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Drosophila melanogaster nostrin, transcript variant H (Nost), mRNA.


LOCUS       NM_001298100            5956 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001298100
VERSION     NM_001298100.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5956)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5956)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5956)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5956)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5956)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5956)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5956)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5956)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5956)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5956)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5956)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5956)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5956)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5956)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5956)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5956)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5956)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5956)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5956)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5956)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5956)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5956)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5956)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5956
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5956
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="Nostrin"
                     /map="8C3-8C4"
                     /db_xref="FLYBASE:FBgn0259734"
                     /db_xref="GeneID:8673992"
     CDS             666..4658
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="CG42388 gene product from transcript CG42388-RH;
                     CG42388-PH; Nost-PH; nostrin"
                     /codon_start=1
                     /product="nostrin, isoform H"
                     /protein_id="NP_001285029.1"
                     /db_xref="FLYBASE:FBpp0310014"
                     /db_xref="GeneID:8673992"
                     /db_xref="FLYBASE:FBgn0259734"
                     /translation="MSQFRDNSWLANARSYGVLKSLRSSARYAKAKSKSAINLNAHLK
                     KQQKLEEGHPEKKRQDKKILRQSVSEDQPIYANVDEVIPIHLEPETGTEVDALMGNAQ
                     PSKMNHLRVHKFKLGGKDNAAMADLPQSENTTNNNNNIGSNNNQKGGAKGFLGRIKRY
                     SVLGNKLGRRNLGSMNLNPPNNVVDNSVSPTKLHTGSYNMTGSHSDDHRLEIGAPILI
                     STTTLDTDRFDVTEARLKQIGGGIAQTSSIVRTLTPRSSDEEEFVDARSSPQQMERDE
                     DLQIADDQVEKNDRDQYGHQFQLPKKQHREEEMGDLKYLDDLEEPEQFETPKHEVEEK
                     LLTANQDVKRPITPITIAIDPPIRRPRIARQQRQSQSVQNLHRSELKVYLHKSNSVAL
                     DMNVTAPAKLGLDLNLPELPELYGASELSLAASDNKENLPAVKPSAERSPIPNGGFMA
                     QQPHFKSLDSFHLNTRSHSNQSSQQSSRQSLACSSSNGEYDFDLKSVSYQSLNAQNLF
                     VSIDELQELTRQINETEDFGKEIDLEYCAHRDQLRPSERRITLLKNKNQTLINFNHNK
                     EKLRKGWHGMKHWLGEEGSKIKEAVRQQTPLKRLAQSRSNLNQSTADASRQSMSPERT
