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Drosophila melanogaster karl, transcript variant C (Karl), mRNA.


LOCUS       NM_001298208            2447 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001298208
VERSION     NM_001298208.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 2447)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2447)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2447)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 2447)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 2447)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 2447)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 2447)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 2447)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 2447)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 2447)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 2447)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 2447)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 2447)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 2447)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 2447)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 2447)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 2447)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 2447)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 2447)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 2447)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 2447)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 2447)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 2447)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2447
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..2447
                     /gene="Karl"
                     /locus_tag="Dmel_CG4139"
                     /gene_synonym="CG4139; Dmel\CG4139; karl"
                     /map="10E3-10E3"
                     /db_xref="FLYBASE:FBgn0030334"
                     /db_xref="GeneID:32131"
     CDS             1125..1925
                     /gene="Karl"
                     /locus_tag="Dmel_CG4139"
                     /gene_synonym="CG4139; Dmel\CG4139; karl"
                     /note="CG4139 gene product from transcript CG4139-RC;
                     CG4139-PC; Karl-PC"
                     /codon_start=1
                     /product="karl, isoform C"
                     /protein_id="NP_001285137.1"
                     /db_xref="FLYBASE:FBpp0312033"
                     /db_xref="GeneID:32131"
                     /db_xref="FLYBASE:FBgn0030334"
                     /translation="MERIMGRNGSLLLTAVLIIILDVLLAPVGANLWTRHNSNAYQTR
                     RRSGPSNRCPKVGAIKNFDLERMMGCWHVVQYYASTEELPEYACMRSHFSFSKEDQHI
                     TMNFSYIFAEDPLREKLVGNITWMIPKFQEPGHWQHTEDIYEGIYNTYVLDTDYDTWG
                     LVMHCAEKKKQPRYLSALLLSRKTSLADNEISFLRGKLPQDIDTSFMFNIGQESCDNL
                     MESSRDDPLAYVVNGRKRAKEIFKIINKPDGRVRASSEARSYEQSEKL"
     misc_feature    1320..1670
                     /gene="Karl"
                     /locus_tag="Dmel_CG4139"
                     /gene_synonym="CG4139; Dmel\CG4139; karl"
                     /note="lipocalin/cytosolic fatty acid-binding protein
                     family; Region: lipocalin_FABP; cd00301"
                     /db_xref="CDD:381182"
     misc_feature    order(1323..1325,1335..1337,1395..1397,1401..1403,
                     1434..1436,1440..1442,1446..1448,1491..1493,1497..1499,
                     1503..1505,1530..1532,1536..1538,1563..1565,1569..1571,
