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Drosophila melanogaster peroxiredoxin 2, transcript variant C


LOCUS       NM_001298273            1051 bp    mRNA    linear   INV 26-DEC-2023
            (Prx2), mRNA.
ACCESSION   NM_001298273
VERSION     NM_001298273.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1051)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1051)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1051)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1051)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1051)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1051)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1051)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1051)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1051)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1051)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1051)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1051)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1051)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1051)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1051)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1051)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1051)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1051)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1051)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1051)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1051)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1051
                     /gene="Prx2"
                     /locus_tag="Dmel_CG1633"
                     /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1;
                     dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783;
                     Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4;
                     PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1"
                     /note="Peroxiredoxin 2"
                     /map="11E11-11E11"
                     /db_xref="FLYBASE:FBgn0040309"
                     /db_xref="GeneID:53578"
     CDS             179..763
                     /gene="Prx2"
                     /locus_tag="Dmel_CG1633"
                     /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1;
                     dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783;
                     Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4;
                     PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1"
                     /EC_number="1.-.-.-"
                     /EC_number="1.11.1.24"
                     /note="CG1633 gene product from transcript CG1633-RC;
                     CG1633-PC; Prx2-PC; jafrac1; peroxiredoxin I; peroxidase;
                     peroxiredoxin 4783; peroxiredoxin 1; thioredoxin
                     peroxidase 1; Jafrac-1"
                     /codon_start=1
                     /product="peroxiredoxin 2, isoform C"
                     /protein_id="NP_001285202.1"
                     /db_xref="FLYBASE:FBpp0308756"
                     /db_xref="GeneID:53578"
                     /db_xref="FLYBASE:FBgn0040309"
                     /translation="MPQLQKPAPAFAGTAVVNGVFKDIKLSDYKGKYLVLFFYPLDFT
                     FVCPTEIIAFSESAAEFRKINCEVIGCSTDSQFTHLAWINTPRKQGGLGSMDIPLLAD
                     KSMKVARDYGVLDEETGIPFRGLFIIDDKQNLRQITVNDLPVGRSVEETLRLVQAFQY
                     TDKYGEVCPANWKPGQKTMVADPTKSKEYFETTS"
     misc_feature    188..703
                     /gene="Prx2"
                     /locus_tag="Dmel_CG1633"
                     /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1;
                     dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783;
                     Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4;
                     PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1"
                     /note="Peroxiredoxin (PRX) family, Typical 2-Cys PRX
                     subfamily; PRXs are thiol-specific antioxidant (TSA)
                     proteins, which confer a protective role in cells through
                     its peroxidase activity by reducing hydrogen peroxide,
                     peroxynitrite, and organic hydroperoxides; Region:
                     PRX_Typ2cys; cd03015"
                     /db_xref="CDD:239313"
     misc_feature    order(188..190,311..316,323..325,512..514,542..544,
                     581..589,593..601,611..616,635..637,680..691)
                     /gene="Prx2"
                     /locus_tag="Dmel_CG1633"
                     /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1;
                     dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783;
                     Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4;
                     PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239313"
     misc_feature    order(305..307,407..412,485..487,491..493,527..529)
                     /gene="Prx2"
                     /locus_tag="Dmel_CG1633"
                     /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1;
                     dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783;
                     Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4;
                     PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1"
                     /note="decamer (pentamer of dimers) interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239313"
     misc_feature    order(308..310,317..319,545..547)
                     /gene="Prx2"
                     /locus_tag="Dmel_CG1633"
                     /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1;
                     dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783;
                     Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4;
                     PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:239313"
     misc_feature    order(317..319,680..682)
                     /gene="Prx2"
                     /locus_tag="Dmel_CG1633"
                     /gene_synonym="1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1;
                     dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783;
                     Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4;
                     PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1"
                     /note="peroxidatic and resolving cysteines [active]"
                     /db_xref="CDD:239313"
ORIGIN      
        1 ttccagtttg tggcgaaata tctggaagtc aagggtaatt gcccttaatc gttagtaatt
       61 gccgccatta gaactccgat ttatagagac ttttagtatg gaattagcat caagttaact
      121 actttacaat tgaaaaccaa ttggaagtta cataggcaag attaaaggtt ataaaataat
      181 gccccagcta cagaagcccg ctcccgcatt cgccggcacc gccgtcgtca acggtgtttt
      241 caaggacatc aagttgagcg actacaaggg caaatacctg gtgcttttct tctacccgct
      301 ggacttcacc ttcgtgtgcc ccaccgagat cattgcgttc tcggagagcg ccgccgagtt
      361 ccgcaagatc aattgcgagg tgatcggttg ctccacggac agccagttca cccacttggc
      421 ctggatcaac acgccaagga agcagggtgg tctgggcagc atggacattc cactgctggc
      481 tgacaagtcg atgaaggtgg cccgcgacta tggagtgctc gatgaggaga ctggcatccc
      541 cttccgcggc ctgttcatca tcgatgacaa gcagaacttg cgccagatca ccgtcaacga
      601 tctgcccgta ggtcgcagtg tggaggagac cctgcgtctc gtccaggcct tccagtacac
      661 cgacaagtac ggcgaggtct gccccgccaa ctggaagccc ggccagaaga ccatggtggc
      721 cgatcccacc aagtccaagg agtacttcga gaccacctcc taaagaggct atctgttcgc
      781 tgaacggggc cgctcctggc gagtgggagt ggattcgaat cgcaaacccc ccgttcaact
      841 aaaaccaata catatactac attatatatc ctacacatta accctagagc gtagaagaag
      901 aagaaactgt gaggcatctt tccctgcaac agcgccaccc aaaaataaga tgataaacac
      961 ctgcagacgc taagcggaaa gtgattattt tttacgtata ttttgtgtgc tttttttttt
     1021 ttgtaattca ccacaataaa cgattgtacg g