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Drosophila melanogaster Nna1 carboxypeptidase (Nna1), transcript


LOCUS       NM_001298298            5582 bp    mRNA    linear   INV 26-DEC-2023
            variant J, mRNA.
ACCESSION   NM_001298298
VERSION     NM_001298298.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5582)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5582)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5582)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5582)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5582)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5582)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5582)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5582)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5582)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5582)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5582)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5582)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5582)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5582)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5582)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5582)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5582)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5582)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5582)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5582)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5582)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5582)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5582)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5582
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5582
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="Nna1 carboxypeptidase"
                     /map="12B3-12B4"
                     /db_xref="FLYBASE:FBgn0265726"
                     /db_xref="GeneID:32329"
     CDS             269..5353
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /EC_number="3.4.17.-"
                     /note="CG44533 gene product from transcript CG44533-RJ;
                     CG44533-PJ; Nna1-PJ; drosophila Nna1 ortholog"
                     /codon_start=1
                     /product="Nna1 carboxypeptidase, isoform J"
                     /protein_id="NP_001285227.1"
                     /db_xref="FLYBASE:FBpp0309522"
                     /db_xref="GeneID:32329"
                     /db_xref="FLYBASE:FBgn0265726"
                     /translation="MQKGVKDKENRNSAMGPEICEVQQHPSKQNDGFLGSFLSKGLKT
                     NQLVVNTDEKTLRPVARLKEPRDLFALPKDKDNDCSQQAPRWPVECQVIEERIIHIPY
                     VPAVPEPLNAPTGNELKPRPVGEENGIVVFSYSPISAVNYEKPKAKKEDDESSDESDY
                     SSDSRQDSTPPSRSTPMRLAGGGECAPGKLNSVSKMINNVDNRSTSASLDDNDDYYDD
                     EYDTSGGYCGGSGEAKEKAIIKDLIEAKKKRYQEEAEVTPVGGGTARNSRAASRSEAS
                     KDASDIDDIWKNNTSEYKPASPRYVLSQFGKNVTKAVIDRIVDHEDLVPPSGSQKVSN
                     QFAVGPVKLPKTNIARLEVAFERSACQDRSKSRLKKKMSSSRRRRESTSDEDSSSSSL
                     GNEEDEEVDDSDSDAENTGSGIGLRRILGSYSARLAGGAEKCPCPGSGSVSDTETLVG
