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LOCUS NM_001298086 10506 bp mRNA linear INV 26-DEC-2023 transcript variant C (nAChRalpha3), mRNA. ACCESSION NM_001298086 VERSION NM_001298086.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 10506) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 10506) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 10506) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 10506) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 10506) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 10506) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 10506) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 10506) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 10506) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 10506) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 10506) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 10506) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 10506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 10506) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 10506) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 10506) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 10506) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 10506) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 10506) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 10506) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 10506) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 10506) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 10506) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..10506 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..10506 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="nicotinic Acetylcholine Receptor alpha3" /map="7E1-7E4" /db_xref="FLYBASE:FBgn0015519" /db_xref="GeneID:31767" CDS 1362..3749 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="CG2302 gene product from transcript CG2302-RC; CG2302-PC; nAChRalpha3-PC; drosophila alpha-like subunit 3; nAcRalpha-7E; nicotinic acetylcholine receptor alpha 7E; Dalpha3" /codon_start=1 /product="nicotinic acetylcholine receptor alpha3, isoform C" /protein_id="NP_001285015.1" /db_xref="FLYBASE:FBpp0308714" /db_xref="GeneID:31767" /db_xref="FLYBASE:FBgn0015519" /translation="MKWFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPV VNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHV PSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFD EQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNE KFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLS ISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQ THTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPP PVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTM STANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGN GNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTT TVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQ QHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPAC QREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMV LDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMPIDIKLSEIASTTAKPNVARPVL" misc_feature 1434..2090 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="extracellular domain of nicotinic acetylcholine receptor subunit alpha-like found in protostomia; Region: LGIC_ECD_nAChR_proto_alpha-like; cd19031" /db_xref="CDD:349832" misc_feature order(1542..1544,1548..1550,1566..1571,1590..1592, 1656..1658,1662..1664,1689..1694,1698..1700,1704..1709, 1719..1721,1725..1730,1740..1748,1752..1754,1782..1784, 1788..1790,1794..1796,1806..1808,1872..1874,2079..2081) /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="pentamer interface [polypeptide binding]; other site" /db_xref="CDD:349832" misc_feature 1809..1853 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="Cys-loop [structural motif]; Region: Cys-loop" /db_xref="CDD:349832" misc_feature 2085..>2354 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="transmembrane domain of nicotinic acetylcholine receptor (nAChR); Region: LGIC_TM_nAChR; cd19064" /db_xref="CDD:349866" misc_feature 2085..2159 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="TM1 helix [structural motif]; Region: TM1 helix" /db_xref="CDD:349866" misc_feature order(2181..2183,2190..2192,2202..2204,2211..2216, 2223..2225,2235..2237,2319..2321,2328..2330,2337..2342, 2346..2354) /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="pentamer interface [polypeptide binding]; other site" /db_xref="CDD:349866" misc_feature 2181..2246 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="TM2 helix [structural motif]; Region: TM2 helix" /db_xref="CDD:349866" misc_feature 2277..2345 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="TM3 helix [structural motif]; Region: TM3 helix" /db_xref="CDD:349866" misc_feature <3408..3641 /gene="nAChRalpha3" /locus_tag="Dmel_CG2302" /gene_synonym="Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3" /note="Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932" /db_xref="CDD:460753" ORIGIN 1 acggcacgcg tttcgcttcg agagagagag agagttaccc gaaaaataac caagcaagca 61 gcacaaaaaa cgcgctaaag tcgccaattg ttgttgttgt cgtcgaaagt cgaaagtcgg 121 ttgtcgcttg tctcgttgtt tcccgttgtt tctcgttgat tgtcgttgtt gttgtcgccg 181 ccgtcgtcgt cggttgttgt cgtattgttg ttgttgctgg ctctctgttt ttttttgcgt 241 tattttgttg ttgccgtcgt cccgccgcct ccgccttcgc cgccccgccc ccttttcgtc 301 tgactgtctg cgtgtgagcg tgtgttggtg tgttgtgtct gtgtcgcgca tgtgaccgcc 361 tcagctgctg aaacttcaaa acaaatattg gaaaattccg aataaaaaaa ggtgtgccag 421 ttagccgaag gaaccgaatg cagattgaaa gctaaagttc gaggaagcca acaggaacca 481 aaacaaggaa gcgagcccct gtccgtgcga aggacctcct gggtctgtgt gcgtgtgtgc 541 gtgtgtgggt gcggcgacac cactaccact accgctatca ctaccactat agcagcatcg 601 ggcgaaatac tttttgtgcc aaggactcgc cctttgtcta tctataccac tccccttgca 