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LOCUS NM_001298077 4521 bp mRNA linear INV 26-DEC-2023 mRNA. ACCESSION NM_001298077 VERSION NM_001298077.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 4521) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 4521) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 4521) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 4521) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 4521) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 4521) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 4521) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 4521) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 4521) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 4521) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 4521) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 4521) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 4521) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 4521) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 4521) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 4521) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 4521) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 4521) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 4521) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 4521) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 4521) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 4521) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 4521) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..4521 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..4521 /gene="Smox" /locus_tag="Dmel_CG2262" /gene_synonym="CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp" /note="Smad on X" /map="7D14-7D15" /db_xref="FLYBASE:FBgn0025800" /db_xref="GeneID:31738" CDS 880..2340 /gene="Smox" /locus_tag="Dmel_CG2262" /gene_synonym="CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp" /note="CG2262 gene product from transcript CG2262-RB; CG2262-PB; Smox-PB; sisters against dpp; temporarily deranged; Smox/dSmad2" /codon_start=1 /product="smad on X, isoform B" /protein_id="NP_001285006.1" /db_xref="FLYBASE:FBpp0309145" /db_xref="GeneID:31738" /db_xref="FLYBASE:FBgn0025800" /translation="MLPFTPQVVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKIKKNS QLEELERAISTQNCQTRCVTVPRSKPAPAGEHLRKGLPHVIYCRLWRWPDLQSQNELK PLDHCEYAFHLRKEEICINPYHYKKIELSILVPKSLPTPPDSIVDYPLDNHTHQIPNN TDYNAAIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAA SAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNMSRL TPPADAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGL LSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATV CKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV TSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS" misc_feature 898..1269 /gene="Smox" /locus_tag="Dmel_CG2262" /gene_synonym="CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp" /note="N-terminal Mad Homology 1 (MH1) domain of receptor regulated SMADs; Region: MH1_R-SMAD; cd10488" /db_xref="CDD:199812" misc_feature order(970..972,982..984,991..993,1081..1086,1093..1107, 