg gtccggacca
     1321 ggatcgtcgg gcaccagcgg agtgagcagc gtcaatggac ccggcacacc caccaatctc
     1381 acgagcggca cagccggatg tctggtcggc ctgctgaaga gacactcgaa cgactcgtcc
     1441 ggagctgttt ctatatcgat ggccgaacgg gaacgcgaga gggagcgcga gatgtttaag
     1501 acctacatcg ccacccaggg ctgtctgctc acccagcaag tgaacacggt gacggacttc
     1561 tggaacatgg tctggcagga gaacacgcgg gtgatcgtca tgaccaccaa ggagtacgag
     1621 cgcggcaaag aaaagtgcgc ccgctactgg ccggacgagg gtagatcgga gcagttcggc
     1681 cacgcgcgga tacagtgcgt ctcggagaac tcgaccagtg actatacgct gcgcgagttc
     1741 ctcgtctcgt ggcgggatca gccggcgcgc cggatctttc actaccattt ccaggtgtgg
     1801 ccggatcacg gagtgcccgc cgatccgggc tgtgtgctca acttcctgca agatgtcaac
     1861 acgcgtcaga gtcacctggc tcaagcgggc gagaagccgg gtccgatctg cgtgcactgc
     1921 tctgcgggca tcggtcgcac tggcaccttt attgtgatcg atatgattct cgatcagatt
     1981 gtgcgcaatg gattggatac tgaaatcgac atccagcgca ccattcagat ggtccgatcg
     2041 cagcgttccg gtcttgtgca aaccgaggcg caatacaagt tcgtctacta tgcggtgcag
     2101 cactatatac agaccctgat cgcccggaaa cgagctgagg agcagagcct gcaggttggc
     2161 cgcgagtaca ccaatataaa gtacacgggc gaaattggaa acgattcaca aagatctcca
     2221 ttaccaccag caatttctag cataagttta gttccgagta agacgccact gacgccgaca
     2281 tcggcggatt tgggcactgg gatgggccta agcatgggcg tgggcatggg cgtcggcaac
     2341 aagcacgcat cgaagcagca gccgccgttg ccggtggtca actgcaacaa taataacaac
     2401 ggcattggca atagcggctg cagcaacggc ggcgggagca gcaccaccag cagcagcaac
     2461 ggcagcagca acggtaacat caacgcccta ctgggcggca tcggcttggg gctgggcggc
     2521 aatatgcgca agtcgaactt ttacagcgac tcgctgaagc agcaacagca gcgcgaggag
     2581 caggctccgg cgggagcagc aaaattcaaa aacattccca aagacatgat cggcttgcga
     2641 ccgccaagcc atgcgcctgc gttgccgccg ccaccgacac cgccgcgcaa aacatgacaa
     2701 atgaatttct aagtcgcgac gcccccttga cacgccccct tgacacgccc ccctgacacc
     2761 cacctccctc cacacgcaca cagaccacat atggttttca ttttaaatgt cacccagccg
     2821 ccgccccaaa cccaaaaccc aatccctcga ctatgtttta ctgttgtacc acgttctacg
     2881 tttttttttt ttttttataa ttgtaatcta tatacttttt tgtaattgtg tgtaatgtaa
     2941 tgtttagttt tatgttattg tctcgcttta tgttgtaagt gttccctgca cacgaaaagc
     3001 agtaacccca ccaccacccc aaaacccaaa acccagcata tttatgtagt agtattgtaa
     3061 gaatccccga accggtagtt gaggatacaa tctgggcgga actgcagcag atccgccaaa
     3121 aaacaaaaac acatttttaa gcagaatcgc agcaacaaaa tataacaccc gttccctgtt
     3181 ccaaaccgct tgaatttggt ggaatcggcc ttgatagtat ttcactttct tgaaaatatt
     3241 cgctttagat aagaaaattg acttgtgaca aatatttaca tgtattgcgc tggttacaaa
     3301 ccacaaaagt tgcttaactt taaattttac gaatcgacat ttatgatatt tcgcatgctt
     3361 gaaaatagtt gtagtttcct atttgggaat cattgaaaaa tccatttata aagcgaaatc
     3421 cagttctggc acgttcaatt tgaatcggtt aatttctaat ctagttggcg aaaaagtgaa
     3481 gaaaagtgaa gtccacctcc tccaaattca acttgaaacg gaaacgggtt accggttgga
     3541 gtgcaaataa agtttttagt gtagtaagtg ttgacaaaat cgatagagaa gaaattagag
     3601 gagtaactga ggcagtaagc acgtaacgat aatgatacaa aaagcgttga ttgtgattcg
     3661 agtgacagcg agaacagaaa ctgaaacagt aacagtaaca gtaacagatg agaacagatg
     3721 cgaatgggat cagtacagaa cagaacagaa cagcggagac gccaaccgaa cagaacagaa
     3781 atgaacagaa gagaagagaa cagattagag gtaaaagaaa aagctaagaa gcgcttaagc
     3841 gtgtcgtccc tagaataaga aaactaatat tacagctcca cagatccaga ttcagatcca
     3901 gatctatatc tctagcagcc aatttctgat ttccccttcc ctcttagttt tcccattaat
     3961 ttagtgattg tgtgtatatt tttaattgta tattgaagat tatttatagc gattgtccat
     4021 tgtgttacat ttcaaatgtt cgaaagaatt gtatttagaa agtttgtact ttagaaatta
     4081 tgcattaatt gtgtgtctgt gtctctctac ccagtctccc tatctctgtc tctctctctc
     4141 tctctccctc actgtctatg cacgagtgtt ttcttaacta agtttattat ttcaacgctg
     4201 aagcgtaatc aaactatata tgcaatattt aagcacagta ccttgggcgc tgcaaagaaa
     4261 ttaaaaaatt ttaaaataaa aacaaactgc taaatcataa atacaaaata tatacaggaa
     4321 ggaataatag cagcgaaatg taaatcaatt agattattgt gcaaatttga gtaatatatt
     4381 taaaacatac ccttatttta tcttatttaa ctttatgctt ttgtaagtgc tttaaattgt
     4441 tattcatctt gatcttgcaa aaaaatgaaa aaaccacaaa actgaaaaac gaatacaaaa
     4501 ctaaaaaaca acacaaatta tatttgtatt tatacagaaa aataaaacat tttatatgcg