Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster Glutamate-cysteine ligase catalytic subunit


LOCUS       NM_001298072            4238 bp    mRNA    linear   INV 26-DEC-2023
            (Gclc), transcript variant C, mRNA.
ACCESSION   NM_001298072
VERSION     NM_001298072.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4238)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4238)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4238)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4238)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4238)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4238)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4238)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4238)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4238)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4238
                     /gene="Gclc"
                     /locus_tag="Dmel_CG2259"
                     /gene_synonym="2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS;
                     DmGCSh; GCL; gclc; gclC; GclC; GCLc; GCLC; Gcs; Gcsh;
                     GCSh; mTOR"
                     /note="Glutamate-cysteine ligase catalytic subunit"
                     /map="7D6-7D6"
                     /db_xref="FLYBASE:FBgn0040319"
                     /db_xref="GeneID:53581"
     CDS             734..2887
                     /gene="Gclc"
                     /locus_tag="Dmel_CG2259"
                     /gene_synonym="2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS;
                     DmGCSh; GCL; gclc; gclC; GclC; GCLc; GCLC; Gcs; Gcsh;
                     GCSh; mTOR"
                     /EC_number="6.3.2.2"
                     /note="CG2259 gene product from transcript CG2259-RC;
                     CG2259-PC; Gclc-PC; glutamate cysteine ligase;
                     glutamate-cysteine ligase; catalytic subunit of glutamate-
                     cysteine ligase; gamma-glutamylcysteine ligase;
                     gamma-Glutamylcysteine synthetase catalytic subunit"
                     /codon_start=1
                     /product="Glutamate-cysteine ligase catalytic subunit,
                     isoform C"
                     /protein_id="NP_001285001.1"
                     /db_xref="FLYBASE:FBpp0309124"
                     /db_xref="GeneID:53581"
                     /db_xref="FLYBASE:FBgn0040319"
                     /translation="MGLLSEGSPLSWEETKALADHVREHGVNQFINLYHRLKDRQGDI
                     LKWGDEVEYIIVKFDDEQKVARVALRAQDLLAQLNEKELADPNGVKSLWRPEYGAYMI
                     EGTPGKPFGGLMAHFNLVEANMRYRREEVTELLAKDECVMSITNFPRLGAPNFTYPLA
                     QPRPEDPLSSARSLYFPDEAIFPGHPRFKTLTRNIRKRRGEKVSIKLKVFKDTKTKLP
                     VEGAPPGEPDVVLLDAMGFGMGCCCLQLTFQACNITEARRLYDQLAPLCPIMLALTAA
                     SPIYRGYLTESDCRWNVISSSVDCRTEEERGLAPLDQQKFRIAKSRYDSIDSYLSPEG
                     AKYNDVPLTYDEKVYQRLVEGGIDHLLAQHVAHLFIRDTVSLFSEKVHQNDNEDTDHF
                     ENIQSTNWQTMRFKPPPPNSSIGWRVEFRPCEAQISDFENAAIVCFVVLLTRVILSYQ