                     DESRSRLAGSNGLHQQDVVCSRNRQAQSRSPLRSVPHTHAATVAAAAAALARGRNRDK
                     DGCLGGKDEKNMGMGVGTTGTSSMGTRTSSPVRNNVFRLSKDQHILLNSMTSQETTGT
                     LISSTSTNQTTTTTNSSQSFLCSDLPQAQFSRSAVGGARFMTNCHPMNPEEYDGLEFE
                     SRFESGNLAKAVQITPTYYELYLRPDLYTSRSKQWFYFRVRRTRRKMLYRFSIVNLVK
                     SDSLYNDGMQPVMYSTLGAKEKSEGWRRCGDNICYYRNDDESASSSANEDDEDNSTYT
                     LTFTIEFEHDDDTVFFAHSYPYTYSDLQDYLMEIQRHPVKSKFCKLRLLCRTLAGNNV
                     YYLTVTAPSSNEENMRRKKSIVVSARVHPSETPASWMMKGLMDFITGDTTVAKRLRHK
                     FIFKLVPMLNPDGVIVGNTRNSLTGKDLNRQYRTVIRETYPSIWYTKAMIRRLIEECG
                     VAMYCDMHAHSRKHNIFIYGCENKRNPEKKLTEQVFPLMLHKNSADRFSFESCKFKIQ
                     RSKEGTGRIVVWMLGITNSYTIEASFGGSSLGSRKGTHFNTQDYEHMGRAFCETLLDY
                     CDENPNKILNLLKQQDRLRSKIIERLMREGSSADEPLNIPLSDYSSDEGNCSSSSDNE
                     GKHSITTSDLEGPCCAPTRAPPSSPEVIHEIRKARRTKVRNKPSKKRGEVVRTTLDLP
                     TTDPGSDLHFSTDDEEHSPTSGHNGYGAVPPLRHTLLQSDLQRRYIEEIGDTVVQKPK
                     ASHMPPELIVTTPSKSGTPGGGKKLDVYKLTPRTAPELDTGIGMMQRQAGGTGTSARR
                     TYSWHNLDQQEIPNGNGGGQGKANFYIGDTKPGIKTMAKPLPRRSVPSNFIPQRHGNV
                     QTADDLQLKLSLKKKVWTGANGDADGRPLAWYKGHSITASQMANTTTTIRSAGGGAAG
                     GGGAGAGAGAGGGGGGQNRNMFPSNGREQTAASGGIAMGVPPAFVGAPRRVRKLEQVD
                     LFNACSQKLMMWQQQEEQRRSHPQQAQRLLKVEDHPQHSRDREQQPFKPMHVVRKSTG
                     TTSQAKVIQALVAAESGGKVKRKSSSMMKIAETTQLVTRFARNRNSAGGSAAQQQQQQ
                     QPPQHMHHQHKRLLFKGQGGVGAMGSRMHSAGVMGNMQGNGGGRAPNKFKTGGLVITA
                     VQQPTNMTGGGSRRMRNAAGLQAKGSNGALGSSTGQMQYQRSNASVQANKSATEISMD
                     AVSLVRKVKTKLKKRKSRTLSTGAPK"
     misc_feature    2135..2542
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     Region: Pepdidase_M14_N; pfam18027"
                     /db_xref="CDD:407865"
     misc_feature    2606..3361
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="Peptidase M14-like domain of ATP/GTP binding
                     protein AGBL-2 and AGBL-3, and related proteins; Region:
                     M14_AGBL2-3_like; cd06907"
                     /db_xref="CDD:349478"
     misc_feature    order(2744..2746,2753..2755,2894..2896,2921..2926,
                     3032..3037,3062..3064,3251..3253)
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="active site"
                     /db_xref="CDD:349478"
ORIGIN      
        1 caaaaaccca tccgtagcat ttgttttttt taatttatat tcaccctttt gtcactcatt
       61 taacacacat gaacgcacga atggaaaaat cgcattccta atcgggagac aaattcagca
      121 caaggctcgt ccatcaatcg catccacgta ttggtggtaa ccaccccctc cacatcaagt
      181 aaagtcacgt taccccaaga agatcccgag gacgtggatt aaagggccag acggaaaaag
      241 aaggatcaga aggaacagcg cacccgaaat gcagaagggc gtcaaggaca aggagaaccg
      301 gaattcggcg atgggtccgg agatctgtga ggtccaacag catccatcta agcaaaacga
      361 tggcttcctt ggcagtttcc tatcgaaggg cctaaagacc aatcagctgg ttgtgaatac
      421 ggatgagaag accctgcgac cagttgcacg tctgaaggaa ccgcgcgatc tcttcgccct
      481 gccgaaggac aaggacaatg actgctcaca gcaggccccc agatggccgg tggaatgcca
      541 ggtcatcgag gagcgcatca tacacattcc gtacgtgccc gctgtgccgg agccgctcaa