                     1575..1577,1602..1604,1608..1610,1614..1616,1650..1652,
                     1656..1658,1662..1664)
                     /gene="Karl"
                     /locus_tag="Dmel_CG4139"
                     /gene_synonym="CG4139; Dmel\CG4139; karl"
                     /note="ligand binding cavity [chemical binding]; other
                     site"
                     /db_xref="CDD:381182"
ORIGIN      
        1 acttgttgct ttagttcgtt tcatttcgtc tcgctgccgc attaagagcc gcttttcgct
       61 tcggtgcgtc tgcgaagggg cggaaggtgg tgctgagaag aggggggtgg cgaatggtgg
      121 gagaaaggcg atggaagggg caaggaagga gctgccgtag aagccggaac tggccgctaa
      181 cgcatcgcaa cgcaatgcgg cgacgaaagt tgcgccgctt ttttgggctg gccaacaaaa
      241 aaccagacgg ctccaaaaga aatgggagaa aaaagcaaaa aaaaaaagac gaagctaaaa
      301 agaagctaaa ctgcagacgc aggcggaaga agaagcggcg gcggcggcgg caaaagtagc
      361 aaccttcgag gatgtccagt ttcattccag tccggtcgtg aaaatgccgc gcaactcgtt
      421 tcgcaataaa gagaaagtgt ccagcggatc gcgctgttcg ttctggcgat cgtaaagaat
      481 aaatttgcag gctattaaaa tgtttcctgt ttccactcac caccgctcaa cgctccccgc
      541 tctcacccgc tcttttccgc atccacttcg ccaccccgaa aatttcgctc tccgcggcga
      601 gaaagttgcc tggaaatctg gaaatctgca tccatgcgac aagtgaaaac aagatgcagc
      661 caaaaatacc tactcccgtt ccccagactc tatatatttc catacaagcc tgcaaatatg
      721 tgtatgtata tgcttacata cataggtatg tgcgcattgg aaggcgttga ctggacttta
      781 ctggcaaacg gacgttataa ttgataagag cgactaactc acccgcgctc ttgagagcaa
      841 ggggaaatgg aacggcggct gattaagttc caatattaaa ctgctgaaaa gagatggcat
      901 cgccttggaa aaccgctaat ctttcggtgc tagcgattac aggaagtaat ggaaagattt
      961 tttagagtgt acttattgct gactgctaat gtcgcatgtt gctcgcggag atggcgcagt
     1021 gccatcgaaa acagttccag ctacagcgca acggagatcg agcgtctgaa cccgccggaa
     1081 gatcaacgac aataaataat tgtagctcac cgtcatccgg attaatggag aggatcatgg
     1141 gcaggaatgg atcgctccta ctgaccgccg tcctcataat tatcctggat gttttgcttg
     1201 caccagtggg tgccaacctg tggacacgac acaatagcaa tgcctatcaa accaggaggc
     1261 gctcaggtcc cagcaatcgg tgtcccaagg tgggagccat taagaacttc gatttggagc
     1321 gcatgatggg ctgttggcac gtggttcagt attacgcatc cacagaggaa cttccggagt
     1381 acgcgtgcat gcgcagtcac ttttcctttt ccaaagagga tcagcatata acgatgaact
     1441 ttagctacat atttgcggag gatccgctgc gcgagaagct cgtgggcaac atcacctgga
     1501 tgatacccaa attccaagag ccaggacatt ggcagcacac ggaggacata tatgagggca
     1561 tctacaacac atacgttctg gacacggact acgacacctg gggcctggtg atgcactgcg
     1621 ccgagaagaa gaagcaacca cgttacctgt ccgccctgct tttgtcgcgg aaaacatcgt
     1681 tggccgacaa cgagatcagc tttctgcgcg gcaagttgcc gcaggatatc gacacatcct
     1741 ttatgtttaa catcgggcag gaatcgtgcg acaatctaat ggaatctagt cgcgacgatc
     1801 cactggccta tgttgtgaat ggacgcaaga gagccaagga aatcttcaaa attatcaata
     1861 agcctgacgg cagagtgcgc gctagtagcg aagcgagaag ctatgagcaa agcgagaagc
     1921 tgtgagcaaa gcgagtcgat ggcagagtaa gagctaagcg agaaacgagc tacattgctc
     1981 tcttttagtt attaatgtga acgtgatgga ttcggacgag gaattttttg catcaagcgc
     2041 aactattaac tttctgttaa aactgtcgtc caccctctta actgaaatag aaatgaaaaa
     2101 ggcgaattca ataatttata taaaaggtta tttacagaat ggaacaagac aaaacaaaat
     2161 aacgtgtgtt ttgaaaataa acggtaatat agcgcagaat ataacaaaac aatcgtacgc
     2221 cctgagcgag ttgaagcgat aaggccttgc tctcgctttt tcgcttaagc tcgcaactcg
     2281 cttcgctctc actctgacat ctttcgagcg attgcgctta aaatgcatgc agtgggttta
     2341 tcgctcgttc ttgtattatt agtctaatca atcaactaag agaaaatatt atacgaaaac
     2401 ccgatttatt ttgtcaataa tacaaattta aataagcact ttcaaac