                     LNFLTPISKVDENMQTAQKRDACRKEKFWFRKSSKTTEQRAAKAQAQAQAQAKAQAQT
                     NGKATLNGNGLANGNGNGSENSDQEEQQPLTNGSAKMNGHGSGTTNGTNGSSNGSSNG
                     TDSDHTDTDDEENELFQLLSINEIFNGKPNVFPGLVPLIRSYLQSMEVDTDTHCTIEQ
                     YLRFIQKRAAGELITTATWMREQVLSHPDYKQDSVVSERINYDLLKRIQGIQEGKQVE
                     PALLGQDYHSKTKTKDFIPPALQKQLAKNGCCEEK"
     misc_feature    1427..2758
                     /gene="Gclc"
                     /locus_tag="Dmel_CG2259"
                     /gene_synonym="2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS;
                     DmGCSh; GCL; gclc; gclC; GclC; GCLc; GCLC; Gcs; Gcsh;
                     GCSh; mTOR"
                     /note="Glutamate-cysteine ligase; Region: GCS; pfam03074"
                     /db_xref="CDD:460796"
ORIGIN      
        1 cacattcaaa atttgtattt aaagtggagc gttttattgt tttgggcatt cgttagtgtt
       61 aataacactg tttacgtcga cggagaattt ggcggcaaag gaaacgcaat accaaagtcg
      121 cgtttaaaga aattacaaat atacaaaata aatacggtaa tttcgagtcg aataattatt
      181 gtgaaatacc cccccacaca cacacacaaa cacactctca cacccacaca ctcagcacaa
      241 ttccaattgg aaagaacctt tccgggcggg ggagcacgtt tcgcgtaaat ttcgcccatg
      301 attttagaga tttcttgatc tctattccgg tggcagccgc atttctataa ttaaaaccga
      361 agctgaacca gcaacagcga ataaaaatcc aatttgaaag aaaaccagtc cgcattatct
      421 gtttacatcc aaagagagca gctgacgccg cagctgtaaa ttagagggtg tgaagtgagg
      481 aaaacacgcg acctgctaac tgaatcattt gttatttttc tttttttgtt cttgtaatac
      541 taataatcgt gaattcaatt tcgatagaaa cacacacaca ccaacacaca tcgcaacacc
      601 aaaaacataa taaggaaata gtgagagcgc aaaaacagcg gtaaattcgg caaataacgt
      661 tacacaaccc accaaaactg cagcgagaga gcggcagaga gcgaaacaga gtgacgaaga
      721 acaaaaagca gcaatgggtc tactgagcga gggcagtcca ctctcctggg aggagaccaa
      781 ggcgctggct gatcatgtgc gtgagcatgg cgtcaatcag ttcatcaact tgtaccacag
      841 actcaaggat cgccagggtg acatattgaa atggggcgac gaggtggagt acattattgt
      901 caagttcgac gatgaacaga aggtggcacg tgtggcgctg cgcgcccagg atctgctggc
      961 acagctcaat gagaaggaac tggccgatcc caatggtgtc aagtcgctgt ggcgtccgga
     1021 atacggagcc tacatgattg agggcacacc gggcaaaccc tttggcggtc tgatggcaca
     1081 cttcaatctg gttgaggcca atatgcgcta tcgtcgcgaa gaggtcaccg agctgctggc
     1141 caaggacgag tgcgttatgt ccattacgaa tttcccacga ctcggcgcac caaatttcac
     1201 ttatccgctt gcccagccgc gtcccgagga tcctctcagt tcagcccgct cgctctactt
     1261 cccggatgag gccatctttc cgggtcaccc gcgtttcaag acactcacgc gtaacattcg
     1321 caagcgacgc ggcgagaagg tgtccatcaa gctaaaagtt ttcaaggaca caaagacgaa
     1381 gctaccggtg gagggtgctc cgcctggcga accggatgtg gtgctcctgg acgccatggg
     1441 cttcggcatg ggctgctgtt gcttgcagct caccttccag gcctgtaaca ttacggaggc
     1501 gcgtcgcctc tacgatcagc tggctcccct ctgtccgatc atgttggctc tgacggccgc
     1561 ttcgcccatt tacaggggct atctaaccga atcggattgt cgatggaatg tgattagctc
     1621 ctcggtggat tgccgcacgg aagaggaacg cggactggcg ccgctggatc agcaaaagtt
     1681 caggatagcc aagtcgcgat acgattcgat tgactcgtat ttgtcgcccg agggagccaa
     1741 atataacgat gtaccgctca catacgatga gaaggtctat cagcgtctgg tggagggcgg
