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LOCUS NM_001414067 2967 bp mRNA linear INV 26-DEC-2023 ACCESSION NM_001414067 VERSION NM_001414067.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 2967) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2967) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2967) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 2967) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 2967) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 2967) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 2967) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 2967) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 2967) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 2967) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 2967) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 2967) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 2967) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 2967) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 2967) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 2967) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 2967) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 2967) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 2967) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 2967) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 2967) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 2967) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 2967) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..2967 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..2967 /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="shaggy" /map="3A8-3B1" /db_xref="FLYBASE:FBgn0003371" /db_xref="GeneID:31248" CDS 307..2682 /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /EC_number="2.7.11.1" /note="CG2621 gene product from transcript CG2621-RS; CG2621-PS; sgg-PS; zestewhite-3; glycogen synthase kinase 3; zeste-white 3; Shaggy/Glycogen synthase kinase 3; GSK3betagr; zeste white 3; shaggy/zeste-white 3; glycogen synthase Kinase-3; Zeste-white3; Shaggy/Zeste-white-3/Glycogen synthase kinase 3beta; zest-white 3; zeste white3; zeste white-3; GSK-3 kinase; saggy; Zw3 kinase; glycogen synthase kinase 3Beta; shaggy-zeste white 3; glycogen synthase kinase-3beta" /codon_start=1 /product="shaggy, isoform S" /protein_id="NP_001401051.1" /db_xref="FLYBASE:FBpp0428456" /db_xref="GeneID:31248" /db_xref="FLYBASE:FBgn0003371" /translation="MIQETSGGQYSTLKVDKSQVVPVAVPRGVRKVVRVVRKKKLAPG SGSVNEASESDGAGSGTTTSGRQNSIDASKPPAKVIKNKRGSLGGGGAAPPIPLVTKK KNKRRSSSEEEASTGNESPIESEPESGSGSSSSSAGSESDTDSETTSSSSSTTESSNA DRKSKANGKHKPLSAAAKAAQSACSSSLVVAAALKKSKPPNRSGSGASIASAGGGGKQ YKDPSMKQLIGKLNDLWPEHSVALSIPKEVDRSKEKLEGAWETTGRDGSKITTVVATP GQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMR KLEHCNIVKLLYFFYSSGEKLAEFPIDLGIFASVLKPQRDEVFLNLVLEYIPETVYKV ARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCD FGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFP GDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINL VSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL VPQLLPKHLQNASGPGGNRPSAGGAASIAASGSTSVSSTGSGASVEGSAQPQSQGTAA AAGSGSGGATAGTGGASAGGPGSGNNSSSGGASGAPSAVAAGGANAAVAGGAGGGGGA GAATAAATATGAIGATNAGGANVTAGVHLMMRQHRKLPLSGKPFVRYTANI" misc_feature 1156..2085 /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; Region: STKc_GSK3; cd14137" /db_xref="CDD:271039" misc_feature order(1186..1200,1210..1212,1249..1251,1255..1257, 1288..1290,1330..1332,1450..1461,1468..1470,1474..1479, 1597..1599,1603..1605,1609..1614,1618..1620,1654..1656, 1663..1665,1696..1698,1702..1713,1717..1719,1831..1833) /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="active site" /db_xref="CDD:271039" misc_feature order(1186..1197,1210..1212,1249..1251,1255..1257, 1330..1332,1450..1461,1468..1470,1603..1605,1609..1614, 1618..1620,1654..1656) /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:271039" misc_feature order(1198..1203,1690..1716,1738..1743,1834..1848, 1852..1857,1867..1869,1927..1938) /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:271039" misc_feature