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Drosophila melanogaster polyhomeotic proximal (ph-p), transcript


LOCUS       NM_057523               5940 bp    mRNA    linear   INV 26-DEC-2023
            variant A, mRNA.
ACCESSION   NM_057523
VERSION     NM_057523.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5940)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5940)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5940)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5940)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5940)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5940)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5940)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5940)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5940)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5940)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5940)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5940)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5940)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5940)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5940)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5940)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5940)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5940)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_057523.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5940
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5940
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="polyhomeotic proximal"
                     /map="2D2-2D3"
                     /db_xref="FLYBASE:FBgn0004861"
                     /db_xref="GeneID:31181"
     CDS             572..5341
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="CG18412 gene product from transcript CG18412-RA;
                     CG18412-PA; ph-p-PA; polyhomeotic; polyhomeotic proxima;
                     Polyhomeotic-proximal; polyhomeotic proximal; ph-proximal"
                     /codon_start=1
                     /product="polyhomeotic proximal, isoform A"
                     /protein_id="NP_476871.2"
                     /db_xref="FLYBASE:FBpp0070416"
                     /db_xref="GeneID:31181"
                     /db_xref="FLYBASE:FBgn0004861"
                     /translation="MDRRALKFMQKRADTESDTTTPVSTTASQGISASAILAGGTLPL
                     KDNSNIREKPLHHNYNHNNNNSSQHSHSHQQQQQQQVGGKQLERPLKCLETLAQKAGI
                     TFDEKYDVASPPHPGIAQQQATSGTGPATGSGSVTPTSHRHGTPPTGRRQTHTPSTPN
                     RPSAPSTPNTNCNSIARHTSLTLEKAQNPGQQVAATTTVPLQISPEQLQQFYASNPYA
                     IQVKQEFPTHTTSGSGTELKHATNIMEVQQQLQLQQQLSEANGGGAASAGAGGAASPA
                     NSQQSQQQQHSTAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGN
                     LLHPGGLGQQPIQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFAGGNYATCIPTN
                     HNQSPQTVLFSPMNVISPQQQQNLLQSMAAAAQQQQLTQQQQQFNQQQQQQLTQQQQQ
                     LTAALAKVGVDAQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQT
                     TQTTQQCVQVSQSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQPFGPNQI
                     ILRNQPDGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQ
                     QVGTTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTA
                     QNQSLLKAKMRNKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVN
                     AAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQMLQQQI
                     AAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVA
                     QAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQV
                     QAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSST
                     TPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVAS
                     IQQAQTQSAQVHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLS
                     TAPPVTVSVTSTAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSP
                     KTPVSGKDTCTTPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQ
                     SNAAVQPPSSTTPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVS
                     TASTTTTSSGTFITSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANE
                     PFPVTRQRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKMEHKAKLK
                     RKRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEA
                     TPKLSESFPILGASTEVPPMSLPVQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSG
                     AAPKSSEVNGTDRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKH
                     LVNAMGMKLGPALKIVAKVESIKEVPPPGEAKDPGAQ"
     misc_feature    3614..>4267
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    5093..5299
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="SAM domain of Ph (polyhomeotic) proteins of
                     Polycomb group; Region: SAM_Ph1,2,3; cd09577"
                     /db_xref="CDD:188976"
     misc_feature    order(5147..5152,5252..5257,5264..5269,5276..5278)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface EH [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
     misc_feature    order(5180..5194,5198..5203,5210..5215,5225..5227,
                     5240..5242)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface ML [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
ORIGIN      
        1 cgtcgctggc gacgtaggca gtgcagttaa aacaagtact tagtgctgtg actgtggctt
       61 aattttatgt aagatcgcgt gcacaggtgc ttagtcgtta cactgagaaa aagaaaagtg
      121 cctgcagcca gcggggagaa gttgaagtgg agtgactgtg agtggaggtt gtactaatta
      181 ctactgcccg tgcacgaaac actcatttac acgcaagcac acacacacac acacacacac
      241 acgagacact gggacttttg tcggattttc gtattcgttt tgtgtacttt tgttgtcttg
      301 cgttccacgt tacatacata tgtatatgtt tggtgttgcc tgttgtatgt ttatatttat
      361 tgccttcaca catgtgcgtg tttgttaatg tacaatataa tacggcaaat agcaaaaaga
      421 gaagaaactg aggactaaaa agaaagcgcc atgccgacta taacaaaaac aaccacgagt
      481 gtctccgccg ccgccgaaaa caaaaacaaa acgcctaagc cgacgcatgc atacctataa
      541 tttattataa atattgtttt tattttgaat aatggatcgt cgtgcattga agtttatgca
      601 aaaaagagcg gacacagaaa gcgatacgac cacacccgtg agcaccacag catcccaggg
      661 gatttcagca tcagcgattc tagcaggagg cactcttccc ttgaaggaca actcgaacat
      721 ccgcgagaag cccctccacc ataactacaa ccacaataac aacaacagct cccagcactc
      781 acactcgcac cagcagcagc aacaacagca ggtgggtggc aagcagctcg agcggccact
      841 aaagtgcctg gaaacgctcg cccagaaggc gggaatcacc ttcgacgaga aatacgatgt
      901 ggccagcccc ccgcatcccg gcattgccca gcagcaggcg acttcaggaa caggcccagc
      961 aacgggatca ggctcagtca cccccacaag ccatcggcac ggaactccgc ccacgggccg
     1021 caggcaaacc cacaccccaa gcactccgaa caggcccagt gctcccagca cacccaacac
     1081 taactgcaac tcaattgccc gccacaccag cctcacgctg gagaaggcgc agaatcccgg
     1141 ccagcaggtg gccgccacca ccacggtgcc actgcagata tcccctgagc agctgcagca
     1201 gttctatgcg agcaatccct acgccattca ggtgaagcaa gagtttccca cgcacacgac
     1261 cagtggcagt ggaactgaac taaagcatgc aaccaacatt atggaagttc agcagcagtt
     1321 gcagctgcag cagcagctgt cggaagccaa cggtggagga gcagcctcgg ccggagccgg
     1381 aggagcagct agtccggcca actcgcagca aagccagcaa cagcagcact ccacagccat
     1441 cagcaccatg tcgccgatgc aattggcagc ggccactgga ggagttggcg gggattggac
     1501 acagggaagg acggtgcagc taatgcaacc ctccaccagt ttcctgtatc cccaaatgat
     1561 tgtgtcggga aatctgttgc atccaggagg cctcggtcag cagccaatcc aggtgatcac
     1621 cgccggcaag ccattccaag gcaacggccc ccagatgctt accaccacga ctcaaaacgc
     1681 caagcaaatg atcggtggcc aagcgggatt cgctggcgga aattacgcga cctgcattcc
     1741 cacaaaccac aatcaatcgc cccagacggt gctcttctca ccgatgaacg tcatttcgcc
     1801 acagcagcaa cagaacctgc tgcaatcaat ggccgctgca gctcagcagc agcaactcac
     1861 ccaacagcag caacagttta accagcagca acaacagcag cttactcagc agcaacagca
     1921 gttgacagct gctctggcca aggtgggagt ggatgcgcag ggcaagctgg cccagaaagt
     1981 ggttcagaaa gtgactacca ccagtagcgc ggtccaggcg gcgacgggtc ctggatctac
     2041 tgggtcaaca cagacccagc aggtgcagca ggttcagcaa cagcagcagc agaccaccca
     2101 aaccactcag cagtgcgtgc aggtttcaca gtcgactttg ccagtcggtg tgggtggaca
     2161 gtctgttcag actgcccaac ttctgaacgc tggccaagcg caacaaatgc agattccctg
     2221 gttcttacag aatgctgcag gactgcagcc gtttgggcca aaccagatca tcctgcgaaa
     2281 ccagccagac ggaacccaag gcatgttcat tcaacagcaa ccggcgacgc agactttgca
     2341 gacccagcaa aaccagatta ttcaatgcaa cgtgacgcag acgcccacta aggcacgcac
     2401 tcaactggat gcacttgctc ccaagcagca acagcagcag cagcaggttg gcactaccaa
     2461 ccagacgcag cagcagcaac tagcggtggc tactgcccag ttgcagcaac agcagcagca