     1801 tatcgatcat ctgttggccc agcatgttgc ccatttgttt atacgcgaca ccgtgtcgct
     1861 gttcagcgag aaggtgcatc aaaacgacaa cgaggatacg gatcatttcg agaacattca
     1921 gtccaccaat tggcagacca tgcgcttcaa gccgccgcca ccgaacagct ccattggctg
     1981 gcgtgtcgag tttcgacctt gcgaggcgca gatcagtgat ttcgagaatg cggccatcgt
     2041 gtgctttgtg gtgctgctca cccgtgtgat tctctcctac cagctgaact tcctaacgcc
     2101 gatcagcaag gtggacgaga acatgcagac ggcccagaag cgagatgctt gtcgcaagga
     2161 gaagttttgg ttccgcaaat cctcgaagac caccgagcag agggcggcca aggcgcaggc
     2221 acaagctcaa gcgcaagcta aagcccaggc ccagacgaat ggcaaggcca ctttgaatgg
     2281 caatggactg gcgaatggaa atgggaatgg cagcgagaac agtgaccagg aagagcagca
     2341 gcctctgacc aacggttcgg ccaagatgaa tggccacgga agtggcacca ctaacggcac
     2401 taatggctcc tccaatggat catcgaatgg caccgatagc gatcacaccg acaccgatga
     2461 cgaggagaat gagctgttcc agctgctgtc catcaatgag atcttcaatg gaaagcccaa
     2521 cgtttttccg ggtctggtgc cattgatccg cagctatttg cagtccatgg aggtggacac
     2581 cgatacgcat tgcaccattg aacagtatct tcgctttatc cagaagcgtg ccgccggcga
     2641 gctaatcacc acggccacct ggatgcgcga acaggtgctt agccacccgg attacaagca
     2701 ggattccgtg gtgagcgagc gcatcaacta cgatttgctg aagcgcatcc aaggcatcca
     2761 ggagggcaag caggtggagc cagcgctgct cggacaagac tatcattcca agacgaagac
     2821 gaaagacttc attccgccgg ccttgcagaa gcagttagcc aagaacggct gctgcgagga
     2881 gaaatgatcg aggagcgcgc tgcggacgcg ttcagcgcag ctggccgccg gtggccggcg
     2941 catgtgattc gggttttgtg ggtccgttcg gatggagtgc ggcatatatg ttgagggcaa
     3001 aggcaaaggc gaaggcgaag gcaacggcaa aacgaaacgg aatggatacg ttacggatac
     3061 ggagcaacat ttatcaatat tatttttaat agcataattt caaacggatt aacaattagc
     3121 gtgcaccaag atcctaattg tggacaaatg ttttgcggcc gtgcgtgacc ttttggaaat
     3181 gaaagtcaag cagaccagga aggaggaggc gacggagaag gagaggatgg attaaggaat
     3241 ggttatgggg cacatgagga tccacgtgcc gtaggatcct ccgccagcca cgatatcctc
     3301 caggaagtca ccatgctctc gtcatcgttt cgatggaact tcgagttcct cgaaccgtcg
     3361 atcgcagccg atttgccata gttatataga gagctaaatg ctaaaccaac tatataccag
     3421 cgtcaagaac tacaacggca acataaatct caactaagtg ccgttccacg agacctacaa
     3481 aaatatgaat acatatagtt caaaacgagg caaggttaaa agtgtatttc tgtttgtttt
     3541 cgtttatatc atatatattt attatactat tcctattctt ataaatgcaa gtacaatgaa
     3601 aagttgttta ttttttttaa tagatatatt tacacacaca cacacacata cacacgcaaa
     3661 tacacatttg tttaaaagtg gcctgctgtt attaaactag atatgataag tacacatata
     3721 acgaaaaaaa caacactgtg ctattataat ttattgtgta tgtgattgtt tccccattat
     3781 gatacgatta tgatttattg tgaccacaag caagcaaata aacggaaaat attgttgaat
     3841 ctttaaactt aatcgaattg ggtcgtccag gacttaggaa ctttttatat gatgccttct
     3901 gaatcaaaca aaaactgtac ttataaacta tttacgccta gtgaacgtta ttacaaaggg
     3961 gtttcccctg tgaattgtag tctaaaatag caaattgcgg ttataactaa tcaaaatgaa
     4021 aaaataaaaa caatatatat actacatatg tgtgccacag gcaaaacgtt taaccagaaa
     4081 aaaaaacttg ctagcattta aataaacatt tttataacgc atcccaagaa ttagcttgcc
     4141 cttaaaatca gtatttttat ataaatcact acacgtactg tcccccacaa acgagttaaa
     4201 tattatatgc aaataaagaa acgttttcct gaaaaccg