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LOCUS NM_001382078 5890 bp mRNA linear INV 26-DEC-2023 variant O, mRNA. ACCESSION NM_001382078 VERSION NM_001382078.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5890) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5890) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5890) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5890) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5890) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5890) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5890) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5890) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5890) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5890) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5890) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5890) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5890) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5890) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5890) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5890) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5890) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5890) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5890) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5890) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5890) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5890) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5890) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5890 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5890 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 517..4347 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RO; CG34412-PO; Tlk-PO; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /transl_except=(pos:4315..4317,aa:OTHER) /product="Tousled-like kinase, isoform O" /protein_id="NP_001368971.1" /db_xref="FLYBASE:FBpp0428136" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MDQFQTSLNPRKLELLESRITGVRMSPGAHLQMSPQNTSSLSQH HPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHL HKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDM LSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSV LTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMP KVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKIND YFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGS AGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQ QQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASV VPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEV SLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLL KEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAER EEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSG VVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNS TQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPD PVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQ SRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANY IKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPER EARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDE NYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPF GHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHE YIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQ SSSSXLPTKRNSNS" misc_feature <2194..>2604 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 3328..4131 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(3337..3339,3376..3378,3382..3384,3490..3492, 3541..3552,3562..3564,3568..3570,3685..3687,3691..3693, 3697..3702,3706..3708,3748..3750,3757..3759,3826..3837) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(3562..3564,3568..3570,3685..3687,3691..3693, 3697..3699,3757..3759,3826..3837) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(3745..3783,3796..3837) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 atatttttag gccatttctg cgtgtgtgcg ttcgtgtgaa tattgtgaat atttttttta 61 ctgtgaaaat agacaaaaat cggctgtgga aaaccgaagt aaacacattt gggaatcatg 121 gcgattggcc cttaacctta acccttaagt gtcgtgccga cagtgccacg ccacaaaccc 181 aaatcccaaa gaaacaaaag cgaaagaaaa aaaaaaaaga acaacaaaaa gctatagttg 241 cagcctctga aagtttaaga caatcgccga tccgatcgga agcggaagat atatgctcgc 301 cacaccaaat ggcatgatga atttgtcact ttattattgc catggctctg acaaatcttg 361 tcgcactcgt tgccgacatt tgcaatcgat caatattaaa atattgaata actaaaccaa 421 ccacgagcta aaagaaaaat ttcagaaaaa cttttgtatc tgaatcgaaa acaaaaaaaa 481 aaacaaattc ctatcggcgc ttataatcac aaagtaatgg atcaatttca aacttcacta 541 aatccgcgga aactcgagct tctggagtct cgaattactg gagtgcggat gtcccccggc 601 gcccatttgc agatgtcccc gcagaacact tcgtccctaa gtcaacacca tccacatcaa 661 cagcaacagt tacaaccccc acagcagcaa caacagcatt tccctaacca tcacagcgcc 721 cagcaacagt cgcagcagca gcagcaacag gagcaacaga atccccagca gcaggcgcaa 781 cagcagcagc agatactccc acatcaacat ttgcagcacc tgcacaagca tccgcatcag 841 ctgcaactgc atcagcagca gcaacaacaa ctccaccagc aacagcagca acacttccac 901 cagcagtcgc tgcaagggct gcatcagggt agcagcaatc cggattcgaa tatgagcact 961 ggctcctcgc atagcgagaa ggatgtcaat gatatgctga gtggcggtgc agcaacgcca 1021 ggagctgcag cagcagcgat tcaacagcaa catcccgcct ttgcgcccac actgggaatg 1081 cagcaaccac cgccgccccc acctcaacac tccaataatg gaggcgagat gggctacttg 1141 tcggcaggca cgaccacgac gacgtcggtg ttaacggtag gcaagcctcg gacgccagcg 1201 gagcggaaac ggaagcgaaa aatgcctcca tgtgccacta gtgcggatga ggcggggagt 1261 ggcggtggct ctggcggagc aggagcaacc gttgttaaca acagcagcct gaagggcaaa 1321 tcattggcct ttcgtgatat gcccaaggta aacatgagcc tgaatctggg cgatcgtctg 1381 ggaggatctg caggaagcgg agtaggagcc ggtggcgccg gaagcggggg aggtggcgct 1441 ggttccggtt ctggaagcgg tggcggcaaa agcgcccgcc tgatgctgcc agtcagcgac 1501 aacaagaaga tcaacgacta tttcaataag cagcaaacgg gcgtgggcgt cggtgtgcca 1561 ggtggtgcgg gaggcaatac cgctggcctt cgaggatcac atacgggagg tggcagcaag 1621 tcaccctcat ccgcccagca gcagcaaacg gcggcacagc agcagggaag cggtgttgcg 1681 acgggaggca gtgcaggcgg ttccgctggc aaccaggtgc aagtgcaaac gagcagcgct 1741 tacgcccttt acccaccagc tagtccccaa acccagacgt cacagcaaca gcagcagcag 1801 caaccgggat cagactttca ctatgtcaac tccagcaagg cgcagcaaca acagcagcgt 1861 caacagcaac agacttccaa tcaaatggtt cctccacacg tggtcgttgg ccttggtggt 1921 catccactga gcctcgcgtc cattcagcag cagacgccct tatcccagca gcaacagcag 1981 caacaacagc agcagcaaca gcagcaactg ggaccaccga ccacatcgac ggcctccgtc 2041 gtgccaacgc atccgcatca actcggatcc ctgggagttg ttgggatggt cggtgtgggt 2101 gttggcgtgg gcgttggagt aaatgtgggt gtgggaccac cactgccacc accaccgccg 2161 atggccatgc cagcggccat tatcacttat agtaaggcca ctcaaacgga ggtgtcgctg 2221 catgaattgc aggagcgcga agcggagcac gaatcgggca aggtgaagct agacgagatg 2281 acacggctgt ccgatgaaca aaagtcccaa attgttggca accagaagac gattgaccag 2341 cacaagtgcc acatagccaa gtgtattgat gtggtcaaga agctgttgaa ggagaagagc 2401 agcatcgaga agaaggaggc gcgacagaag tgcatgcaga atcgcctcag gctcggacag 2461 tttgttaccc aacgagtggg cgccacattc caggagaact ggacggacgg ctatgcgttc 2521 caggagctga gtcggcggca agaagaaata accgctgagc gtgaagagat agatcggcag 2581 aaaaagcagc tgatgaaaaa gcgtccggcg gagtccggac gcaagcgcaa caacaacagt 2641 aaccagaaca accagcagca gcagcaacag caacaccagc aacagcagca gcaacaaaat 2701 tccaactcga acgattccac gcagctgacg agcggagttg ttaccggtcc aggcagtgat 2761 cgtgtgagcg taagcgtcga cagcggattg ggtggcaata atgcgggcgc gatcggtggc 2821 ggaaccgttg gtggtggcgt tggaggtggt