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LOCUS NM_001298253 5344 bp mRNA linear INV 26-DEC-2023 mRNA. ACCESSION NM_001298253 VERSION NM_001298253.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5344) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5344) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5344) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5344) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5344) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5344) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5344) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5344) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5344) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5344) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5344) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5344) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5344) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5344) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5344) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5344) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5344) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5344) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5344) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5344) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5344) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5344) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5344 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5344 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="hemipterous" /map="11D10-11D10" /db_xref="FLYBASE:FBgn0010303" /db_xref="GeneID:32256" CDS 659..4120 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /EC_number="2.7.12.2" /note="CG4353 gene product from transcript CG4353-RF; CG4353-PF; hep-PF; hemipterus; Mitogen-activated protein kinase kinase 7; hempiterous; JNK kinase; hemipterous; JNK-Kinase" /codon_start=1 /product="hemipterous, isoform F" /protein_id="NP_001285182.1" /db_xref="FLYBASE:FBpp0309264" /db_xref="GeneID:32256" /db_xref="FLYBASE:FBgn0010303" /translation="MSTIEFETIGSRLQSLEAKLQAQNESHDQIVLSGARGPVVSGSV PSARVPPLATSASAATSATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASASSS SSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPT PPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLS SNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELM SMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNI KLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATA RSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPEL LAQPFIRIYESAKVDVPNWFQSIKDNRLRANGDPTLQRATATGSAIGSGAGSLAGSGS GSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTP TATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQR KLSNGSHHPHYKYNDESPKKESMFSSIGQSILRNLTTSPFSQKKHNSTATTIPLPHNN QTLITDAATAAAAAATATTPPNIAATVLTTTPTTTPTWRLPTENSQAYDSCDSSSNAT TTTLNLGLSSPSPSLPRKQFPTESPTLQLTSQQQQQPQRLQPGNQSPIVLQRFYHQQN QLREKEAAERYQQQRQQPPVGVTSTNPFHSNYVPPPPSTHSTSSQSSTQSTCSQIAIN PASISPSSGSGTGNMAGLGIGSAPASGLGAAGHFGAGGTGEQLQYQPLPIAAEATGTS PTLQSRSPEQQSDYGGNGNMVASKLSKLYARRQLLGQSSSSGASNSSLDGCSREQHDA ATSPVASSMDRDQEPVHPQPPAYRSVVNNGSGGKSYYYRTLSAASSSSNTSQSTSPTT EPLPGGGTSSFLRRYASSGPGGSISTPPSPHILAGLDRRHRSPDPPPRYNRGQSPLLL RKNLLELSGQPPGSPLLHRRYVSASPPLPPPRRGSESVPGSPQHFRTRIHYTPEPQRR IYRTIDQ" misc_feature 1199..2086 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; Region: PKc_MKK7; cd06618" /db_xref="CDD:270791" misc_feature order(1265..1279,1289..1291,1328..1330,1334..1336, 1427..1429,1475..1486,1490..1495,1502..1504,1616..1618, 