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Drosophila melanogaster neuropilin and tolloid-like, transcript


LOCUS       NM_001298282            6903 bp    mRNA    linear   INV 26-DEC-2023
            variant B (Neto), mRNA.
ACCESSION   NM_001298282
VERSION     NM_001298282.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6903)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6903)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6903)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6903)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6903)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6903)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6903)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6903)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6903)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6903)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6903)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6903)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6903)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6903)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6903)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6903)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6903)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6903)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6903)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6903)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6903)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6903)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6903)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6903
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6903
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /old_locus_tag="Dmel_CG15753"
                     /old_locus_tag="Dmel_CG32635"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="Neuropilin and tolloid-like"
                     /map="11F7-12A2"
                     /db_xref="FLYBASE:FBgn0265416"
                     /db_xref="GeneID:32303"
     CDS             597..3065
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /old_locus_tag="Dmel_CG15753"
                     /old_locus_tag="Dmel_CG32635"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="CG44328 gene product from transcript CG44328-RB;
                     CG44328-PB; Neto-PB; neuropilin and tolloid-like"
                     /codon_start=1
                     /product="neuropilin and tolloid-like, isoform B"
                     /protein_id="NP_001285211.1"
                     /db_xref="FLYBASE:FBpp0308760"
                     /db_xref="GeneID:32303"
                     /db_xref="FLYBASE:FBgn0265416"
                     /translation="MRRRGSTCSAQQPQQRPHKQQQQQQQQNQRLIPGQRCSLLMLLI
                     VGQAVYASAGSEIIANRSASAGESLIMLSNFTVATPPPAPRFTSPFREQDVAEGEELA
                     GGGQVDWLDEQHPLTISRPPRAGRSERQAEEDQVDRCRLFVEGDPTKNELYSPEYPNL
                     YPKNINCTRVITAPKGQIIRLDFRNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCG
                     TDFPPEITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDLNCTIDKGGFEG
                     FINSTDVPAEIWEQVNRNKIALDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDI
                     FPEQTVMPLRVKNFCGSAGESITAESNILHLRFYADQTAINSTFGILFTAFRERGAAC
                     TEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGCTSEAAGQSEHVVIIVIVFGLILGG
                     MVITFIVNCIRKIIRDQKIIREHIRESKESKLDEMGRNSKGRSRENISRQKHSQTSLQ
                     ILDDVSNRYYREAVPLSSQSSKADFKEKEHSILRRHADMTQTSLCGVGEDDGESSSTT