                     QRDVTESCEDVTERTEMESSMSHRNSEEDLSPHAKRFKDEGQNGFEELRRYVKQGGDF
                     SKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPGSVADAWRGVATEMESRSDIH
                     RQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAARVLGEWRASEAKAKKASHTAA
                     RENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAV
                     KRADVEYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARLISDMN
                     PILGGLSTRLQPQLDACNVAKDMQVVRHIRRNSEGPSEQLLPDFYCEHTTLAMNRERR
                     KHALIKLLQLVKTDLERERRSRDGLRGLSQSLNHQEHQNITDKLYHIRSMLTYLEGAR
                     LKLHSALLELDHKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSM
                     LAHDITDITTNHEDELPDENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETN
                     FTSQPKIISTTNAAIAVSVKSKTLANLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQ
                     DSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQNPTINGQVQTQHFYQNAQEL
                     QKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDGWWLGALRNHIGI
                     FPATYVEECA"
     misc_feature    2652..3389
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase
                     TRaffic INducer (NOSTRIN); Region: F-BAR_NOSTRIN; cd07658"
                     /db_xref="CDD:153342"
     misc_feature    order(2667..2669,2676..2678,2697..2699,2706..2711,
                     2718..2720,2727..2732,2739..2744,2751..2753,2763..2765,
                     2772..2774,2784..2786,2859..2861,2868..2870,3189..3191,
                     3201..3203,3276..3278,3288..3290,3297..3299,3306..3311,
                     3318..3320,3330..3332,3339..3341,3351..3353,3363..3365,
                     3372..3377,3384..3386)
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153342"
     misc_feature    4491..4649
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="Src homology 3 domain of Nitric Oxide Synthase
                     TRaffic INducer; Region: SH3_Nostrin; cd11823"
                     /db_xref="CDD:212757"
     misc_feature    order(4506..4508,4512..4514,4521..4523,4533..4535,
                     4587..4592,4629..4631,4635..4640)
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212757"
ORIGIN      
        1 ctcgtttagt tcgccgtttc gtagaagagc gacgagagcg catgcggctt ttccagcgcg
       61 gtttttccac caaaacttcg gcgacctgtg tactattatt tatattttta ttacattttt
      121 ttttattgtt ttttctttct acctgcgaac gctttgctcg ccttgaactg gagtgcttcg
      181 tttttgagta gtgcatctct gccttttgct ggcgagtgct acaattgtcg cacgtaatcg
      241 tgctggcagt tacgcctcag aaagcagcca aaaaaaaaag aaaaaaaaac gcagatacaa
      301 gatacaaaag tatctcgaac acatgcgtta cgctcagctg actcgtcgtg tgtgtgagtg
      361 tatcgtagtg tcgttgtgtg tgtgtgctaa caaattggtt agataaatta aacaaaaact
      421 gtgaaattcg cgaatcaaaa aaaaaaaaaa aacaaaagta aaataaaagt tacacaaacg
      481 aaatacgcga aggaaaagcg acgagctgaa actgaaagca aacaatcagc cgggctgacc
      541 agtagtaaat gctttaaact tcaattataa aatttaaatt gaaaaaaata aaaaaaacac
      601 atatagttca caataccgca tcataatatc ctacccgcat cctaaccccc gccgctggcc
      661 aaaatatgtc acaattccgc gataattcat ggctcgccaa tgcgcgatca tacggcgttt
      721 tgaagagttt gagaagctcg gcacgttatg ccaaggccaa atccaagtcg gccattaatc