661 ctcttcgcgg aataacgtgg aacaaatgaa ggaggaagcg caggaatgag gcgatgtgaa 721 gcaaaaggac aacgaggaca gcaaggaaca caacaaaggc aaaaccggaa gaaggccacc 781 aaattgaaga acacacacat ttgaagaatt ttaatcgaaa actgccaaga aacaagtata 841 tttacaaata tatttatata ccttgtaagc caaaaaaaaa aaacaaaaat aagaaaaaaa 901 cgaccgtaca ttaatagatc taaaatatat agatacatat atagagaaat atgttatatt 961 tactatgaaa tcgaggagca tggaagcgat acccagaata ataatcgatg taaataaatg 1021 ctgccaattc gattacactg cgaattaaga actgcaactg agatgcatag aacgcacaac 1081 aacaatccca gaaataccag gaatccacaa tccatgaaga gaaagttcac ttttcccgcg 1141 acagctgcgc ctgcgcctta aaaactagac ataaacatat atatatatat atatcgtatc 1201 gatcttggaa ctattaaatt gaaaggattg gagccgccag agccgaggat tatatatata 1261 tatatagtca tatatatata tatatatata gagcgagaga gagagacggg gcagatccac 1321 caccgcagca caggcaaaaa aagcgtgcag agggaaatga gatgaagtgg tttcaagtga 1381 ccatagatat gattcttgtg ctttcattta tatcaagcag cacagcgaat ccggatgcga 1441 aacgattgta cgacgatttg ctgagcaact acaacaaact ggtacgaccg gtggtcaatg 1501 tgacggacgc gctcaccgtt cgcatcaagc tgaagctatc gcaactgatc gatgtcaatc 1561 tgaagaacca gataatgacc accaatctgt gggtggagca gtcctggtac gactacaagc 1621 tcaagtggga gcccaaggag tatggcggcg tcgagatgct tcacgtgccc tccgatcaca 1681 tctggcgtcc ggacatcgtt ctctacaaca acgccgatgg caatttcgag gtgacgctgg 1741 ccaccaaggc cacgttgaat tacacaggac gcgtcgagtg gcgaccgccg gcgatttaca 1801 agagctcctg cgaaatcgac gtggagtact ttcccttcga cgagcagacc tgcgtcatga 1861 agttcggcag ctggacatac gatggatttc aggtggatct gcggcacatc gacgagctga 1921 acggcaccaa tgtcgtggag gtgggcgtgg atctgtccga gttctatacg tccgtcgaat 1981 gggatatcct cgaagttcct gcagtgcgaa acgagaagtt ctacacgtgc tgcgatgagc 2041 catatctgga catcaccttc aacataacga tgcgtcggaa gactctcttc tataccgtca 2101 acctgatcat tccctgcatg ggcatcagtt ttctcaccat cctcgtattc tacctgccat 2161 cggatagtgg cgagaaggtc tcattaagca tatccattct gctgtcgctc actgtgttct 2221 tcctgctgct ggcggaaatc attccgccca catcgctggt ggtgccgctg ctgggaaagt 2281 ttgtgctctt caccatgata ctggatacct tcagcatctg tgtgactgta ttggtgctga 2341 acattcactt ccggtcgccg caaacgcaca cgatggctcc ttgggtgcgg accgtgttca 2401 tcaaccagct gccccgcttc ctggtcatgc gacgtccgct ctatccgatc agcgagatga 2461 tcaaatcctc gcgccgccta atggtgcgca cctgcaatgg actcgaactg agggatcaaa 2521 taccaccgct gccaccgccg gtggccttgt ctcgtatgca ccacagcccg aagacgacat 2581 cgcgtagcac ctcgccgcat ctgcagcacc gcgtgcaaac ctacaacctg atggacgagt 2641 gcggcatggg catgggcggc ggtgcctcta ccattaccgg ccatttgagc tccctgtatc 2701 cgccgacgat gtcgacggcc aaccaacaga cctcgaccac atcatcgctg atcgatgccc 2761 agtaccacaa tcagtaccag cagacgggcg gttcgctgct ggaccatcca cttacgccca 2821 ccaagttccg ccaaatgact tcgacctcca gccagacggg tcagaatggc agcgggaacg 2881 gtaacggtaa cggtggctac ggcgggcatg gccagagcgg tggccatcat ctgtatcgac 2941 agcagtcgag ctgctcggcg aatttctcgc cgctgccgca gcacgcccac caggcgcacg 3001 cctccaccac caccagcgat ctgggcatgg ccaatccgaa tgtgataaaa tcgacgacga 3061 cggttaactc ggtggccacc gcctcgacgc tggcggactc ctgctgcagc ggcaccattc 3121 