1622..1633,1637..1639,1667..1672,1679..1681,1718..1729, 1733..1735,1820..1822,1847..1849) /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="active site" /db_xref="CDD:270791" misc_feature order(1265..1279,1283..1285,1289..1291,1328..1330, 1334..1336,1427..1429,1475..1486,1490..1495,1499..1504, 1622..1624,1628..1633,1637..1639,1670..1672) /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270791" misc_feature order(1274..1279,1616..1618,1622..1630,1679..1681, 1718..1729,1733..1735,1820..1822,1847..1849) /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270791" misc_feature 1667..1735 /gene="hep" /locus_tag="Dmel_CG4353" /gene_synonym="CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7" /note="activation loop (A-loop); other site" /db_xref="CDD:270791" ORIGIN 1 ggctgatgca tcgatgtttt tttacatcac tattgtacac gcgatttagg cagcaaaaac 61 gtacaaaagc gagtgatcaa attgtgccag tgataccgcc gcccgcggtc gcgaaacgaa 121 tcgattgcag aagtgcgaca aacagcgccg cgaaaggaaa acaaccgatg aaatattctc 181 ccaaaaaagg aggaaaaaat cgcaagttgt tgttgccgtt gctgctgaaa aagaaagaga 241 gagagggcgc tgcgtgtatg cctgtgtgtg tgcgtgtgtg ggggtgagga tgtctctctc 301 taatgcacag tgactgtgtt ttcctttttt cgattttgtt tttgtgcccc cccttggcaa 361 acaacaaaag tccaagcaat cctttatttt tgcaagtgta aagtttacag tgtatgtgtg 421 ccgccgaaca acaacaacat cagcgacaaa acaaacaggg cgcacagcaa aacaattcac 481 acacacacgc accctccccc gcctgcgcgc gcttgtgtgt gtgtgagaga gagggagtga 541 gtgagaggaa aatcgaagaa gtgctggcca aaaaacggcg aaaaaaattt aataaatacc 601 aaaatccaac gatactagca actaactata aaaaatcgaa ccaaatcgac tcgatataat 661 gtccaccatt gagttcgaaa cgatcggcag tcggctgcaa tccttggagg caaagctcca 721 ggcgcagaat gagtcccacg accagatcgt cctctccggt gcgcgcggcc ctgtcgtttc 781 cggttccgtt ccatctgccc gcgtcccgcc cctggcgaca tccgcatccg cagccacatc 841 cgccacccac gcaccttcct tgggcgcagg ttccgtttcc ggatcgggta tcagcatagc 901 ccagcgtcca gcacctccag ttcctcatgc gacgcccttc ggcagcgcca gcgcctcgtc 961 atcatcctca tccgcatccg catttgcatc cgcagcaccg gcgacgggca ccttcggtgg 1021 aacatacacc ccgccgacaa ctagagtgtc gcgagccacg cccacactgc ccatgctttc 1081 tagtggtccc ggtggtggac tgaatcgtac gcggccggtg atacttccgc tgcccacgcc 1141 gccacatcct ccagtttcgg aaacggacat gaagctgaag atcatcatgg agcagaccgg 1201 caagctgaac atcaacgggc ggcagtatcc gacggacatc aatgacctca agcacctggg 1261 cgacctgggc aatgggacta gcggcaatgt ggtgaagatg atgcacctgt ccagcaacac 1321 gatcatcgcc gtgaagcaga tgcgacgcac tggcaacgcg gaggagaaca aacgcatcct 1381 gatggatctg gatgttgtgc tcaaatcgca cgactgcaag tacattgtca agtgccttgg 1441 ctgcttcgtt cgcgatccgg atgtgtggat ctgcatggag ctgatgtcca tgtgctttga 1501 caagctgctc aagctgtcca agaagccggt gccggaacag atcctgggca aggtcacagt 1561 ggcgacggtc aacgcattgt cctacttgaa ggacaagcac ggagtcatcc atcgagatgt 1621 gaagccctcg aacattctga tcgatgagcg cgggaacatc aagctctgtg atttcgggat 1681 cagcggacgc ctggtggact ccaaggccaa cactcgatcc gccggctgtg cagcttatat 1741 ggcgccggag cgcatcgacc ccaagaaacc aaagtacgac attcgcgcag atgtgtggtc 1801 actgggcata acgctggtgg agctggccac agcgcgatcc ccgtacgagg gatgcaacac 1861 ggacttcgag gtgctcacca aggtgcttga ctcggagccg ccgtgtttgc catacggcga 1921 gggttacaac tttagtcagc agttccgcga tttcgtcatc aagtgcctca caaagaacca 1981 tcaggatcga cccaagtatc cggagctttt ggcccagccc ttcatccgga tttatgaatc 2041 agccaaagta gatgtgccca attggtttca gagcatcaag gataaccgac tgcgcgccaa 2101 tggcgatcca acgctccaga gggcaacggc gactggaagt gcgatcggtt ctggggccgg 2161 atctctcgca ggatcaggat caggatccgc aggtggagct gtaaaatatg gtagggcgac 2221 aacgtatgcg gggcagagtc ccacaaatcc gcagaagaca ataaaaccca ctcagatacc 2281 gagttaccag cagcaacagt cgcagttttt catgcaatca gccacacaac tacctcaaac 