      781 tcaatgccca tctgaagaag cagcagaagc tggaggaagg acatcccgaa aagaagaggc
      841 aggataagaa aatactcaga cagagtgtca gtgaggatca gccgatctat gcgaatgtgg
      901 acgaggttat accgatccat ttagaaccgg aaaccggaac cgaagtcgat gctctaatgg
      961 gtaatgcaca gccgtcaaag atgaaccacc tgcgggtgca caaattcaag ctgggcggca
     1021 aagataatgc cgccatggcc gatttgcccc aatcggaaaa caccaccaac aataacaata
     1081 atatcggaag caataataat caaaaaggcg gtgcaaaagg atttctggga aggattaagc
     1141 gctactcagt gttgggaaat aaactgggac gtcgtaatct cggcagtatg aatttgaatc
     1201 cgccgaataa tgtcgttgat aattccgttt cgcccactaa actccatact ggaagctaca
     1261 atatgaccgg tagccattcc gatgatcatc gcctggaaat cggagctccg attttaatat
     1321 cgactacaac attggacacc gaccgtttcg atgtcacgga ggcgagactc aaacagattg
     1381 gcggcggcat agcccagacc tccagtatag taagaaccct gacgcccagg agttcggatg
     1441 aggaggagtt tgtggacgcc aggagtagtc cgcaacaaat ggaaagggat gaggatctgc
     1501 aaatcgctga tgatcaggtc gaaaagaacg atcgcgatca gtatggtcat caatttcagc
     1561 ttcctaagaa acaacatcgt gaagaagaga tgggggactt aaaatatcta gacgatctgg
     1621 aggaaccaga acaatttgag acgcccaaac acgaggtgga ggaaaagctc ctgactgcca
     1681 accaggatgt gaagcgcccc ataacgccca taaccattgc catagatccc ccaatcagac
     1741 gaccacgtat tgcccgccag caaaggcaat cgcaatccgt tcagaatctg catcgcagcg
     1801 aactgaaggt atacctgcac aagtccaact ccgtggcgct ggacatgaat gtcacggctc
     1861 cggcaaagct gggcttggac ttgaatctgc ccgagttgcc ggaactctat ggagccagcg
     1921 agctcagttt ggcggccagt gataataagg aaaatctgcc agcggtgaag ccatccgctg
     1981 agcgatcgcc cataccaaat ggtggcttca tggcccagca gccacatttc aagagcctag
     2041 actcgttcca cctgaacacc cgctcccatt cgaatcagag ctcccaacag agttcccgcc
     2101 aaagcttggc ctgcagcagc agcaatgggg aatacgactt tgatctgaag tcggtgagct
     2161 atcagagcct gaatgcccag aatctgttcg tttcgattga cgaactgcag gagctaacgc
     2221 gtcagatcaa cgaaacggag gattttggca aggagatcga tctggagtac tgcgcgcatc
     2281 gcgatcaatt gagacccagt gaacgcagga tcaccctgct gaagaacaaa aaccaaacgt
     2341 tgatcaactt caatcacaac aaggagaagc tgcgtaaggg ctggcacggc atgaagcact
     2401 ggctgggcga ggagggctcc aagattaagg aggcagtgcg tcaacagacg cccctcaaac
     2461 gtctggccca atcacggagc aatcttaacc agtcaactgc ggatgccagt cgccagtcaa
     2521 tgtcgccgga acgcactcaa cgcgatgtaa ccgagagctg tgaggatgtc accgaacgca
     2581 ccgaaatgga gtcgtccatg tcgcaccgaa acagcgagga ggatctgtcg ccgcatgcca
     2641 agcggttcaa ggatgaggga cagaacggct tcgaggaact ccggcgatat gtgaagcagg
     2701 gcggtgattt tagcaaggag ctcatctttg tcctgcagga gagagccgat tcggagctga
     2761 tctactccaa gtcgctatcg aaactggcca acaagctgaa caaagcgggc agggaaattc
     2821 ccgggagcgt ggccgacgcc tggcgtggag tggctacgga gatggagagc cgcagcgaca
     2881 tccatcgcca gttggcagcc tcgctaacgg atgagctggt caagccgctc aagatcgtcg
     2941 tcgaaggaca tcacaaggcg cgcaaggcgg tggaaagcaa cgtggacaag gcggcgcgag
     3001 tactgggcga atggcgagcc agcgaggcga aagccaagaa ggcctcccat acggcggcgc
     3061 gcgagaacga gaagctgcag gacgcaatgc tggacgtgcg catccagaag tcaccatcga
     3121 ttgccctgct ccaccaggga cccaacaagc aggccgcaga aaaggagctc aagtcagcgg
     3181 agaaggattg cgtcaagctg gataacaagc gcaagaaggc cgaggaggcg gtgaagcgtg
     3241 cggatgtgga atactacacc ctgtgcgtgc gttcggagcg agcacgcgta gactgggaga
     3301 tggccgtgct ccggggaagt gcccaactgc agagcagcga acagcagcgg ctgggcaata
