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LOCUS NM_057278 5422 bp mRNA linear INV 26-DEC-2023 transcript variant A, mRNA. ACCESSION NM_057278 VERSION NM_057278.5 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5422) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5422) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5422) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5422) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5422) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5422) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5422) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5422) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5422) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5422) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5422) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5422) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5422) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5422) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5422) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5422) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5422) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5422) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5422) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5422) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5422) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5422) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5422) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_057278.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5422 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5422 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="beta amyloid protein precursor-like" /map="1B9-1B10" /db_xref="FLYBASE:FBgn0000108" /db_xref="GeneID:31002" CDS 207..2870 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="CG7727 gene product from transcript CG7727-RA; CG7727-PA; Appl-PA; amyloid Precursor-Like protein; APP-like; amyloid precursor protein-like; beta amyloid protein precursor-like; amyloid precursor protein like; beta-amyloid-protein-precursor-like" /codon_start=1 /product="beta amyloid protein precursor-like, isoform A" /protein_id="NP_476626.2" /db_xref="FLYBASE:FBpp0070104" /db_xref="GeneID:31002" /db_xref="FLYBASE:FBgn0000108" /translation="MCAALRRNLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQ IYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKI GGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFVRW NQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPA AQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATAGGS PNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSL KSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTA QPTSDPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPK AAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQAL TEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERL IDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILD KYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQ SQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEAT VSSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRRE FAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQNVTT HHPIVREEKIVPNMQINGYENPTYKYFEVKE" misc_feature 282..800 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="amyloid A4; Region: A4_EXTRA; smart00006" /db_xref="CDD:128326" misc_feature 1368..1946 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="E2 domain of amyloid precursor protein; Region: APP_E2; pfam12925" /db_xref="CDD:463752" misc_feature 2100..