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Drosophila melanogaster tyramine beta hydroxylase, transcript


LOCUS       NM_001298067            3771 bp    mRNA    linear   INV 26-DEC-2023
            variant C (Tbh), mRNA.
ACCESSION   NM_001298067
VERSION     NM_001298067.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3771)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3771)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3771)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3771)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3771)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3771)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3771)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3771)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3771)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3771)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3771)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3771)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3771)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3771)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3771)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3771)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3771)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3771)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3771)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3771)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3771)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3771)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3771)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3771
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3771
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="Tyramine beta hydroxylase"
                     /map="7D2-7D2"
                     /db_xref="FLYBASE:FBgn0010329"
                     /db_xref="GeneID:31718"
     CDS             214..2226
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /EC_number="1.14.17.-"
                     /EC_number="1.14.17.1"
                     /note="CG1543 gene product from transcript CG1543-RC;
                     CG1543-PC; Tbh-PC; dopamine beta hydroxylase; tyrosine
                     beta hydroxylase; tyramine beta-hydroxylase;
                     Tyrosine-beta-hydroxylase; tyramine betahydroxylase;
                     tyramine beta-monooxygenase; tyroside beta-hydroxylase;
                     tyramine beta hydroxylase; tyramine-beta-hydroxylase"
                     /codon_start=1
                     /product="tyramine beta hydroxylase, isoform C"
                     /protein_id="NP_001284996.1"
                     /db_xref="FLYBASE:FBpp0309355"
                     /db_xref="GeneID:31718"
                     /db_xref="FLYBASE:FBgn0010329"
                     /translation="MLKIPLQLSSQDGIWPARFARRLHHHHQLAYHHHKQEQQQQQQQ
                     QQQQQAKQKQKQNGVQQGRSPTFMPVMLLLLMATLLTRPLSAFSNRLSDTKLHEIYLD
                     DKEIKLSWMVDWYKQEVLFHLQNAFNEQHRWFYLGFSKRGGLADADICFFENQNGFFN
                     AVTDTYTSPDGQWVRRDYQQDCEVFKMDEFTLAFRRKFDTCDPLDLRLHEGTMYVVWA
                     RGETELALEDHQFALPNVTAPHEAGVKMLQLLRADKILIPETELDHMEITLQEAPIPS
                     QETTYWCHVQRLEGNLRRRHHIVQFEPLIRTPGIVHHMEVFHCEAGEHEEIPLYNGDC
                     EQLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGFNPYVRLEVHFNNPEKQSGL
                     VDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGYCVADCTRAALPA
                     TGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKPRVLPG
                     DALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFI
                     YMKRTEHQHGVHLNGARSSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGR
                     SSWEGVAATPVQIRIPIHRKLCPNYNPLWLKPLEKGDCDLLGECIY"
     misc_feature    529..870
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="DOMON domain; Region: DOMON; pfam03351"
                     /db_xref="CDD:460893"
     misc_feature    1006..1383
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     N-terminal domain; Region: Cu2_monooxygen; pfam01082"
                     /db_xref="CDD:460053"
     misc_feature    1438..1908
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     C-terminal domain; Region: Cu2_monoox_C; pfam03712"
                     /db_xref="CDD:461021"
ORIGIN      
        1 agtttatgaa aagagggtat caagtagtct tgtttatgca aacacatcat cgatggactt
       61 cgcctatcaa taattgtgca atatcaacat ttgcagcagc agccatagcg aattaatttc
      121 aaagtgtttg gctattagtg attagcgata aacgatatcc gagaacaata attccgccac
