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Drosophila melanogaster heavyweight (hwt), transcript variant D,


LOCUS       NM_001298227            6221 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001298227
VERSION     NM_001298227.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6221)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6221)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6221)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6221)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6221)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6221)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6221)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6221)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6221)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6221)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6221)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6221)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6221)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6221)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6221)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6221)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6221)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6221)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6221)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6221)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6221)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6221)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6221)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6221
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6221
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="heavyweight"
                     /map="11A12-11B1"
                     /db_xref="FLYBASE:FBgn0264542"
                     /db_xref="GeneID:32202"
     CDS             292..4641
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="CG43921 gene product from transcript CG43921-RD;
                     non-AUG (AUC) translation initiation; CG43921-PD; hwt-PD"
                     /codon_start=1
                     /transl_except=(pos:292..294,aa:Met)
                     /product="heavyweight, isoform D"
                     /protein_id="NP_001285156.1"
                     /db_xref="FLYBASE:FBpp0311960"
                     /db_xref="GeneID:32202"
                     /db_xref="FLYBASE:FBgn0264542"
                     /translation="MSENEESVLEIAICDDYSLPVDFVKKRPSSFDPCLAEAIPANPE
                     HWIAPSPQTEFLPFGEAQQALQLQPAAAAATAAATTSAAAAANATAAAPQLPPPLPVP
                     VATLPNQAATAAAAATAAILATHQQQQQQQHQHLSNNNNNGGSTHGQQHTHSNNNNTL
                     PVGAQQQQQQQHQQQRATLQHPPLPNSNIKQASVKLIEGYSDPKDTRNHKKVYHKKAK
                     KRSTTGHKRHQQQQQQQQPHQQQLQQQQQQTLPTPRSAQQQQQLQQKLQQRHSTYNNN
                     NGNSRKDKRNSQYNSDSSAPKSSDDEADIDEEVEQQPLPVPQAPVQSASQPAAGLNSP
                     DSISDDLVRPLPPQLQRSPRKLTVAPAEHNKRQPSPYYYSDLLKSRDKDKDKDKDKDK
                     DKDKDKDKDKDKDKERDKDREDFKLKCRQSTASEPPQQTQTQLGGYRKSSSLDVPPAE
                     EQPEAESHEEEDPRTGQDSQSTPKRYSFTEEGVHIIRCETPSTSTSEESDCSECLKRR
                     EWHARALALVRKTCNVQPRNQNPTGSELQLQLQHCDAGEGELLKCCPPPPAPAENQSQ
                     VQPMPPHRLLGPAAVCGACITSAPASSLAGGRGSELGDDLEEEYFRPRSIFYVHPHGV