                     TATHEMMTKAAMSAVPSNACDMGCQTRESLFVNSPGIGPSAGPGVGVAVGIGIAVAPG
                     GGVATLMRQKSSSSSLGVGGGAGGGAMMMPPPPPRFFSTFGYEPSGSPAVATLTRRSM
                     HQQQQHPQMPRQESMEMEERHSGRSHYGGLLVTSTAKQPQEICHHHHQHQQQHQQQHQ
                     QQQQQQQQQQQQQQRMHHAHPHPPSIAARLPAMKGHGTVMGQTTILPGGNKQQQQHQQ
                     KNEESKVFIDIRNSAPDVIIMTSH"
     misc_feature    1047..1352
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /old_locus_tag="Dmel_CG15753"
                     /old_locus_tag="Dmel_CG32635"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; Region: CUB;
                     cd00041"
                     /db_xref="CDD:238001"
     misc_feature    order(1047..1049,1053..1055,1134..1136,1152..1154,
                     1266..1268,1338..1340,1344..1346,1350..1352)
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="heterodimerization interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238001"
     misc_feature    <1488..1748
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /old_locus_tag="Dmel_CG15753"
                     /old_locus_tag="Dmel_CG32635"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; Region: CUB;
                     cd00041"
                     /db_xref="CDD:238001"
     misc_feature    1770..1874
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /old_locus_tag="Dmel_CG15753"
                     /old_locus_tag="Dmel_CG32635"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(1785..1787,1809..1811,1842..1847)
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(1821..1823,1830..1832,1842..1844,1860..1865)
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    1851..1865
                     /gene="Neto"
                     /locus_tag="Dmel_CG44328"
                     /gene_synonym="CG12727; CG15751; CG15752; CG15753;
                     CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO;
                     tld-like"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
ORIGIN      
        1 cccagtctac gtcgagttgg ccacgtgtac ggacacgcgg cgcggttcgc tttctccggt
       61 gacagcacat tcgatattaa cgtttcacta ccaaaaaaaa aaaaacatcg cgattggttg
      121 ctaatagaca agcaccagag atacgatttt aaaatcttaa ggttttgctt ttgttcaaaa
      181 gaaatacaaa tttttttgtt tggttgtttg tgtgacagtg acagtgccag tgtgaaagtg
      241 tgtgtgtgtg aaaagcttgc cggcttgaaa aatgcgcgcc aaaaattgag atattttcgc
      301 ggagcgcagc ggcaacaaaa acaaataaaa acaacatttc gcaacgcagc caaaggaggc
      361 gacaacacgc aaatagacac tctgaagtgt atggtcgttg gaattcgcaa atctaaggac
      421 tggcaaatta aaaactaaat gacgcatgat taacaaacgc tctgctgttc gttgtcggaa
      481 tttttgcgtt acgtgtgagg gactcttact gcgagcggag cagcagaaag agagggtgca
      541 agtaggctag agcgaggcgg agactataag actgaagctg gcaaacctca cacaaaatgc
      601 gaagaagagg aagcacttgc agcgcacaac aaccacagca gcggccacac aaacagcagc
      661 agcagcagca gcagcaaaat caaaggttaa tccccggcca acgctgttcg ctgctaatgt
      721 tgctaattgt tggccaagca gtttacgctt ctgccggcag tgagataatc gcaaatcgtt
      781 cggcttcagc tggcgaatcg ttgataatgc tgtcgaattt caccgttgcc acgccgcctc
      841 ccgccccaag attcaccagt ccctttcggg agcaggatgt ggctgagggg gaggagttgg
      901 cgggtggagg gcaggtcgat tggttggacg agcagcatcc gctgaccatt tcccgaccgc
      961 caagagcagg acgcagcgag cggcaggcag aagaggatca ggtggaccgc tgtcgtctct
     1021 ttgtcgaggg ggatcccacc aagaatgagc tgtacagccc cgagtatccc aacttgtatc
     1081 cgaagaacat caactgcacc cgggtgataa cagcgccaaa gggacaaatc atacgcctgg
     1141 actttcgcaa ctcgtttaat atcgaggcca aggaggggtg caaatttgat tttctcgaaa
     1201 tacgagatgg ccagtacggt ttctctacgc tgattggcaa gttctgcggc accgactttc