agatccacca gggcatgggc gccggagccg cttgccagtc gtcggagctg ctgcaccatc 3181 agcagttgca ccaccagcag atgcatcacc agcagcaaca gcagcagcag cagcagcatc 3241 accaccacca gcgacccacc acctcggcag cggcggcagc agcagcggca gccgccggcg 3301 gacccagcac ctcggcagcg gcagctgcag cagcggcggc agcggcggcc ggaacgccac 3361 ccccaccgcc tccgccggcg ggcgtctgtg atattctgcc cgcctgccag cgcgagggcg 3421 ggccgcactg ctgttcgggg cgtggcaatg tgcgccaacg gtggcacacc tgtccggaac 3481 tccacaaggc catggacggg gtcacctaca ttgcggatca gacgcgcaag gaagaggaga 3541 gcacaagggt gaaagaggac tggaagtacg tggccatggt gctcgatcgc ctgttcctgt 3601 ggatcttcac aatagccgtg gtcgtcggca ccgctggcat tatcctgcag gctccgacgc 3661 tctacgacac ccggatgccc atcgatataa agctatcgga gatcgcctcg acgacggcca 3721 agccgaatgt ggccaggcct gtgttgtaaa cggatcgata attatcggtt cgcgcggatc 3781 gatcgatatt cagtatttcg aagaaaccac aaaccacaca cacagtctga tggagcaaaa 3841 cacaagtaat gaatgaaatt cgcatttgtt ttttctttaa ccagagacgg aggatagaaa 3901 aaaaaaagaa agaaaaaaaa taacaaaaaa aaaataacca caaaacttgt tccagaaaaa 3961 caaagagaag cgacgacgag aatccaagta actataacta ataaattgta tttgttgtat 4021 acataaatgg tataactaac tataaataat ttgtacacta atgtttaaac aggcaacgat 4081 gctaaacaaa aacggttttt tttctaggca acctaaaatg aacagagaga caaaagtgac 4141 gaaaaagcaa aaaacagaaa acagataaaa tacgaattaa ttaagtaaaa caattcaact 4201 gaaacgaagc gcaaaatagt atgcaacaga taaacaaata cgatttatgg taataattga 4261 gagcgaaatt aaattagtga aattaaatta gcctagccaa aacatcaaga ataacggaaa 4321 caaaaaaaaa acacaaaaca aaacaaaaaa aaatcgtgta tttgttgaac aagaaagtga 4381 gtagatgaag gacaacatta gttagctaag cgaatcaaca taaaggaaca ggaaaaaagc 4441 caacaaaaat ggcatatgtg tgtaaaagtg tgtgtgtgtc tgcactgaaa gaaaaacgta 4501 ggaagagaga acgcgacgtt gtttgccatt tagagccttt gaataccatt taacttgaag 4561 agattaattc caacttttga atgtagttgc atacatacat acataacaat agctcacaga 4621 aagttaacag agaacatttt gcctttaaat caagacaaat gcatcttgaa gatagtttcc 4681 ataaatatta taatgttttt aaagttttct atggaaatct ttggctgatt gtttgcaaat 4741 ttttatatgt aaaagcgtat ctgttaagga agttatgata aatcaaattt agagacttac 4801 gacgacgcga agaagccctc ttttttccat tttgaatact tctgctcgat tcattacatt 4861 ttctccgtgt gcatgagtgt gcgtgctgcc gtgtgtgtgt gtgtgtgtgt gtgcatatgt 4921 gtgactgcaa atgaggcatg caaattagtg caaataaagc gagagaaagt aagagggaaa 4981 gagtgtaaga gtgagaaggg ggggtagagt gcgggaaacc ggaaaagccc ccgcaccctc 5041 aacatcaccc acaccacgct ttcgccttgg ggcaattagt tagcacaaag ctttagttat 5101 tatgcccaag tgtacgtggg cctgtatgcg tgttggtgcg agcgcatgtg tgtgcatagt 5161 aaataatcac cattagaaat tcaaattcaa ttttggcgct tgcactgcct aattggcaaa 5221 agcgcgtcca agttgctagt gattttttat tttttttttt tagttttagt ttttagtttt 5281 gtttttggcc gcccaattaa catttcccac gctcgccgcg ctcataattt atgctaattt 5341 ccagttgcat aattcactga aaacgaaagc agcagcaaca aataacacgg caagttaatg 5401 gccaaataaa aaggcaagtt accttacctt cgcctttgaa ttttttctgg tcttaaatat 5461 agctattgct atatttgcag tcccgtttat ttgccttaca ctttttttta tggcccataa 5521 aatcaaatga tgcctgatta gggggagcca acaaaaaagg taacaaacag gacattgata 5581 gcggggaaat