order(1288..1290,1474..1476,1597..1599,1603..1605, 1663..1665,1696..1698,1702..1713,1717..1719,1831..1833) /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:271039" misc_feature order(1651..1683,1687..1719) /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="activation loop (A-loop); other site" /db_xref="CDD:271039" misc_feature order(1738..1740,1843..1848,1852..1857,1864..1869, 1927..1944) /gene="sgg" /locus_tag="Dmel_CG2621" /gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]" /note="axin binding site [polypeptide binding]; other site" /db_xref="CDD:271039" ORIGIN 1 gctttaaatg ccaaaattgt gttcaaaatc tttcgtcaaa tattccaata aattaacttc 61 aaggacggac ggccatcacc ttttagcctt attatcatta aacaaagcgc tactttcgca 121 aaaccatcgt tgctattttg acttgaccac aagtcactag aatcagtaac catatcggcc 181 aacaagaagg cagctaaaca aggacccact cgcgatgtga aagtcaagag cacggccatc 241 gagagcggcc cctccaagcc cccgccggac aaacatctgg agcgccagtt tgtccagtcg 301 gtgaatatga ttcaagaaac cagtggcggc cagtactcca cgctcaaggt ggataagtca 361 caggtggtgc ccgtggcggt gccgcgcggt gtccgcaagg tggtgcgagt ggttcgcaaa 421 aagaagctgg cacccggcag tgggtcagtg aacgaggcca gtgaatcgga tggtgctggc 481 tctggcacca ccacctccgg caggcagaac tccatagacg ccagcaaacc gcccgccaag 541 gtcatcaaga ataaaagggg ctccctgggc ggtggtggtg cagcgccacc cataccgttg 601 gtcactaaaa aaaagaacaa acgtcgatcg tccagcgagg aggaggcgag caccggcaac 661 gaaagcccca tcgaatccga gccggaatcc ggttcgggca gcagctcctc cagcgcaggc 721 agcgaatctg atacggatag cgaaaccacc agcagtagtt cctccaccac cgagtcctcc 781 aatgcggatc gcaagtcgaa ggccaatggc aagcacaaac ccctttccgc cgcggccaag 841 gcggcccagt ccgcctgctc atcgtcgttg gtggtggccg ccgctctgaa gaaaagcaaa 901 ccgccgaacc ggagcggcag tggggccagc atcgccagtg ccggcggagg aggaaagcag 961 tacaaggacc caagcatgaa acaactgatc ggcaagctga acgacctgtg gcccgagcac 1021 agtgttgcac tgtccattcc aaaggaggtc gataggagca aggagaagct ggagggcgcc 1081 tgggagacga caggtcgcga tggttctaaa atcacaacag ttgttgcaac acccggccaa 1141 ggcaccgatc gcgtacaaga ggtctcctat acagacacaa aggtcatcgg caatggcagc 1201 ttcggcgtcg tgttccaggc aaagctctgc gataccggcg aactggtggc aatcaaaaaa 1261 gttttacaag acagacgatt taagaatcgc gaattgcaaa taatgcgcaa attggagcat 1321 tgtaatattg tgaagctttt gtactttttc tattcgagtg gtgaaaagct ggccgagttc 1381 cccatcgatt tgggcatatt cgcgagtgtg ctgaagcccc agcgtgatga agtatttttg 1441 aatttagtcc tcgaatatat accagaaacc gtatacaaag tggctcgcca atatgccaaa 1501 accaagcaaa cgataccaat caactttatt cggctctaca tgtatcaact gttcagaagt 1561 ttggcctaca tccactcgct gggcatttgc catcgtgata tcaagccgca gaatcttctg 1621 ctcgatccgg agacggctgt gctgaagctc tgtgactttg gcagcgccaa acagctgctg 1681 cacggcgagc cgaatgtatc gtatatctgc tcccggtatt accgcgcccc cgagctcatc 1741 tttggcgcca tcaattatac aacaaagatc gatgtctgga gtgccggttg cgttttggcc 1801 gaactgctgc tgggccagcc catcttccct ggcgattccg gtgtggatca gctcgtcgag 1861 gtcatcaagg tcctgggcac accgacaaga gaacagatac gcgaaatgaa tccaaactac 1921 acggaattca agttccctca gattaagagt catccatggc agaaagtttt ccgtatacgc 1981 actcctacag aagctatcaa cttggtgtcc ctgctgctcg agtatacgcc cagtgccagg 2041 atcacaccgc tcaaggcctg cgcacatccg ttcttcgatg agctacgcat ggagggtaat 2101 cacaccttgc ccaacggtcg cgatatgccg ccgctgttca acttcacaga gcatgagctc 2161 tcaatacagc ccagcctagt gccgcagttg ttgcccaagc atctgcagaa cgcatccgga 2221 cctggcggca atcgaccctc ggccggcgga gcagcctcca ttgcggccag cggctccacc 2281 agcgtctcgt caacgggcag tggtgcctcg gtggaaggat ccgcccagcc acagtcgcag 2341 ggtacagcag cagctgcggg atccggatcg ggcggagcaa cagcaggaac cggcggagcg 2401 agtgccggtg gacccggatc tggtaacaac agtagcagcg gcggagcatc gggagcgccg 2461 tccgctgtgg ctgccggagg agccaatgcc gccgtcgctg gcggtgctgg tggtggtggc 2521 ggagccggtg cggcgaccgc agctgcaaca gcaactggcg ctataggcgc gactaatgcc 2581 ggcggcgcca atgtaacagc tggtgtccat ctcatgatgc ggcaacatcg caagttgccg 2641 ttgtcgggga agcccttcgt ccgctatacg gccaacattt gattgcgatg ctatccgagc 2701 atcgttcctc tatccatcta ttataagcaa acgcctgaaa tccaagcaaa acccaggaaa 2761 gatatacgaa tagatctagt aaggaagccg tagaagaagc atgctatttg ggggcaaaga 2821 gtggaaatca tgaatcaaga attgagacaa gaattgcgaa tcaagacata acattttgca 2881 gattcaagaa gaagatgttc tcaaaaacaa attattgctg tagttatctt ttcagttgaa 2941 tataaatcag ttatttccaa gtcattt