     1261 cgccggagat cacctcgaag gagcggtatt tgtggcttca tttccactcc gacgagacca
     1321 tcgagtacac cggattcagt gcggtctatg agtatctgga caggagtcgg gatgcgccca
     1381 gcaccgatct caactgcacc atcgataagg gcggcttcga gggcttcatc aactccacgg
     1441 atgttccggc cgagatctgg gagcaggtca atcgcaataa gatcgcgctg gactgcatct
     1501 ggcgcattca ggtcaaggag aattggaaga tatttctcaa gtttctggac ttcaagctga
     1561 gcaagccgaa cgattgtcaa accaacttcc tggatatatt cccggagcag acggtgatgc
     1621 cactgagggt taagaacttt tgcggttcag ctggcgagag tattacggcg gagtcaaata
     1681 tcctgcactt gcgcttctac gcagatcaaa ccgcgattaa ctcgacattt ggcattctgt
     1741 tcacggcgtt ccgggaacgt ggagctgcct gcaccgagga cgagtacgat tgcgaggacg
     1801 cgacctgcat atcaaaggat ttgaaatgta ataacctaga caattgtaaa tttcgatggg
     1861 acgaggaggg ctgcacgagc gaggcggccg gccaatcgga gcacgtggtc atcatcgtga
     1921 ttgtgtttgg cctgatactc ggcggaatgg tcattacgtt catcgtcaat tgcatacgca
     1981 agataatacg tgatcagaag ataatacgcg agcacatccg agagtcgaag gagagcaagc
     2041 tggacgagat gggccgcaac tccaagggac gctcgcggga gaatatatcc aggcaaaagc
     2101 actcgcaaac atcgctgcag atcctggatg atgtatccaa tcgatactat cgcgaggcgg
     2161 ttccactatc gtcgcagtcc agcaaggcgg acttcaagga gaaggagcac agcattctgc
     2221 gccgccatgc cgatatgacg caaacaagtc tctgcggcgt tggcgaggat gatggcgaat
     2281 cctcatcgac gacgacggcc acacacgaga tgatgactaa ggcggccatg tcggcggtgc
     2341 cctccaatgc atgcgacatg ggctgtcaga cgagggaatc gctgtttgtc aacagtcccg
     2401 gaattggacc gtcggcgggt cctggtgttg gtgttgctgt tggcatcggt atcgccgtcg
     2461 ctcccggcgg cggtgttgcc acgctaatga gacaaaagtc cagctcctca tcgctgggcg
     2521 ttggtggtgg cgctgggggc ggggccatga tgatgccgcc cccgccaccg cgattcttct
     2581 ccacctttgg ctatgagcca tcgggatcgc cggcggtggc aacgctgaca aggcgcagca
     2641 tgcaccagca gcagcaacat ccgcagatgc cgcgccaaga gtccatggag atggaggagc
     2701 gacacagcgg ccgctcgcac tacggcggcc tgctggtgac ctcgacggcc aagcagccgc
     2761 aggagatctg tcaccatcat caccagcatc agcagcagca tcagcagcag catcagcagc
     2821 agcagcagca gcagcagcag caacagcaac agcagcagcg catgcaccat gcacatccgc
     2881 atccgccgag tattgctgca cgtttgcctg cgatgaaggg gcatggaaca gtcatgggac
     2941 agactacgat cctgcccggc ggcaacaagc agcagcagca acatcagcaa aagaacgagg
     3001 agtccaaagt gtttatcgac atacggaatt cagcgccaga cgtgattatc atgacgtccc
     3061 attgacattt aaggatggcc cgccaatcag caacaacaac aacgacggta gagagcacga
     3121 ggagcaggag gagcagcagc agcagcagca gctgcagcag gaggagcagc agcaacatcg
     3181 gcgcaaagag gatgcgttgc agcaactgga catcggccaa catattaacc gcagccgcag
     3241 cgtcgctgat gacacaacaa ggacaccgag gaggcgcgtt gcaatcagac aaaggggcgg
     3301 tggtgctgct ggtgtttttt cgctacgccc acccacgtcc acgcccacac ccgcacccac
     3361 aaccacccac catcgcccac acatccgcat ccggttcgca ttccgttgca ctcgtttggt
     3421 tcttaaagca aggtgaatgc gttctttttt aaactgctgc agtcacaagt tttttcgtaa
     3481 tgaagacttc gaaactttat cagtaactat tgttttaaaa aagtttttaa actcactata
     3541 tagtatttgg gaacttgctt atgagcgcag aatgtacata cagttgcgtt taatttattt
     3601 atgttattta atatttaatg ggtcaccttc agctcataag ctccttgaaa aacacttaat
     3661 tgtacatatt tatttcaatt gataactttg ttaaatattc aaacatatat tcgccgcaac
     3721 tgagtatata tgaatatatt tagaatgcag gacgattgca tctgcaatta cttttggttc
     3781 gacctatgta catttttatt cgaaatttcc acaccaagtg caggatgtca aatggccgaa
     3841 atggttgggc aaaataaatg gtgtaacagc caattgaagg gcctttaaga cgacataagc
     3901 ccactaatag ctggacagca actggggctg actgggcgag acaaatggaa gatgtgtgtc
     3961 ggtccattgg cctcggccag cccctttgca atagccatct gggtaatagg aggagcgaag
     4021 ggtcctggcc aggagaaaac tctaagagag agagagagag agagctgttc cagttgttgt