      181 cgatctgccg gccgtgcaat ctcaaatctc aaaatgctta aaattccgct gcagctgagc
      241 agtcaggatg gcatttggcc agcccgattc gccaggcgac tccatcacca ccaccaactg
      301 gcttatcatc atcacaagca ggagcagcag cagcagcagc agcagcagca gcagcagcag
      361 gcgaaacaga aacaaaagca aaatggagtg cagcaaggac gttcgccgac atttatgcca
      421 gtgatgctgc tcctcctaat ggccacactg ctcacgcgcc cgctgagcgc cttctccaac
      481 cgcttatccg acacaaagct gcacgagatc tacctggacg acaaggagat taagctgagc
      541 tggatggtcg actggtacaa gcaggaggtg ctcttccact tgcagaatgc tttcaacgaa
      601 cagcaccgct ggttctatct gggtttctcc aagcgcggcg gcctggcgga tgcggatatt
      661 tgcttttttg agaatcagaa tggattcttc aatgcggtaa ccgatacgta caccagtccg
      721 gatggacagt gggtgagacg ggactaccag caggactgtg aggtcttcaa gatggatgag
      781 ttcacgttgg cgtttaggcg caagtttgac acctgcgacc ctttggattt gcgactccat
      841 gagggcacaa tgtacgtggt ttgggcccgt ggtgaaacgg aactggccct ggaggatcac
      901 cagttcgctc tgcccaatgt gacggcaccg cacgaggcgg gtgttaagat gctacagcta
      961 ctacgggccg acaagatact tatacccgaa accgagttgg atcacatgga gatcacactg
     1021 caggaggcgc caattcccag tcaggagacc acgtactggt gtcacgttca gcgactggag
     1081 ggcaatctcc ggcgtcgcca tcatatcgtt cagttcgagc cgctcatccg aacgccgggc
     1141 atcgtgcatc acatggaagt gtttcactgc gaggccggtg agcacgagga gattcccctg
     1201 tacaacggcg actgtgaaca gttgccgcca cgggccaaga tctgctcaaa agtgatggtc
     1261 ctgtgggcca tgggcgcggg cacctttacc tatcctccgg aagccggtct accaatcggc
     1321 ggacccggct tcaatccgta cgttcgactg gaggtacatt tcaataatcc ggagaagcag
     1381 tcgggcttgg tggacaactc cggctttcgc atcaagatgt cgaagacact gcgtcagtat
     1441 gacgccgccg ttatggaact gggtctggag tacaccgaca aaatggccat tccgcctggc
     1501 caaaccgctt tcccgctgag cggctattgt gtggcggact gcacacgagc cgctctgccg
     1561 gcgacgggca tcatcatctt tggctctcag ctgcatacgc atctgcgtgg cgttcgcgtc
     1621 ctaacccggc actttcgcgg cgaacaggag ctgcgcgagg tgaaccgcga tgactactac
     1681 tcgaatcact tccaggagat gcgcaccctg cactacaagc cgcgtgtcct gcccggcgac
     1741 gctttggtaa ccacttgtta ctacaatacc aaggatgaca agaccgccgc cctcggcgga
     1801 ttctccatca gcgatgagat gtgcgtcaac tatatccact actatccggc caccaaactg
     1861 gaggtctgca agagttccgt ttccgaggag acgctcgaga attactttat ttacatgaag
     1921 cgcacggagc atcagcatgg cgtgcatttg aatggagcca ggtcgtccaa ttaccggagc
     1981 atcgaatgga cccagccgcg tatcgatcag ctgtacacca tgtacatgca ggagccgctg
     2041 agcatgcagt gcaacaggtc cgatggcact cgcttcgagg ggcggtctag ctgggagggc
     2101 gtggctgcga cgcccgtaca aattcgcata cccattcacc gcaaactgtg ccccaactac
     2161 aatccgctgt ggctgaagcc attggagaag ggcgattgcg atttgctggg ggagtgcatc
     2221 tattaggggc gccgtacatt aggcattagg cgaataggcg aatgggggcg tggcatagca
     2281 cacactcaca cccacaccca cacacacaca cacacataca gcacatacaa cacacgcgca
     2341 cggcatggat aatatgagaa tttcgatttc aacagtcgcc tatgcaaaag ctaaactcat
     2401 tcacgtctat tttgaaagct taactcatga atacttttga atatttagca aaaaaagctt
     2461 gaaaacagat ctaaaaacat ttaaaaaaag gttattttac tcctattttg gttagttagt
     2521 tcttactaac agtaactaac tgatagccta aatgtttctg ttgactttac tttgaaattc
     2581 gcaacagaaa tcagaggaat cacttttttt ttgttttgtt ttttacgcct tatggaagtt
     2641 tgactgtagt cgctttgtat tttacccttt atctgcatgg tcattagcat tatcaacgcg
     2701 tttgtatgtg tgcgtgtgtg tgtgtgtgtg tgtgtgtaag ggcaacaggg caaaacaaat
     2761 gttttcactc tttaaataac taatgcattt accaatcctg cccatgttgt tcaccctttt
     2821 tactttcact ttcactttgc tttcgccttt gactttgttt gtgccctttg cccttgttgt
     2881 tttggccagc ctttgaaatt tgccgactga cagcgccgcc aggctagaac gtttaatacg
     2941 acacagctta caaagcatgg cccacacgca cacacacaca cacacacaca caagcgcgcg
     3001 cgcacagaaa cacacacaca caagcgcact gaacttggct gagacgaaac tgtagcatac
     3061 ttctcagcgc cagctgaaaa attaaatggc caactgactg aatgaaacgg aacgtactta
     3121 aacggacaaa ctggccggaa acaagatggc caagaaatgg atggcggact cactctgttt
     3181 atacaatata aatgagcaaa cttttgatgc aacccgacgt tgccaagtct aattaccaag
     3241 aaactcggcg agaaagacgg acaaaaatcg aaagagaaaa aaatatatat taaattggta
     3301 tgagatctta ttggaaatgt gaaaagttgg cgcagagggg atcatgggac atggtagatg
     3361 ggctaccaac agccaggagc ttaccacatg cacccatgtg tttctttcac aaaaagggga
     3421 atcctctagt cgccccattc gattccctat taatccaacc ctatcagtac cttcacgctt
     3481 ttcttacttt tcactaccgt tgaacctatc gacataaatg caccaacaca tacacatcca
     3541 cacaaccaca ccgacataca tttgagtaaa catgtaatgg atacgtttaa gtgtagccaa
     3601 catacatatg taagatgtga taattgttct atggctataa atgaaatata tatacacatg
     3661 aatatataaa ctatgtagat gaaatattta taaaaaacaa aaaccaagcg aaagcgaaac
     3721 caaaaaaaaa gtaaaatgta taattatcta ataaaaactg accaccatac c