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Drosophila melanogaster Upf1 RNA helicase (Upf1), transcript


LOCUS       NM_001298216            4709 bp    mRNA    linear   INV 26-DEC-2023
            variant B, mRNA.
ACCESSION   NM_001298216
VERSION     NM_001298216.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4709)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4709)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4709)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4709)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4709)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4709)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4709)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4709)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4709)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4709)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4709)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4709)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4709)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4709)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4709)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4709)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4709)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4709)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4709)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4709)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4709)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4709)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4709)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4709
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4709
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="Upf1 RNA helicase"
                     /map="10F4-10F4"
                     /db_xref="FLYBASE:FBgn0030354"
                     /db_xref="GeneID:32153"
     CDS             374..3916
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /EC_number="3.-.-.-"
                     /EC_number="3.6.4.13"
                     /note="CG1559 gene product from transcript CG1559-RB;
                     CG1559-PB; Upf1-PB; up-frameshift suppressor 1"
                     /codon_start=1
                     /product="Upf1 RNA helicase, isoform B"
                     /protein_id="NP_001285145.1"
                     /db_xref="FLYBASE:FBpp0309612"
                     /db_xref="GeneID:32153"
                     /db_xref="FLYBASE:FBgn0030354"
                     /translation="MSVDTYAPSSALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTS
                     QSQTQNDQLEIAQRCSAGDSHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKY
                     CGIHDPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILEC
                     YSCGVRNVFVLGFIPAKADSVVVLLCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAW
                     LVKQPSEQGQLRARQISAAQINKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDG
                     YQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMKLM
                     HGDELRLHYVGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIW
                     KCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPHLP
                     DLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAV
                     DQLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETG
                     ELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTE
                     PECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQ
                     YRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGS
                     GTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLY
                     QEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNP
                     KVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTII
                     ADAKEVMVPGSIYDRSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGYGTPSSNSM
                     VGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLHHDSIGYISNEHGAAALGNMPVPVGMF
                     MNMSNIPPRFYNQHQQAIMAVKQNRAIQQQTGNFSPGNSGPGVTGVGVGRSATPGGNK
                     KTNKLGKSRVTGGGTGGAPLTQGSSVCNAAPYSQHPMPLSLQMTQPSGFALSQQPELS
                     QDFGQISQMDGLLSQDVAFNASGERSLNQFSQPY"
     misc_feature    665..1120
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="RNA helicase (UPF2 interacting domain); Region:
                     UPF1_Zn_bind; pfam09416"
                     /db_xref="CDD:401391"
     misc_feature    1277..1543
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="1B domain of eukaryotic UPF1 RNA helicase and
                     related proteins; Region: 1B_UPF1-like; cd21407"
                     /db_xref="CDD:394815"
     misc_feature    order(1379..1387,1439..1441)
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="nucleic acid substrate binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:394815"
     misc_feature    1436..3013
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="DNA helicase, putative; Region: TIGR00376"
                     /db_xref="CDD:273041"
     misc_feature    1724..2425
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="DEXXQ-box helicase domain of UPF1; Region:
                     DEXXQc_UPF1; cd18039"
                     /db_xref="CDD:350797"
     misc_feature    order(1724..1732,1739..1741,1796..1816,2309..2311,
                     2420..2425)
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350797"
     misc_feature    order(1880..1888,1952..1963,2114..2116,2162..2164,
                     2168..2170,2321..2323,2327..2329)
                     /gene="Upf1"
                     /locus_tag="Dmel_CG1559"
                     /gene_synonym="CG1559; Dm-Upf1; Dmel\CG1559; DmUpf1;
                     dUPF1; smg-2; upf1; UPF1; Upf1p"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:350797"
ORIGIN      
        1 gatagacccc tcgtgagtca aatgcaaact gacgtatatt tattactggc aaaacaggcc
       61 gggcaaattt gttgaacaag caagaaagtt ttcgcttttt ttaatcctac attccccgca
      121 atagcgtggg aatctcgtac agactcaatt taaaacacac aacagccaca gtttcgaaag
      181 agtgccgaac ggcgggctcc cgaacacgga aagcgcgaaa cgcacacacg acaccatcgc
      241 cataccataa tcatcgcggc cacgctccaa gcttaggaat ttttcaattc cggaaacact
      301 gaccaagcga tccgtggtct aggagcaggt actatagcat aatcaccttg ggtgagaaga
      361 aacaacaggc gccatgagcg tggacacgta cgcgcccagc tcggcgctct cgttcctgga
      421 catggacgac aacgagctgc ttccgggagc ggatactcaa cccacgcagt acgattaccg
      481 cgactttacc atgccctcca cctcgcagag ccagacccag aacgatcagc tggagattgc
      541 ccaacgctgc tctgccggag actcgcatcc acgactggcc agcatcacca acgatctggc
      601 cgatctgcag ttcgaagagg aggacgacga gcctggcagc tcgtatgtga aggagctgcc
      661 gccgcatgcg tgcaagtatt gcggcatcca tgatccagcc acggtggtca tgtgcaacaa
      721 ctgccgcaaa tggttttgca acggtcgtgg aagcacttcc ggttcgcaca tcatcaacca
      781 tctggtgagg gccaagcatc gcgaggtgac gctccacggg gaaggtcccc tgggcgagac
      841 aatcctggag tgctactcct gtggtgtgcg caacgtcttt gtgctgggct tcattccggc
      901 caaggccgat tctgtggtcg tgctgctctg ccgtcagccg tgtgccgccc agaattcgct
      961 aaaggatatg aactgggacc aggaacagtg gaagcctcta attgcagacc gctgcttttt
     1021 ggcctggctg gtaaagcaac ccagcgaaca gggacagctg cgagctcgcc aaatctcagc
     1081 cgctcagatc aacaagctgg aggagctatg gaaggagaat attgaggcca cgtttcagga
     1141 tctggagaag ccaggcattg actcggagcc agcacatgtg ctactccgct acgaggatgg
     1201 ctatcagtac gagaagacct ttgggccgct ggtccgcctt gaggccgaat acgaccaaaa
     1261 actgaaggag tctgccacgc aggagaacat cgaagtacgc tgggacgtcg gcctcaacaa
     1321 aaagaccatt gcctacttta cgctggcgaa gaccgattcg gacatgaagc tcatgcatgg
     1381 cgacgagctg cgcctgcatt atgtgggcga gctgtacaat ccgtggagcg agatcggcca
     1441 cgttatcaag gtgccggaca atttcggcga tgacgtcggc ctggagctga aatcctcaac
     1501 gaatgccccg gttaagtgca ccagtaactt tacggtggac ttcatctgga agtgcacgtc