1114..1116,1171..1173) /gene="Smox" /locus_tag="Dmel_CG2262" /gene_synonym="CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:199812" misc_feature order(1063..1065,1198..1200,1234..1236,1249..1251) /gene="Smox" /locus_tag="Dmel_CG2262" /gene_synonym="CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp" /note="Zn binding site [ion binding]; other site" /db_xref="CDD:199812" misc_feature 1732..2304 /gene="Smox" /locus_tag="Dmel_CG2262" /gene_synonym="CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp" /note="C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3; Region: MH2_SMAD_2_3; cd10985" /db_xref="CDD:199826" misc_feature order(1783..1785,1798..1803,1807..1809,1840..1854, 1864..1866,1876..1878,1885..1887,1891..1896,1912..1917, 1921..1929,1936..1938,2143..2145,2152..2154,2161..2163, 2173..2175,2179..2181,2191..2199,2212..2214,2218..2220, 2230..2232,2245..2247,2251..2253,2257..2259,2263..2265, 2272..2277,2281..2286,2293..2298) /gene="Smox" /locus_tag="Dmel_CG2262" /gene_synonym="CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp" /note="trimer interface [polypeptide binding]; other site" /db_xref="CDD:199826" ORIGIN 1 cacagtcggt cacactattg ttgggcagca agtctgggca cactgcaact ttgcgaatag 61 caaaatcgcg aaacgcaaaa aattatatta ctcccataaa gcacaattcg aacgtaaagt 121 gaactactaa cgtatagaaa ataaacacaa agagcataac ataagaacaa acaacaagga 181 ggcgtttaaa tatttatcaa aataagttct ctgttcttgt tgtgcctctg tgtgtttgtg 241 tctgtgcgct cgtttaactg tgtgtgtgct ccttgcgtgt cggtgtgcgg tgcctgtgct 301 ttggtgtgcg tgtgcgtata gctgtcactt tctggcgcgc acacaagata tatacacaca 361 gaaatttgaa gaagcggtgc ccaccacacg gccccctccc cgttccagac aaccatcaac 421 gccaccagca ccaccaccac caccccctcc tgttggcgcg gctcggctcg gctcggctgg 481 atgtgtgcgc ccggttccgg tgccttttgg ttaccgttcc cgtgcatctg gacctggaag 541 cagtgtgtgc gtgcgagtga gcgggcacga tagaagttga aagagcaggc gaaaggagca 601 agagcaggac gacagaggag ctcgagttgc cggtaccgtt acagatcaga agtgcacaag 661 ggaagcagca gcagcattag gactgttcca gttccacttc ccagtcccgt tccagtattc 721 cagagaaggt gatcgaaata aaactaaaac taaaactcga ccaacgccag cagtgagagc 781 agtattcaaa aggcaacgca gagttggagg aggaggagct agtggacgcg gaggacacca 841 ggaaagccca ggagaactcc ccccccctga gaccctgaga tgttgccatt caccccgcag 901 gtggtcaagc gtttgttagc actcaaaaag ggcaacgagg acaacagcgt cgagggcaag 961 tggtcagaga aggccgtcaa gaatctggtc aagaagatca agaagaattc gcagctggag 1021 gagctagagc gcgcgatctc cacacagaac tgccagacgc ggtgcgtgac ggtgccgcgc 1081 agcaagccag ctcccgccgg cgagcatctg cgcaagggtc tgccgcacgt catctattgc 1141 cgcctgtggc gctggcccga tctccagagt cagaatgaac taaagcccct cgatcattgc 1201 gagtacgcct tccatttgcg caaggaggag atctgcataa atccgtacca ctacaaaaaa 1261 attgaactgt ccatcctggt gcccaaatcg ctgcccacgc cgcccgactc cattgtggac 1321 tatccgctgg acaaccatac gcaccagata cccaacaaca ccgattacaa tgcggcgatc 1381 attcgcagcg cctcgttgag tccgccgcag tacatggaat tgggcggtgc cgggcccgtt 1441 tccgtatcat cgtctgccag ttcgacgcca gcgactgccg ccggtggtgg tggtggtccc 1501 tcctcgtcgt cgtcgtcgtc atcgtccgcc gcctccgcct atcaacagca acagcagcag 1561 ctgtcctttg gccaaaacat ggactctcaa tcgagtgtgc ttagtgtggg cagcagcatt 1621 cccaacaccg gcaccccgcc gcccggctat atgagcgagg atggtgaccc catcgatcct 1681 aacgacaaca tgaacatgtc gcgtctaacg ccgcccgccg atgcagcgcc ggtgatgtac 1741 cacgagccgg ccttttggtg ttccatctcc tactatgagc taaatacgcg tgtcggcgag 1801 acgttccatg