     3361 tgcacaactt tgcccagcag tatgcacgcc tcatctcgga catgaatccg atactcggtg
     3421 gcctgagcac acgcctgcag ccgcaactcg atgcttgcaa tgtggctaag gatatgcaag
     3481 tggtgcgcca catccgccgc aattcggagg gacccagtga gcaactccta ccggactttt
     3541 actgcgaaca caccacgctg gccatgaatc gggagcgtcg caagcacgct ctgatcaagc
     3601 tgctgcagct ggtcaagacg gatctggagc gggagcgacg atcccgcgac ggattgaggg
     3661 gactgtcgca atcgcttaac catcaggagc atcagaacat caccgataag ctgtaccaca
     3721 ttcgttccat gctgacctat ttggagggcg cccgtctcaa gctgcactct gccctcttgg
     3781 agctggacca caagcccaga gccactcacc cactggccca gcacattcat atcacccgtg
     3841 accgcactgg tttgcagcag agcatcctga aggtgcccaa ctggctgaag aacaacgaca
     3901 agtcgcagac gcagcaatcg accagtatgc tggcccacga catcaccgac ataaccacta
     3961 accacgagga tgagcttccc gacgagaact gctcccacct gcacagcagt agccatagca
     4021 acaataatag caacggctcc tgcacagatg tcagttcggt ggtgaagcct tttaaccgaa
     4081 gcaaaagcaa catcgagacc aatttcacca gtcaaccaaa gataatctcg acgacaaatg
     4141 ccgcgattgc cgtgtccgtt aagtccaaaa ccctggccaa tctgcaggat ggccatcaca
     4201 ataaccaaca gcaccatcat catcatcata atcatcacag cgatcgcggc caggcggatg
     4261 gtggatccaa tcagcaggac tctgatttcg atgagttcag ctcgcaggac gaggacgacg
     4321 agccgcagca gccgcagcaa caaccgcagc cgttgcaatc gcagcagcag caacagcagc
     4381 cgttgctgca aaatccaacc atcaatggcc aagtgcagac gcagcatttc tatcagaatg
     4441 cgcaggaact gcagaagggc caaaagaacg gatccgttcc gatactggga cgctgcaagg
     4501 cactgtatag ctacaccccg aagctctacg acgagctgga actgagtccc ggcgacatca
     4561 tcgaggtgca tgccaaacag gacgacggct ggtggctggg cgccctgcgc aatcacatcg
     4621 gcatctttcc ggccacctat gtggaggagt gcgcctagtt ctagttggga aacgccctgc
     4681 cagcttccct ccatagctat aaaaaacaaa aaaaaaacgt gcgaatatgt gtgtgtgtgt
     4741 gtgtgcgact gccagaggag tgtgtgtttg ccttgtggag cgatttgttt gacatgaaac
     4801 caccgaagga gaaagtaatc ccaaggcgat ttagggttta tttgcaacat tgctgacaat
     4861 caaatgattt acattgattt cacttcaact tctatctatt taaacgctaa tatgattgtt
     4921 tattgacaaa tgaaaatgaa acaaatgaaa atttattttt agaaaagatc atttaaactc
     4981 cgctgaaaaa ttgagaatag ttacacttta aagaagttta attctttttg ttttccctat
     5041 aagcggaaaa atgtactgca tatgtcttgt gcttaaaaaa ttatttgcct aaacggaact
     5101 taagaaaata tcttgaaaaa aaaagctgta agaaagcgaa gaaacaacaa atatttacgt
     5161 tttcgtgtaa tttgtgcatt cagcactaat ttttcacttt aaaagaaaac attaagaatt
     5221 aatcacttaa cttcattgaa aacgaacaaa atcgagaaag caaatacttc atttttgtta
     5281 gaacattttt ttttgtaaaa atgaaaatat tttgctttgc ttatattatg ggcttactaa
     5341 gccattttct tggtagccaa gttaaatgaa acgaaaacaa aaactcaatt aaatactgag
     5401 tgaagaatat ttaatacatt gacatttttt caaggagaga atatatcttg atttttttta
     5461 acatttgatc gactaaccat tttcatattt ttcgccataa aaaaaccgtt tttaatttgt
     5521 tagctttagc cctatattat tttatttgat ttatgccctg attggcttca agggtttatt
     5581 ttaatcgttt agttttatat caaacaaatc gatccacttt agttttacga acttagctaa
     5641 cctgctcttg actaaatgct aatcccaagg acaggccttt gcattaagca ttaagctatg
     5701 taatctacga gtaaagattg tattaatttt atatatatat attttttttt tattatgtta
     5761 actaccaatt acagtttatg tttagcctcc agttgagtca tttaccattt atcgatcctg
     5821 cacattaatt gtagcgctgg tcctcataaa taaagcaaca tattgttatt tcattattat
     5881 catttttttt ttattgcata tgcataatgg aacgacatac atatgtataa atatatatta
     5941 ttatattcaa catgcg