                     HECIECAQPAQPATVPAPTLSNPSLDIYGDDEDEVDGDEDEDEEDDSEDIMGSRRRQI
                     YETAFDCKIAKSDDDLDEVDRITNCSVLLQLSNGNGGDISKVTGSSKTRAECKRAKNS
                     KNQALQEQTGEAHVQVHHVEAELGKLQLSQVDQQNQNQNQSQNQQHGVSATGSGASAS
                     STQQLPVRGYTPSPPSTAPLPMKFPGKHDRYLNMNSIRSAPNLPAANPAHPRLRDLRL
                     PIQSMRHQCGGSSNDNSLTDSAYVNPPSTNSNSNAASASASASVSATGSAAPRRPRSF
                     VLESGRVLELRRSAQGHQGGQSTHHHHHHHHHAPGSRRNRHGQSQGQTTGGGHNYSST
                     ESIATSSSGGSMESLRSSTSEGNRSTSSSESRHSSSLSSHSSESGSGGSGGSGGSSVA
                     YPLRPAPLLLHSKLHILSPISDKSSQEPASASASEQSQQPSQQLAPMASQEDDSTTSG
                     APAGNQVQVNASLKQPRSNRGAPNKALLQLADELLGSDSGISLHSREDGKPQALALQR
                     LTLPKLQLIGAEGTTTSATASGAGGSSATGGSSGAGGSGSGSVVASGSTGIQQDLRDL
                     PFDMPKLRRRKTLQQEAACTSGSATSVDLGELPFDMPKLRRRLRANQAEINNLLMHST
                     ESSGISQASSSHSMRDDQKMSSKLDTALFRQNLTLNLNESRQATKQFGSLDLRGLNSN
                     KELNMNLSQGYVTAVDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCES
                     TKQDYSLSLKGAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAE
                     HMCLIEPVIAQLL"
     misc_feature    4330..4623
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /old_locus_tag="Dmel_CG11146"
                     /old_locus_tag="Dmel_CG15729"
                     /old_locus_tag="Dmel_CG32653"
                     /old_locus_tag="Dmel_CG42251"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="Src homology 2 domain found in SH2
                     domain-containing adapter proteins B, D, E, and F (SHB,
                     SHD, SHE, SHF); Region: SH2_SHB_SHD_SHE_SHF_like; cd09945"
                     /db_xref="CDD:198198"
     misc_feature    order(4357..4359,4411..4413,4474..4476,4480..4482)
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198198"
     misc_feature    order(4477..4479,4564..4566)
                     /gene="hwt"
                     /locus_tag="Dmel_CG43921"
                     /gene_synonym="43921; BcDNA:GH02424; CG11146; CG15729;
                     CG32653; CG42251; CG43921; Dmel\CG43921; lincRNA.981"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198198"
ORIGIN      
        1 agttcagcat cagactttgc aacgcacgca actgcacgca aataacgcgg gcgtcgcagt
       61 cacgtcgccg ccgacggccc acaaacatca aaaaacgaac aaaactacag tgattagaag
      121 ttaggcgaac attttctggt acgcaaagaa ccaaacaaga acaattcgcg aacagtgact
      181 tttaaatcag cttataaact gtaaattgtt gttacacatt ttttctaaat attttgttgt
      241 tgtgagtgag caaaactttc agtgtaaagt caaaaacaca cagccacaca tatcagtgaa
      301 aacgaggaaa gtgtgctaga gattgccatc tgtgatgatt acagcctgcc cgtagacttt
      361 gttaaaaaac gaccgtccag ctttgatccg tgcctggcgg aggcgatacc agcgaatccc
      421 gagcattgga tagcacccag tccgcaaacc gagtttctgc catttggtga agcccaacaa
      481 gcgttgcagc tacaaccagc agcagcagca gcaacagcag cagcaacaac atctgcagca
      541 gcagcggcaa acgcaacagc agcagctcct caactaccgc caccgctgcc cgttcccgtg
      601 gcaacattgc ccaatcaggc ggcgacggca gcagcagcag caacagctgc gattttggcc
      661 actcaccagc aacagcagca gcagcagcat cagcatttga gcaacaacaa caacaacggc
      721 ggcagcacac acggccaaca gcatacgcac agcaacaata acaacacatt gccagtaggg
      781 gcacagcagc agcaacagca gcagcatcaa caacaacgtg caacattgca acatccaccg
      841 ctgcccaaca gcaacatcaa gcaggcatcg gtgaaattaa tcgaaggata ttcagatcca