2341 aacaaccaca acaccgacgg caacgacaaa ctgtttcggc ggcagcggaa acggaaatgg 2401 aagaggaaac ggcagcggcg gaagcggaaa tggtagcgga agcagcagca gtgccagtcc 2461 tctatcgcca ccaagcgccg gtatcggcga tcttaaccgg ctttatcgca aatcgccgtt 2521 catgcagcga aaactgagca acggatccca tcatccgcac tacaaatata acgacgagag 2581 ccccaagaag gagtccatgt ttagtagcat cggtcaatcg attctacgca atctgacaac 2641 atcgcccttc agccaaaaga aacacaattc aactgcaaca acaataccac tgccgcacaa 2701 caaccaaaca ttgatcacgg atgcagcaac agcagcagca gcggcggcaa cagcaacaac 2761 accgccaaat attgcagcta cagtgctcac gacaacgcca acgaccacgc ccacttggcg 2821 cctgccaacg gaaaattccc aagcctacga cagctgtgat agtagtagta atgcgaccac 2881 gacgaccttg aatttgggcc tctcctcacc ctccccctcg ttgccgcgca agcaattccc 2941 cacagaatcg ccgaccctgc aactcacgag tcagcagcag cagcagccac agcgattgca 3001 gccgggcaat cagagcccca tagtgctgca gcgcttctac caccagcaga atcagctgcg 3061 cgagaaggag gcggctgagc ggtatcagca gcagcgccag cagccgcccg ttggagtgac 3121 cagcacgaat ccgtttcaca gcaactatgt gccgccgccg ccatcaacgc actccacctc 3181 tagtcagtcc tccacgcagt cgacgtgttc gcaaatcgcc atcaatcccg ccagcatatc 3241 cccatcgtct ggttccggaa cgggaaacat ggcgggattg ggaatcggtt cggctccggc 3301 atcgggattg ggggcagctg gtcactttgg agcgggcggc actggcgagc agctgcagta 3361 tcagccgctg cccatcgccg ccgaggcaac gggaacgagt cccacgctcc agtctagatc 3421 accggaacag cagtcggatt atggaggaaa cggcaacatg gtggccagta agctgagcaa 3481 gctgtacgca cgccgacaac ttttgggcca gagctccagc agcggagcga gcaatagcag 3541 cctggacggt tgcagtcggg agcaacacga tgcagccacg tcgccggtgg cgtccagcat 3601 ggatcgagac caggagccag tgcatccgca gccgccggcg tacaggagcg ttgtgaataa 3661 cggcagcggt ggcaagtctt actactatcg caccttgtcg gcggccagca gcagtagcaa 3721 taccagccag agcacctcgc ccacgacgga accgctgccc ggcggtggca ccagtagctt 3781 tctgcgtcgc tatgcaagca gtggaccggg aggtagcatc agcacgccgc ccagtccgca 3841 tatcttggcg ggattggatc gcaggcatcg aagtccagat ccgccgccac gctacaatcg 3901 cggacagtca ccgctattgc tgcgcaagaa tctgctggag ctgagtggcc agccgcccgg 3961 ctctccgctg ctgcaccgaa gatacgtttc ggcttcgccg ccgctgccgc caccgcgtcg 4021 aggctctgaa agcgtgccgg gatcaccgca gcatttccgc actcgcatcc actatacacc 4081 cgagccccag agacgcatct accgtacgat agatcaatga gtagcgctgc aaatcatggt 4141 catgtgatgc tggtatggct tcgacgacga tgccgccgac gctgctgttc acgacgacaa 4201 tcaggacgag gaggtgggac tattggagcc catttccctg cccgtctcgt cagcagtcgg 4261 cgactcgctg tcgatgccgg cgtatgcagg tggcctgggc accaggttgt ccggagccga 4321 acggcgaatc ggcgatcgtc ggacgtgttc ggccagcgga tcgtattcca gcttgtatac 4381 ggataaggac gaatggccag gtggatcgtc cggtggggca tcgggtacat cgacgaccag 4441 agctggatat ccgtggacat gtgattgatg acaaacgaaa gtgttcaaaa gtcttatacg 4501 tttaagtgct tgagcctcag cgattcatct gtatccgcat ctgctagaca cttcgtttcg 4561 ttgcgcagct ccaattgtac atagacatat atcttaaggg acctatatag acacatccga 4621 taatagtgca atagttgaaa gcaattctgt tcgcccaaca accgcgcccc cccctgtaac 4681 caagtctata ctgttctata tatctctgta tctgtatctc cttcaatggt aactctgtaa 4741 tcaaaagttt acactttaca caacgtaact tatttaatcg tagctctaaa aagaaaatga 4801 aacaaaatag ctaaatcgaa aaaaaagggg aaaatccaag agaaagaatg agaaatttaa 4861 atgatttgta gctttgtata tagagaggaa gcgaagtgca aaatgtcgtt gcatttgctg 4921 tttgcaattt gttttagttt atatgtttca ttaaacatca acttgtatgc tgagtggaag 4981 ggaaaccgac aagaaacaac cacattaaca atggaattat tgtactgatt attataattg 5041 tttaatttat tatgtaagcg gcaacaagcg acaattcaaa ttcaagtctc gttttgtttt 5101 tttatttcaa atgggtggaa cggattcctt tttttcagaa cttttatatg gcgaaaggga 5161 agtatggaag taaatggaga tataaacagt tcagaaagac aacgtatttg gaattgattt 5221 aatgattaaa tcaaaagtat tttgaatagc ttcagaagta caagccaaat agctttccat 5281 acacttagtt tctagtttcc accctcctat taatataaag aaaataaaaa aaaaaagaaa 5341 aaac