ggtgttggag gcggtggtgt cggaggcggc 2881 ggtggacgtg gactttctcg cagcaattcg acgcaggcca atcaggctca attgctgcac 2941 aacggcggtg gtggttcggg cggcaatgtc ggcaactcgg gcggcgttgg cgaccgcttg 3001 tcagatcgag gaggaggagg tggcggcatc ggcggaaacg atagcggcag ctgctcggac 3061 tcgggcactt tcctgaagcc agaccccgta tcgggtgcct acacagcgca ggagtattac 3121 gagtacgatg agatcctcaa gttgcgacaa aatgccctca aaaaggagga cgccgacctg 3181 cagctggaga tggagaagct ggagcgggag cgcaatctgc acatccgaga gctcaagcgg 3241 attcttaacg aggatcagtc ccgctttaac aatcatcccg tgctgaatga tcgctatctt 3301 ctgttgatgc tcctgggcaa gggcggcttc tcagaggtcc acaaggcctt cgacctgaag 3361 gagcaacgct atgtcgcatg taaggtgcac caattaaaca aggattggaa ggaggataag 3421 aaagctaatt atatcaaaca cgctttgcgg gaatacaaca ttcacaaggc actggatcat 3481 ccgcgggtcg tcaagctata cgatgtcttc gagatcgatg cgaattcctt ttgcacagtg 3541 ctcgaatact gtgatggcca cgatctggac ttctatttga agcaacataa gactataccc 3601 gagcgtgaag cgcgctcgat aataatgcag gttgtatctg cactcaagta tctaaatgag 3661 attaagcctc cagttatcca ctacgatctg aagcccggca acattctgct taccgagggc 3721 aacgtctgcg gcgagattaa gatcaccgac ttcggtctgt caaaggtgat ggacgacgag 3781 aattacaatc ccgatcacgg catggatctg acctctcagg gggcgggaac ctactggtat 3841 ctgccacccg agtgctttgt cgtgggcaaa aatccgccga aaatctcctc caaagtggac 3901 gtatggagtg tgggtgttat cttctaccag tgtctgtacg gcaaaaagcc cttcggtcac 3961 aatcagtcgc aggccacgat tctcgaggag aatacgatcc tgaaggccac cgaagtgcag 4021 ttctccaaca agccaaccgt ttctaacgag gccaagagtt tcattcgggg atgcttggcc 4081 tatcgcaagg aggatcgcat ggatgtgttc gcactggcca ggcacgagta cattcagcca 4141 ccgataccga aacatgggcg cggttcgctc aatcagcaac agcaggcgca acaacagcag 4201 cagcaacaac agcaacagca gcagcaacag tcgtcgacgt cacaggccaa ttctacaggc 4261 cagacatctt tctctgccca catgtttggc aatatgaatc agtcgagttc gtcctagctg 4321 ccaaccaagc gcaattcgaa ctcataattc gccgccgccg cagtagcagc agctacatta 4381 gctgccagta gtcaacagca acttcaacac cagcaacagc aactccaaat ccagcaatac 4441 cagcagaatc agcaacttca tttgcaaaac agcagtagca attatgcggc cacgcttcta 4501 gatgcagcgg ccttttgcta cgaaaccgtg atggatgcag cccacttcca aaacaacaat 4561 aataacagca ccatcatcaa gaacaatatg cagacaatgc cggcaaacgc tgccaatgct 4621 gctgcagctg cagggggagg gggaacaccg acctatcagg ggaaatacaa gcgctggcag 4681 cagcaacagt tacaacagca ggcgcaactc caacagcagc agcacaagct gctgttgcag 4741 caagagctgc tctaaaatat gaagggaatg atgacaagcg agtttaagag aacgaggagc 4801 tgcctgccac actgccgccg tcagcaataa caacatccca agaaaattca cagcgagtcg 4861 caaaagcatc aacaaacaaa gcaaaaaacg caaaaaagga ttacaaagac gcagagaata 4921 ggggacattt gcaatgggaa ataacaaatt attgcattat ctgctggatt gtgattgtgg 4981 ttcaaacatt aaaaatacac ttactcatac acacaaggta gacactgcag actaattttg 5041 ccttaaaaga aacaaaacga ataatgttaa ctgtaaattt tcactttgtg tccatgcata 5101 gttactagta atgatgatat aaatatataa atatatataa aatataaaaa ttatataaat 5161 gtataaattt atatttatat atatatatat atatatatat atatatctgc ataaacattg 5221 aagcatacta gtaaatcttt ataaatatat ttatatatat atttatctct tccttttaac 5281 gcttttaatc ggaaaaaaca tcccaattat attttaattc aatttgaaat ataaaagtca 5341 tttttgtttg ttttgtatca aaatccaaaa aaaattgatt taaatataaa aataccataa 5401 acattaacac cacacacaca cacacacaca catatatata tatatatata tatatatata 5461 tatatacata tatatataca tttgtatata gtcgtatctg aaccacaaac aaatccacag 5521 ataaaaaaaa ctgaaaaatt catagaatca aaccattttt ttatatgcca caaagaaaag 5581 aaaataagta gaaatgcaag aaaaatcgag aaaaagcgta attcatgaga tcagatcgga 5641 tcagaaaaat caacagaaaa taaacctatt tgaagtaaaa tacttctaaa tacatagtaa 5701 actaatgtaa tagtttttat taaaattaca catatatgta tcgatatata tacatgtttt 5761 ttttttttta attttaaaat tataattgta atgcactatg cgtaaattgt attaaatatt 5821 aatatccaag gcatattaat agaaatatat atacatatat aaaacctgca aaaaaaaaac 5881 atgaactacc