      901 aaggatacgc gcaatcacaa aaaggtctat cacaaaaagg ccaagaaacg ctcgactact
      961 ggccacaagc ggcatcagca acagcagcag caacagcagc cgcatcagca gcaattgcag
     1021 cagcagcaac agcaaacgtt gccaacgcct agaagtgcgc agcagcaaca gcaactgcag
     1081 caaaagttac agcagcggca ttccacctac aacaacaaca acggcaactc aagaaaggat
     1141 aaacgcaaca gtcaatacaa ttcagactcc tcggctccga aatcctccga cgacgaggcg
     1201 gacatcgacg aagaggttga gcagcaaccg ctgcccgtgc cacaagcacc tgtccagagt
     1261 gcttcacaac cagcggccgg actcaactcg ccggattcca tatccgatga cctggtgcgt
     1321 ccgcttccac cgcaactgca gcgcagtccg cgcaaactga ccgtcgctcc ggcggagcac
     1381 aacaagcgcc agccctcgcc ctactactac tccgatctgc tcaagagtcg tgacaaggac
     1441 aaggataaag acaaggacaa ggacaaagac aaggacaagg ataaagacaa ggacaaggac
     1501 aaggacaagg aacgggacaa ggacagggag gactttaagc tcaagtgtcg ccagtcgacg
     1561 gccagtgaac cgccgcagca aacccagaca cagttgggtg gctaccggaa gagctccagc
     1621 ttggatgtgc cgccggcgga ggagcagccg gaagcagaga gtcacgaaga ggaggatccc
     1681 cggacgggac aggactctca atccacgccc aagcgttaca gtttcaccga ggagggtgta
     1741 cacatcattc gctgcgagac gcccagcacc agtacttccg aggaatccga ttgcagtgag
     1801 tgcctcaagc gacgcgagtg gcacgctcgt gccttagcct tagtccgcaa gacctgcaac
     1861 gttcagccaa ggaatcagaa tcccactggc agcgagcttc agctgcagtt gcagcattgc
     1921 gacgccggcg agggcgaact gcttaagtgc tgtccaccgc caccggctcc agcggagaac
     1981 cagtctcagg tccagccgat gccaccgcac cgcctgctgg gaccagcagc cgtgtgcgga
     2041 gcctgcatca catccgctcc tgcctcctcc ttggccggcg gacggggcag cgagctcggc
     2101 gatgatctgg aagaggagta cttccggccg cgcagcatct tctatgtgca tccacatggc
     2161 gtccacgagt gcatcgagtg cgcccagcca gcccagcctg cgactgttcc agcgccaacg
     2221 ctgagcaatc catcgctcga tatctacggc gacgacgagg acgaagtgga cggtgacgag
     2281 gacgaggacg aagaggacga ctccgaggac atcatgggca gccggcggcg gcagatctat
     2341 gagacggcct tcgactgcaa gatagccaag tcggatgacg atctagatga ggtggatcgc
     2401 attaccaatt gctcggtctt gctgcagttg agtaatggca acggtggtga catcagcaag
     2461 gtaaccggct cttcgaagac gcgggccgag tgcaagcgag ccaaaaactc caaaaatcag
     2521 gctctgcaag agcaaacggg cgaggcccat gtacaagtgc atcatgtgga ggcggagctg
     2581 ggcaagctgc agctgagtca agtggaccag cagaatcaga atcagaacca gagccaaaac
     2641 cagcagcatg gtgtgagtgc taccggtagt ggagcaagtg catccagcac gcagcagctg
     2701 cccgtgcggg gatatacccc atcgccgcca tcgacggctc cgctgccgat gaaatttccc
     2761 ggcaaacatg atcgctacct gaacatgaac agcatcagga gtgcacccaa tctgcccgcc
     2821 gccaatccag cgcatccccg tctccgggat ctccgtctgc ccatccagtc catgcggcat
     2881 cagtgcggcg gcagcagcaa tgacaacagt ctcaccgaca gcgcctacgt gaatccgccc
     2941 tcgaccaact cgaattcgaa tgcggcatcg gcttccgcct cggcctccgt ctcggcaacc
     3001 ggatcagcag ctccacgccg accgcgatct tttgtcctcg aatcgggccg ggtgctagag
     3061 ctgcgacgca gtgcccaggg ccatcagggt ggccagtcga cccaccatca ccatcatcat
     3121 catcatcatg cgccggggag cagaagaaat cgccatggcc aaagccaggg gcaaacgacc
     3181 ggtggtggcc acaactacag cagcaccgag agcattgcca cctcgagcag tggcggcagc
     3241 atggaatcgc tgcgttccag caccagcgag ggcaatcgca gcacctccag ctccgagtcg
     3301 cggcactcca gttcgctgag ctctcacagc tcggagagcg gcagcggtgg cagcggcggt
     3361 agcggaggct ccagtgtggc ctatcccctg cgaccggctc ccctgctgct acactccaag
     3421 ctgcacatcc tgagtcccat ttccgacaag tcctcgcagg aaccggcatc ggccagtgcc
     3481 tcggagcaat cacagcagcc gtcccagcag ctggcgccga tggcgtcgca ggaagacgat