>2252 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="DDRGK domain; Region: DDRGK; pfam09756" /db_xref="CDD:370664" misc_feature 2709..2858 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="Beta-amyloid precursor protein C-terminus; Region: APP_amyloid; pfam10515" /db_xref="CDD:463129" ORIGIN 1 actcgcagtc gtttgtgagc gttcgcagcg ccagcaaagt gttaaacgaa tagccaacaa 61 agcaaataca attaaccaga actggaagca cgtcagtcca gccgcagaag cagctaagtt 121 cagaccaaac tcggagattc ccagccagga gataggacca ggagccaacc agacgaggag 181 caaagaagca gaaaagagtg cgaacaatgt gcgccgcgct gcgtcgtaat ttgttgctga 241 ggagcctctg ggtcgtcctg gccattggca ctgctcaggt tcaggccgca tcgccgcgat 301 gggagcccca gattgccgtt ctctgtgagg ccggacaaat ctaccagccg cagtatcttt 361 ccgaggaggg acgctgggtg acggacctta gcaagaagac aaccggtccc acatgtttgc 421 gtgataaaat ggatttgctt gattactgca agaaggccta tcccaaccga gacataacca 481 acattgtgga gtcgtcccac taccagaaga tcggcggctg gtgtcgccag ggggcattga 541 atgcggctaa gtgcaaggga tcccaccgat ggatcaagcc attccgctgt ctcggaccat 601 tccaatctga cgccctgcta gttcccgagg gctgtctgtt cgaccacatc cacaacgcct 661 cccgatgctg gccatttgtg aggtggaacc aaaccggagc agccgcttgc caggagcgcg 721 gaatgcagat gcgcagcttc gccatgcttc tgccctgcgg aatctcggtc ttctccggag 781 tggagttcgt ctgctgtccc aagcacttca aaaccgatga aattcatgta aagaagaccg 841 acttgccggt gatgccggca gctcagatca atagcgccaa tgacgagctg gtgatgaatg 901 acgaagacga cagcaacgac tcgaactact cgaaggatgc caatgaagac gatctggacg 961 atgaggatga tttgatgggt gatgatgagg aggacgatat ggtggcggat gaggcagcta 1021 ccgcaggcgg aagccccaac accggttcct caggtgactc aaatagcgga tctttggatg 1081 acataaatgc ggagtacgat agcggagagg agggtgacaa ctacgaggag gacggtgctg 1141 gttccgaaag cgaggctgag gttgaggcct cctgggatca gagcggaggg gcgaaggttg 1201 tgtccctaaa aagcgattcc tcatccccgt ctagcgctcc ggttgctccc gcccccgaga 1261 aggcacctgt gaagtccgaa tcggtcacga gcactcctca gctgtctgcc tctgccgctg 1321 cttttgtagc tgccaattct ggaaactcgg gaaccggagc cggagcacca ccatccactg 1381 cacaacccac atcggatccc tacttcaccc attttgatcc gcactacgag caccagagct 1441 acaaagtaag tcagaaacgc cttgaggaat cgcaccgcga gaaggtcacg cgcgttatga 1501 aggactggtc cgatctcgag gagaagtacc aggacatgcg cctagcggat cccaaggcag 1561 cccagtcatt taagcagcgg atgacggctc gcttccagac ttctgttcag gcactcgagg 1621 aagaaggcaa cgccgagaag caccagctgg ccgccatgca ccagcagcgc gttttggccc 1681 acatcaacca gcggaagcgc gaggccatga cctgctacac ccaggccctg actgagcagc 1741 ccccgaatgc ccaccacgtt gagaagtgtc tacagaagct gctgcgcgcc ctgcacaagg 1801 accgggccca cgccttggcc cactaccggc acctattgaa ctctggagga cctggtggac 1861 tagaagcagc tgcttcggag cgtccacgca cgctggagcg cctaatcgac atcgatagag 1921 ccgtaaacca gtcgatgacc atgctcaagc gctatccgga gctctccgcc aagattgccc 1981 agctgatgaa tgactacatt ctggcactgc gcagcaagga tgacattccc ggctcctcgc 2041 tgggaatgag cgaggaggcg gaggccggca ttctggacaa gtaccgcgtc gagatcgagc 2101 gcaaggtggc cgagaaagag cgactacggc tggcggagaa gcagcgcaag gagcagcgtg 2161 ccgctgagcg ggaaaaactg cgcgaggaga agctgcgcct ggaggccaaa aaggtggacg 2221 acatgctcaa gtcacaggtg gccgagcagc agtcccagcc gacccagtcg tcaacccaat 2281 cgcaggcgca gcagcagcag caggaaaaga gccttcccgg caaggagctg ggtcccgacg 2341 cagctctggt cacagcggcc aatcccaacc tagagaccac caaaagcgag aaggatctgt 2401 cggacactga gtatggggag gcaacagtga gcagcaccaa ggtgcagacc gtgctgccaa 2461 cggtcgacga cgatgccgtc cagcgggcag tggaggacgt agccgccgcc gtcgcccacc 