     2521 actcactgca gcagctctgc agcgaccagg agcccctgtc atgccccaca atggaactca
     2581 agtgcgtccg gccagttccg tatccacaca gactgcccag aaccagagcc tgctgaaggc
     2641 caaaatgcgc aacaagcagc agccggtgcg ccccgcttta gccacattga aaaccgaaat
     2701 cggtcaagtc gcaggacaaa ataaggtagt aggccacctg accaccgtgc agcagcagca
     2761 acaggcgacg aatctccagc aggtggttaa tgcggcgggc aacaaaatgg ttgtgatgag
     2821 cacaacgggc actccgatca ccctgcagaa tggacagacc cttcatgcag ccactgcggc
     2881 aggagtcgac aagcagcaac agcagctaca actgtttcag aaacagcaaa tcctgcaaca
     2941 acaacaaatg ttgcaacagc agattgctgc cattcaaatg cagcagcagc aagcggctgt
     3001 tcaggcccag caacaacagc agcaacaggt ctctcagcag cagcaggtta acgcccagca
     3061 acagcaagcg gtggcgcaac aacaacaggc agtcgcgcag gctcagcaac agcagaggga
     3121 gcaacagcag caagttgccc aagcccaggc gcagcatcaa caggctctcg cgaatgccac
     3181 tcagcaaatc cttcaggtgg cgccaaatca attcatcacg tcccaccagc aacagcagca
     3241 gcagcaactt cacaaccaac tgatacagca gcagctacag caacaggcgc aggcacaagt
     3301 tcaagcccaa gtgcaggctc aagcgcaaca gcaacaacag cagcgagagc agcagcagaa
     3361 tattatccag cagattgtgg tgcaacagtc tggagcgact tctcaacaga cttcccagca
     3421 gcaacagcac caccaatccg ggcaactaca gctaagtagc gtgcccttct cagtttcttc
     3481 gtcaacgacg ccagccggaa tagctacctc tagtgctctg caggcagccc tctccgcctc
     3541 tggcgccatc tttcagacag ctaagccggg tacttgcagt tcctcctccc ccacaagcag
     3601 tgtggtcaca attaccaacc agagcagcac tcctttggtc accagcagta cggtggccag
     3661 tatacagcag gctcagacgc aatctgctca ggtccaccaa catcagcagc taatcagcgc
     3721 cacaattgcc ggagggactc aacaacagcc acagggaccg ccatcactta cacccaccac
     3781 aaatccaatt ttggccatga cctcgatgat gaatgctaca gtgggtcacc tttccactgc
     3841 tccgcctgta actgtttctg tgacaagcac cgctgttact tcgtcgccgg gtcagctggt
     3901 tctcttaagc acggctagta gcggtggagg aggtagcata ccagccacgc ccaccaaaga
     3961 gacaccttcg aaagggccca ccgcaaccct ggtgcccatt ggttcgccca agactcctgt
     4021 atcaggaaag gacacctgca ctacccccaa atcatctact cctgccactg tcagcgcatc
     4081 cgtagaggcc agtagttcca caggcgaagc cctgtccaat ggagatgcct cagataggtc
     4141 ttccacgccg tcaaagggcg ctaccactcc caccagcaag caaagcaatg cagcagtgca
     4201 gccaccgagt agcaccactc ccaacagtgt cagtgggaaa gaagagccga agctggcaac
     4261 ctgcggcagt ttaacgtccg caacatcaac ttcaaccacg acaacgatca ccaatgggat
     4321 tggagtagcc agaacgacag ccagcacggc tgtctcaacc gctagcacaa ccactaccag
     4381 ttctggcacc tttatcacaa gttgcaccag cacaaccaca accaccacgt cgagtatcag
     4441 taatggatcg aaggatctcc ccaaggcgat gattaagccg aacgtcttaa ctcacgtcat
     4501 cgatggcttc atcatccagg aggccaacga gccatttccc gtcaccagac agcgatatgc
     4561 agacaaagac gtcagcgatg agccgccaaa gaaaaaggca accatgcagg aggacatcaa
     4621 gctaagtgga atagcatcag ctccaggctc ggatatggtt gcttgcgagc agtgtggaaa
     4681 gatggagcac aaagcaaagc tgaaacggaa gcgctactgt tcgccaggat gctcgaggca
     4741 ggcaaagaac ggcatcggtg gagttggatc aggagagacg aacggcctgg ggacaggtgg
     4801 tatagttggg gtggacgcca tggcattggt ggacaggctg gatgaagcca tggctgagga
     4861 gaagatgcag acagaggcca ccccaaagct ttcagaatcg tttcctattt tgggagcctc
     4921 aacagaagta cctccaatgt cactgccagt ccaagcggcg atttctgcgc cctcgcctct
     4981 tgcaatgcct ctaggatcgc cattgtcagt tgcacttcca actcttgcac cactgtctgt
     5041 agtcacttct ggcgcggcgc ccaagtcttc ggaagtgaat ggaacagatc gtccgccaat
     5101 cagcagctgg agtgtggacg atgtcagcaa cttcattcga gaactgcctg gttgtcagga
     5161 ctacgtggac gactttatac agcaggagat cgacggccaa gcgcttctgt tgctcaagga
     5221 gaagcatttg gtgaacgcta tgggcatgaa gctgggtcca gctcttaaaa ttgtggccaa
     5281 ggtggagtcc attaaggagg tcccgccacc tggcgaggcc aaggatccag gagcgcagta
     5341 gggcagctag agcacgaaaa gccgaaaaag atgatctcct aaccgagcag tggacctggt
     5401 tcaaccaagt ctgtcgtgcc aggtgattct gattcaatcg ggcaggcgaa aaggacgcga
     5461 atccatttgc aaaatattat tagcatcagg ccatcaggtc ttaaacccat tgactttgta
     5521 catactccca agatcactta taagcatatt catttataaa ttaaactaac agtcaacagt
     5581 caaaaacgaa tggaattact taaactaagg aaaagctatg aattaattgc cagccaagta
     5641 aatgaataaa gtacatttta taaataagca taagtttata gtctaagtag catattaata
     5701 actcccaacg tcatggatag tttgtacaag tattttaatc ttaggaatca aatgtagcac
     5761 tatgattgtt ctaacaacta agaattttaa gcctatgaat aataattgat atctaaatgt
     5821 gaatttgaac tttttactaa ataatatttg aatgcctaga cctaagcttt tttttcaaga
     5881 tttttttttt gcaattgctg aagaaattaa aatggcactg aatagtgttt aataaatgtg