     3541 tccacaacga gtggcgcacc agcagggaac caagtccagg tgaatgcctc cttgaagcag
     3601 ccgcgtagca atcggggtgc accaaataag gccctgctcc agctggccga tgagctactg
     3661 ggttcggata gtgggatatc gctgcattcc cgggaggatg gaaaaccgca ggccttagcg
     3721 ctacagcgtt taacgctgcc caagctacag ttgattggtg ctgaaggaac aacaacgtcg
     3781 gcaacggcct ccggagcagg aggtagctca gcaacgggtg gcagtagcgg cgctggagga
     3841 tcaggatccg gttcggtagt tgccagcgga tcgactggca tacagcagga tctgcgcgat
     3901 ttgcccttcg atatgcccaa actgaggcga cgcaagacgc tgcaacagga ggccgcctgc
     3961 acatcgggca gtgccacgtc cgtcgatctc ggcgagctgc ccttcgacat gcccaagttg
     4021 cgacgacgcc tgagggccaa ccaggcggag atcaataacc tgctgatgca cagcaccgaa
     4081 tccagtggca tctcgcaggc ttcctccagt cattcgatgc gcgacgacca aaagatgtcc
     4141 agcaagttgg atacggcact ttttcggcag aatctcactc taaaccttaa tgaatcgcga
     4201 caggcgacca aacagtttgg cagcctggat ctgcgtggtc tcaatagcaa caaggagcta
     4261 aacatgaatc tcagccaggg atatgtcact gctgtggatc taatcgatgt gacaattccg
     4321 ctggagcggc agggttggta ccatggtgcc ataacgcgaa ttgaggcgga gaccacactg
     4381 cgtccgctgt ccgagggatc cttcctggtg cgcaactgcg agtccacgaa gcaggactat
     4441 tcgctatccc tcaagggcgc caagggcttt atgcacatgc gcatccagcg caacgagact
     4501 ggacagtaca tccttggcca gtttagtcgt cccttcgaga cggtaccgga gatgatccgg
     4561 cacttttgcc tcaaccggct gccagtgcgc ggtgccgagc acatgtgtct gatcgagccg
     4621 gtcatcgccc agctgctcta gagaggctcc aagaactcga aggacaccgg gatgtggcca
     4681 atcggaggct ttagaggctc caggggatgg ggaaccaaaa cagaataaca tattaatagc
     4741 gtgtagagaa cgtagaaacc tatgtgaacg atgtgtatgc actagttata tatgcgagtt
     4801 agttgtaaaa ggatgatggc aattttttca tgtttttttt tttttgcctc gaactttgta
     4861 tgtcggtcta ctaaagtaca cacacacaaa cacaaaactc actcactaat acacgaacta
     4921 gtttagcgtt taaagtacgt agcacattca gacaatacca gcaaattaca aaaaccaaac
     4981 aacaaacgat atttatatag aaggcatata tacaagcgag acgatatata caaaagcata
     5041 tagatacgga taacaaaagc acttgacgac agttgctaaa aacgtagcgg tacatgatga
     5101 tcccaaatgc ggacaaagat ggtacagatt ttagatgtgt ttacaccgaa ccgagcatca
     5161 gattaggagc aactaattgt agcattgggc gccaaaagta aaaacaaaaa aaactcttcc
     5221 attggctaaa gatttatggt agaacacata caactcactt ctagcgatta tatggtcgaa
     5281 acttatgcaa cttttcgcag cacacacaca cacacacaca aacactcgcc cactagcacc
     5341 gcccagcatc gtccgattat tcagataatt acgccattat ttataaatcc taattccttt
     5401 ggcgacggat gctagtgggc atcgcttaag gcacgtttac actaagaaaa gttttagcaa
     5461 gcaactctaa aaatttgttg attaatttta tgttaccaaa acgaagaaaa acgaacaaaa
     5521 aatctaaaat atgtatatct atatgtatga aaactaactt tagcaagagc gatgtcacat
     5581 tttttttttt ggtcttagct gtaggtcaga ggtacgcgaa atagaacgct caaagcgctt
     5641 ttggttaaag gatcgaaacg aataggatca gatcagatcg gatcggatca gaaggaattg
     5701 gaggattgat cggatcggat cggatcgaat cgatagggat ggttagaagg ggcaaggata
     5761 tagcaacgca tatgaaatgt cagtttaagt gttagtttct aattgagcga acgaagggca
     5821 gactctatat atatatacat aaatatatat atatatattg aatgctacaa aatgatatat
     5881 acttactatt tatatttcta tatatacatc tatatatata tatatatata tatacatata
     5941 tatatatacg atattaaaga gcagtcaatg gttttttggt tccagttccg aaagagaagc
     6001 aagtgtcagg atgcaggatg ctaattaact aattaactaa ttattgtttc tggcagtttt
     6061 ctgttccacc ttcgtaccgc cgagcaatac aactgatttc cagtatccca aacccaaagt
     6121 tatgtttata tgtgtgtgcc aaagtattat tctagtcgta tgtatgtgaa tcgaatctcc
     6181 gtgtgaatat cagcgcgtta tatttttttc gatatgttga t