cctcgcagcc ctcgatcacg gtggatggct ttaccgatcc ctccaattcg 1861 gagcgctttt gcctcggact gctgtctaat gtgaatcgca acgaggtcgt ggagcagaca 1921 cgtcgccaca tcggcaaggg cgtacggctt tactatattg gcggtgaggt attcgcagaa 1981 tgtctgagcg attcgtccat tttcgtacag agcccaaatt gtaatcagcg atatggctgg 2041 catccggcca ccgtatgcaa gataccgccc ggttgcaacc taaagatctt caacaaccag 2101 gagtttgccg ccctgctgtc gcagtccgtg tcgcagggat tcgaagcggt ctaccaattg 2161 acacgcatgt gcaccatccg catgtcgttc gtcaagggct ggggcgccga atatcgccgc 2221 cagacggtga cctcaacgcc ctgctggatc gaactccatc tgaacgggcc gctccagtgg 2281 ctggatcgcg tgctcacaca gatgggttcg ccacggctgc cgtgcagctc catgtcataa 2341 gcgcacggcc ggttccggtt ttcaatcttc cccctccccc aattttccgc acagaaagcg 2401 ccggagttta aggcccattt ttgggtttga aagaagatcc acagaaatcc cagtaaacgg 2461 ctctgacaag taacactgac gatgaatgga tactatcctc aagaatttgc ggtagtcaat 2521 atcgtttatt atcgattttt attcacattc gagagaaatt tcaatggtta ttaagatgaa 2581 attggtatgc aatcaatgtg cttttgttcg gctttgtagt gatgtagttt aaataccctc 2641 tgtcagggta taaaatttaa ttatgtcact agctctagaa aaagtacatt tcacttgccg 2701 aaagctgtac aaattgatgt tgaaaaaaac tacttgaatc cttgatgtaa caagaacttc 2761 cgcatcatcc aaaaatacta tatacagctc tattcatgtt gaatatgacc cgagattcat 2821 cagtgttact agtcagcagc tccgcgggat atcaaaatga gaatcggaat tggtttcaaa 2881 gagaaaacca agaaaaattc tgagagcaca tatgaaataa gttcaggcaa attatatacg 2941 agtacataaa tgagtaattg aaaaacaaat ggtagatgca aaccagatgc agatatatct 3001 atatacaaag agcacacact tacatgtggg atatatatct ttacaagcat atatgagaga 3061 gaacatgtat ttggcgttac aagtttagga ctatatattg tgtaggtgga aacgtggaga 3121 gagttacagt tttcgataag aagcaacaat ttttttaaac attttacata caaaaaaaaa 3181 aaaaaaaaaa gaaaaccaaa agcacatgag gaaataaccg aaatggaacc gaccaggaac 3241 acaaaaaaac caaaagatac cccgaatctg tgtgcgtaaa gttggtagcg ctagaagcga 3301 gagagtcaaa attctttgag aaagaagcaa aacaattaaa ttggtgattt ggaacaaaaa 3361 tgaatgagca aaacaggaac tgggatttat caagcttgaa gcttacacac acagacacac 3421 taccatacat tgcaaatgta cataagacca aaataatgaa attattcacg caggacctcc 3481 acttgatcga gtatgggatt atagatatat ccgtttgaag atggttgtta aacgtttcga 3541 ttttcgctta gtacgtgtgt gttaaaaaat tcgtaaactc ttaaagcgca gtcagctctt 3601 gttagtcgta atatccgtaa aatgcgatca tatatcctat gtgtaaagca cttgcccaac 3661 aaaatttgaa tgccgcaagc caggtctggc ccatctaagg tgccattttg ttcagaactg 3721 catttattgt gtaccaaatg agagattctt gattctttta cagcatcgta tttgaaacga 3781 tagcttaacc aaccaatatg caatatggtt tgccgttgct ggccggattt tgcttggcaa 3841 gtgcacgttt ttcttgggtc tagatcttaa gtctatatat gtaacaaaat tcgctagctt 3901 atcttaacgt ttaaagagcc caaatccagt ttaagttcaa gttcaaattg tttttacgtc 3961 aatatttgct gattctttta attcttttgt ttttttttgc ccattgcttc gctgttacga 4021 ccaaaaataa ctgtaccgcc tggccagtgt tgggcagtga atggtgcgtg gcgggcagtg 4081 ttgcctagcg cacttgtcct ctggttccgg cgaaacttta atttaagttt tgtctattgt 4141 ttgccccctt tgttgctttt aagtttctca cgtgtgcagt ttagtgctaa gacacttagt 4201 cctgattgtc aatcaatcga ataaacgacc gcgaacgaga ttgtgttttg ttaattggct 4261 ctaatcactg tttttaatca aacaattgtt ttcgtatttc cggctaagcc cgcaaataat 4321 gtaatgtaat ccttaagtta tgcctaaacg aaacaaagca atgcaggcga acatgcaaca 4381 gcaacagtca acagtcctcc gaggacacaa ccacagagaa ccagcaaccc cgtacccgta 4441 actttataaa gtataaatac aaatatatac atatatctaa tatgcaagca tgcagataaa 4501 gacaaacaga atcgtatata t