      601 tgctccgacg ggaaacgagc tgaaaccgcg tcccgttggc gaggagaacg gcattgtggt
      661 gttcagctac agtccaatta gtgccgtcaa ctatgaaaag cccaaggcga agaaggagga
      721 cgatgagtcc agcgacgaat cggactattc ctcggactct cgccaggatt cgacgccgcc
      781 gagccgatcc acgcccatgc gcctggccgg cggcggtgaa tgtgcacctg gcaaactgaa
      841 cagcgtgtcc aagatgatca acaatgtgga caatcggtca accagtgcgt ccctagacga
      901 caacgatgac tactacgatg atgagtacga tacgtccggc ggttattgtg gtggaagcgg
      961 tgaggccaaa gagaaggcca tcattaagga tctcatcgag gcgaagaaga aacgctacca
     1021 ggaggaggca gaggtcacac ccgtaggtgg tggcacagcc cgaaattcga gagccgccag
     1081 ccgttcggag gccagcaagg atgccagcga tatcgacgat atctggaaga acaataccag
     1141 cgaatataag ccagcctcgc cgcgctacgt cctcagccag tttggaaaga atgtgaccaa
     1201 ggcggtgatc gatcggatcg tggatcacga agatctcgtc ccgccatcgg gatcccaaaa
     1261 ggtatcgaac cagttcgccg taggccccgt caagttgccc aaaacaaata tagcccgctt
     1321 agaggtggcc tttgagcgaa gtgcctgcca agatcgatcc aaatcgcgtt tgaaaaagaa
     1381 aatgagtagc agtcgtcggc gtagggaaag cacctctgac gaggactcca gtagctctag
     1441 tttgggtaat gaagaagatg aagaggtgga tgattccgat tcggacgcag agaatacagg
     1501 aagtggcatt ggcttgcgca gaatcttggg aagctattcg gcccgtctcg ctggtggcgc
     1561 cgaaaagtgt ccttgtcccg gttccggatc cgtttcggat acggaaactt tggtgggaga
     1621 cgagagcagg agcaggctgg ctggctctaa tggcctgcat cagcaagatg ttgtatgctc
     1681 taggaatcgg caggcgcaat cgcgatcccc attacgatcg gtaccccaca cccatgcggc
     1741 cactgtggcg gcggcggcag cggcgctcgc cagggggcgc aaccgcgaca aggacggttg
     1801 tctgggtggc aaggatgaaa agaatatggg catgggagtg ggaacaactg gcacaagctc
     1861 gatgggcact cgcacctcct ctcccgttcg caataacgtc ttccggctga gtaaggatca
     1921 gcacatattg ctgaattcga tgaccagcca ggagacgacc ggcactttaa tctcgtcgac
     1981 aagtactaac caaacgacga cgaccaccaa ctcgtcgcaa tcgtttcttt gctccgattt
     2041 accccaagcg cagtttagcc gttcggccgt cggtggtgcc cgcttcatga ccaattgcca
     2101 tcccatgaat ccggaggagt acgatggact ggagtttgaa tcgcgcttcg agagcggcaa
     2161 cctggccaag gcggtccaaa ttacgcccac ctactacgag ctctacctgc gacccgatct
     2221 ctataccagc cggtccaagc aatggttcta cttccgtgtg cgacgcacca ggcgcaagat
     2281 gctctaccgc ttctccattg tcaatctggt gaagtcggac agtctttaca acgatggtat
     2341 gcagccggtc atgtactcca cgctgggcgc caaggagaag agcgaaggct ggcgcagatg
     2401 cggcgacaac atctgctact atcggaacga tgatgaaagt gccagcagta gcgccaacga
     2461 ggatgacgag gacaactcca catacacgct gacctttacc attgagttcg agcacgacga
     2521 cgacacggtg ttctttgcgc acagctatcc gtacacctat agcgacctgc aggactacct
     2581 catggagatc caacgccatc cggtcaagtc aaagttctgc aagctgcgcc tgctctgccg
     2641 caccttggct ggcaataatg tctactatct gacggtgacg gcgccctcat ccaacgagga
     2701 gaacatgcgg cggaagaaat cgattgtggt atcggcacgt gtccatccca gcgagacgcc
     2761 agcctcgtgg atgatgaagg gtctgatgga cttcatcacc ggggacacaa cagtggccaa
     2821 gcggttgcgg cacaagttca tttttaaatt ggtgcccatg ctaaatccgg acggagtcat
     2881 tgtgggcaat acacgtaact cgctgaccgg caaggacctg aaccgccagt accgaacggt
     2941 aatacgcgag acatatccat ccatttggta taccaaagcc atgattagaa gactgattga
     3001 ggaatgcggc gtggccatgt actgtgatat gcacgctcac tcacgcaagc acaacatatt
     3061 catatatggc tgtgagaaca aacgcaaccc ggagaagaag ttaaccgagc aggtctttcc