cccctttttt gcattcggaa aacagcaagt tttaaaatct acgcaacata 5641 acagatttat gttagccaga gggaaatttt aacagcagcc aggcgacaaa agtttcattt 5701 tcgctattgc cttcttcgaa aagggaaatt tctttattat tctttatatc tatatttccc 5761 caactagcta ttaatttcaa ttaagaaaat attttgagaa atattagctc ttaaatgggt 5821 ttatctttaa aaatgcatac attatcttct tttaattatt tttttaaatc attttaaaaa 5881 ggtgttactg caattgtttt gtgatttttg gtcgccattc aatgattgcc aaagccaaca 5941 aaaaccacat tgcgtgtgtc gtcacaagca agtgtcaatc acagtcaccg cagtgcaatt 6001 gtcctgccac gcccccatta ccgcccaccc acacgcacac acaacaaaac acttttccag 6061 tttttaatta aatgaaatgc aagcgaagag ttatagcaga cactgcgcca gagcgagacg 6121 gggcgataag tgaaatgcac acaaaatgaa aagccattaa cgaaatatta tatctgaaga 6181 tggagggagt agcaatgtca gctgcatccg gtttgggata taaaaagcgc acaaatttcg 6241 gaagtttttc tgcaccaaga gaaacagttg tgcgtgttag ccaaaaagtt taaaaatatt 6301 tgtactaaat ttcccagttt tgggcaacac agaaatatct tgaaaagcta ttcagtttcg 6361 aaaatagctg aagcttggtg tttagaggaa tttctagatt ttttcctagt gtctttgatg 6421 ttatttatgc gcaaggcatt taataggtta cccccgaatt atgactcgcc ccaagtgaag 6481 aagaagtaat tcggtcatgg agggggaggg cggggggttg cttgttggag accgcaaatc 6541 ataattgttg cggacacaca agacacaaca aactcaaatg gatggtccag gagttggggt 6601 ggtggtgtgg tggagtggac tcctccacgt ggtcataaca atgcaatctg tgtggccaca 6661 cacaaaaagg acattagccc tgctcctttc cacgccagtt tgctttgctt tcagccattg 6721 gctgttgctg gtgcttgtgg atttgacctt tatactttat actttatact ttgttatgta 6781 ttttatttta ttgggtcgcc aatgagcgat gagtatgaac actgaaagtg cttaagatac 6841 tgtgaaatga gctgggacgg cttggaaagc ggttaaccgc ttaaccggtt cataaccgat 6901 acggattcct gaaaatgctc tataacggat atgccaaagc tgattaaaac atttcagcga 6961 aagcaattga gccgtatatc tctaaatccc tttcaaccaa ccatacaatg caattttgaa 7021 ttcaaaaagc tcgtcaacga acaaaaaggg gaaacctatg ctctgccaat tgttggacca 7081 acaaaatgga atggcaaaaa aaaaaacgaa aaaaaaaggc aaaagcttag ccggaaatat 7141 ccatcattga acatttccca ctgtaccggc gttttatcta tgggcccgcg tgtttcgcgt 7201 gtcgcttccc caaacgcaac gggcaataca aaagcaatca taaagttata gcccggtcga 7261 aacagtcgcc acttcggtcg tgccacactg cctgcaccga ccatactgct gccagttggc 7321 catttccatt tccatttcca ctaacgtggc cggttttcgg tccagttgct ggcccccaat 7381 gaactcgaag caaaaaccaa ctttacaccc tagggcgaca ttatccacca ggcagaacat 7441 ccacccatcc gcccactttc taaaaaacag cgctgatgtg ttgtctttac accacacaaa 7501 tattgtagtg aattttcagg tgaatttcta cttcaaaagt atttgaattc ataattgatt 7561 tgaataattt tcgatatttt tttgataggc ttatttattg tctgggtttt aaatcttatt 7621 atatgctctt ttttttatta aagatcgctg gcatttccgc ttttcctttg cccatttccc 7681 ccattttacc cacaaccatg tcatttaatg tcctatctat gttactgctt cttttttcgc 7741 ccaccttttt ggctcaataa gagcgacgaa tttattgctt gctaatagga aaacagcctc 7801 cctttggact tttccacaag cccccaacat tttccccatt ttcctcggct tttccctcgt 7861 tttgcgggac gacaaagttt gtccacattt tttgtttgct ttgttggaat gggaatggga 7921 atgggaatcg ggaatgggaa tcccctggag cagaggaaaa atatgttttc aacataattt 7981 cattcattat attcgaattg ttattgttgt tggtctgttg gccgatgttg gcgctcattt 8041 tcagccgacc