     4081 agccggcgga ccgcaattgc tggcgacatt tgccggacat tctacggctg cgacagcggc
     4141 attttctgct cagaaaacaa tgcgaacgca ggacacagat acggatgggg atgcggatcc
     4201 ggatgcggat gcgaatgcag atacaaatac gtggtagtgg gagtgggaat gaatgtgggc
     4261 cggacagaca ctaagcagac cgctgacaac gtggcgtatg agcaacatgt tccagaacat
     4321 tgttatcgga ctccattcta gcattctagc aagcatacac acctttccac attttcactt
     4381 ttcccccaaa agccggtttg cagcttggaa aaatgctcga caggaacttc ttcatttaca
     4441 tgcattgcgg acgtggtcca tttcacgacg atgtcgcggc cagagtccat ccatcacggg
     4501 cacgtgctcg tggctccatt tcggtcttgg ctccggcgac atttggggta ggggtttggg
     4561 gttttgcaac gggatatggc tctcttgccg cgccccctgc aacttccaac aagctatttg
     4621 cgtgaaaatg gttttttttt ttaattgaaa tcggagtggt ccactgcgct agttttatga
     4681 aattcattct ctcctctatt aaaaaaccac atcaagtcct ccatttgaat ccgttaatta
     4741 ataatgaccg aaaatttggc cagcaacagt ggcgggttta tttgtgtttt cggcaacaaa
     4801 aatatgttgg gaaattcttt agtgctcttc atgtgtgttt ttctatataa gttctttgtg
     4861 aaatagcaca aatcatattg aaatcattta gcttgaaatt ttattttatc tatcttaaat
     4921 tttattcaaa tatatttaaa atataagttg aaagctcaaa ggccttaaag tgaaaaccga
     4981 agtatttccc taactaatgt tgacattcgt gcagcactcg atgggttaac gaaggaccta
     5041 ggtaatctat ttagttcatc ttgcatctaa atccctttca attagataaa ttagctgtgg
     5101 ccacagatat ctccgcacct gtaaaaagtt tccccactca caatctggaa ttcgttggtc
     5161 cgcaattagc gtggtcaccg taatgcggtt gcttttgggt tttcggtttt cggttttggg
     5221 tattcggatt tctggtattc agttggccag gatcatcccg accgacaatt tgagtggtct
     5281 gagtggtttc gatggtgtaa atattgtcgc agctggccaa aaaaaaaagt ggtggaatgg
     5341 cttctgcaaa aataaagatg acaatgacaa tgaggaagcg agggtgtggc aaatccattt
     5401 gattgattga atttaaagag cagcgacagt cacgcgggaa aacgggggaa aattacaaga
     5461 ccgatgtctg ataatgataa tggtggtgat gatgatgatg gtgcagtgct gcacgatttt
     5521 tatattgctc tagggaaagc tcaaatcatt agagtgatta aaggtcgagc tgacttgaca
     5581 agagttcctt tgacttgact cggaccctca tcaacttgag ctctctcaaa tcagtcatgg
     5641 agaattctta agctctaaat tctgtcaaaa tgaattcagc caattgtaat gttttttttc
     5701 ccccccgatg aaagtttgta cttatactgg taaatttctt tcacacttct attaagctta
     5761 ctacgtattt taagcatctt gacccttatc atcttgtctc tcaaatcagc caaggatata
     5821 gctttcagca tcaagtttat gcaaatatac taaacacgat aagtcagcaa agaaaatgtt
     5881 gccaattgtg tattttttgt gagacaattt tacactgcta acatttgttt aaattttcta
     5941 caaaatccaa aacatttttc aacataaaat ttatttttaa gacacgcaaa acgaactaaa
     6001 aatgcaaaaa aactaatgaa tatacatgca aaatgtacat ttatttttag gaaacattca
     6061 ctattatatt ttgttagctt ttctaaaaaa aaaaataaac taatttagga ccaaaggttc
     6121 caacttagaa aaattaacac tttccctaaa cacatcattt tagaaaatac gtatgtaaag
     6181 atctgtttgt acataaaact aaagagaaaa tttacgtttt tttaggctta agcaagaccc
     6241 acttataatt gttaaatgaa tttttattaa tttgttgtaa ccctgaaacc cgtagtgaac
     6301 tttttctagg taaaatttaa gatgaaattt agcgatttta ctaaaaaaaa aaacagatac
     6361 aagcatcaag aaactatatt aaagtataaa acactaaagc taaaaaaaaa ggaaatcgat
     6421 aacaatgtgt actataagtc agctatgcct aggattaagt taaatgtata atattttttt
     6481 ttataaaaac atatacataa atactgaaag tatcaaaatg aactacagag aaacccagca
     6541 aaaaagaata tttaaaacct tgtctttttt ttcaaaatga ctgcaagcat tgtaattgta
     6601 attgtaaatt gtcgagcgac aaaaaatgta tacacatacg agcatccaaa taaatacttg
     6661 aaaaaatgct tcaaaatgta tggattaaat ggatatggcg aaagagataa gagcatagaa
     6721 tatacccttc tcgccaaaaa ttttccttgc gagtgtttgt attcccatct aggcattcct
     6781 aaaggaatcc ttaggacttt ataccgaagg gtattgtgtg tgaggatttg tgagtatctg
     6841 aatatctgaa tgtgtgtaaa ataagcccaa agcgatcgaa taaaaattaa ttttgtggaa
     6901 atg