     3121 gctgatgctg cacaagaaca gtgcggatcg gttctccttc gagagctgca agttcaaaat
     3181 tcagcgcagc aaggagggca ccggacgtat cgtggtctgg atgctgggca tcaccaacag
     3241 ctatacgatc gaagcctcct ttggcggctc ctcgctggga tcgcgcaagg gtacgcactt
     3301 caacacgcag gattacgagc acatgggacg agcattttgt gagacacttc tggactactg
     3361 cgatgagaat ccgaacaaaa ttttaaattt actcaaacaa caggacaggc tacgatcaaa
     3421 aattatcgaa agactgatgc gagaaggctc tagtgccgac gaaccattga atattcccct
     3481 gtcagattac tcaagcgacg agggcaactg cagctccagt tcggataatg agggtaaaca
     3541 ctcgataacg acatccgatc tggagggacc atgttgtgct cccacccgag caccgcccag
     3601 ttcgcctgag gtcatacacg aaatccgcaa ggcgcgtcgc actaaggtaa ggaataagcc
     3661 ttcaaagaaa cgtggcgagg tggtgcgcac caccctggac ctgcccacaa cggatcccgg
     3721 ctcggatctg cacttctcca ccgacgacga ggagcactcg ccgacgtccg gacataatgg
     3781 ttacggtgca gtgcctccgc tccggcatac gctgctccag agcgatctgc agaggcggta
     3841 catcgaggaa attggcgata cggtggtgca gaaaccaaag gcgtcgcaca tgccgccgga
     3901 actgattgtg accacacctt cgaagagcgg cactccgggc ggtgggaaaa aactggatgt
     3961 ctacaagctg acgcctcgaa ctgctccaga attggacacg ggtattggca tgatgcaacg
     4021 gcaggccggc ggaactggca catccgccag acgcacctat tcgtggcaca atctcgatca
     4081 gcaggagatt cccaatggca acggcggtgg tcagggcaag gccaactttt acataggcga
     4141 taccaagcca ggaataaaga cgatggcaaa accgctcccc agaaggagtg tcccgagcaa
     4201 cttcattccc cagagacatg gaaatgtgca aacggccgat gacctgcagc ttaagctttc
     4261 gctgaagaag aaagtctgga ctggtgcgaa cggggatgcg gatggtcgcc ctctggcctg
     4321 gtacaagggt cactcgataa cagcatccca aatggccaac actacgacga ccatacgaag
     4381 tgcaggcggt ggtgctgcag gaggaggagg agctggagct ggagctggag cgggtggagg
     4441 tggcggtggt cagaaccgaa acatgttccc ctccaatggc agggagcaga cagctgcgtc
     4501 tggtggcatc gccatgggtg tgccacccgc ctttgtggga gcaccacgaa gagtcagaaa
     4561 actggagcaa gttgatctgt tcaatgcttg ttctcagaag ctgatgatgt ggcagcaaca
     4621 agaggagcaa cggcgctccc atccgcaaca ggcgcagcgc ctactgaagg ttgaggatca
     4681 tccgcaacat tcaagggacc gggagcagca gcccttcaag cccatgcacg tggtcagaaa
     4741 gtcaacggga acgaccagcc aggccaaagt cattcaggct ttggtggcag ccgaatccgg
     4801 cggtaaggtg aaacgcaagt ccagcagcat gatgaagata gcagagacca cgcagctggt
     4861 gactcgattc gcccggaatc gcaacagcgc cggaggatcc gcagcacagc agcagcagca
     4921 gcagcagcca ccacaacata tgcaccacca gcataagcgg ttgttgttca agggccaagg
     4981 cggagtgggg gcaatgggct ctcgaatgca ctctgccggc gtgatgggta acatgcaggg
     5041 caacggcgga ggacgtgcgc ccaacaaatt caagaccggc ggacttgtga tcaccgccgt
     5101 gcagcaaccg accaatatga ccggtggagg ctccaggcgg atgagaaatg cagccggatt
     5161 gcaggccaag ggcagcaatg gcgccttggg ttcatccacc ggtcaaatgc aataccagcg
     5221 cagcaatgcc agtgtccagg ccaacaaatc cgcaacagaa atctccatgg acgccgtaag
     5281 tctggtgcgg aaggtgaaga ccaaactgaa gaagcgcaaa tcccgcactt tgtcaaccgg
     5341 agcaccgaaa taattgaccc agaatctccg ccaggtgcat caccgagttt tttcattcaa
     5401 aattttagtc aaatttaatc cgttttagac ccgtccgttt ttgttacgta aaaaagcgat
     5461 aagaaaatga ttagcaaaat taactaaata attgataaca cctataggcg tattttatgc
     5521 atatgtaaac ccgatctctg tacctacagt taatccctaa aatatgtaat gttgaaagtc
     5581 ct