2521 aggaggccga gccgcaggtg cagcacttca tgacccacga cctgggccac cgcgaatcga 2581 gcttctcgct gcgccgcgag ttcgcgcaac atgcacacgc ggccaaagag ggccgcaacg 2641 tctacttcac gctctccttc gccgggatcg ccctgatggc ggccgttttc gttggcgtgg 2701 ccgtggccaa atggcgaaca tcgcgctcgc cgcacgccca gggcttcatc gaggtcgacc 2761 agaacgtcac aacacaccat cccattgtgc gcgaggagaa gatcgtgccc aacatgcaga 2821 tcaatgggta cgagaatccg acctacaagt atttcgaagt gaaagagtaa gcgagatggc 2881 aagatggcag catgggcgcg gctggcaaga gcgagcgagt ggcacacatc aacaacaaca 2941 gtaaacgcaa ctgcagccac cgcgatttca aaatggaaaa acttaagcgt attattaaag 3001 cagatgggaa gagaaatgat tttttttcgt gaaatgagcg cagtttcaat aagaaagaat 3061 gaaagggtag aagaagaaag ataaattcaa taaatggtaa tatatctata tattaaatta 3121 aagcaagcag aaaggcaaca atataaagca agcaattaaa tttaagtatt tgaatgttta 3181 acaaaacgcc gtaaacatcc tttccagctc tctctttctc ttcccctgtc tctgtctctg 3241 tcccatcacc acacacacac acatcaacaa caatggcaca cactcacaca cacttgcctc 3301 taactttgtg attcttcttg agcgccagct acgcaaagag agtagaagtg ctgaagtgaa 3361 gatcatacac gcagccgaac gaagagtggt ggagcggggg aggagaggat ggagaagagc 3421 ggaagaagag caaaacaaaa gatattccta gtaaataaat tgtcgacaca cacatcacat 3481 ccacattcaa acaccgagtc acccgcagaa cagtcacacc cacactcaca catacagtgt 3541 caggaatgcg caaaaaagac acaaacgcat tcatgcctgc ttcgtagcat atttttgagc 3601 gtttcgtggc attagaacgc ttgcaagccg atcgcaattc ttaccaaaaa cctacgccat 3661 taattagagc ggcagcgaga gctaaaagat aagagcagga ggcagaaaca ccaacacaca 3721 gacacggaat ctcgcacact gagacacttg tgaacctaag agctacctac gcgtactaat 3781 ccctatacga tcgtgcatat gcgcttgtgt atatgtcgaa ctttctctct ctgtaagcca 3841 cacacactca ccagagaagg gaatagaaca cacaaaccat acacaaacca cacacgcata 3901 cacgcaaaat atatacaaaa tatttacagc aaagccagaa gaaatgtcca taaatgtatt 3961 tatgtatcta tacacgagcc acacaaagca aaggtcgaag gtcagccagc tagggaagaa 4021 tgacgacgct tggcgggctt tgaatataat atacgaatca gctatgtaac agaaacaatg 4081 caaaacgcta agctaattgc agacagaaac aaaagaagga aaaccaaata ttaaaatgaa 4141 agcgaacaaa ttttagaact ttttctgcat attttgtgtg taagtcgatg gtcgaacaaa 4201 aacaacaaga acaaaaagaa tttctctctt ttttacgtac attttcaccg aaaagacagc 4261 acaaaacaag acagcagtta caactcacaa ctcacagctc acacccacac agcacacaca 4321 cacacacaca cacgctgcac acacacacac acacacacac tgaacggagc ccttgagcca 4381 agtagagttg agttgttgca tttcatatcg aaggcttcgc aagtgttgca taattgcctt 4441 agagccaact gcggcagaaa tcagataagc gggctcggcg aatcgcaaaa tccagagagc 4501 tcgcagctcg gagacggcac cacctggagt ggacgcttcg aagaacccga ggcccagaga 4561 taaaccaatt tgaaacggct agttcatttc acggctcgat tgcttggcaa atatttggcc 4621 tgttttgttc gagcatcgag atactgttac tcaatcaagc ccaataatcg aaatgctttc 4681 cccgctgaaa gccgacaagt ggctgccctt ctcagttcgt tttccattta cgatttacgt 4741 ttaatttcca ttgccaaatt ggccattttc ttggtgtgac tcacttcggc tgagattaag 4801 tgaaagcaca cactaacaca tcacagctga aattcatgtt cagatcaaag ctaaatcaaa 4861 agtgcagcga aagtcgatat ttttcaaatg tacaaaaaca aaactggaaa ctgagaaaac 4921 aacacctaaa ttcaaaccaa aatatttgct gtacctcaaa atatatatat tctgtttcat 4981 acattaattt gtgactagcc agctttcgat cggtttaagc ttaggcatta ttcgtggccc 5041 cattttcagc ataagttctc attcgaatta aactaaattg tattggcaat tggcaattgg 5101 caatttgaac ggcatgaatc ttgggattgt ttagatcact tggctctatt gaaaagatcc 5161 gggctaagat tgttaccacg ttttaaaagc atggcaatca aggcaaatca acggcgctcc 5221 gcgacacaca cataaacaga cgcgttatat aatgtattac aaacatatat atatttcaag 5281 aggaaaaccc aaatggcaaa tcaactacac aaaaagcaaa taagaagaaa tcttactagt 5341 caaagcttga atatttttta ttttattcat taatgcaaca agaacaacaa caaaaatgaa 5401 aaaagtatac atatatataa at