cattatcggg ccacgccccc ccttcaatct cttctcgcgg agaaagacgc 8101 aaggtgtggg cgtgtagcat tttggctaat ttgaatttga tttcattcgg aaagtttgcc 8161 gtttttggca tttgtttcat ggcgctgttt tgattctcgt gcgacaagtg caaatgattg 8221 tgctcgtgag ttgattaatt gaaaatgaat gcgcgggtag gggtgaaatt gattatcgtt 8281 ttgcaaccaa tttttggatt ttcttgaaat ttatcgaaat tatctctagc caaaaaaaaa 8341 acacaaaaag agaaggtcgg aatatggaac aattcatcat cagcttgttt tgccagaccc 8401 aattaaattc agcgaaatta aaaggatact aaatatttgg cccgaaattc ggcgaaaaca 8461 tccttagcac aaatgaaatg aacctctaag gtttcacagg aatacaaaaa aaaaaataga 8521 tgttccacaa atacggattt aaaaagtcct ctcgcggccc aaaaaaaaaa aaaaagaaaa 8581 tcctttcaaa tgcgtgagtg tgcgtgcgtg tcatatatat cactagtcac taaattaaaa 8641 aaaataaaca aaaaggaaaa aacaggcgtt gaagaaaacc taattaataa acatatttat 8701 atggtaattg gagcaagcat acgaaaaccg actcaagcga cagcgaaacc aaagtgtaaa 8761 aatgttgaaa tattttttac aaatcgaatc gggctaaaaa gctaacaaaa tgcccaaaaa 8821 tggggctaaa aggggttgca ctttggacat taattgaact cgaccctttg gggtcgctac 8881 catttgccac aggacattgt gtgctccagc agtttataca taaacgcata gatatatgaa 8941 tataaatata taaatatata tatataaaga tatttgggat cgggggcatt gtggggccgg 9001 cgaaactaac actaaaatga taatgaaaaa atcgagcaaa tcgcataaag gagacatttt 9061 ttttagaacg tacctttaat agaacgatta agaagcgttc acgcagaaca actaacacta 9121 attttaatgc atacatttaa tggtaaaatt aacataaaac caaaactaac aaatgacatt 9181 gataagcgat atacacagcg aaaggaaatt agcaaaattg tttaataata agcgaagcaa 9241 accaaacacg aattgaatta acttttaaga acataacaaa caaaaaaaaa accgaaaaaa 9301 aaaacgaaca agaaattaag acaagatatt taaacgaagc caagaaaaaa aaactataaa 9361 attatacgat ttacaaaact aagaacaaca aaaaataatt gtaaaaatag agacaacttt 9421 tttttgctca aagccagggg gcagatccct caccctcatt cactttccca aaaaaaaaat 9481 aaatacattt aaacacgaaa ataaaaaata tatttcgcgg cacgtaaaaa tttgttcgtc 9541 acgaatgtaa accaaccaca aaaaatccaa cacaaaacga ttttctaaac gaaatgtttg 9601 cagaaattgg ccaacccaaa accaaataat gtttaaaatt aaaccaacat tcaagtaaaa 9661 ccacaagaag ataagaaaga aaaaacataa gaaattataa ttaaaaccaa aacttagctt 9721 ctagtgagag aatttttaaa acaaagcaaa aatgaaacga tagaaaatgc cccagaaacc 9781 aaaatatgaa acaatgttaa caaatcgagg aaggattaat ataaaaatgg aataataaga 9841 tcggctagcc gacactcaaa tacccttgca atcgattaca aaagtctaga atcatgaaaa 9901 tggaatacga actcaaatct ttcaaaaaaa aaaaatatcc tctttactgt tactttaatt 9961 actaagatac tttttactga gtttttttaa attgaagaaa ttttttagtt tacagaccta 10021 atacgtaaat atgttgtaca attaaacagt tctaaaatcg attccgatta tgaaatgagc 10081 aaatgagaat tcatgttgag aacgtacgat tgcaaggata tcaaaaacaa agtttcgaag 10141 gaagaaacgc gaaacctaaa accaaatgag aaaccgaaat ttaactagag aattcttttc 10201 aaatatcaaa taaagcaaga acattaataa tataatataa tatttcagcc acgatgggag 10261 agctaagaag tgaataaaac aaacgaatgc aaccaaccca gtaacaacaa caacaacaca 10321 cacacacatt tcaattgcgc tcgtttagcc catatatagt atatttcaat taaaagaacg 10381 aaaaaaaaaa caacacatta caatatttca atatgtcatt aagtcacagc gaataaacaa 10441 caacaataag ttgaaggcga cttacaaatc taaacgagag agaaactgcg atcgtgtgtg 10501 cgaggg