     1561 atttgatcgc atgacacgtg ctctgtgcaa attcgccatc gatcgcaatt cagtgtcgaa
     1621 cttcatctac tcgcgcctgt tgggccacgg tcgtgcggat tccaacgacg aggtgctgtt
     1681 ccgcggccca caacccaagc tcttcagtgc cccgcatctg ccggatttga atcgcagcca
     1741 ggtgtatgcc gtgaaacacg cgcttcagcg tccgctctcg ctaatccaag ggccgcctgg
     1801 cacgggcaaa accgtgacct cggcgaccat cgtttaccag ctggtcaagc tccatggtgg
     1861 cacagtgctg gtgtgcgctc ccagcaacac ggccgtggat cagctaactg agaagatcca
     1921 ccgaacaaac cttaaagtgg tgcgtgtttg cgccaagagc cgtgaggcca tcgatagccc
     1981 ggtaagcttc ctggcgctgc acaaccaaat ccgtaacatg gagaccaact cggagctaaa
     2041 gaagctgcag cagctgaaag acgagaccgg cgagctgagc tcagcagacg aaaagcgata
     2101 ccgcaacctg aaacgtgccg ccgagaacca actgctggag gctgccgacg ttatctgctg
     2161 cacatgcgta ggcgccggcg atggtcgtct atcgcgagtc aagttcacct cgatcctgat
     2221 cgatgagtct atgcagtcga cggagccgga gtgcatggtg ccagtggtgc tgggcgctaa
     2281 gcagctgatc ctcgtgggcg atcactgcca gctgggaccg gttgttatgt gcaagaaagc
     2341 agctcgtgcc ggcctctcgc aaagtttgtt cgagcgcctg gtggttctgg gcatccgtcc
     2401 gttccggctg gaggtgcaat atcgcatgca ccccgagctg tcccagttcc cgtccaactt
     2461 cttctacgag ggatcgctgc aaaacggcgt ctgcgcggag gatcgtcgcc ttaagcttga
     2521 tttcccctgg ccacagccgg agagaccgat gttctttctg gtaacacagg gacaggagga
     2581 gattgccggc tccggcacct ctttcctcaa ccgcacagag gcggccaacg tggaaaagat
     2641 tacgacgcga ttccttaagg caggcatcaa gccggaacaa attggaatca tcacgcctta
     2701 cgaaggtcag cgcgcttacc tggtgcagta catgcaatac cagggcagcc tgcactctcg
     2761 tctataccag gagatcgaga tcgccagtgt ggacgcgttc cagggacgtg agaaggacat
     2821 cattatcatg tcttgcgtgc gatctaacga acgtcaaggc atcggctttt tgaacgaccc
     2881 acgtcgcctt aatgttgccc ttacacgggc caagttcggg atcatcattg tgggcaatcc
     2941 caaagtgctc gccaagcagc agctgtggaa ccatctgctc aacttctaca aggaccgtaa
     3001 ggtgctcgtc gagggatctc tgaataacct taaggagtcg ctaatccact tccagaagcc
     3061 caaaaagctt gtcaacagca tgaacattgg ggcacacttt atgtccacca ttattgccga
     3121 tgccaaggaa gtgatggtgc caggctccat ttacgaccgc agtggcggtt acggccaagg
     3181 tcgccaaatg gtgggacagt caatgaatgg cggacagtac ggtggcagtg gaggtggtcc
     3241 ctacggaaac tcacccctcg gctacggtac tcccagctcc aattccatgg tgggctttgg
     3301 cctgggcaac ggaggcaatg gcgcggccgg tggcaacaac aacttcggag gggctggacc
     3361 cagttgggcg gctgcccacc tccaccacga ctccattggc tatatatcca acgagcatgg
     3421 agcagcagca ctgggcaaca tgccagttcc ggttggcatg ttcatgaaca tgagcaatat
     3481 tccgccgcgt ttctacaacc agcaccagca ggcgatcatg gcggtcaagc agaatcgcgc
     3541 cattcaacaa cagacgggta atttctctcc cggtaactcg ggtcctggag tcactggagt
     3601 cggagtcgga cgaagcgcca ccccaggcgg caataagaag accaacaagc tgggaaaatc
     3661 gcgcgtaacg ggcggtggaa ctggcggggc accgctaaca caaggaagct cggtatgcaa
     3721 tgctgctcca tacagtcagc acccgatgcc tttgtcgctg cagatgaccc agcccagcgg
     3781 atttgctctg tcccagcagc cggaactttc acaggacttt gggcaaatat cgcagatgga
     3841 cggtttgcta tcccaggatg ttgcctttaa cgcgtcgggc gagcggagct tgaatcagtt
     3901 ctcacagcct tattgagaat ccggttggag gtgcaacaac tacaaacgat aacaagcaac
     3961 acaaacgaaa caacaacaaa ctcaactttg aagtcatcat caaggagtag catcagtagg
     4021 cagcaggaaa aagcagagag gaccatcacg ggaacaacga cagatgcggg aaacaatgcg
     4081 acctaagaac attaggacaa agcgggacat taaaagatgg caaatcgaga cgaggcagcg
     4141 tgatagatgg agacggatat ggcaagatgt ggagttacaa agtaataaag aagactgaga
     4201 cgggagagag atgtcgaaag atcgaaatat cgagagcaaa tcactgtagg ctgccaggat
     4261 gcacagctgc agttgctgtt tccgtagcgc cgcgggccat ggagtcatag ccaggcgaca
     4321 tgccattggc caccggccat tggccattgg tcacgagtgc gctcccgaga cggagttcgc
     4381 ccacggatga gccaatctgc cagcaaggcg ccacacaaga tggacaactt ctcgacacgt
     4441 ttcttttctc ttttgccagc ccaggattcg cagccggagc ctaacaaaga cgcaatcact
     4501 cccgcccagg acatgtattc accaagtggc ttatcttcta accttcttct ggcctctagt
     4561 gcagcagcca atctttagct cctgttttaa cattttccca cccaaagcgg tttataccga
     4621 tccccatata tgtatgccca ctgttgtaca tttttggact cttttttgat gcatttgtta
     4681 tcctaacaaa cacgaaaaca aaatcaaac